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333 results on '"Smith, Amanda M."'

3. Extractivism and the ecology of research infrastructure: digitizing precarious materialities in Iquitos, Peru

Author

Smith, Amanda M

Subjects
Information and Computing Sciences, Language, Communication and Culture, Library and Information Studies, Life on Land, Industry, Innovation and Infrastructure, Infrastructure, digital colonialism, cultural preservation, extractivism, Amazonia, Infraestruturas, colonialismo digital, preservacao cultural, extrativismo, preservacion cultural
Published
2024

8. Social Determinants of Health Mediate Racial Disparities in Cardiovascular Disease in Men With Prostate Cancer

Author

Demissei, Biniyam G., Ko, Kyunga, Huang, Anran, Lee, Daniel J., Doucette, Abigail G., Smith, Amanda M., Wilcox, Nicholas S., Reibel, Jacob, Sun, Lova, Agarwal, Manuj, Haas, Naomi B., Hollis, Genevieve, Shpilsky, Jason E., Takvorian, Samuel U., Vaughn, David J., Chen, Jinbo, Hubbard, Rebecca A., Powell-Wiley, Tiffany, Yancy, Clyde, Narayan, Vivek, and Ky, Bonnie

Published
2024
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20. Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability

Author

Teekakirikul, Polakit, Zhu, Wenjuan, Xu, Xinxiu, Young, Cullen B., Tan, Tuantuan, Smith, Amanda M., Wang, Chengdong, Peterson, Kevin A., Gabriel, George C., Ho, Sebastian, Sheng, Yi, Moreau de Bellaing, Anne, Sonnenberg, Daniel A., Lin, Jiuann-huey, Fotiou, Elisavet, Tenin, Gennadiy, Wang, Michael X., Wu, Yijen L., Feinstein, Timothy, Devine, William, Gou, Honglan, Bais, Abha S., Glennon, Benjamin J., Zahid, Maliha, Wong, Timothy C., Ahmad, Ferhaan, Rynkiewicz, Michael J., Lehman, William J., Keavney, Bernard, Alastalo, Tero-Pekka, Freckmann, Mary-Louise, Orwig, Kyle, Murray, Steve, Ware, Stephanie M., Zhao, Hui, Feingold, Brian, and Lo, Cecilia W.

Published
2022
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23. Remethylation of Dnmt3a −/− hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing

Author

Ketkar, Shamika, Verdoni, Angela M., Smith, Amanda M., Bangert, Celia V., Leight, Elizabeth R., Chen, David Y., Brune, Meryl K., Helton, Nichole M., Hoock, Mieke, George, Daniel R., Fronick, Catrina, Fulton, Robert S., Ramakrishnan, Sai Mukund, Chang, Gue Su, Petti, Allegra A., Spencer, David H., Miller, Christopher A., and Ley, Timothy J.

Published
2020

37. Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome

Author

Smith, Amanda M., LaValle, Taylor A., Shinawi, Marwan, Ramakrishnan, Sai M., Abel, Haley J., Hill, Cheryl A., Kirkland, Nicole M., Rettig, Michael P., Helton, Nichole M., Heath, Sharon E., Ferraro, Francesca, Chen, David Y., Adak, Sangeeta, Semenkovich, Clay F., Christian, Diana L., Martin, Jenna R., Gabel, Harrison W., Miller, Christopher A., and Ley, Timothy J.

Published
2021
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40. Congenital heart defects caused by FOXJ1

Author

Padua, Maria B, primary, Helm, Benjamin M, additional, Wells, John R, additional, Smith, Amanda M, additional, Bellchambers, Helen M, additional, Sridhar, Arthi, additional, and Ware, Stephanie M, additional

Published
2023
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43. Rationale and design of the Children's Oncology Group study AAML1831 integrated cardiac substudies in pediatric acute myeloid leukemia therapy.

Author

Leger, Kasey J., Robison, Nora, Narayan, Hari K., Smith, Amanda M., Tsega, Tenaadam, Chung, Jade, Daniels, Amber, Zhen Chen, Englefield, Virginia, Demissei, Biniyam G., Lefebvre, Benedicte, Morrow, Gemma, Dizon, Ilona, Gerbing, Robert B., Pabari, Reena, Getz, Kelly D., Aplenc, Richard, Pollard, Jessica A., Chow, Eric J., and Tang, W. H. Wilson

Published
2023
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45. Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies

Author

Cole, Christopher B., Russler-Germain, David A., Ketkar, Shamika, Verdoni, Angela M., Smith, Amanda M., Bangert, Celia V., Helton, Nichole M., Guo, Mindy, Klco, Jeffery M., O'Laughlin, Shelly, Fronick, Catrina, Fulton, Robert, Chang, Gue Su, Petti, Allegra A., Miller, Christopher A., and Ley, Timothy J.

Subjects
Methyltransferases -- Research, Gene mutation -- Research, Hematopoietic growth factors -- Research, Myeloid leukemia -- Diagnosis -- Care and treatment, T cells -- Research, Health care industry
Abstract

The gene that encodes de novo DNA methyltransferase 3A (DNMT3A) is frequently mutated in acute myeloid leukemia genomes. Point mutations at position R882 have been shown to cause a dominant negative loss of DNMT3A methylation activity, but 15% of DNMT3A mutations are predicted to produce truncated proteins that could either have dominant negative activities or cause loss of function and haploinsufficiency. Here, we demonstrate that 3 of these mutants produce truncated, inactive proteins that do not dimerize with WT DNMT3A, strongly supporting the haploinsufficiency hypothesis. We therefore evaluated hematopoiesis in mice heterozygous for a constitutive null Dnmt3a mutation. With no other manipulations, [Dnmt3a.sup.+/-] mice developed myeloid skewing over time, and their hematopoietic stem/progenitor cells exhibited a long-term competitive transplantation advantage. [Dnmt3a.sup.+/-] mice also spontaneously developed transplantable myeloid malignancies after a long latent period, and 3 of 12 tumors tested had cooperating mutations in the Ras/MAPK pathway. The residual Dnmt3a allele was neither mutated nor downregulated in these tumors. The bone marrow cells of [Dnmt3a.sup.+/-] mice had a subtle but statistically significant DNA hypomethylation phenotype that was not associated with gene dysregulation. These data demonstrate that haploinsufficiency for Dnmt3a alters hematopoiesis and predisposes mice (and probably humans) to myeloid malignancies by a mechanism that is not yet clear., Introduction The DNA methyltransferase 3A (DNMT3A) gene is mutated in approximately 37% of acute myeloid leukemia (AML) patients with a normal karyotype (and ~25% of all AML cases) (1) and [...]

Published
2017
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46. Supplemental Tables from Prospective Evaluation of Sunitinib-Induced Cardiotoxicity in Patients with Metastatic Renal Cell Carcinoma

Author

Narayan, Vivek, primary, Keefe, Stephen, primary, Haas, Naomi, primary, Wang, Le, primary, Puzanov, Igor, primary, Putt, Mary, primary, Catino, Anna, primary, Fang, James, primary, Agarwal, Neeraj, primary, Hyman, David, primary, Smith, Amanda M., primary, Finkelman, Brian S., primary, Narayan, Hari K., primary, Ewer, Steven, primary, ElAmm, Chantal, primary, Lenihan, Daniel, primary, and Ky, Bonnie, primary

Published
2023
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47. Supplementary Figure 3 from Essential Requirement for PP2A Inhibition by the Oncogenic Receptor c-KIT Suggests PP2A Reactivation as a Strategy to Treat c-KIT+ Cancers

Author

Roberts, Kathryn G., primary, Smith, Amanda M., primary, McDougall, Fiona, primary, Carpenter, Helen, primary, Horan, Martin, primary, Neviani, Paolo, primary, Powell, Jason A., primary, Thomas, Daniel, primary, Guthridge, Mark A., primary, Perrotti, Danilo, primary, Sim, Alistair T.R., primary, Ashman, Leonie K., primary, and Verrills, Nicole M., primary

Published
2023
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48. Supplementary Figure 6 from Essential Requirement for PP2A Inhibition by the Oncogenic Receptor c-KIT Suggests PP2A Reactivation as a Strategy to Treat c-KIT+ Cancers

Author

Roberts, Kathryn G., primary, Smith, Amanda M., primary, McDougall, Fiona, primary, Carpenter, Helen, primary, Horan, Martin, primary, Neviani, Paolo, primary, Powell, Jason A., primary, Thomas, Daniel, primary, Guthridge, Mark A., primary, Perrotti, Danilo, primary, Sim, Alistair T.R., primary, Ashman, Leonie K., primary, and Verrills, Nicole M., primary

Published
2023
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49. Supplementary Figure 2 from Essential Requirement for PP2A Inhibition by the Oncogenic Receptor c-KIT Suggests PP2A Reactivation as a Strategy to Treat c-KIT+ Cancers

Author

Roberts, Kathryn G., primary, Smith, Amanda M., primary, McDougall, Fiona, primary, Carpenter, Helen, primary, Horan, Martin, primary, Neviani, Paolo, primary, Powell, Jason A., primary, Thomas, Daniel, primary, Guthridge, Mark A., primary, Perrotti, Danilo, primary, Sim, Alistair T.R., primary, Ashman, Leonie K., primary, and Verrills, Nicole M., primary

Published
2023
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50. Supplementary Figure 9 from Essential Requirement for PP2A Inhibition by the Oncogenic Receptor c-KIT Suggests PP2A Reactivation as a Strategy to Treat c-KIT+ Cancers

Author

Roberts, Kathryn G., primary, Smith, Amanda M., primary, McDougall, Fiona, primary, Carpenter, Helen, primary, Horan, Martin, primary, Neviani, Paolo, primary, Powell, Jason A., primary, Thomas, Daniel, primary, Guthridge, Mark A., primary, Perrotti, Danilo, primary, Sim, Alistair T.R., primary, Ashman, Leonie K., primary, and Verrills, Nicole M., primary

Published
2023
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