193 results on '"Smil, David"'
Search Results
2. Discovery of Conformationally Constrained ALK2 Inhibitors
3. Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors
4. A chemical biology toolbox to study protein methyltransferases and epigenetic signaling
5. A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues
6. Bromo-deaza-SAH: A potent and selective DOT1L inhibitor
7. Leveraging an open science approach for PET radiotracer discovery: radiolabelling and preliminary neuroimaging of 11C-labelled activin receptor-like kinase 2 inhibitors
8. sj-pdf-1-jbx-10.1177_24725552211026261 – Supplemental material for Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors
9. Leveraging Open Science Drug Development for PET: Preliminary Neuroimaging of 11C-Labeled ALK2 Inhibitors
10. Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics**
11. Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors
12. Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics
13. Part 1: efficient strategies for the construction of variably substituted bicyclo[5.3.1]undecenones (AB taxane ring systems)
14. Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma
15. Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma
16. Identification and characterization of the first fragment hits for SETDB1 Tudor domain
17. SP-013 - Leveraging an open science approach for PET radiotracer discovery: radiolabelling and preliminary neuroimaging of 11C-labelled activin receptor-like kinase 2 inhibitors
18. A Chemical Biology Toolbox for the Study of Protein Methyltransferases and Epigenetic Signaling
19. Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)
20. Tethered α-boryl radical cyclizations of haloalkyl boronates
21. Potassium allyl- and crotyltrifluoroborates: Stable and efficient agents for allylation and crotylation
22. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6
23. Correction to Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening
24. Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product
25. Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening
26. Functional interdependence of BRD4 and DOT1L in MLL leukemia
27. Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1)
28. Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor
29. MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin
30. MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin
31. Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies
32. Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
33. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
34. Discovery of a Dual PRMT5–PRMT7 Inhibitor
35. A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)
36. Protein Interferon-Stimulated Gene 15 Conjugation Delays but Does Not Overcome Coronavirus Proliferation in a Model of Fulminant Hepatitis
37. Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumoniae and Staphylococcus aureus
38. (R)-β-lysine-modified elongation factor P functions in translation elongation
39. Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors
40. Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors
41. Sulfamides as novel histone deacetylase inhibitors
42. Crystal structures ofKlebsiella pneumoniaepantothenate kinase in complex with N-substituted pantothenamides
43. Strategy to Target the Substrate Binding site of SET Domain Protein Methyltransferases
44. Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors
45. Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction
46. (R)-β-Lysine-modified Elongation Factor P Functions in Translation Elongation
47. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.
48. Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.
49. Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5
50. An Allosteric Inhibitor of Protein Arginine Methyltransferase 3
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.