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16 results on '"Slocum, Cheyanne"'

3. Evaluation of the rapid Idylla IDH1-2 mutation assay in FFPE glioma samples

Author

Solomon, James P., primary, Munoz-Zuluaga, Carlos, additional, Slocum, Cheyanne, additional, Dillard, Alicia, additional, Cong, Lin, additional, Wang, Jiajing, additional, Lindeman, Neal, additional, Kluk, Michael, additional, Liechty, Benjamin, additional, Pisapia, David, additional, Rennert, Hanna, additional, and Velu, Priya D., additional

Published
2024
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4. Data from Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors

Author

Galbraith, Kristyn, primary, Serrano, Jonathan, primary, Shen, Guomiao, primary, Tran, Ivy, primary, Slocum, Cheyanne C., primary, Ketchum, Courtney, primary, Abdullaev, Zied, primary, Turakulov, Rust, primary, Bale, Tejus, primary, Ladanyi, Marc, primary, Sukhadia, Purvil, primary, Zaidinski, Michael, primary, Mullaney, Kerry, primary, DiNapoli, Sara, primary, Liechty, Benjamin L., primary, Barbaro, Marissa, primary, Allen, Jeffrey C., primary, Gardner, Sharon L., primary, Wisoff, Jeffrey, primary, Harter, David, primary, Hidalgo, Eveline Teresa, primary, Golfinos, John G., primary, Orringer, Daniel A., primary, Aldape, Kenneth, primary, Benhamida, Jamal, primary, Wrzeszczynski, Kazimierz O., primary, Jour, George, primary, and Snuderl, Matija, primary

Published
2024
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5. Supplementary Table 2 from Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors

Author

Galbraith, Kristyn, primary, Serrano, Jonathan, primary, Shen, Guomiao, primary, Tran, Ivy, primary, Slocum, Cheyanne C., primary, Ketchum, Courtney, primary, Abdullaev, Zied, primary, Turakulov, Rust, primary, Bale, Tejus, primary, Ladanyi, Marc, primary, Sukhadia, Purvil, primary, Zaidinski, Michael, primary, Mullaney, Kerry, primary, DiNapoli, Sara, primary, Liechty, Benjamin L., primary, Barbaro, Marissa, primary, Allen, Jeffrey C., primary, Gardner, Sharon L., primary, Wisoff, Jeffrey, primary, Harter, David, primary, Hidalgo, Eveline Teresa, primary, Golfinos, John G., primary, Orringer, Daniel A., primary, Aldape, Kenneth, primary, Benhamida, Jamal, primary, Wrzeszczynski, Kazimierz O., primary, Jour, George, primary, and Snuderl, Matija, primary

Published
2024
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6. Supplementary Table 1 from Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors

Author

Galbraith, Kristyn, primary, Serrano, Jonathan, primary, Shen, Guomiao, primary, Tran, Ivy, primary, Slocum, Cheyanne C., primary, Ketchum, Courtney, primary, Abdullaev, Zied, primary, Turakulov, Rust, primary, Bale, Tejus, primary, Ladanyi, Marc, primary, Sukhadia, Purvil, primary, Zaidinski, Michael, primary, Mullaney, Kerry, primary, DiNapoli, Sara, primary, Liechty, Benjamin L., primary, Barbaro, Marissa, primary, Allen, Jeffrey C., primary, Gardner, Sharon L., primary, Wisoff, Jeffrey, primary, Harter, David, primary, Hidalgo, Eveline Teresa, primary, Golfinos, John G., primary, Orringer, Daniel A., primary, Aldape, Kenneth, primary, Benhamida, Jamal, primary, Wrzeszczynski, Kazimierz O., primary, Jour, George, primary, and Snuderl, Matija, primary

Published
2024
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8. Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors

Author

Galbraith, Kristyn, primary, Serrano, Jonathan, additional, Shen, Guomiao, additional, Tran, Ivy, additional, Slocum, Cheyanne C., additional, Ketchum, Courtney, additional, Abdullaev, Zied, additional, Turakulov, Rust, additional, Bale, Tejus, additional, Ladanyi, Marc, additional, Sukhadia, Purvil, additional, Zaidinski, Michael, additional, Mullaney, Kerry, additional, DiNapoli, Sara, additional, Liechty, Benjamin L., additional, Barbaro, Marissa, additional, Allen, Jeffrey C., additional, Gardner, Sharon L., additional, Wisoff, Jeffrey, additional, Harter, David, additional, Hidalgo, Eveline Teresa, additional, Golfinos, John G., additional, Orringer, Daniel A., additional, Aldape, Kenneth, additional, Benhamida, Jamal, additional, Wrzeszczynski, Kazimierz O., additional, Jour, George, additional, and Snuderl, Matija, additional

Published
2023
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9. Additional file 2 of Towards a single-assay approach: a combined DNA/RNA sequencing panel eliminates diagnostic redundancy and detects clinically-relevant fusions in neuropathology

Author

Slocum, Cheyanne C., Park, Hyeon Jin, Baek, Inji, Catalano, Jeff, Wells, Martin T., Liechty, Benjamin, Mathew, Susan, Song, Wei, Solomon, James P., and Pisapia, David J.

Abstract

Additional file 2: Figure S1. Immunohistochemical staining patterns for IDH1 R132H (top row), ATRX (middle row), and p53 (bottom row). IHC for IDH1 R132H was classified as either positive or negative. The staining pattern for ATRX was designated as either preserved if nuclear staining was present, lost if there was no nuclear staining, or inconclusive if staining was present in some tumor cells but absent in others. Staining for p53 was separated into one of four categories: 0 if there was absent staining for p53 indicative of a truncating mutation, 1 if the pattern of staining was as expected for central nervous system tissue and therefore not concerning for an underlying mutation, 2 if the stain was inconclusive or concerning for a subclonal mutation, or 3 if there was strong staining in a large number of tumor cells concerning for the presence of an underlying missense mutation.

Published
2022
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16. Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors.

Author

Galbraith K, Serrano J, Shen G, Tran I, Slocum CC, Ketchum C, Abdullaev Z, Turakulov R, Bale T, Ladanyi M, Sukhadia P, Zaidinski M, Mullaney K, DiNapoli S, Liechty BL, Barbaro M, Allen JC, Gardner SL, Wisoff J, Harter D, Hidalgo ET, Golfinos JG, Orringer DA, Aldape K, Benhamida J, Wrzeszczynski KO, Jour G, and Snuderl M

Subjects
Humans, Retrospective Studies, Gene Fusion, Oncogene Proteins, Fusion genetics, DNA Methylation genetics, Brain Neoplasms diagnosis, Brain Neoplasms genetics
Abstract

DNA methylation is an essential molecular assay for central nervous system (CNS) tumor diagnostics. While some fusions define specific brain tumors, others occur across many different diagnoses. We performed a retrospective analysis of 219 primary CNS tumors with whole genome DNA methylation and RNA next-generation sequencing. DNA methylation profiling results were compared with RNAseq detected gene fusions. We detected 105 rare fusions involving 31 driver genes, including 23 fusions previously not implicated in brain tumors. In addition, we identified 6 multi-fusion tumors. Rare fusions and multi-fusion events can impact the diagnostic accuracy of DNA methylation by decreasing confidence in the result, such as BRAF, RAF, or FGFR1 fusions, or result in a complete mismatch, such as NTRK, EWSR1, FGFR, and ALK fusions., Implications: DNA methylation signatures need to be interpreted in the context of pathology and discordant results warrant testing for novel and rare gene fusions., (©2023 American Association for Cancer Research.)

Published
2024
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