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2,199 results on '"Slutsky, Arthur"'

2. Mental health sequelae in survivors of cardiogenic shock complicating myocardial infarction. A population-based cohort study

Author

Fernando, Shannon M., Qureshi, Danial, Talarico, Robert, Vigod, Simone N., McIsaac, Daniel I., Sterling, Lee H., van Diepen, Sean, Price, Susanna, Di Santo, Pietro, Kyeremanteng, Kwadwo, Fan, Eddy, Needham, Dale M., Brodie, Daniel, Bienvenu, Oscar Joseph, Combes, Alain, Slutsky, Arthur S., Scales, Damon C., Herridge, Margaret S., Thiele, Holger, Hibbert, Benjamin, Tanuseputro, Peter, and Mathew, Rebecca

Published
2024
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3. A New Global Definition of Acute Respiratory Distress Syndrome.

Author

Arabi, Yaseen, Arroliga, Alejandro, Bernard, Gordon, Bersten, Andrew, Brochard, Laurent, Calfee, Carolyn, Combes, Alain, Daniel, Brian, Ferguson, Niall, Gong, Michelle, Gotts, Jeffrey, Herridge, Margaret, Laffey, John, Liu, Kathleen, Machado, Flavia, Martin, Thomas, McAuley, Danny, Mercat, Alain, Moss, Marc, Mularski, Richard, Pesenti, Antonio, Qiu, Haibo, Ramakrishnan, Nagarajan, Ranieri, V, Riviello, Elisabeth, Rubin, Eileen, Slutsky, Arthur, Thompson, B, Twagirumugabe, Theogene, Ware, Lorraine, Wick, Katherine, and Matthay, Michael

Subjects
ARDS, acute lung injury, pulmonary edema, Humans, Prospective Studies, Reproducibility of Results, Respiratory Distress Syndrome, Oximetry, Oxygen
Abstract

Background: Since publication of the 2012 Berlin definition of acute respiratory distress syndrome (ARDS), several developments have supported the need for an expansion of the definition, including the use of high-flow nasal oxygen, the expansion of the use of pulse oximetry in place of arterial blood gases, the use of ultrasound for chest imaging, and the need for applicability in resource-limited settings. Methods: A consensus conference of 32 critical care ARDS experts was convened, had six virtual meetings (June 2021 to March 2022), and subsequently obtained input from members of several critical care societies. The goal was to develop a definition that would 1) identify patients with the currently accepted conceptual framework for ARDS, 2) facilitate rapid ARDS diagnosis for clinical care and research, 3) be applicable in resource-limited settings, 4) be useful for testing specific therapies, and 5) be practical for communication to patients and caregivers. Results: The committee made four main recommendations: 1) include high-flow nasal oxygen with a minimum flow rate of ⩾30 L/min; 2) use PaO2:FiO2 ⩽ 300 mm Hg or oxygen saturation as measured by pulse oximetry SpO2:FiO2 ⩽ 315 (if oxygen saturation as measured by pulse oximetry is ⩽97%) to identify hypoxemia; 3) retain bilateral opacities for imaging criteria but add ultrasound as an imaging modality, especially in resource-limited areas; and 4) in resource-limited settings, do not require positive end-expiratory pressure, oxygen flow rate, or specific respiratory support devices. Conclusions: We propose a new global definition of ARDS that builds on the Berlin definition. The recommendations also identify areas for future research, including the need for prospective assessments of the feasibility, reliability, and prognostic validity of the proposed global definition.

Published
2024

6. Clinical relevance of timing of assessment of ICU mortality in patients with moderate-to-severe Acute Respiratory Distress Syndrome

Author

Villar, Jesús, González-Martin, Jesús M., Añón, José M., Ferrando, Carlos, Soler, Juan A., Mosteiro, Fernando, Mora-Ordoñez, Juan M., Ambrós, Alfonso, Fernández, Lorena, Montiel, Raquel, Vidal, Anxela, Muñoz, Tomás, Pérez-Méndez, Lina, Rodríguez-Suárez, Pedro, Fernández, Cristina, Fernández, Rosa L., Szakmany, Tamas, Burns, Karen E. A., Steyerberg, Ewout W., and Slutsky, Arthur S.

Published
2023
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8. Strategies for lung- and diaphragm-protective ventilation in acute hypoxemic respiratory failure: a physiological trial.

Author

Dianti, Jose, Fard, Samira, Wong, Jenna, Chan, Timothy, Del Sorbo, Lorenzo, Fan, Eddy, Amato, Marcelo, Granton, John, Burry, Lisa, Reid, W, Zhang, Binghao, Ratano, Damian, Keshavjee, Shaf, Slutsky, Arthur, Brochard, Laurent, Ferguson, Niall, and Goligher, Ewan

Subjects
Diaphragm-protective ventilation, Hypoxemic respiratory failure, Lung-protective ventilation, Mechanical ventilation, Diaphragm, Humans, Lung, Positive-Pressure Respiration, Respiration, Artificial, Respiratory Insufficiency
Abstract

BACKGROUND: Insufficient or excessive respiratory effort during acute hypoxemic respiratory failure (AHRF) increases the risk of lung and diaphragm injury. We sought to establish whether respiratory effort can be optimized to achieve lung- and diaphragm-protective (LDP) targets (esophageal pressure swing - 3 to - 8 cm H2O; dynamic transpulmonary driving pressure ≤ 15 cm H2O) during AHRF. METHODS: In patients with early AHRF, spontaneous breathing was initiated as soon as passive ventilation was not deemed mandatory. Inspiratory pressure, sedation, positive end-expiratory pressure (PEEP), and sweep gas flow (in patients receiving veno-venous extracorporeal membrane oxygenation (VV-ECMO)) were systematically titrated to achieve LDP targets. Additionally, partial neuromuscular blockade (pNMBA) was administered in patients with refractory excessive respiratory effort. RESULTS: Of 30 patients enrolled, most had severe AHRF; 16 required VV-ECMO. Respiratory effort was absent in all at enrolment. After initiating spontaneous breathing, most exhibited high respiratory effort and only 6/30 met LDP targets. After titrating ventilation, sedation, and sweep gas flow, LDP targets were achieved in 20/30. LDP targets were more likely to be achieved in patients on VV-ECMO (median OR 10, 95% CrI 2, 81) and at the PEEP level associated with improved dynamic compliance (median OR 33, 95% CrI 5, 898). Administration of pNMBA to patients with refractory excessive effort was well-tolerated and effectively achieved LDP targets. CONCLUSION: Respiratory effort is frequently absent  under deep sedation but becomes excessive when spontaneous breathing is permitted in patients with moderate or severe AHRF. Systematically titrating ventilation and sedation can optimize respiratory effort for lung and diaphragm protection in most patients. VV-ECMO can greatly facilitate the delivery of a LDP strategy. TRIAL REGISTRATION: This trial was registered in Clinicaltrials.gov in August 2018 (NCT03612583).

Published
2022

10. ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies

Author

Grasselli, Giacomo, Calfee, Carolyn S., Camporota, Luigi, Poole, Daniele, Amato, Marcelo B. P., Antonelli, Massimo, Arabi, Yaseen M., Baroncelli, Francesca, Beitler, Jeremy R., Bellani, Giacomo, Bellingan, Geoff, Blackwood, Bronagh, Bos, Lieuwe D. J., Brochard, Laurent, Brodie, Daniel, Burns, Karen E. A., Combes, Alain, D’Arrigo, Sonia, De Backer, Daniel, Demoule, Alexandre, Einav, Sharon, Fan, Eddy, Ferguson, Niall D., Frat, Jean-Pierre, Gattinoni, Luciano, Guérin, Claude, Herridge, Margaret S., Hodgson, Carol, Hough, Catherine L., Jaber, Samir, Juffermans, Nicole P., Karagiannidis, Christian, Kesecioglu, Jozef, Kwizera, Arthur, Laffey, John G., Mancebo, Jordi, Matthay, Michael A., McAuley, Daniel F., Mercat, Alain, Meyer, Nuala J., Moss, Marc, Munshi, Laveena, Myatra, Sheila N., Ng Gong, Michelle, Papazian, Laurent, Patel, Bhakti K., Pellegrini, Mariangela, Perner, Anders, Pesenti, Antonio, Piquilloud, Lise, Qiu, Haibo, Ranieri, Marco V., Riviello, Elisabeth, Slutsky, Arthur S., Stapleton, Renee D., Summers, Charlotte, Thompson, Taylor B., Valente Barbas, Carmen S., Villar, Jesús, Ware, Lorraine B., Weiss, Björn, Zampieri, Fernando G., Azoulay, Elie, and Cecconi, Maurizio

Published
2023
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12. Heparin Dose Intensity and Organ Support-Free Days in Patients Hospitalized for COVID-19

Author

Godoy, Lucas C., Neal, Matthew D., Goligher, Ewan C., Cushman, Mary, Houston, Brett L., Bradbury, Charlotte A., McQuilten, Zoe K., Tritschler, Tobias, Kahn, Susan R., Berry, Lindsay R., Lorenzi, Elizabeth, Jensen, Tom, Higgins, Alisa M., Kornblith, Lucy Z., Berger, Jeffrey S., Gong, Michelle N., Paul, Jonathan D., Castellucci, Lana A., Le Gal, Grégoire, Lother, Sylvain A., Rosenson, Robert S., Derde, Lennie P.G., Kumar, Anand, McVerry, Bryan J., Nicolau, Jose C., Leifer, Eric, Escobedo, Jorge, Huang, David T., Reynolds, Harmony R., Carrier, Marc, Kim, Keri S., Hunt, Beverley J., Slutsky, Arthur S., Turgeon, Alexis F., Webb, Steven A., McArthur, Colin J., Farkouh, Michael E., Hochman, Judith S., Zarychanski, Ryan, and Lawler, Patrick R.

Published
2024
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13. Predicting ICU Mortality in Acute Respiratory Distress Syndrome Patients Using Machine Learning: The Predicting Outcome and STratifiCation of severity in ARDS (POSTCARDS) Study*

Author

Villar, Jesús, González-Martín, Jesús M., Hernández-González, Jerónimo, Armengol, Miguel A., Fernández, Cristina, Martín-Rodríguez, Carmen, Mosteiro, Fernando, Martínez, Domingo, Sánchez-Ballesteros, Jesús, Ferrando, Carlos, Domínguez-Berrot, Ana M., Añón, José M., Parra, Laura, Montiel, Raquel, Solano, Rosario, Robaglia, Denis, Rodríguez-Suárez, Pedro, Gómez-Bentolila, Estrella, Fernández, Rosa L., Szakmany, Tamas, Steyerberg, Ewout W., Slutsky, Arthur S., Ambrós, Alfonso, del Campo, Rafael, Bueno-González, Ana, Hornos-López, Carmen, Pita-García, Lidia, Díaz-Lamas, Ana M., Arrojo, Regina, Soler, Juan A., Conesa-Cayuela, Luís A., del Saz-Ortiz, Ana M., Capilla, Lucia, Fernández, Lorena, Blanco, Jesús, Muriel, Arturo, Blanco-Schweizer, Pablo, Aldecoa, César, Rico-Feijoo, Jesús, Pérez, Alba, Martín-Alfonso, Silvia, Domínguez, Ana M., Díaz-Domínguez, Francisco J., González-Luengo, Raúl I., Carriedo, Demetrio, Soro, Marina, Belda, Javier, Gutiérrez, Andrea, Aguilar, Gerardo, Ferrando, Carlos, Civantos, Belén, Hernández, Mónica, Andaluz, David, Nogales, Leonor, Parrilla, Dácil, Peinado, Eduardo, Pérez-Méndez, Lina, González-Higueras, Elena, Vidal, Anxela, Pérez, César, and Kacmarek, Robert M.

Published
2023
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14. Prognostic factors associated with favourable functional outcome among adult patients requiring extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: A systematic review and meta-analysis

Author

Tran, Alexandre, Rochwerg, Bram, Fan, Eddy, Belohlavek, Jan, Suverein, Martje M., Poll, Marcel C.G. van de, Lorusso, Roberto, Price, Susanna, Yannopoulos, Demetris, MacLaren, Graeme, Ramanathan, Kollengode, Ling, Ryan Ruiyang, Thiara, Sonny, Tonna, Joseph E., Shekar, Kiran, Hodgson, Carol L., Scales, Damon C., Sandroni, Claudio, Nolan, Jerry P., Slutsky, Arthur S., Combes, Alain, Brodie, Daniel, and Fernando, Shannon M.

Published
2023
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15. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19

Author

Lawler, Patrick R, Goligher, Ewan C, Berger, Jeffrey S, Neal, Matthew D, McVerry, Bryan J, Nicolau, Jose C, Gong, Michelle N, Carrier, Marc, Rosenson, Robert S, Reynolds, Harmony R, Turgeon, Alexis F, Escobedo, Jorge, Huang, David T, Bradbury, Charlotte A, Houston, Brett L, Kornblith, Lucy Z, Kumar, Anand, Kahn, Susan R, Cushman, Mary, McQuilten, Zoe, Slutsky, Arthur S, Kim, Keri S, Gordon, Anthony C, Kirwan, Bridget-Anne, Brooks, Maria M, Higgins, Alisa M, Lewis, Roger J, Lorenzi, Elizabeth, Berry, Scott M, Berry, Lindsay R, Aday, Aaron W, Al-Beidh, Farah, Annane, Djillali, Arabi, Yaseen M, Aryal, Diptesh, Baumann Kreuziger, Lisa, Beane, Abi, Bhimani, Zahra, Bihari, Shailesh, Billett, Henny H, Bond, Lindsay, Bonten, Marc, Brunkhorst, Frank, Buxton, Meredith, Buzgau, Adrian, Castellucci, Lana A, Chekuri, Sweta, Chen, Jen-Ting, Cheng, Allen C, Chkhikvadze, Tamta, Coiffard, Benjamin, Costantini, Todd W, de Brouwer, Sophie, Derde, Lennie PG, Detry, Michelle A, Duggal, Abhijit, Džavík, Vladimír, Effron, Mark B, Estcourt, Lise J, Everett, Brendan M, Fergusson, Dean A, Fitzgerald, Mark, Fowler, Robert A, Galanaud, Jean P, Galen, Benjamin T, Gandotra, Sheetal, García-Madrona, Sebastian, Girard, Timothy D, Godoy, Lucas C, Goodman, Andrew L, Goossens, Herman, Green, Cameron, Greenstein, Yonatan Y, Gross, Peter L, Hamburg, Naomi M, Haniffa, Rashan, Hanna, George, Hanna, Nicholas, Hegde, Sheila M, Hendrickson, Carolyn M, Hite, R Duncan, Hindenburg, Alexander A, Hope, Aluko A, Horowitz, James M, Horvat, Christopher M, Hudock, Kristin, Hunt, Beverley J, Husain, Mansoor, Hyzy, Robert C, Iyer, Vivek N, Jacobson, Jeffrey R, Jayakumar, Devachandran, Keller, Norma M, Khan, Akram, Kim, Yuri, Kindzelski, Andrei L, King, Andrew J, Knudson, M Margaret, Kornblith, Aaron E, and Krishnan, Vidya

Subjects
Cardiovascular, Clinical Trials and Supportive Activities, Clinical Research, Hematology, Transplantation, Good Health and Well Being, Adult, Aged, Anticoagulants, COVID-19, Female, Hemorrhage, Heparin, Heparin, Low-Molecular-Weight, Hospital Mortality, Humans, Male, Middle Aged, Survival Analysis, Thrombosis, COVID-19 Drug Treatment, ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundThrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve outcomes in noncritically ill patients who are hospitalized with Covid-19.MethodsIn this open-label, adaptive, multiplatform, controlled trial, we randomly assigned patients who were hospitalized with Covid-19 and who were not critically ill (which was defined as an absence of critical care-level organ support at enrollment) to receive pragmatically defined regimens of either therapeutic-dose anticoagulation with heparin or usual-care pharmacologic thromboprophylaxis. The primary outcome was organ support-free days, evaluated on an ordinal scale that combined in-hospital death (assigned a value of -1) and the number of days free of cardiovascular or respiratory organ support up to day 21 among patients who survived to hospital discharge. This outcome was evaluated with the use of a Bayesian statistical model for all patients and according to the baseline d-dimer level.ResultsThe trial was stopped when prespecified criteria for the superiority of therapeutic-dose anticoagulation were met. Among 2219 patients in the final analysis, the probability that therapeutic-dose anticoagulation increased organ support-free days as compared with usual-care thromboprophylaxis was 98.6% (adjusted odds ratio, 1.27; 95% credible interval, 1.03 to 1.58). The adjusted absolute between-group difference in survival until hospital discharge without organ support favoring therapeutic-dose anticoagulation was 4.0 percentage points (95% credible interval, 0.5 to 7.2). The final probability of the superiority of therapeutic-dose anticoagulation over usual-care thromboprophylaxis was 97.3% in the high d-dimer cohort, 92.9% in the low d-dimer cohort, and 97.3% in the unknown d-dimer cohort. Major bleeding occurred in 1.9% of the patients receiving therapeutic-dose anticoagulation and in 0.9% of those receiving thromboprophylaxis.ConclusionsIn noncritically ill patients with Covid-19, an initial strategy of therapeutic-dose anticoagulation with heparin increased the probability of survival to hospital discharge with reduced use of cardiovascular or respiratory organ support as compared with usual-care thromboprophylaxis. (ATTACC, ACTIV-4a, and REMAP-CAP ClinicalTrials.gov numbers, NCT04372589, NCT04505774, NCT04359277, and NCT02735707.).

Published
2021

16. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.

Author

ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Lawler, Patrick R, Goligher, Ewan C, Berger, Jeffrey S, Neal, Matthew D, McVerry, Bryan J, Nicolau, Jose C, Gong, Michelle N, Carrier, Marc, Rosenson, Robert S, Reynolds, Harmony R, Turgeon, Alexis F, Escobedo, Jorge, Huang, David T, Bradbury, Charlotte A, Houston, Brett L, Kornblith, Lucy Z, Kumar, Anand, Kahn, Susan R, Cushman, Mary, McQuilten, Zoe, Slutsky, Arthur S, Kim, Keri S, Gordon, Anthony C, Kirwan, Bridget-Anne, Brooks, Maria M, Higgins, Alisa M, Lewis, Roger J, Lorenzi, Elizabeth, Berry, Scott M, Berry, Lindsay R, Aday, Aaron W, Al-Beidh, Farah, Annane, Djillali, Arabi, Yaseen M, Aryal, Diptesh, Baumann Kreuziger, Lisa, Beane, Abi, Bhimani, Zahra, Bihari, Shailesh, Billett, Henny H, Bond, Lindsay, Bonten, Marc, Brunkhorst, Frank, Buxton, Meredith, Buzgau, Adrian, Castellucci, Lana A, Chekuri, Sweta, Chen, Jen-Ting, Cheng, Allen C, Chkhikvadze, Tamta, Coiffard, Benjamin, Costantini, Todd W, de Brouwer, Sophie, Derde, Lennie PG, Detry, Michelle A, Duggal, Abhijit, Džavík, Vladimír, Effron, Mark B, Estcourt, Lise J, Everett, Brendan M, Fergusson, Dean A, Fitzgerald, Mark, Fowler, Robert A, Galanaud, Jean P, Galen, Benjamin T, Gandotra, Sheetal, García-Madrona, Sebastian, Girard, Timothy D, Godoy, Lucas C, Goodman, Andrew L, Goossens, Herman, Green, Cameron, Greenstein, Yonatan Y, Gross, Peter L, Hamburg, Naomi M, Haniffa, Rashan, Hanna, George, Hanna, Nicholas, Hegde, Sheila M, Hendrickson, Carolyn M, Hite, R Duncan, Hindenburg, Alexander A, Hope, Aluko A, Horowitz, James M, Horvat, Christopher M, Hudock, Kristin, Hunt, Beverley J, Husain, Mansoor, Hyzy, Robert C, Iyer, Vivek N, Jacobson, Jeffrey R, Jayakumar, Devachandran, Keller, Norma M, Khan, Akram, Kim, Yuri, Kindzelski, Andrei L, and King, Andrew J

Subjects
ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Humans, Thrombosis, Hemorrhage, Heparin, Heparin, Low-Molecular-Weight, Anticoagulants, Hospital Mortality, Survival Analysis, Adult, Aged, Middle Aged, Female, Male, COVID-19, Hematology, Clinical Trials and Supportive Activities, Transplantation, Clinical Research, Cardiovascular, General & Internal Medicine, Medical and Health Sciences
Abstract

BackgroundThrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve outcomes in noncritically ill patients who are hospitalized with Covid-19.MethodsIn this open-label, adaptive, multiplatform, controlled trial, we randomly assigned patients who were hospitalized with Covid-19 and who were not critically ill (which was defined as an absence of critical care-level organ support at enrollment) to receive pragmatically defined regimens of either therapeutic-dose anticoagulation with heparin or usual-care pharmacologic thromboprophylaxis. The primary outcome was organ support-free days, evaluated on an ordinal scale that combined in-hospital death (assigned a value of -1) and the number of days free of cardiovascular or respiratory organ support up to day 21 among patients who survived to hospital discharge. This outcome was evaluated with the use of a Bayesian statistical model for all patients and according to the baseline d-dimer level.ResultsThe trial was stopped when prespecified criteria for the superiority of therapeutic-dose anticoagulation were met. Among 2219 patients in the final analysis, the probability that therapeutic-dose anticoagulation increased organ support-free days as compared with usual-care thromboprophylaxis was 98.6% (adjusted odds ratio, 1.27; 95% credible interval, 1.03 to 1.58). The adjusted absolute between-group difference in survival until hospital discharge without organ support favoring therapeutic-dose anticoagulation was 4.0 percentage points (95% credible interval, 0.5 to 7.2). The final probability of the superiority of therapeutic-dose anticoagulation over usual-care thromboprophylaxis was 97.3% in the high d-dimer cohort, 92.9% in the low d-dimer cohort, and 97.3% in the unknown d-dimer cohort. Major bleeding occurred in 1.9% of the patients receiving therapeutic-dose anticoagulation and in 0.9% of those receiving thromboprophylaxis.ConclusionsIn noncritically ill patients with Covid-19, an initial strategy of therapeutic-dose anticoagulation with heparin increased the probability of survival to hospital discharge with reduced use of cardiovascular or respiratory organ support as compared with usual-care thromboprophylaxis. (ATTACC, ACTIV-4a, and REMAP-CAP ClinicalTrials.gov numbers, NCT04372589, NCT04505774, NCT04359277, and NCT02735707.).

Published
2021

18. A physiology-based mathematical model for the selection of appropriate ventilator controls for lung and diaphragm protection.

Author

Zhang, Binghao, Ratano, Damian, Brochard, Laurent, Georgopoulos, Dimitrios, Duffin, James, Long, Michael, Schepens, Tom, Telias, Irene, Slutsky, Arthur, Goligher, Ewan, and Chan, Timothy

Subjects
Decision support, Mathematical modelling, Mechanical ventilation, Respiration, Diaphragm, Humans, Lung, Models, Theoretical, Respiration, Artificial, Ventilators, Mechanical
Abstract

Mechanical ventilation is used to sustain respiratory function in patients with acute respiratory failure. To aid clinicians in consistently selecting lung- and diaphragm-protective ventilation settings, a physiology-based decision support system is needed. To form the foundation of such a system, a comprehensive physiological model which captures the dynamics of ventilation has been developed. The Lung and Diaphragm Protective Ventilation (LDPV) model centers around respiratory drive and incorporates respiratory system mechanics, ventilator mechanics, and blood acid-base balance. The model uses patient-specific parameters as inputs and outputs predictions of a patients transpulmonary and esophageal driving pressures (outputs most clinically relevant to lung and diaphragm safety), as well as their blood pH, under various ventilator and sedation conditions. Model simulations and global optimization techniques were used to evaluate and characterize the model. The LDPV model is demonstrated to describe a CO2 respiratory response that is comparable to what is found in literature. Sensitivity analysis of the model indicate that the ventilator and sedation settings incorporated in the model have a significant impact on the target output parameters. Finally, the model is seen to be able to provide robust predictions of esophageal pressure, transpulmonary pressure and blood pH for patient parameters with realistic variability. The LDPV model is a robust physiological model which produces outputs which directly target and reflect the risk of ventilator-induced lung and diaphragm injury. Ventilation and sedation parameters are seen to modulate the model outputs in accordance with what is currently known in literature.

Published
2021

20. Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia

Author

Lee, Chel Hee, Banoei, Mohammad M., Ansari, Mariam, Cheng, Matthew P., Lamontagne, Francois, Griesdale, Donald, Lasry, David E., Demir, Koray, Dhingra, Vinay, Tran, Karen C., Lee, Terry, Burns, Kevin, Sweet, David, Marshall, John, Slutsky, Arthur, Murthy, Srinivas, Singer, Joel, Patrick, David M., Lee, Todd C., Boyd, John H., Walley, Keith R., Fowler, Robert, Haljan, Greg, Vinh, Donald C., Mcgeer, Alison, Maslove, David, Mann, Puneet, Donohoe, Kathryn, Hernandez, Geraldine, Rocheleau, Genevieve, Trahtemberg, Uriel, Kumar, Anand, Lou, Ma, dos Santos, Claudia, Baker, Andrew, Russell, James A., and Winston, Brent W.

Published
2024
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21. Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern

Author

Onodera, Yu, Liang, Jady, Li, Yuchong, Griffin, Bryan, Thanabalasingam, Thenuka, Lu, Cong, Zhu, JiaYi, Liu, Mingyao, Moraes, Theo, Zheng, Wenhua, Khateeb, Jasmin, Khang, Julie, Huang, Yongbo, Jerkic, Mirjana, Nakane, Masaki, Baker, Andrew, Orser, Beverley, Chen, Ya-Wen, Wirnsberger, Gerald, Penninger, Josef M., Rotstein, Ori D., Slutsky, Arthur S., Li, Yimin, Mubareka, Samira, and Zhang, Haibo

Published
2023
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24. Respiratory indications for ECMO: focus on COVID-19

Author

Supady, Alexander, Combes, Alain, Barbaro, Ryan P., Camporota, Luigi, Diaz, Rodrigo, Fan, Eddy, Giani, Marco, Hodgson, Carol, Hough, Catherine L., Karagiannidis, Christian, Kochanek, Matthias, Rabie, Ahmed A., Riera, Jordi, Slutsky, Arthur S., and Brodie, Daniel

Published
2022
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25. Prognostic factors associated with mortality among patients receiving venovenous extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis

Author

Tran, Alexandre, Fernando, Shannon M, Rochwerg, Bram, Barbaro, Ryan P, Hodgson, Carol L, Munshi, Laveena, MacLaren, Graeme, Ramanathan, Kollengode, Hough, Catherine L, Brochard, Laurent J, Rowan, Kathryn M, Ferguson, Niall D, Combes, Alain, Slutsky, Arthur S, Fan, Eddy, and Brodie, Daniel

Published
2023
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33. Canada's response to the initial 2 years of the COVID-19 pandemic: a comparison with peer countries

Author

Razak, Fahad, Shin, Saeha, Naylor, C. David, and Slutsky, Arthur S.

Subjects
Europe -- Comparative analysis -- Health aspects -- Economic aspects, Japan -- Comparative analysis -- Health aspects -- Economic aspects, Canada -- Comparative analysis -- Health aspects -- Economic aspects, United States -- Comparative analysis -- Health aspects -- Economic aspects, Epidemics -- Statistics -- Control -- Economic aspects -- United States, Vaccination -- Statistics -- Economic aspects, Health
Abstract

The first known diagnosis of SARS-CoV-2 infection in Canada was in a patient in hospital in Toronto on Jan. 25, 2020. (1) At the time, few anticipated the intensity and [...]

Published
2022
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34. Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis

Author

Fernando, Shannon M., Tran, Alexandre, Sadeghirad, Behnam, Burns, Karen E. A., Fan, Eddy, Brodie, Daniel, Munshi, Laveena, Goligher, Ewan C., Cook, Deborah J., Fowler, Robert A., Herridge, Margaret S., Cardinal, Pierre, Jaber, Samir, Møller, Morten Hylander, Thille, Arnaud W., Ferguson, Niall D., Slutsky, Arthur S., Brochard, Laurent J., Seely, Andrew J. E., and Rochwerg, Bram

Published
2022
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36. Hybrid immunity from severe acute respiratory syndrome coronavirus 2 infection and vaccination in Canadian adults: A cohort study.

Author

Brown, Patrick E., Sze Hang Fu, Newcombe, Leslie, Xuyang Tang, Nagelkerke, Nico, Birnboim, H. Chaim, Bansal, Aiyush, Colwill, Karen, Mailhot, GeneviÃ?ve, Delgado-Brand, Melanie, Tursun, Tulunay, Qi, Freda, Gingras, Anne-Claude, Slutsky, Arthur S., Pasic, Maria D., Companion, Jeffrey, Bogoch, Isaac I., Morawski, Ed, Lam, Teresa, and Reid, Angus

Published
2024
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39. COVID-19-associated autoimmunity as a feature of acute respiratory failure

Author

Trahtemberg, Uriel, Fritzler, Marvin J., Rottapel, Robert, dos Santos, Claudia C., Di Battista, Alex P., Slutsky, Arthur S., and Baker, Andrew J.

Subjects
Autoimmunity, Autoantibodies, Coronaviruses, Acute respiratory distress syndrome, Health care industry, University of Toronto
Abstract

Author(s): Uriel Trahtemberg [sup.1], Marvin J. Fritzler [sup.2], Robert Rottapel, Claudia C. dos Santos, Alex P. Di Battista, Arthur S. Slutsky, Andrew J. Baker Author Affiliations: Dear Editor, Coronavirus disease [...]

Published
2021
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40. The PANDORA Study: Prevalence and Outcome of Acute Hypoxemic Respiratory Failure in the Pre-COVID-19 Era

Author

Villar, Jesús, Mora-Ordoñez, Juan M., Soler, Juan A., Mosteiro, Fernando, Vidal, Anxela, Ambrós, Alfonso, Fernández, Lorena, Murcia, Isabel, Civantos, Belén, Romera, Miguel A., Mira, Adrián, Díaz-Domínguez, Francisco J., Parrilla, Dácil, Martínez-Carmona, J. Francisco, Martínez, Domingo, Pita-García, Lidia, Robaglia, Denis, Bueno-González, Ana, Sánchez-Ballesteros, Jesús, Pereyra, Ángel E., Hernández, Mónica, Chamorro-Jambrina, Carlos, Cobeta, Pilar, González-Luengo, Raúl I., Montiel, Raquel, Nogales, Leonor, Fernández, M. Mar, Arocas, Blanca, Valverde-Montoro, Álvaro, del Saz-Ortiz, Ana M., Olea-Jiménez, Victoria, Añón, José M., Rodríguez-Suárez, Pedro, Fernández, Rosa L., Fernández, Cristina, Szakmany, Tamas, González-Martín, Jesús M., Ferrando, Carlos, Kacmarek, Robert M., Slutsky, Arthur S., Añón, José M., Civantos, Belén, Hernández, Mónica, González, Elena, Solano, Rosario, Díaz-Domínguez, F. Javier, Carriedo, Demetrio, González Luengo, Raul I., Ferrando, Carlos, Arocas, Blanca, Belda, Javier, Soro, Marina, Aguilar, Gerardo, Pastor, Ernesto, Fernández, Lorena, Sánchez-Ballesteros, Jesús, Muriel, Arturo, Blanco-Schweizer, Pablo, de Ayala, José Ángel, Blanco, Jesús, Aldecoa, César, Pérez, Alba, Rico-Feijoo, Jesús, Nogales, Leonor, Andaluz, David, Parra, Laura, Soler, Juan A., Martínez, Domingo, del Saz-Ortiz, Ana M., Ambrós, Alfonso, Bueno-González, Ana, Hornos-López, Carmen, Montiel, Raquel, Parrilla, Dácil, Peinado, Eduardo, Prieto, Isidro, Chico, Mario, Romera, Miguel A., Chamorro-Jambrina, Carlos, Mora-Ordoñez, Juan M., Martínez-Carmona, J. Francisco, Valverde-Montoro, Álvaro, Olea-Jiménez, Victoria, Alba, Paco, Corpas, Ruth, Mosteiro, Fernando, Pita-García, Lidia, Merayo, Eleuterio, Martínez, Chanel, de Célis-Álvarez, Ángeles, Martín-Delgado, Carmen, Mira, Adrián, Cobeta, Pilar, Pestaña, David, del Mar Fernández, María, Tarancón, Concepción, Cortés-Díaz, Silvia, Vidal, Anxela, Robaglia, Denis, Pérez, César, Murcia, Isabel, Pereyra-Pache, Ángel E., Szakmany, Tamas, Villar, Jesús, Fernández, Rosa L., Fernández, Cristina, Rodríguez-Pérez, Pedro, González-Martín, Jesús M., Kacmarek, Robert M., and Slutsky, Arthur S.

Published
2022
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42. Understanding the Post COVID-19 Condition (Long COVID) in Adults and the Expected Burden for Ontario

Author

Quinn, Kieran L., primary, Katz, Gabrielle M., additional, Bobos, Pavlos, additional, Sander, Beate, additional, McNaughton, Candace D., additional, Cheung, Angela M., additional, Herridge, Margaret S., additional, Atzema, Clare L., additional, Born, Karen B., additional, Chan, Christine, additional, Chien, Vincent, additional, Kaplan, David M., additional, Kwong, Jeffrey, additional, Leung, Susan, additional, Mishra, Sharmistha, additional, Morris, Andrew M., additional, Rendely, Alexandra, additional, Slutsky, Arthur S., additional, Stalteri, Rosa, additional, and Razak, Fahad A., additional

Published
2022
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44. Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study

Author

Lissoni, Alfredo, Rossi, Nicola, Guzzardella, Amedeo, Valsecchi, Carlo, Madotto, Fabiana, Bevilacqua, Francesca, Di Laudo, Marco, Querci, Lorenzo, Seccafico, Carmen, Grasselli, Giacomo, Tonetti, Tommaso, Protti, Alessandro, Langer, Thomas, Girardis, Massimo, Bellani, Giacomo, Laffey, John, Carrafiello, Gianpaolo, Carsana, Luca, Rizzuto, Chiara, Zanella, Alberto, Scaravilli, Vittorio, Pizzilli, Giacinto, Grieco, Domenico Luca, Di Meglio, Letizia, de Pascale, Gennaro, Lanza, Ezio, Monteduro, Francesco, Zompatori, Maurizio, Filippini, Claudia, Locatelli, Franco, Cecconi, Maurizio, Fumagalli, Roberto, Nava, Stefano, Vincent, Jean-Louis, Antonelli, Massimo, Slutsky, Arthur S, Pesenti, Antonio, and Ranieri, V Marco

Published
2020
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45. Current and evolving standards of care for patients with ARDS

Author

Menk, Mario, Estenssoro, Elisa, Sahetya, Sarina K., Neto, Ary Serpa, Sinha, Pratik, Slutsky, Arthur S., and Summers, Charlotte

Subjects
Patients -- Care and treatment, Medical colleges, Acute respiratory distress syndrome -- Care and treatment, Health care industry
Abstract

Care for patients with acute respiratory distress syndrome (ARDS) has changed considerably over the 50 years since its original description. Indeed, standards of care continue to evolve as does how this clinical entity is defined and how patients are grouped and treated in clinical practice. In this narrative review we discuss current standards - treatments that have a solid evidence base and are well established as targets for usual care - and also evolving standards - treatments that have promise and may become widely adopted in the future. We focus on three broad domains of ventilatory management, ventilation adjuncts, and pharmacotherapy. Current standards for ventilatory management include limitation of tidal volume and airway pressure and standard approaches to setting PEEP, while evolving standards might focus on limitation of driving pressure or mechanical power, individual titration of PEEP, and monitoring efforts during spontaneous breathing. Current standards in ventilation adjuncts include prone positioning in moderate-severe ARDS and veno-venous extracorporeal life support after prone positioning in patients with severe hypoxemia or who are difficult to ventilate. Pharmacotherapy current standards include corticosteroids for patients with ARDS due to COVID-19 and employing a conservative fluid strategy for patients not in shock; evolving standards may include steroids for ARDS not related to COVID-19, or specific biological agents being tested in appropriate sub-phenotypes of ARDS. While much progress has been made, certainly significant work remains to be done and we look forward to these future developments., Author(s): Mario Menk [sup.1] [sup.2], Elisa Estenssoro [sup.3] [sup.4], Sarina K. Sahetya [sup.5], Ary Serpa Neto [sup.6] [sup.7] [sup.8], Pratik Sinha [sup.9], Arthur S. Slutsky [sup.10], Charlotte Summers [sup.11], Takeshi [...]

Published
2020
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46. Evaluation of PEEP and prone positioning in early COVID-19 ARDS

Author

Mittermaier, Mirja, Pickerodt, Philipp, Kurth, Florian, de Jarcy, Laure Bosquillon, Uhrig, Alexander, Garcia, Carmen, Machleidt, Felix, Pergantis, Panagiotis, Weber, Susanne, Li, Yaosi, Breitbart, Astrid, Bremer, Felix, Knape, Philipp, Dewey, Marc, Doellinger, Felix, Weber-Carstens, Steffen, Slutsky, Arthur S., Kuebler, Wolfgang M., Suttorp, Norbert, and Müller-Redetzky, Holger

Published
2020
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48. The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline

Author

Rochwerg, Bram, Einav, Sharon, Chaudhuri, Dipayan, Mancebo, Jordi, Mauri, Tommaso, Helviz, Yigal, Goligher, Ewan C., Jaber, Samir, Ricard, Jean-Damien, Rittayamai, Nuttapol, Roca, Oriol, Antonelli, Massimo, Maggiore, Salvatore Maurizio, Demoule, Alexandre, Hodgson, Carol L., Mercat, Alain, Wilcox, M. Elizabeth, Granton, David, Wang, Dominic, Azoulay, Elie, Ouanes-Besbes, Lamia, Cinnella, Gilda, Rauseo, Michela, Carvalho, Carlos, Dessap-Mekontso, Armand, Fraser, John, Frat, Jean-Pierre, Gomersall, Charles, Grasselli, Giacomo, Hernandez, Gonzalo, Jog, Sameer, Pesenti, Antonio, Riviello, Elisabeth D., Slutsky, Arthur S., Stapleton, Renee D., Talmor, Daniel, Thille, Arnaud W., Brochard, Laurent, and Burns, Karen E. A.

Published
2020
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49. Biotrauma during ultra-low tidal volume ventilation and venoarterial extracorporeal membrane oxygenation in cardiogenic shock: a randomized crossover clinical trial

Author

Amado-Rodríguez, Laura, Del Busto, Cecilia, López-Alonso, Inés, Parra, Diego, Mayordomo-Colunga, Juan, Arias-Guillén, Miguel, Albillos-Almaraz, Rodrigo, Martín-Vicente, Paula, López-Martínez, Cecilia, Huidobro, Covadonga, Camporota, Luigi, Slutsky, Arthur S., and Albaiceta, Guillermo M.

Published
2021
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