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4. Pneumococcal Carriage

Author

Crook, Derrick W., primary, Brueggemann, Angela B., additional, Sleeman, Karen L., additional, and Peto, Timothy E. A., additional

Published
2014
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6. Guidelines for collection, analysis and presentation of vaccine safety data in surveillance systems

Author

Bonhoeffer, Jan, primary, Bentsi-Enchill, Adwoa, additional, Chen, Robert T., additional, Fisher, Margaret C., additional, Gold, Michael S., additional, Hartman, Katharina, additional, Heininger, Ulrich, additional, Hoet, Bernard, additional, Jefferson, Thomas, additional, Khuri-Bulos, Najwa, additional, Kohl, Katrin, additional, Marcy, S. Michael, additional, Nalin, David, additional, Pless, Robert, additional, Sanabria-Rojas, Hernan, additional, Sleeman, Karen, additional, and Wise, Robert, additional

Published
2009
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7. Guidelines for collection, analysis and presentation of vaccine safety data in pre- and post-licensure clinical studies

Author

Bonhoeffer, Jan, primary, Bentsi-Enchill, Adwoa, additional, Chen, Robert T., additional, Fisher, Margaret C., additional, Gold, Michael S., additional, Hartman, Katharina, additional, Heininger, Ulrich, additional, Hoet, Bernard, additional, Jefferson, Thomas, additional, Khuri-Bulos, Najwa, additional, Kohl, Katrin S., additional, Marcy, S. Michael, additional, Nalin, David, additional, Pless, Robert, additional, Sanabria-Rojas, Hernan, additional, Sleeman, Karen, additional, and Wise, Robert, additional

Published
2009
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14. Invasive Pneumococcal Disease in England and Wales: Vaccination Implications.

Author

Sleeman, Karen, Griffiths, David, Moxon, E. R., Crook, D. W., Knox, Kyle, George, Robert, Miller, Elizabeth, Waight, Pauline, Efstratiou, A., Broughton, K., and Mayon-White, Richard T.

Subjects
*STREPTOCOCCUS pneumoniae, *PNEUMOCOCCAL vaccines, *DRUG resistance
Abstract

Provides information on a study which examined the epidemiology of invasive pneumococcal disease (IPD) or Streptococcus pneumoniae in England, Wales, which will aid in planning the use of of pneumococcal vaccines. Subjects and methods; Serotype distribution of IPD; Drug resistance.

Published
2001

15. Genetic Diversity and Carriage Dynamics of Neisseria lactamica in Infants

Author

Bennett, Julia S., Griffiths, David T., McCarthy, Noel D., Sleeman, Karen L., Jolley, Keith A., Crook, Derrick W., and Maiden, Martin C. J.

Abstract

Neisseria lactamica, a harmless human commensal found predominantly in the upper respiratory tracts of infants, is closely related to Neisseria meningitidis, a pathogen of global significance. Colonization with N. lactamica may be responsible for the increase in immunity to meningococcal disease that occurs during childhood, when rates of meningococcal carriage are low. This observation has led to the suggestion that N. lactamica whole cells or components are potential constituents of novel meningococcal vaccines. However, the dynamics of carriage and population diversity of N. lactamica in children are poorly understood, presenting difficulties for the choice of representative isolates for use in vaccine development. This problem was addressed by the multilocus sequence typing of N. lactamica isolates from two longitudinal studies of bacterial carriage in infants. The studies comprised 100 and 216 subjects, with N. lactamica carriage monitored from age 4 weeks until age 96 weeks and from age 2 weeks until age 24 weeks, respectively. The maximum observed carriage rate was 44% at 56 weeks of age, with isolates obtained on multiple visits for the majority (54 of 75, 72%) of carriers. The N. lactamica isolates were genetically diverse, with 69 distinct genotypes recovered from the 75 infants. Carriage was generally long-lived, with an average rate of loss of under 1% per week during the 28 weeks following acquisition. Only 11 of the 75 infants carried more than one genotypically unique isolate during the course of the study. Some participants shared identical isolates with siblings, but none shared identical isolates with their parents. These findings have implications for the design of vaccines based on this organism.

Published
2005

16. Acquisition of Streptococcus pneumoniaeand Nonspecific Morbidity in Infants and Their Families

Author

Sleeman, Karen L., Daniels, Lesley, Gardiner, Marion, Griffiths, David, Deeks, Jonathan J., Dagan, Ron, Gupta, Sunetra, Moxon, E Richard, Peto, Tim E., and Crook, Derrick W.

Abstract

Most children are believed to acquire Streptococcus pneumoniaeasymptomatically, with only a few developing overt S. pneumoniaedisease. This study investigates the relationship between acquisition of S. pneumoniaeand mild nonspecific infection leading to general practitioner (GP) consultation.

Published
2005
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