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2. A Pathway to Excellence

Author

Smoller, Bruce R.

Subjects
Histology, Paediatric medicine, bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBX History of medicine, bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJW Paediatric medicine
Abstract

The First 100 Years of Pathology and Laboratory Medicine at the University of Rochester School of Medicine and Dentistry, 1921-2020

Published
2020

6. Spiny Keratoderma

Author

Pukhalskaya, Tatsiana, Smoller, Bruce R., Rongioletti, Franco, editor, and Smoller, Bruce R., editor

Published
2021
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13. Skin Tumors

Author

Reyes Barron, Cynthia, Smoller, Bruce R., Lin, Fan, Series Editor, Yang, Ximing J., Series Editor, Ding, Yi, editor, and Zhang, Linsheng, editor

Published
2021
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20. The New York State SARS-CoV-2 Testing Consortium: Regional Communication in Response to the COVID-19 Pandemic

Author

Crawford, James M., Aguero-Rosenfeld, Maria E., Aifantis, Ioannis, Cadoff, Evan M., Cangiarella, Joan F., Cordon-Cardo, Carlos, Cushing, Melissa, Firpo-Betancourt, Aldolfo, Fox, Amy S., Furuya, Yoko, Hacking, Sean, Jhang, Jeffrey, Leonard, Debra G.B., Libien, Jenny, Loda, Massimo, Mendu, Damadora Rao, Mulligan, Mark J., Nasr, Michel R., Pecora, Nicole D., Pessin, Melissa S., Prystowsky, Michael B., Ramanathan, Lakshmi V., Rauch, Kathleen R., Riddell, Scott, Roach, Karen, Roth, Kevin A., Shroyer, Kenneth R., Smoller, Bruce R., Spitalnik, Steven L., Spitzer, Eric D., Tomaszewski, John E., Waltman, Susan, Willis, Loretta, and Sumer-King, Zeynep

Published
2021
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21. A diagnostically challenging case of CD8+ primary cutaneous gamma/delta T-cell lymphoma

Author

Pitch, Michelle A, Kim, Kevin H, Manning, Trey, Smoller, Bruce R, Wong, Henry K, and Kaley, Jennifer R

Subjects
general dermatology, medical dermatology, oncology, cutaneous lymphoma, CD8, gamma-delta T cells
Abstract

Primary cutaneous gamma/delta T-cell lymphoma (PCγδTCL) is a rare form of cutaneous lymphoma characterized by abnormal clonal proliferation of mature, activated gamma-delta T cells expressing the γδ heterodimer of the T-cell receptor (TCR). As an entity, PCγδTCL has recently undergone diagnostic revision since its introduction in the 2008 WHO classification of cutaneous lymphomas and confirmedin 2016. Nonetheless, diagnosis remains difficult both clinically and histologically, given its broad range of clinical manifestations and immunohistochemical phenotypes. Herein, we present a rare case of CD8+ PCγδTCL with a discussion highlighting theheterogeneity within this entity.

Published
2017

22. A peculiar in situ case of cutaneous leukocytoclastic vasculitis induced by urinary infection.

Author

Velez, Ana Maria Abreu, Smoller, Bruce R., and Howard, Michael S.

Subjects
*LEUKOCYTOCLASTIC vasculitis, *VON Willebrand factor, *RIBOSOMAL proteins, *IMMUNE complexes, *BLOOD vessels
Abstract

Cutaneous leukocytoclastic vasculitis (LCV) is a disease thought to be related to the presence of immune complex deposition within small blood vessel walls. A 58-year-old female presented with purpuric papules on both legs, occurring concurrent with urinary symptoms. Histologically, an intraepidermal blister with luminal fragmented neutrophils was present. A dermal infiltrate was observed surrounding blood vessels; mild perivascular leukocytoclastic debris favored a diagnosis of LCV. Both direct immunofluorescence and immunohistochemistry staining also favored a diagnosis of LCV. Reactivity of the involved vessels was observed to multiple antibodies and complement, with overexpression of von Willebrand factor, CD15, and CD45. The ribosomal protein Phospho-S6 was also detected within the involved vessels, and on the blister roof and floor. The clinical triggering factor was a urinary infection that had progressed to urosepsis; the symptoms were effectively treated. We present an unusual case, where multiple immune reactions correlate with clinical and histologic changes characteristic of LCV. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Claudin-4 Upregulation in Acantholytic and Autoimmune-Mediated Bullous Disorders.

Author

Bui, Chau M., Vuong, Huy G., Le, Minh-Khang, Rybski, Kristin J., Zengin, Hatice B., Tang, Haiming, and Smoller, Bruce R.

Subjects
PEMPHIGUS, BULLOUS pemphigoid, KERATOSIS follicularis, PEMPHIGUS vulgaris, TIGHT junctions, HAIR follicles
Abstract

Claudin-4 is a key component of tight junctions, which play an important role in the formation of the epidermal barrier by forming a circumferential network in the granular layer that serves as a gatekeeper of the paracellular pathway. The aim of this study is to illustrate claudin-4 immunohistochemical staining patterns of different blistering disorders. We collected 35 cases, including two Hailey–Hailey disease, one Darier disease, three Grover disease, one acantholytic acanthoma, two warty dyskeratoma, 11 pemphigus vulgaris (PV) including six mucosal PV, and two pemphigus foliaceus. For comparison, we included five cases of normal skin, five eczema, and three bullous pemphigoid cases. Claudin-4 demonstrated weak-to-moderate expression in keratinocytes located in the stratum granulosum, keratinocytes surrounding hair follicles, and adnexal glands. Further, claudin-4 exhibited moderate-to-strong membranous staining in disrupted keratinocytes surrounding and within the acantholytic and bullous areas in 16/22 of the acantholytic cases (not seen in the six cases of mucosal PV) and all three bullous pemphigoids. This finding suggests that claudin-4 is upregulated in these conditions, which may be a compensatory response to the disrupted barrier function. This finding could shed light on the molecular mechanisms underlying disrupted barrier function in blistering disorders, independent of the specific underlying disease mechanism. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Panniculitis

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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27. Papulosquamous Diseases

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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28. Granulomatous Eruptions

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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30. Interface Dermatoses

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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32. Vesiculobullous Diseases

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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33. Muscle and Bone Proliferations

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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34. Neural Proliferations

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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35. Adipocyte Proliferations

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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37. Spongiotic Dermatitis

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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38. Fibrous Proliferations

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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39. Diseases of the Hair and Nails

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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40. Keratinous Cysts and Hamartomas

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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41. Hematopoietic Proliferations

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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42. Vascular Anomalies

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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45. Disorders of Pigmentation

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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47. Fungal Diseases

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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48. Deposition Disorders

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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49. Nutritional Disorders

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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50. Insect Bites and Infestations

Author

Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., Smoller, Bruce R., Phung, Thuy L., Wright, Teresa S., Pourciau, Crystal Y., and Smoller, Bruce R.

Published
2017
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