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24 results on '"Smith, Nicholas K."'

3. A parabrachial hub for the prioritization of survival behavior

Author

Goldstein, Nitsan, primary, Maes, Amadeus, additional, Allen, Heather N., additional, Nelson, Tyler S., additional, Kruger, Kayla A., additional, Kindel, Morgan, additional, Smith, Nicholas K., additional, Carty, Jamie R.E., additional, Villari, Rachael E., additional, Cho, Ella, additional, Marble, Erin L., additional, Khanna, Rajesh, additional, Taylor, Bradley K., additional, Kennedy, Ann, additional, and Betley, J. Nicholas, additional

Published
2024
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5. Supplementary Table S2 from Ovarian Cancers Harboring Inactivating Mutations in CDK12 Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications

Author

Popova, Tatiana, primary, Manié, Elodie, primary, Boeva, Valentina, primary, Battistella, Aude, primary, Goundiam, Oumou, primary, Smith, Nicholas K., primary, Mueller, Christopher R., primary, Raynal, Virginie, primary, Mariani, Odette, primary, Sastre-Garau, Xavier, primary, and Stern, Marc-Henri, primary

Published
2023
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6. Data from Ovarian Cancers Harboring Inactivating Mutations in CDK12 Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications

Author

Popova, Tatiana, primary, Manié, Elodie, primary, Boeva, Valentina, primary, Battistella, Aude, primary, Goundiam, Oumou, primary, Smith, Nicholas K., primary, Mueller, Christopher R., primary, Raynal, Virginie, primary, Mariani, Odette, primary, Sastre-Garau, Xavier, primary, and Stern, Marc-Henri, primary

Published
2023
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7. Supplementary Figures from Ovarian Cancers Harboring Inactivating Mutations in CDK12 Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications

Author

Popova, Tatiana, primary, Manié, Elodie, primary, Boeva, Valentina, primary, Battistella, Aude, primary, Goundiam, Oumou, primary, Smith, Nicholas K., primary, Mueller, Christopher R., primary, Raynal, Virginie, primary, Mariani, Odette, primary, Sastre-Garau, Xavier, primary, and Stern, Marc-Henri, primary

Published
2023
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8. Supplementary Figure Legend from Ovarian Cancers Harboring Inactivating Mutations in CDK12 Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications

Author

Popova, Tatiana, primary, Manié, Elodie, primary, Boeva, Valentina, primary, Battistella, Aude, primary, Goundiam, Oumou, primary, Smith, Nicholas K., primary, Mueller, Christopher R., primary, Raynal, Virginie, primary, Mariani, Odette, primary, Sastre-Garau, Xavier, primary, and Stern, Marc-Henri, primary

Published
2023
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9. Supplementary Methods from Ovarian Cancers Harboring Inactivating Mutations in CDK12 Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications

Author

Popova, Tatiana, primary, Manié, Elodie, primary, Boeva, Valentina, primary, Battistella, Aude, primary, Goundiam, Oumou, primary, Smith, Nicholas K., primary, Mueller, Christopher R., primary, Raynal, Virginie, primary, Mariani, Odette, primary, Sastre-Garau, Xavier, primary, and Stern, Marc-Henri, primary

Published
2023
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15. Hunger‐driven adaptive prioritization of behavior.

Author

Smith, Nicholas K. and Grueter, Brad A.

Subjects
*HYPOTHALAMUS, *HUNGER, *CONTROL (Psychology), *NEURAL circuitry, *PEPTIDES, *FOOD consumption, *NEURONS
Abstract

In order to survive, an animal must adapt its behavioral priorities to accommodate changing internal and external conditions. Hunger, a universally recognized interoceptive signal, promotes food intake though increasingly well‐understood neural circuits. Less understood, is how hunger is integrated into the neural computations that guide nonfeeding behaviors. Within the brain, agouti‐related peptide neurons in the arcuate nucleus of the hypothalamus have been found to powerfully stimulate feeding in addition to mediating other hunger‐driven behavioral phenotypes. In this review, we compile the behavioral plasticity downstream of hunger and present identified or potential molecular and neural circuit mechanisms. We catalogue hunger's ability to increase exploration, decrease anxiety, and alter social behavior, among other phenotypes. Finally, we suggest paths forward for understanding hunger‐driven behavioral adaptation and discuss the benefits of understanding state‐dependent modulation of neural circuits controlling behavior. [ABSTRACT FROM AUTHOR]

Published
2022
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18. Bile diversion, a bariatric surgery, and bile acid signaling reduce central cocaine reward

Author

Reddy, India A., primary, Smith, Nicholas K., additional, Erreger, Kevin, additional, Ghose, Dipanwita, additional, Saunders, Christine, additional, Foster, Daniel J., additional, Turner, Brandon, additional, Poe, Amanda, additional, Albaugh, Vance L., additional, McGuinness, Owen, additional, Hackett, Troy A., additional, Grueter, Brad A., additional, Abumrad, Naji N., additional, Flynn, Charles Robb, additional, and Galli, Aurelio, additional

Published
2018
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19. Ovarian Cancers Harboring Inactivating Mutations in CDK12 Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications

Author

Popova, Tatiana, primary, Manié, Elodie, additional, Boeva, Valentina, additional, Battistella, Aude, additional, Goundiam, Oumou, additional, Smith, Nicholas K., additional, Mueller, Christopher R., additional, Raynal, Virginie, additional, Mariani, Odette, additional, Sastre-Garau, Xavier, additional, and Stern, Marc-Henri, additional

Published
2016
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20. Genomic hallmarks of homologous recombination deficiency in invasive breast carcinomas

Author

Manié, Elodie, primary, Popova, Tatiana, additional, Battistella, Aude, additional, Tarabeux, Julien, additional, Caux‐Moncoutier, Virginie, additional, Golmard, Lisa, additional, Smith, Nicholas K., additional, Mueller, Christopher R., additional, Mariani, Odette, additional, Sigal‐Zafrani, Brigitte, additional, Dubois, Thierry, additional, Vincent‐Salomon, Anne, additional, Houdayer, Claude, additional, Stoppa‐Lyonnet, Dominique, additional, and Stern, Marc‐Henri, additional

Published
2015
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22. Tucson's image problem could be fixed with a good symbol.

Author

Smith, Nicholas K.

Subjects
SIGNS & symbols, BRAND name products, ECONOMICS
Abstract

In this article the author discusses aspects of the importance of providing Tucson, Arizona with a recognizable sign or icon. He cited the book "Tourism and the Branded City: Film and Identity on the Pacific Rim" which says that a successful city brand contributes to its economic growth and happiness of its inhabitants. Furthermore, he mentions symbols that represents other cities like the Golden Gate Bridge of San Francisco, California and the Alamo fortress in San Antonio, Texas.

Published
2011

24. A parabrachial hub for the prioritization of survival behavior.

Author

Goldstein N, Maes A, Allen HN, Nelson TS, Kruger KA, Kindel M, Smith NK, Carty JRE, Villari RE, Cho E, Marble EL, Khanna R, Taylor BK, Kennedy A, and Betley JN

Abstract

Long-term sustained pain in the absence of acute physical injury is a prominent feature of chronic pain conditions. While neurons responding to noxious stimuli have been identified, understanding the signals that persist without ongoing painful stimuli remains a challenge. Using an ethological approach based on the prioritization of adaptive survival behaviors, we determined that neuropeptide Y (NPY) signaling from multiple sources converges on parabrachial neurons expressing the NPY Y1 receptor to reduce sustained pain responses. Neural activity recordings and computational modeling demonstrate that activity in Y1R parabrachial neurons is elevated following injury, predicts functional coping behavior, and is inhibited by competing survival needs. Taken together, our findings suggest that parabrachial Y1 receptor-expressing neurons are a critical hub for endogenous analgesic pathways that suppress sustained pain states.

Published
2024
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