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Molecular genetic diagnostic tests, which detect genetic abnormalities before symptoms appear, will almost certainly be a part of medicine in the 21st century. The Johns Hopkins University School of Medicine launched a voluntary program to genetically test people with a 50 percent risk of Huntington's disease, a genetically transmitted degenerative brain disease causing mental deterioration. Fifty- five persons received DNA analyses. Twelve people tested positive and 30 tested negative, while the tests of 13 proved inconclusive. Patients responded to the test results with reactions ranging from joy and relief to sadness and demoralization. No severe depressive reactions were noted in the short term from the knowledge of the test results. The data suggest that people who receive genetic test results are able to cope well, at least over the short term, when education, pretest counseling, psychological support and regular follow-up accompany the test., ABSTRACT: Clinical medicine in the 21st century is almost certain to include wide-scale use of molecular genetic diagnostic tests. In September 1986, The Johns Hopkins University School of Medicine initiated a voluntary program of presymptomatic genetic testing for Huntington's disease for persons at 50% risk. DNA analyses using the D4S10 (G8), D4S43, and D4S95 locus probes have been performed for 55 people. Twelve of the tests have yielded positive results, 30 were negative, and 13 were uninformative. Initial reactions ranged from joy and relief to disappointment, sadness, and demoralization. Thus far, there have been no severe depressive reactions. Although the sample size is small, our data suggest that people who receive genetic test results cope well, at least over the short term, when the testing is performed in a clinical context that includes education, pretest counseling, psychological support, and regular follow-up.

Contrasts two ways of reasoning about psychiatric disorders, the disease concept and the life-story method. Implications for the development of professional self-confidence in fledgling psychiatrists; Formulation of the patient's personality and situation.

Twenty patients with the diagnosis hysterical personality disorder were compared with a matched control group pf patients with other personality and neurotic diagnoses. Subjects' moods were assessed with a visual analogue scale 4 times a day for 5 consecutive days. Patients with a primary discharge diagnosis of hysterical personality disorder showed greater variability of mood than controls. Since emotional lability is said to be a characteristic hysterical trait, the results are taken as empirical support for the validity of one of the clinical judgements inherent in the diagnostic process. [ABSTRACT FROM AUTHOR]