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15. Tumor cell-specific Serpin A1 expression in vulvar squamous cell carcinoma

Author

Lagerstedt, M, Huotari-Orava, R, Nyberg, R, Nissinen, L, Farshchian, M, Laasanen, S-L, Snellman, E, Mäenpää, J, Kähäri, V-M, Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, and Tampere University

Subjects
Vulvar squamous cell carcinoma, p53, p16, Naisten- ja lastentaudit - Gynaecology and paediatrics, Serpin A1, Lichen sclerosus
Published
2019

16. Hyperspectral imaging system in the delineation of Ill-defined basal cell carcinomas : a pilot study

Author

Salmivuori, M., Neittaanmäki, N., Pölönen, Ilkka, Jeskanen, L., Snellman, E., Grönroos, M., Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, and Tampere University

Subjects
ihosyöpä, kuvantaminen, skin cancer, basal cell carcinoma, hyperspectral imaging, spektrikuvaus, Matematiikka - Mathematics, Fysiikka - Physical sciencesSyöpätaudit - Cancers, imaging, spectral imaging, margins, tyvisolusyöpä, BCC
Abstract

Background Basal cell carcinoma (BCC) is the most common skin cancer in the Caucasian population. Eighty per cent of BCCs are located on the head and neck area. Clinically ill‐defined BCCs often represent histologically aggressive subtypes, and they can have subtle subclinical extensions leading to recurrence and the need for re‐excisions. Objectives The aim of this pilot study was to test the feasibility of a hyperspectral imaging system (HIS) in vivo in delineating the preoperatively lateral margins of ill‐defined BCCs on the head and neck area. Methods Ill‐defined BCCs were assessed clinically with a dermatoscope, photographed and imaged with HIS. This was followed by surgical procedures where the BCCs were excised at the clinical border and the marginal strip separately. HIS, with a 12‐cm2 field of view and fast data processing, records a hyperspectral graph for every pixel in the imaged area, thus creating a data cube. With automated computational modelling, the spectral data are converted into localization maps showing the tumour borders. Interpretation of these maps was compared to the histologically verified tumour borders. Results Sixteen BCCs were included. Of these cases, 10 of 16 were the aggressive subtype of BCC and 6 of 16 were nodular, superficial or a mixed type. HIS delineated the lesions more accurately in 12 of 16 of the BCCs compared to the clinical evaluation (4 of 16 wider and 8 of 16 smaller by HIS). In 2 of 16 cases, the HIS‐delineated lesion was wider without histopathological confirmation. In 2 of 16 cases, HIS did not detect the histopathologically confirmed subclinical extension. Conclusions HIS has the potential to be an easy and fast aid in the preoperative delineation of ill‐defined BCCs, but further adjustment and larger studies are warranted for an optimal outcome. peerReviewed

Published
2019

22. 115 Hexylaminolevulinate and Aminolevulinic acid Nanoemulsion have Similar Tolerability, Initial Efficacy and Cosmetic Outcome as Methylaminolevulinate in Photodynamic Therapy of Basal Cell Carcinoma in a Prospective Randomized Double-blinded Trial

Author

Salmivuori, M.K., primary, Grönroos, M., additional, Tani, T., additional, Pölönen, I., additional, Räsänen, J., additional, Annala, L., additional, Snellman, E., additional, and Neittaanmäki, N., additional

Published
2019
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25. 5‐aminolaevulinic acid nanoemulsion is more effective than methyl‐5‐aminolaevulinate in daylight photodynamic therapy for actinic keratosis: a nonsponsored randomized double‐blind multicentre trial

Author

Räsänen, J.E., primary, Neittaanmäki, N., additional, Ylitalo, L., additional, Hagman, J., additional, Rissanen, P., additional, Ylianttila, L., additional, Salmivuori, M., additional, Snellman, E., additional, and Grönroos, M., additional

Published
2019
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28. Ablative fractional laser‐assisted photodynamic therapy for lentigo maligna: a prospective pilot study.

Author

Räsänen, J.E., Neittaanmäki, N., Jeskanen, L., Pölönen, I., Snellman, E., and Grönroos, M.

Subjects
PHOTODYNAMIC therapy, LONGITUDINAL method, PILOT projects, LENTIGO, DRUG side effects
Abstract

Background: Lentigo maligna (LM) is an in situ form of melanoma carrying a risk of progression to invasive lentigo maligna melanoma (LMM). LM poses a clinical challenge, with subclinical extension and high recurrence rates after incomplete surgery. Alternative treatment methods have been investigated with varying results. Photodynamic therapy (PDT) with methylaminolaevulinate (MAL) has already proved promising in this respect. Objectives: To investigate the efficacy of ablative fractional laser (AFL)‐assisted PDT with 5‐aminolaevulinic acid nanoemulsion (BF‐200 ALA) for treating LM. Methods: In this non‐sponsored prospective pilot study, ten histologically verified LMs were treated with AFL‐assisted PDT three times at 2‐week intervals using a light dose of 90 J/cm2 per treatment session. Local anaesthesia with ropivacaine was used. Four weeks after the last PDT treatment the lesions were treated surgically with a wide excision and sent for histopathological examination. The primary outcome was complete histopathological clearance of the LM from the surgical specimen. Patient‐reported pain during illumination and the severity of the skin reaction after the PDT treatments were monitored as secondary outcomes. Results: The complete histopathological clearance rate was 7 out of 10 LMs (70%). The pain during illumination was tolerable, with the mean pain scores for the PDT sessions on a visual assessment scale ranging from 2.9 to 3.8. Some severe skin reactions occurred during the treatment period, however. Conclusions: Ablative fractional laser‐assisted PDT showed moderate efficacy in terms of histological clearance. It could constitute an alternative treatment for LM but due to the side effects it should only be considered in inoperable cases. Linked Commentary: L. Marini et al. J Eur Acad Dermatol Venereol 2020; 34: 440–441. https://doi.org/10.1111/jdv.16262 [ABSTRACT FROM AUTHOR]

Published
2020
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34. Hyperspectral imaging system in the delineation of Ill‐defined basal cell carcinomas: a pilot study.

Author

Grönroos, M., Salmivuori, M., Snellman, E., Neittaanmäki, N., Pölönen, I., and Jeskanen, L.

Abstract

Background: Basal cell carcinoma (BCC) is the most common skin cancer in the Caucasian population. Eighty per cent of BCCs are located on the head and neck area. Clinically ill‐defined BCCs often represent histologically aggressive subtypes, and they can have subtle subclinical extensions leading to recurrence and the need for re‐excisions. Objectives: The aim of this pilot study was to test the feasibility of a hyperspectral imaging system (HIS) in vivo in delineating the preoperatively lateral margins of ill‐defined BCCs on the head and neck area. Methods: Ill‐defined BCCs were assessed clinically with a dermatoscope, photographed and imaged with HIS. This was followed by surgical procedures where the BCCs were excised at the clinical border and the marginal strip separately. HIS, with a 12‐cm2 field of view and fast data processing, records a hyperspectral graph for every pixel in the imaged area, thus creating a data cube. With automated computational modelling, the spectral data are converted into localization maps showing the tumour borders. Interpretation of these maps was compared to the histologically verified tumour borders. Results: Sixteen BCCs were included. Of these cases, 10 of 16 were the aggressive subtype of BCC and 6 of 16 were nodular, superficial or a mixed type. HIS delineated the lesions more accurately in 12 of 16 of the BCCs compared to the clinical evaluation (4 of 16 wider and 8 of 16 smaller by HIS). In 2 of 16 cases, the HIS‐delineated lesion was wider without histopathological confirmation. In 2 of 16 cases, HIS did not detect the histopathologically confirmed subclinical extension. Conclusions: HIS has the potential to be an easy and fast aid in the preoperative delineation of ill‐defined BCCs, but further adjustment and larger studies are warranted for an optimal outcome. [ABSTRACT FROM AUTHOR]

Published
2019
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47. Clinical Associations of the Risk Alleles of HLA-Cw6 and CCHCR1*WWCC in Psoriasis

Author

Suomela, S, primary, Kainu, K, additional, Onkamo, P, additional, Tiala, I, additional, Himberg, J, additional, Koskinen, L, additional, Snellman, E, additional, Karvonen, SL, additional, Karvonen, J, additional, Uurasmaa, T, additional, Reunala, T, additional, Kivikäs, K, additional, Jansén, CT, additional, Holopainen, P, additional, Elomaa, O, additional, Kere, J, additional, and Saarialho-Kere, U, additional

Published
2007
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