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179 results on '"Smirnov, Alexander Yu."'

5. Advances in Optical and Microwave Nonreciprocity

Author

Kutsaev, Sergey V, Krasnok, Alex, Romanenko, Sergey N., Smirnov, Alexander Yu., Taletski, Kirill, and Yakovlev, Vyacheslav

Subjects
Physics - Applied Physics, Physics - Optics
Abstract

Modern photonic and quantum technologies demand reciprocity breaking, e.g., isolators, full-duplex systems, noise isolation in quantum computers, motivating searching for practical approaches beyond magnet-based devices. This work overviews the up-and-coming advances in optical nonreciprocity, including new materials (Weyl semimetals, topological insulators, metasurfaces), active structures, time-modulation, PT-symmetry breaking, nonlinearity, quantum nonlinearity, unidirectional gain and loss, chiral quantum states, and valley polarization.

Published
2020

13. A Combination of Library Screening and Rational Mutagenesis Expands the Available Color Palette of the Smallest Fluorogen-Activating Protein Tag nanoFAST

Author

Baleeva, Nadezhda S., primary, Bogdanova, Yulia A., additional, Goncharuk, Marina V., additional, Sokolov, Anatolii I., additional, Myasnyanko, Ivan N., additional, Kublitski, Vadim S., additional, Smirnov, Alexander Yu., additional, Gilvanov, Aidar R., additional, Goncharuk, Sergey A., additional, Mineev, Konstantin S., additional, and Baranov, Mikhail S., additional

Published
2024
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14. Generation of hypermagnetic helicity and leptogenesis in early universe

Author

Semikoz, V. B., Smirnov, Alexander Yu., and Sokoloff, D. D.

Subjects
High Energy Physics - Phenomenology, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We study hypermagnetic helicity and lepton asymmetry evolution in plasma of the early Universe before the electroweak phase transition (EWPT) accounting for chirality flip processes via inverse Higgs decays and sphaleron transitions which violate the left lepton number and wash out the baryon asymmetry of the Universe (BAU). In the scenario where the right electron asymmetry supports the BAU alone through the conservation law $B/3 - L_{eR}=const$ at temperatures $T>T_{RL}\simeq 10~TeV$ the following universe cooling leads to the production of a non-zero left lepton (electrons and neutrinos) asymmetry. This is due to the Higgs decays becoming more faster when entering the equilibrium at $T=T_{RL}$ with the universe expansion, $\Gamma_{RL}\sim T> H\sim T^2$ , resulting in the parallel evolution of the right and the left electron asymmetries at $T

Published
2016
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15. Leptogenesis in the Symmetric Phase of the Early Universe: Baryon Asymmetry and Hypermagnetic Helicity Evolution

Author

Semikoz, Victor B. and Smirnov, Alexander Yu.

Subjects
High Energy Physics - Phenomenology, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We investigate the evolution of the baryon asymmetry of the Universe (BAU) in its symmetric phase before the electroweak phase transition (EWPT) induced by leptogenesis in the hypermagnetic field of an arbitrary structure and with a maximum hypermagnetic helicity density. The novelty of this work is that the BAU has been calculated for a continuous hypermagnetic helicity spectrum. The observed BAU $B_{obs} = 10^{-10}$ that can be in large-scale hypermagnetic fields satisfying the wave number inequality $k \leq k_{max}$ grows with increasing $k_{max}$. We will also show that the initial right-handed electron asymmetry $\xi_{eR}(\eta_0)$ used in our leptogenesis model as a free parameter cannot take too large values, $\xi_{eR}(\eta_0) = 10^{-4}$, because this leads to a negative BAU by the EWPT time. In contrast, a sufficiently small initial right-handed electron asymmetry, $\xi_{eR}(\eta_0)$, provides its further growth and the corresponding BAU growth from zero to some positive value,including the observed $B_{obs} = 10^{-10}$., Comment: 9 pages, 3 figures

Published
2015
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16. Facile Condensation of 2‐Aminobenzaldehydes into Azolo[4,5‐b]Quinolones.

Author

Opryshko, Victoria E., Zaitseva, Elvira R., Ivanov, Dmitrii S., Eshtukov‐Shcheglov, Artur V., Tyurin, Anton P., Mikhaylov, Andrey A., Smirnov, Alexander Yu., and Baranov, Mikhail S.

Subjects
QUINOLONE antibacterial agents, CONDENSATION, QUINOLINE, RING formation (Chemistry), AMINATION
Abstract

An operationally simple approach to azolo[4,5‐b]quinolines based on the condensation of 2‐aminobenzaldehydes with various azolones is developed. A series of 22 compounds was synthesized typically in good yields (40–92 %). [ABSTRACT FROM AUTHOR]

Published
2024
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21. [3+2] Cycloaddition of N‐benzylazomethine Methylide with Various Arylidene‐Azolones.

Author

Tiushina, Irina V., Sokolov, Anatolii I., Smirnov, Alexander Yu., Dubinnyi, Maxim A., Ivanov, Dmitrii S., Korlyukov, Alexander A., Mikhaylov, Andrey A., and Baranov, Mikhail S.

Subjects
BIOACTIVE compounds, RING formation (Chemistry)
Abstract

Spirocyclic skeletons are highly attractive for design of biologically active compounds. [3+2] Cycloaddition of N‐benzylazomethine methylide with various arylidene‐azolones achieve to synthesize promising series of substituted spirocyclic structures. Systematic study of the scope and stereochemical outcome of [3+2]‐cycloaddition was performed. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Synthesis of Spiro[imidazole‐4,3′‐pyrrolo[1,2‐a]quinolin]‐ 5‐ones via 1,3‐Dipolar Cycloaddition of Quinolinium Ylides with Arylydeneimidazol‐4‐ones.

Author

Molchanova, Marina V., Ikonnikova, Viktoria A., Smirnov, Alexander Yu., Solyev, Pavel N., Baranov, Mikhail S., and Mikhaylov, Andrey A.

Subjects
RING formation (Chemistry), YLIDES, ISOXAZOLIDINES, DRUG target, PHARMACEUTICAL chemistry, HIV
Abstract

Design of spirocyclic scaffolds, which are able for direct interaction with biological targets, is a developing trend in medicinal chemistry. In continuation of the previous work on HIV‐1 inhibitors, a synthetic approach towards spiro[imidazole‐4,3′‐pyrrolo[1,2‐a]quinolin]‐5‐ones via 1,3‐dipolar cycloaddition of quinolinium ylides with arylydeneimidazol‐4‐ones was outlined. Derivatives with various substitution pattern were prepared in 42–86 % yields. Use of 2,2,2‐trifluoroethanol as a solvent is crucial for successful preparation of the derivatives, its role is sought as prolonging lifetime of the cycloadducts. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Synthesis of Densely Substituted Pyridines through 1,2‐Oxazine‐6‐ones Inverse Electron Demand Diels–Alder Reaction.

Author

Ivanov, Dmitrii S., Smirnov, Alexander Yu., Zaitseva, Elvira R., Mikhaylov, Andrey A., and Baranov, Mikhail S.

Subjects
*DIELS-Alder reaction, *ELECTRONS, *ENAMINES
Abstract

Densely substituted pyridines are synthesized from available 1,2‐oxazin‐6‐ones and enamines through tandem hetero‐Diels–Alder and retro‐Diels–Alder reaction in 45–98 % yield. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Photoinduced [1,5]-hydride shift triggered cyclization.

Author

Baleeva, Nadezhda S., Smirnov, Alexander Yu., Zaitseva, Elvira R., Ivanov, Dmitrii S., Sokolov, Anatolii I., Mikhaylov, Andrey A., Myasnyanko, Ivan N, and Baranov, Mikhail S.

Subjects
*RING formation (Chemistry), *LEWIS acidity, *LIGHT sources, *MALONATES
Abstract

ortho-Dialkylaminoarylidene malonates undergo hydrogen transfer mediated cyclization in the absence of a catalyst under LED irradiation. This activation mode is found to be relatively general and could be applied to a number of other acceptor motifs in the arylidene substrates tested. Variation of the light source wavelength opens an extra option for fine tuning of the reaction conditions, making the described method almost universal. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Meta-CF 3 -Substituted Analogues of the GFP Chromophore with Remarkable Solvatochromism.

Author

Perfilov, Maxim M., Zaitseva, Elvira R., Baleeva, Nadezhda S., Kublitski, Vadim S., Smirnov, Alexander Yu., Bogdanova, Yulia A., Krasnova, Svetlana A., Myasnyanko, Ivan N., Mishin, Alexander S., and Baranov, Mikhail S.

Subjects
FLUOROPHORES, SOLVATOCHROMISM, ENDOPLASMIC reticulum, IMIDAZOLONES, APROTIC solvents, FLUORESCENCE
Abstract

In this work, we have shown that the introduction of a trifluoromethyl group into the me-ta-position of arylidene imidazolones (GFP chromophore core) leads to a dramatic increase in their fluorescence in nonpolar and aprotic media. The presence of a pronounced solvent-dependent gradation of fluorescence intensity makes it possible to use these substances as fluorescent polarity sensors. In particular, we showed that one of the created compounds could be used for selective labeling of the endoplasmic reticulum of living cells. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Ultralightweight Power System for Human-Portable Linac-Based X-Ray Sources

Author

Ivanov, Evgeny, Kutsaev, Sergey V., Pronikov, Alexey, and Smirnov, Alexander Yu.

Abstract

Industrial human-portable X-ray sources are widely used by security, nuclear safeguard, and defense agencies. However, the employed sources have significant energy, dose, size, weight, and power (SWaP) limitations, greatly affecting their practical application. RF linear accelerators (linacs) can serve as a flexible, reliable, and robust type of X-ray source if they can match the size, weight, cost, and imaging performance requirements of conventional ones. One of the most critical elements affecting these parameters is the high-voltage pulsed power supply system or modulator, which can make the largest contribution to the total weight and dimensions of the accelerator. In this article, we present the design and demonstration results of a novel ultra lightweight power system based on a 24-kV solid-state Marx modulator for a hand-portable 0.15–2.0-MeV Ku -band linac-based X-ray source.

Published
2023
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37. NanoLuc Luciferase as a Fluorogen-Activating Protein for GFP Chromophore Based Fluorogens.

Author

Bogdanova, Yulia A., Zaitseva, Elvira R., Smirnov, Alexander Yu., Baleeva, Nadezhda S., Gavrikov, Alexey S., Myasnyanko, Ivan N., Goncharuk, Sergey A., Kot, Erik F., Mineev, Konstantin S., Mishin, Alexander S., and Baranov, Mikhail S.

Subjects
GREEN fluorescent protein, FLUORESCENT proteins
Abstract

In this work, we showed that the well-known NanoLuc luciferase can act as a fluorogen activating protein for various arylidene-imidazolones structurally similar to the Kaede protein chromophore. We showed that such compounds can be used as fluorescent sensors for this protein and can also be used in pairs with it in fluorescent microscopy as a genetically encoded tag. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Ultrafast High-Voltage Kicker System for Ion-Clearing Gaps

Author

Smirnov, Alexander Yu., primary, Agustsson, Ronald, additional, Benson, Stephen V., additional, Gavryushkin, Dmitry, additional, Guo, Jiquan, additional, Kutsaev, Sergey V., additional, Moro, Adam, additional, Park, Gunn Tae, additional, Smirnov, Alexei V., additional, Wang, Haipeng, additional, and Zhang, Shukui, additional

Published
2021
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41. O‐Alkylation Redirected Condensation of 5‐Hydroxy‐1,2‐oxazine‐6‐ones with Primary Amines for Synthesis of 5‐Hydroxyiminopyridine‐2,6(1H,3H)‐diones

Author

Nizovtsev, Alexey V., primary, Sokolov, Anatolii I., additional, Smirnov, Alexander Yu., additional, Mikhaylov, Andrey A., additional, Myasnyanko, Ivan N., additional, Belozerova, Olga A., additional, Baleeva, Nadezhda S., additional, Usmanova, Liliia, additional, and Baranov, Mikhail S., additional

Published
2021
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42. Micro-Raman Characterization of Structural Features of High-k Stack Layer of SOI Nanowire Chip, Designed to Detect Circular RNA Associated with the Development of Glioma

Author

Ivanov, Yuri D., primary, Malsagova, Kristina A., additional, Popov, Vladimir P., additional, Kupriyanov, Igor N., additional, Pleshakova, Tatyana O., additional, Galiullin, Rafael A., additional, Ziborov, Vadim S., additional, Dolgoborodov, Alexander Yu., additional, Petrov, Oleg F., additional, Miakonkikh, Andrey V., additional, Rudenko, Konstantin V., additional, Glukhov, Alexander V., additional, Smirnov, Alexander Yu., additional, Usachev, Dmitry Yu., additional, Gadzhieva, Olga A., additional, Bashiryan, Boris A., additional, Shimansky, Vadim N., additional, Enikeev, Dmitry V., additional, Potoldykova, Natalia V., additional, and Archakov, Alexander I., additional

Published
2021
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44. BF3 Mediated [1,5]‐Hydride Shift Triggered Cyclization: Thioethers Join the Game.

Author

Zaitseva, Elvira R., Smirnov, Alexander Yu., Timashev, Vladimir I., Malyshev, Vadim I., Zhigileva, Ekaterina A., Mikhaylov, Andrey A., Medvedev, Michael G., Baleeva, Nadezhda S., and Baranov, Mikhail S.

Subjects
*SULFIDES, *RING formation (Chemistry), *MALONATES, *SULFUR, *STYRENE, *BORON trifluoride
Abstract

2‐(2‐(Benzylthio)benzylidene)malonates can undergo the 1,5‐hydride shift triggered cyclization resulting in thiachromanes in 45–84 % yield. Boron trifluoride as a reaction promotor is the key to success. DFT calculations revealed that the reaction proceeds via a chelate BF2 complex, which was confirmed by NMR‐analysis. Experimental and theoretical comparison of nitrogen, sulfur and carbon analogues revealed that sulfur derivatives have the highest activation barrier for the hydride transfer due to the unfavorable transition state geometry, which explains the lack of previous reports on 1,5‐hydride shifts in (alkylthio)styrenes. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Color Tuning of Fluorogens for FAST Fluorogen‐Activating Protein

Author

Myasnyanko, Ivan N., primary, Gavrikov, Alexey S., additional, Zaitseva, Snizhana O., additional, Smirnov, Alexander Yu., additional, Zaitseva, Elvira R., additional, Sokolov, Anatolii I., additional, Malyshevskaya, Kseniya K., additional, Baleeva, Nadezhda S., additional, Mishin, Alexander S., additional, and Baranov, Mikhail S., additional

Published
2021
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48. NanoFAST: structure-based design of a small fluorogen-activating protein with only 98 amino acids

Author

Mineev, Konstantin S., primary, Goncharuk, Sergey A., additional, Goncharuk, Marina V., additional, Povarova, Natalia V., additional, Sokolov, Anatolii I., additional, Baleeva, Nadezhda S., additional, Smirnov, Alexander Yu., additional, Myasnyanko, Ivan N., additional, Ruchkin, Dmitry A., additional, Bukhdruker, Sergey, additional, Remeeva, Alina, additional, Mishin, Alexey, additional, Borshchevskiy, Valentin, additional, Gordeliy, Valentin, additional, Arseniev, Alexander S., additional, Gorbachev, Dmitriy A., additional, Gavrikov, Alexey S., additional, Mishin, Alexander S., additional, and Baranov, Mikhail S., additional

Published
2021
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49. NanoFAST: Structure-based design of a small fluorogen-activating protein with only 98 amino acids

Author

Mineev, Konstantin S., primary, Goncharuk, Sergey A., additional, Goncharuk, Marina V., additional, Povarova, Natalia V., additional, Baleeva, Nadezhda S., additional, Smirnov, Alexander Yu., additional, Myasnyanko, Ivan N, additional, Ruchkin, Dmitry A., additional, Bukhdruker, Sergey, additional, Remeeva, Alina, additional, Mishin, Alexey, additional, Borshchevskiy, Valentin, additional, Gordeliy, Valentin, additional, Arseniev, Alexander S., additional, Gorbachev, Dmitriy A., additional, Gavrikov, Alexey S., additional, Mishin, Alexander S., additional, and Baranov, Mikhail S., additional

Published
2020
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50. Synthesis of julolidine derivatives via SnCl4-promoted spirocyclization of (1-alkyltetrahydroquinolin-8-yl)methylidene-1H-imidazol-5(4H)-ones.

Author

Shirokova, Vasilissa V., Smirnov, Alexander Yu., Zaitseva, Elvira R., Baleeva, Nadezhda S., Mikhaylov, Andrey А., and Baranov, Mikhail S.

Subjects
*IMIDAZOLES, *SPIROKETALS
Abstract

(1-Alkyltetrahydroquinolin-8-yl)methylidene-1H-imidazol-5(4H)-ones undergo spirocyclization by the action of SnCl4 via 1,5-hydride shift to form spirocyclic julolidine derivatives in 68–97% yields. [ABSTRACT FROM AUTHOR]

Published
2022
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