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169 results on '"Sleiman, Intissar"'

2. Functional trajectories during hospitalization: a prognostic sign for elderly patients

Author

Sleiman, Intissar, Rozzini, Renzo, Barbisoni, Piera, Morandi, Alessandro, Ricci, Antonella, Giordano, Alessandro, and Trabucchi, Marco

Subjects
Aged patients -- Care and treatment, Aged patients -- Prognosis, Mortality -- United States, Mortality -- Statistics, Hospital care -- Influence, Hospital care -- Demographic aspects, Health, Seniors
Abstract

Background. Clinicians have used measurements of pathological conditions and functional status to capture the heterogeneity of older individuals for prognostic purposes. However, the literature pays low attention to physical functional changes. Methods. A retrospective cohort study to investigate the association between functional changes during hospitalization and 3-month mortality. A total of 1,119 acutely ill elderly patients admitted to four beds arranged like a high-dependency area in a geriatric unit (mean age 80.6 [+ or -] 7.8 years) were subdivided into four groups according to degree of functional decline at admission in comparison with the premorbid level and ability or inability to regain function at discharge: with moderate loss, able to regain (group a) and unable to regain function (group b); and with severe loss, able to regain (group c) and unable to regain function (group d) during hospitalization. Age, gender, cognitive and functional status (basic activities of daily living-[BADL]), serum albumin, Acute Physiology Score, Acute Physiology and Chronic Health Evaluation II score, comorbid conditions, number of drugs, and length of stay were collected. Results. Total 3-month mortality was 17.9%. Mortality rate was 10.7%, 17.6%, 14.5%, and 36.7% in groups a, b, c, and d, respectively. In three different multivariate Cox models including BADLs before admission, at admission, and at discharge, inability to regain function during hospitalization was an independent factor associated with 3-month mortality. Conclusions. In acutely ill elderly patients, lack of function regain during hospitalization is associated with higher mortality rate at 3 months, compared with those capable to regain the baseline functional status. Key Words: Function change--Elderly patients--Acute care--Hospital.

Published
2009

17. Effect of antihypertensive treatment with candesartan or ealapril on extracellular matrix of subcutaneous small resistance arteries of hypertensive patients with non-insulin dependent diabetes mellitus

Author

Rizzoni, Damiano, Porteri, Enzo, Rodella, Luigi Fabrizio, Rezzani, Rita, DE CIUCEIS, Carolina, Boari, Gianluca, Sleiman, Intissar, Paiardi, Silvia, Bianchi, Rossella, Ruggeri, Giuseppina, Muiesan, Maria Lorenza, Salvetti, Massimo, Zani, Francesca, Miclini, Marco, and AGABITI ROSEI, Enrico

Published
2004

18. Effetto del trattamento antiipertensivo con candesartan o enalapril sulla matrice extracellulare delle piccole arterie di resistenza sottocutanee in pazienti ipertesi con diabete mellito non insulino-dipendente

Author

Boari, Gianluca, DE CIUCEIS, Carolina, Rizzoni, Damiano, Porteri, Enzo, Sleiman, Intissar, Rodella, Luigi Fabrizio, Rezzani, Rita, Paiardi, Silvia, Bianchi, Rossella, Ruggeri, Giuseppina, Muiesan, Maria Lorenza, Salvetti, Massimo, Zani, Francesca, Miclini, Marco, and AGABITI ROSEI, Enrico

Published
2004

42. Effect of highly active antiretroviral therapy (HAART) and hepatitis C Co-infection on hyperlipidemia in HIV-infected patients: a retrospective longitudinal study

Author

Castelli Francesco, Sleiman Intissar, Quiros Roldan Eugenia, Patroni Andrea, Puoti Massimo, Carosi Giampiero, Cadeo Gian Pietro, Torti Carlo, Tinelli Carmine, Davide Bertelli, and Tomasoni Lina

Subjects
Adult, Male, medicine.medical_specialty, Longitudinal study, Hepatitis C virus, Population, Hypercholesterolemia, HIV Infections, medicine.disease_cause, Cohort Studies, Internal medicine, Antiretroviral Therapy, Highly Active, medicine, Prevalence, Humans, Pharmacology (medical), Longitudinal Studies, Prospective Studies, Adverse effect, education, Triglycerides, Retrospective Studies, Hypertriglyceridemia, education.field_of_study, business.industry, virus diseases, Hepatitis C, Hepatitis C, Chronic, Viral Load, medicine.disease, CD4 Lymphocyte Count, Regimen, Chronic infection, Infectious Diseases, Cholesterol, Italy, Immunology, Female, business
Abstract

Lipid abnormalities are among the most frequent treatment-limiting adverse events during HAART in HIV-infected individuals. Lipid disturbances have also been associated with hepatitis C virus (HCV) chronic infection in HIV-uninfected participants. HAART-induced lipid abnormalities may then have peculiar features in HIV-HCV co-infected individuals.To estimate the prevalence and incidence rates of hypertriglyceridemia and hypercholesterolemia and to identify associated factors in a large clinic population of HIV patients after HAART has been initiated.We performed a retrospective longitudinal follow-up study in a large cohort of HIV patients on their first HAART.The clinical databases of two major clinical centers in Italy participating in the MASTER study were merged. Treatment-emerging metabolic disorders in patients on their first HAART regimen (PI-based or NNRTI-based) who were stable for at least 4 months were prospectively analyzed by baseline parameters, drug regimens, and viroimmunological outcome of therapy. Follow-up was continued for 24 months or until drug discontinuation, whichever came first.Two hundred and eighty two (282) HIV-infected patients undergoing HAART (203 PI + 79 NNRTI; 65 including stavudine [d4T]) met inclusion criteria and were enrolled in the study from 1997 to 2001. Mean follow-up was 18.5 +/- 6.7 months. After HAART had been initiated, a statistically significant mean increase in total cholesterol over time was observed in comparison to baseline (p.0001), without difference between treatment groups (PI vs. NNRTI, with or without d4T). In the univariate analysis, predictive factors for HAART-induced hypercholesterolemia were baseline total plasma cholesterol and triglycerides values and CD4+ cell count differential increase over time, while a negative correlation was found with zalcitabine-including regimens and baseline HCV seropositivity. At multivariate analysis, only high baseline total plasma cholesterol and triglycerides values retained their predictive value and baseline HCV seropositivity was significantly associated with lower increase in total cholesterol values under HAART, regardless of treatment groups (p.001).HCV co-infection is an independent factor preventing the emergence of treatment-limiting total cholesterol increase under any HAART regimen, possibly reflecting impaired total cholesterol synthesis in the liver or total cholesterol hypercatabolism. On the contrary, no HCV influence on triglycerides plasma levels was noted. Our data do not suggest any favoring role of specific treatment or drugs (PI and/or d4T) on total cholesterol and triglycerides increase under HAART.

Published
2002

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