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Fifty-one adolescents aged 15 to 16 years and 43 young persons aged 21 to 32 years from risk and control groups were examined, their blood samples were tested for C-reactive protein (CRP) and C-terminal telopeptides (CTTP), by using immunoassay. Elevated CRP concentrations were found in risk-group adolescents and young persons as compared with healthy and comparison individuals, which suggested the development of an inflammatory process. The patients from these groups were observed to have increased CTTP. Thus, laboratory tests may be used for early diagnosis of inflammatory diseases of the periodontium.

The opportunity of use stimulated by sucrose solutions and urea test pH changes of the mixed saliva were investigated with the purpose of an estimation of efficiency of antiseptic and hygienic means action. Research is carried out on 37 students who have been specially picked up in 3 groups: "A" -- with low activity of caries without periodontitis, "B" -- caries-susceptible and "C" -- with gingivitis and periodontitis. It appeared possible with the help of pH-measuring of saliva to compare antiseptic action in an oral cavity of 4 popular antiseptics: the combined gel with chlorhexidine and metronidazole, and also anticarious toothpaste in the form of application and in combination with cleaning teeth by a brush. The offered tests allow to reveal primary action of antiseptic means for the microflora causing either caries or inflammatory periodontal disease.