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146 results on '"Smolka, M N"'

6. Genomic architecture of human neuroanatomical diversity

Author

Toro, R, Poline, J-B, Huguet, G, Loth, E, Frouin, V, Banaschewski, T, Barker, G J, Bokde, A, Büchel, C, Carvalho, F M, Conrod, P, Fauth-Bühler, M, Flor, H, Gallinat, J, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Lawrence, C, Lemaître, H, Mann, K, Nees, F, Paus, T, Pausova, Z, Rietschel, M, Robbins, T, Smolka, M N, Ströhle, A, Schumann, G, and Bourgeron, T

Published
2015
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10. Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents

Author

Desrivières, S, Lourdusamy, A, Tao, C, Toro, R, Jia, T, Loth, E, Medina, L M, Kepa, A, Fernandes, A, Ruggeri, B, Carvalho, F M, Cocks, G, Banaschewski, T, Barker, G J, Bokde, A LW, Büchel, C, Conrod, P J, Flor, H, Heinz, A, Gallinat, J, Garavan, H, Gowland, P, Brühl, R, Lawrence, C, Mann, K, Martinot, M LP, Nees, F, Lathrop, M, Poline, J-B, Rietschel, M, Thompson, P, Fauth-Bühler, M, Smolka, M N, Pausova, Z, Paus, T, Feng, J, and Schumann, G

Published
2015
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11. White-matter microstructure and gray-matter volumes in adolescents with subthreshold bipolar symptoms

Author

Martinot, Paillère M-L, Lemaitre, H, Artiges, E, Miranda, R, Goodman, R, Penttilä, J, Struve, M, Fadai, T, Kappel, V, Poustka, L, Conrod, P, Banaschewski, T, Barbot, A, Barker, G J, Büchel, C, Flor, H, Gallinat, J, Garavan, H, Heinz, A, Ittermann, B, Lawrence, C, Loth, E, Mann, K, Paus, T, Pausova, Z, Rietschel, M, Robbins, T W, Smolka, M N, Schumann, G, and Martinot, J-L

Published
2014
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16. Boys do it the right way: Sex-dependent amygdala lateralization during face processing in adolescents

Author

Schneider, S., Peters, J., Bromberg, U., Brassen, S., Menz, M. M., Miedl, S. F., Loth, E., Banaschewski, T., Barbot, A., Barker, G., Conrod, P. J., Dalley, J. W., Flor, H., Gallinat, J., Garavan, H., Heinz, A., Itterman, B., Mallik, C., Mann, K., Artiges, Eric, Paus, T., Poline, B. J., Rietschel, M., Reed, L., Smolka, M. N., Spanagel, R., Speiser, C., Ströhle, A., Struve, M., Schumann, G., and Büchel, C.

Published
2011
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26. OR2-1Low μu-Opioid Receptor Status in Alcohol Dependence Identified by Combined Positron Emission Tomography and Post-Mortem Brain Analysis

Author

Hermann, D, primary, Hirth, N, additional, Reimold, M, additional, Batra, A, additional, Smolka, M N, additional, Hoffmann, S, additional, Kiefer, F, additional, Noori, H R, additional, Sommer, W H, additional, Reischl, G, additional, La Fougère, C, additional, Mann, K, additional, Spanagel, R, additional, and Hansson, A C, additional

Published
2017
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28. Correlated gene expression supports synchronous activity in brain networks

Author

Richiardi, J., Altmann, A., Milazzo, A.-C., Chang, C., Chakravarty, M. M., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Bromberg, U., Buchel, C., Conrod, P., Fauth-Buhler, M., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Lemaitre, H., Mann, K. F., Martinot, J.-L., Nees, F., Paus, T., Pausova, Z., Rietschel, M., Robbins, T. W., Smolka, M. N., Spanagel, R., Strohle, A., Schumann, G., Hawrylycz, M., Poline, J.-B., Greicius, M. D., Albrecht, L., Andrew, C., Arroyo, M., Artiges, E., Aydin, S., Bach, C., Barbot, A., Barker, Gareth, Boddaert, N., Bokde, A., Bricaud, Z., Bruehl, R., Cachia, A., Cattrell, A., Constant, P., Dalley, J., Decideur, B., Desrivieres, S., Fadai, T., Briand, F. G., Heinrichs, B., Heym, N., Hubner, T., Ireland, J., Ittermann, B., Jia, T., Lathrop, M., Lanzerath, D., Lawrence, C., Ludemann, K., Macare, C., Mallik, C., Mangin, J.-F., Mann, K., Martinot, J.- L., Mennigen, E., Mesquita de Carvahlo, F., Mignon, X., Miranda, Ruben, Muller, K., Nymberg, C., Paillere, M.-L., Poustka, L., Rapp, M., Robert, G., Reuter, J., Ripke, S., Robbins, Trevor, Rodehacke, S., Rogers, J., Romanowski, A., Ruggeri, B., Schmal, C., Schmidt, D., Schneider, S., Schumann, M., Schubert, F., Schwartz, Y., Smolka, M., Sommer, W., Speiser, C., Spranger, T., Stedman, A., Steiner, S., Stephens, D., Strache, N., Struve, M., Subramaniam, N., Topper, L., Whelan, R., Williams, S., Yacubian, J., Zilbovicius, M., Wong, C. P., Lubbe, S., Martinez-Medina, L., Fernandes, A., Tahmasebi, A., and IMAGEN consortium

Subjects
Multidisciplinary
Published
2015

30. Disentangling the autism−anxiety overlap: fMRI of reward processing in a community-based longitudinal study

Author

Mikita, N, primary, Simonoff, E, additional, Pine, D S, additional, Goodman, R, additional, Artiges, E, additional, Banaschewski, T, additional, Bokde, A L, additional, Bromberg, U, additional, Büchel, C, additional, Cattrell, A, additional, Conrod, P J, additional, Desrivières, S, additional, Flor, H, additional, Frouin, V, additional, Gallinat, J, additional, Garavan, H, additional, Heinz, A, additional, Ittermann, B, additional, Jurk, S, additional, Martinot, J L, additional, Paillère Martinot, M L, additional, Nees, F, additional, Papadopoulos Orfanos, D, additional, Paus, T, additional, Poustka, L, additional, Smolka, M N, additional, Walter, H, additional, Whelan, R, additional, Schumann, G, additional, and Stringaris, A, additional

Published
2016
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33. Genomic architecture of human neuroanatomical diversity

Author

Toro, R, primary, Poline, J-B, additional, Huguet, G, additional, Loth, E, additional, Frouin, V, additional, Banaschewski, T, additional, Barker, G J, additional, Bokde, A, additional, Büchel, C, additional, Carvalho, F M, additional, Conrod, P, additional, Fauth-Bühler, M, additional, Flor, H, additional, Gallinat, J, additional, Garavan, H, additional, Gowland, P, additional, Heinz, A, additional, Ittermann, B, additional, Lawrence, C, additional, Lemaître, H, additional, Mann, K, additional, Nees, F, additional, Paus, T, additional, Pausova, Z, additional, Rietschel, M, additional, Robbins, T, additional, Smolka, M N, additional, Ströhle, A, additional, Schumann, G, additional, and Bourgeron, T, additional

Published
2014
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34. EFhd2/Swiprosin-1 is a common genetic determinator for sensation-seeking/low anxiety and alcohol addiction

Author

Mielenz, D, Reichel, M, Jia, T, Quinlan, E B, Stöckl, T, Mettang, M, Zilske, D, Kirmizi-Alsan, E, Schönberger, P, Praetner, M, Huber, S E, Amato, D, Schwarz, M, Purohit, P, Brachs, S, Spranger, J, Hess, A, Büttner, C, Ekici, A B, Perez-Branguli, F, Winner, B, Rauschenberger, V, Banaschewski, T, Bokde, A L W, Büchel, C, Conrod, P J, Desrivières, S, Flor, H, Frouin, V, Gallinat, J, Garavan, H, Gowland, P, Heinz, A, Martinot, J-L, Lemaitre, H, Nees, F, Paus, T, Smolka, M N, Schambony, A, Bäuerle, T, Eulenburg, V, Alzheimer, C, Lourdusamy, A, Schumann, G, and Müller, C P

Abstract

In many societies, the majority of adults regularly consume alcohol. However, only a small proportion develops alcohol addiction. Individuals at risk often show a high sensation-seeking/low-anxiety behavioural phenotype. Here we asked which role EF hand domain containing 2 (EFhd2; Swiprosin-1) plays in the control of alcohol addiction-associated behaviours. EFhd2 knockout (KO) mice drink more alcohol than controls and spontaneously escalate their consumption. This coincided with a sensation-seeking and low-anxiety phenotype. A reversal of the behavioural phenotype with β-carboline, an anxiogenic inverse benzodiazepine receptor agonist, normalized alcohol preference in EFhd2 KO mice, demonstrating an EFhd2-driven relationship between personality traits and alcohol preference. These findings were confirmed in a human sample where we observed a positive association of the EFhd2 single-nucleotide polymorphism rs112146896 with lifetime drinking and a negative association with anxiety in healthy adolescents. The lack of EFhd2 reduced extracellular dopamine levels in the brain, but enhanced responses to alcohol. In confirmation, gene expression analysis revealed reduced tyrosine hydroxylase expression and the regulation of genes involved in cortex development, Eomes and Pax6, in EFhd2 KO cortices. These findings were corroborated in Xenopus tadpoles by EFhd2 knockdown. Magnetic resonance imaging (MRI) in mice showed that a lack of EFhd2 reduces cortical volume in adults. Moreover, human MRI confirmed the negative association between lifetime alcohol drinking and superior frontal gyrus volume. We propose that EFhd2 is a conserved resilience factor against alcohol consumption and its escalation, working through Pax6/Eomes. Reduced EFhd2 function induces high-risk personality traits of sensation-seeking/low anxiety associated with enhanced alcohol consumption, which may be related to cortex function.

Published
2018
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35. The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans

Author

Gonzalez, D A, Jia, T, Pinzón, J H, Acevedo, S F, Ojelade, S A, Xu, B, Tay, N, Desrivières, S, Hernandez, J L, Banaschewski, T, Büchel, C, Bokde, A L W, Conrod, P J, Flor, H, Frouin, V, Gallinat, J, Garavan, H, Gowland, P A, Heinz, A, Ittermann, B, Lathrop, M, Martinot, J-L, Paus, T, Smolka, M N, Rodan, A R, Schumann, G, and Rothenfluh, A

Abstract

Ubiquitously expressed genes have been implicated in a variety of specific behaviors, including responses to ethanol. However, the mechanisms that confer this behavioral specificity have remained elusive. Previously, we showed that the ubiquitously expressed small GTPase Arf6 is required for normal ethanol-induced sedation in adult Drosophila. Here, we show that this behavioral response also requires Efa6, one of (at least) three Drosophila Arf6 guanine exchange factors. Ethanol-naive Arf6 and Efa6 mutants were sensitive to ethanol-induced sedation and lacked rapid tolerance upon re-exposure to ethanol, when compared with wild-type flies. In contrast to wild-type flies, both Arf6 and Efa6 mutants preferred alcohol-containing food without prior ethanol experience. An analysis of the human ortholog of Arf6 and orthologs of Efa6 (PSD1-4) revealed that the minor G allele of single nucleotide polymorphism (SNP) rs13265422 in PSD3, as well as a haplotype containing rs13265422, was associated with an increased frequency of drinking and binge drinking episodes in adolescents. The same haplotype was also associated with increased alcohol dependence in an independent European cohort. Unlike the ubiquitously expressed human Arf6 GTPase, PSD3 localization is restricted to the brain, particularly the prefrontal cortex (PFC). Functional magnetic resonance imaging revealed that the same PSD3 haplotype was also associated with a differential functional magnetic resonance imaging signal in the PFC during a Go/No-Go task, which engages PFC-mediated executive control. Our translational analysis, therefore, suggests that PSD3 confers regional specificity to ubiquitous Arf6 in the PFC to modulate human alcohol-drinking behaviors.

Published
2018
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38. Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate

Author

Kiefer, F, primary, Witt, S H, additional, Frank, J, additional, Richter, A, additional, Treutlein, J, additional, Lemenager, T, additional, Nöthen, M M, additional, Cichon, S, additional, Batra, A, additional, Berner, M, additional, Wodarz, N, additional, Zimmermann, U S, additional, Spanagel, R, additional, Wiedemann, K, additional, Smolka, M N, additional, Heinz, A, additional, Rietschel, M, additional, and Mann, K, additional

Published
2010
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40. Serotonergic Effects of Smoking are Independent from the Human Serotonin Transporter Gene Promoter Polymorphism: Evidence from Auditory Cortical Stimulus Processing

Author

Gallinat, J., primary, Kunz, D., additional, Lang, U. E., additional, Kalus, P., additional, Juckel, G., additional, Eggers, J., additional, Mahlberg, R., additional, Staedtgen, M., additional, Wernicke, C., additional, Rommelspacher, H., additional, and Smolka, M. N., additional

Published
2005
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43. HOW REPRESENTIVE IS REPRESENTIVE?

Author

Zimmer, A, primary, Klein, O, additional, Nakovics, H, additional, Lem??nager, T, additional, Georgi, A, additional, Nikitopoulos, J A., additional, Fischbach, S, additional, Kr??mer, R, additional, Croissant, B, additional, Kluge, M, additional, Gann, H, additional, Batra, A, additional, Smolka, M N., additional, and Mann, K, additional

Published
2004
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45. PROJECT PREDICT - DESIGN AND PRELIMINARY RESULTS.

Author

Nikitopoulos, J A., primary, Georgi, A, additional, Lemenager, T, additional, Kr??mer, R, additional, Klein, O, additional, Batra, A, additional, Br??ck, R, additional, Diehl, A, additional, Heinz, A, additional, Smolka, M N., additional, and Mann, K, additional

Published
2004
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47. CENTRAL PROCESSING OF ALCOHOL CUES AND CRAVING CORRELATE WITH DOPAMINE D2 RECEPTORS IN VENTRAL STRIATUM.

Author

Heinz, A, primary, Siessmeier, T, additional, Wrase, J, additional, Hermann, D, additional, Gr??sser, S M., additional, Flor, H, additional, Braus, D F., additional, Buchholz, H -G., additional, Gr??nder, G, additional, Schreckenberger, M, additional, Smolka, M N., additional, R??sch, F, additional, Mann, K, additional, and Bartenstein, P, additional

Published
2004
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49. Dopamine-Modulated Aversive Emotion Processing Fails in Alcohol-Dependent Patients.

Author

Kienast, T., Schlagenhauf, F., Rapp, M. A., Wrase, J., Daig, I., Buchholz, H.-G., Smolka, M. N., Gründer, G., Kumakura, Y., Cumming, P., Charlet, K., Bartenstein, P., Hariri, A. R., and Heinz, A.

Subjects
ALCOHOLISM, EMOTIONS, BRAIN imaging, DOPAMINE, DETOXIFICATION (Substance abuse treatment)
Abstract

Introduction: Negative mood states after alcohol detoxification may enhance the relapse risk. As recently shown in healthy volunteers, dopamine storage capacity (Vd) in the left amygdala was positively correlated with functional activation in the left amygdala and anterior cingulate cortex (ACC) during an emotional task; high functional connectivity between the amygdala and the ACC, a region important for emotion regulation, was associated with low trait anxiety. Based on these findings, we now tested whether detoxified alcohol-dependent patients have a disrupted modulation of the anterior cingulate cortex activation in response to aversive stimuli by amygdala dopamine. Furthermore, we asked whether disrupted functional coupling between amygdala and ACC during aversive processing is related to trait anxiety. Methods: We used combined 6-[18F]-fluoro- L - DOPA positron emission tomography (PET), functional magnetic resonance imaging (fMRI) and Spielberger's state-trait anxiety questionnaire (STAI) in 11 male detoxified alcohol-dependent patients compared to 13 matched healthy controls. Results: Unlike healthy controls, patients showed no significant correlation between our PET metric for dopamine storage capacity (FDOPAVd), in left amygdala and activation in left ACC. Moreover, the functional connectivity between amygdala and ACC during processing of aversive emotional stimuli was reduced in patients. Voxelbased morphometry did not reveal any discernible group differences in amygdala volume. Discussion: These results suggest that dopamine-modulated corticolimbic circuit function is important for responding to emotional information such that apparent functional deficits in this neuromodulatory circuitry may contribute to trait anxiety in alcohol-dependent patients. [ABSTRACT FROM AUTHOR]

Published
2013
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50. Anxiety is associated with reduced central serotonin transporter availability in unmedicated patients with unipolar major depression: a [11C]DASB PET study.

Author

Reimold, M., Batra, A., Knobel, A., Smolka, M. N., Zimmer, A., Mann, K., Solbach, C., Reischl, G., Schwärzler, F., Gründer, G., Machulla, H-J, Bares, R., and Heinz, A.

Subjects
PSYCHOLOGICAL stress, ANXIETY, THALAMUS, MENTAL depression, SEROTONIN, NEUROTRANSMITTERS
Abstract

Serotonergic dysfunction may contribute to negative mood states in affective disorders. Some in vivo imaging studies showed reduced availability of serotonin transporters (5-HTT) in the brainstem and thalamus of patients with major depression. We tested the hypothesis that 5-HTT availability is reduced in unmedicated unipolar patients with major depression compared to healthy control subjects matched for gender, age, genotype and smoking status. Availability of 5-HTT was measured in vivo with positron emission tomography and [11C]-3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (DASB) in the midbrain, thalamus and amygdala. DASB binding was correlated with the severity of depression (Beck's Depression Inventory), anxiety (Spielberger's State-Trait Anxiety Inventory) and personality traits (Temperament and Character Inventory). Patients with major depression displayed reduced 5-HTT availability in the thalamus (P=0.005). In patients, low serotonin transporter availability correlated with high anxiety (thalamus: r=−0.78, P=0.004; midbrain: r=−0.78, P=0.004; amygdala: r=−0.80, P=0.003). Correlations with severity of depression were weaker and did not survive correction for multiple testing. These results support the hypothesis that central serotonergic dysfunction is associated with negative mood states in affective disorders. In the thalamus, a low serotonin reuptake capacity may interfere with thalamic control of cortical excitability and contribute to anxiety rather than depression per se in major depression.Molecular Psychiatry (2008) 13, 606–613; doi:10.1038/sj.mp.4002149; published online 12 February 2008 [ABSTRACT FROM AUTHOR]

Published
2008
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