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4. Health Utility Score in Thai Patients with Chronic Rhinosinusitis: Pre‐ and Postoperative Analyses.

Author

Sangubol, Melissa, Snidvongs, Kornkiat, Lawpoolsri, Saranath, Mongkolkul, Kittichai, Kowatanamongkon, Patlada, and Chitsuthipakorn, Wirach

Abstract

Background: Endoscopic sinus surgery (ESS) can increase the health utility score (HUS) of patients with chronic rhinosinusitis (CRS) who require the surgery. HUS varies depending on the geographical or living environment. HUS in CRS has never been evaluated in Thailand. The objective of this study was to evaluate the HUS of Thai patients with CRS before and after ESS through multiple approaches. Methods: Thai patients (age ≥ 18) with CRS scheduled for ESS were enrolled in this prospective study. The preoperative (baseline) demographics, 22‐items sinonasal outcome test, endoscopic score, and CT score were recorded. The HUS was evaluated using four methods: the EuroQoL‐5 Dimension‐5 level (EQ‐5D‐5L), Visual Analog Scale (VAS), Standard gamble (SG), and Time trade‐off (TTO); at baseline, three months and six months post‐operation. Results: Data from 60 patients were analyzed. The mean baseline HUS scores by EQ‐5D‐5L, VAS, SG, and TTO were 0.75, 0.65, 0.79, and 0.85, respectively. The postoperative HUS significantly improved to 0.96, 0.91, 0.96, 0.97 at three months, and 0.97, 0.92, 0.97, and 0.98 at six months, respectively. ESS raised the HUS by 0.12–0.27 points. Among the four methods, VAS showed the lowest HUS at all time points. Conclusion: The preoperative HUS in Thai patients with CRS generally increased to near‐perfect values after the ESS. The increase in HUS reflecting the improved general quality of life, was demonstrated at three and up to six months after ESS. Level of Evidence: 4 Laryngoscope, 134:2070–2076, 2024 [ABSTRACT FROM AUTHOR]

Published
2024
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5. Endonasal thermal imaging in the assessment of nasal obstruction and airflow

Author

Seresirikachorn, Kachorn, primary, Png, Lu Hui, additional, Do, Timothy Quy-Phong, additional, Kalish, Larry, additional, Campbell, Raewyn G., additional, Rimmer, Janet, additional, Alvarado, Raquel, additional, Raji, Nelufer, additional, Choy, Christine, additional, Snidvongs, Kornkiat, additional, Sacks, Raymond, additional, and Harvey, Richard J., additional

Published
2023
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14. Aerosol Concentrations During Otolaryngology Procedures in a Negative Pressure Isolation Room

Author

Seresirikachorn, Kachorn, primary, Sirinara, Patthrarawalai, additional, Tangjaturonrasme, Napadon, additional, Panyametheekul, Sirima, additional, Ngamsritrakul, Thawat, additional, Supaphan, Uraiwan, additional, Boonroung, Thirayu, additional, Ongphichetmetha, Napassorn, additional, Koosrivinij, Saraporn, additional, and Snidvongs, Kornkiat, additional

Published
2023
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24. Corticosteroid nasal irrigations after endoscopic sinus surgery for recalcitrant chronic rhinosinusitis

Author

Snidvongs, Kornkiat

Subjects
otorhinolaryngologic diseases, Other education not elsewhere classified
Abstract

Chronic rhinosinusitis (CRS) is a heterogeneous disease with multiple pathogenic factors and various inflammatory mechanisms. Although high eosinophil content in the sinus tissue has been acknowledged as a marker of recalcitrant CRS, eosinophilic chronic rhinosinusitis (ECRS) is traditionally diagnosed by its phenotypes other than structured histopathology profiling. Osteitis is another marker associated with recalcitrant inflammation. However, the pathogenesis of osteitis in patients without previous sinus surgery is poorly understood. Patients with ECRS and patients with osteitis have higher disease severity and poorer treatment outcomes. Both observed changes are thought to be features of disordered inflammation. Currently, topical steroid is the first line drug recommended for treating CRS. Although having strong anti-inflammatory effects, topical steroid sprays provide poor sinus delivery. Published randomized controlled trials on the efficacy of topical steroids in CRS use either nasal delivery (nasal drop, nasal spray) or sinus delivery (sinus catheter, sinus irrigation) in patients with or without sinus surgery. This heterogeneity influences topical drug delivery and distribution. This thesis examines the basis of diagnosis, characterisation of the inflammatory process, influence of surgery and device in drug delivery and proposes a revised treatment of CRS with postoperative corticosteroid nasal irrigation which combines the therapeutic effects of sinus surgery and sinus delivery of corticosteroid for an inflammatory condition. In this treatment paradigm, the purpose of sinus surgery is to create access for topical therapies rather than a fundamental concept of relieving ostiomeatal obstruction. Even for the challenging subgroups of ECRS and patients with osteitis, had favourable outcomes and even greater improvement than the non ECRS subgroup. When CRS is managed as an inflammatory condition with local mucosal inflammation controlled with effectively delivered pharmaceutical solutions, therapy is greatly optimized compared to traditional regimes.

Published
2022
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28. Empty Nose Syndrome Pathophysiology: A Systematic Review

Author

Kanjanawasee, Dichapong, primary, Campbell, Raewyn G., additional, Rimmer, Janet, additional, Alvarado, Raquel, additional, Kanjanaumporn, Jesada, additional, Snidvongs, Kornkiat, additional, Kalish, Larry, additional, Harvey, Richard J., additional, and Sacks, Raymond, additional

Published
2021
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29. Empty Nose Syndrome Pathophysiology: A Systematic Review.

Author

Kanjanawasee, Dichapong, Campbell, Raewyn G., Rimmer, Janet, Alvarado, Raquel, Kanjanaumporn, Jesada, Snidvongs, Kornkiat, Kalish, Larry, Harvey, Richard J., and Sacks, Raymond

Abstract

Objective: The pathophysiology of empty nose syndrome (ENS) remains unclear despite significant research. The pathophysiologic mechanism of ENS was systematically reviewed. Data Sources: MEDLINE and Embase. Review Methods: Data were systematically reviewed for studies that provided original data on pathophysiology. Results: A total of 2476 studies were screened, and 19 met the inclusion criteria: 13 case-control and 6 cross-sectional. Nine pathophysiologic themes were identified. • Demographics: ENS symptoms had no relationship with climatic factors. • Symptomatology: ENS patients demonstrated high symptom severity. • Mental health: Anxiety and depression including hyperventilation were reported in >50% of ENS patients and correlated with ENS symptom severity. • Anatomic features: Structural changes in response to turbinate surgery were similar between ENS and non-ENS patients. • Airflow analysis: Airflow parameters were similar between ENS and non-ENS patients after turbinate surgery. On computational fluid dynamic analysis, differences were found on multiple outcomes. • Diagnostic testing: The menthol detection test was impaired in ENS, and cotton placement in the airway improved ENS symptoms. • Cognitive function: Functional magnetic resonance imaging showed activation in emotional processing area during breathing. • Olfactory function: Subjective impairment was reported in ENS, but quantitative measures were similar to non-ENS patients. • Mucosal physiology/innate immunity: Turbinate histopathology in ENS showed a tissue-remodeling pattern. Nasal nitric oxide level was lower in ENS patients. Conclusion: There is evidence of high comorbid mental health disorders in ENS patients. An abnormal trigeminal-thermoreceptor response may be present in some patients. The influence of altered airflow and the evidence of surgery as the cause for ENS are unclear. [ABSTRACT FROM AUTHOR]

Published
2022
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30. International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Author

Orlandi, Richard, Kingdom, Todd T., Smith, Timothy L., Bleier, Benjamin, DeConde, Adam, Luong, Amber, Poetker, David M., Soler, Zachary, Welch, Kevin C., Wise, Sarah K., Adappa, Nithin, Alt, Jeremiah A., Anselmo-Lima, Wilma Terezinha, Bachert, Claus, Baroody, Fuad M., Batra, Pete S., Bernal-Sprekelsen, Manuel, Beswick, Daniel, Bhattacharyya, Neil, Chandra, Rakesh K., Chang, Eugene, Chiu, Alexander, Chowdhury, Naweed, Citardi, Martin J., Cohen, Noam, Conley, David B., DelGaudio, John, Desrosiers, Martin, Douglas, Richard, Anderson Eloy, Jean, Fokkens, Wytske J., Gray, Stacey T., Gudis, David A., Hamilos, Daniel L., Han, Joseph K., Harvey, Richard, Hellings, Peter, Holbrook, Eric H., Hopkins, Claire, Hwang, Peter, Javer, Amin R., Jiang, Rong-San, Kennedy, David, Kern, Robert, Laidlaw, Tanya, Lal, Devyani, Lane, Andrew, Lee, Heung-Man, Lee, Jivianne T., Levy, Joshua M., Lin, Sandra Y., Lund, Valerie, McMains, Kevin C., Metson, Ralph, Mullol, Joaquim, Naclerio, Robert, Oakley, Gretchen, Otori, Nobuyoshi, Palmer, James N., Parikh, Sanjay R., Passali, Desiderio, Patel, Zara, Peters, Anju, Philpott, Carl, Psaltis, Alkis J., Ramakrishnan, Vijay R., Ramanathan, Murugappan, Roh, Hwan-Jung, Rudmik, Luke, Sacks, Raymond, Schlosser, Rodney J., Sedaghat, Ahmad, Senior, Brent, Sindwani, Raj, Smith, Kristine, Snidvongs, Kornkiat, Stewart, Michael, Suh, Jeffrey, Tan, Bruce K., Turner, Justin H., van Drunen, Cornelis M., Voegels, Richard, Wang, De-Yun, Woodworth, Bradford A., Wormald, Peter-John, Wright, Erin D., Yan, Carol, Zhang, Luo, and Zhou, Bing

Abstract

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS.

Published
2021

35. Biologics for chronic rhinosinusitis

Author

Chong, Lee-Yee, additional, Piromchai, Patorn, additional, Sharp, Steve, additional, Snidvongs, Kornkiat, additional, Webster, Katie E, additional, Philpott, Carl, additional, Hopkins, Claire, additional, and Burton, Martin J, additional

Published
2021
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36. International consensus statement on allergy and rhinology: rhinosinusitis 2021

Author

Orlandi, Richard R., primary, Kingdom, Todd T., additional, Smith, Timothy L., additional, Bleier, Benjamin, additional, DeConde, Adam, additional, Luong, Amber U., additional, Poetker, David M., additional, Soler, Zachary, additional, Welch, Kevin C., additional, Wise, Sarah K., additional, Adappa, Nithin, additional, Alt, Jeremiah A., additional, Anselmo‐Lima, Wilma Terezinha, additional, Bachert, Claus, additional, Baroody, Fuad M., additional, Batra, Pete S., additional, Bernal‐Sprekelsen, Manuel, additional, Beswick, Daniel, additional, Bhattacharyya, Neil, additional, Chandra, Rakesh K., additional, Chang, Eugene H., additional, Chiu, Alexander, additional, Chowdhury, Naweed, additional, Citardi, Martin J., additional, Cohen, Noam A., additional, Conley, David B., additional, DelGaudio, John, additional, Desrosiers, Martin, additional, Douglas, Richard, additional, Eloy, Jean Anderson, additional, Fokkens, Wytske J., additional, Gray, Stacey T., additional, Gudis, David A., additional, Hamilos, Daniel L., additional, Han, Joseph K., additional, Harvey, Richard, additional, Hellings, Peter, additional, Holbrook, Eric H., additional, Hopkins, Claire, additional, Hwang, Peter, additional, Javer, Amin R., additional, Jiang, Rong‐San, additional, Kennedy, David, additional, Kern, Robert, additional, Laidlaw, Tanya, additional, Lal, Devyani, additional, Lane, Andrew, additional, Lee, Heung‐Man, additional, Lee, Jivianne T., additional, Levy, Joshua M., additional, Lin, Sandra Y., additional, Lund, Valerie, additional, McMains, Kevin C., additional, Metson, Ralph, additional, Mullol, Joaquim, additional, Naclerio, Robert, additional, Oakley, Gretchen, additional, Otori, Nobuyoshi, additional, Palmer, James N., additional, Parikh, Sanjay R., additional, Passali, Desiderio, additional, Patel, Zara, additional, Peters, Anju, additional, Philpott, Carl, additional, Psaltis, Alkis J., additional, Ramakrishnan, Vijay R., additional, Ramanathan, Murugappan, additional, Roh, Hwan‐Jung, additional, Rudmik, Luke, additional, Sacks, Raymond, additional, Schlosser, Rodney J., additional, Sedaghat, Ahmad R., additional, Senior, Brent A., additional, Sindwani, Raj, additional, Smith, Kristine, additional, Snidvongs, Kornkiat, additional, Stewart, Michael, additional, Suh, Jeffrey D., additional, Tan, Bruce K., additional, Turner, Justin H., additional, van Drunen, Cornelis M., additional, Voegels, Richard, additional, Wang, De Yun, additional, Woodworth, Bradford A., additional, Wormald, Peter‐John, additional, Wright, Erin D., additional, Yan, Carol, additional, Zhang, Luo, additional, and Zhou, Bing, additional

Published
2021
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39. European Position Paper on Rhinosinusitis and Nasal Polyps 2020

Author

Fokkens, Wytske, Lund, Valerie, Hopkins, Claire, Hellings, Peter, Kern, Robert, Reitsma, Sietze, Toppila- Salmi, Sanna, Bernal-Sprekelsen, Manuel, Mullol, Joaquim, Alobid, Isam, Anselmo- Lima, Wilma Terezinha, Bachert, Claus, Baroody, Fuad, von Buchwald, Christian, Cervin, Anders, Cohen, Noam, Constantinidis, Jannis, De Gabory, Ludovic, Desrosiers, Martin, Diamant, Zuzana, Douglas, Richard, Gevaert, Philippe, Hafner, Anita, Harvey, Richard, Joos, Guy, Kalogjera, Livije, Knill, Andrew, Kocks, Janwillem, Landis, Basile, Limpens, Jacqueline, Lebeer, Sarah, Lourenco, Olga, Matricardi, Paolo, Meco, Cem, O’Mahony, Liam, Philpott, Carl, Ryan, Dermot, Schlosser, Rodney, Senior, Brent, Smith, Timothy, Teeling, Thijs, Tomazic, Peter Valentin, Wang, De Yun, Wang, Dehui, Zhang, Luo, Agius, Adrian, Ahlström-Emanuelsson, Cecilia, Alabri, Rashid, Albu, Silviu, Alhabash, Saied, Aleksic, Aleksandra, Aloulah, Mohammad, Al- Qudah, Mohannad, Alsaleh, Saad, Baban, Muaid Aziz, Baudoin, Tomislav, Balvers, Tijmen, Battaglia, Paolo, Bedoya, Juan David, Beule, Achim, Bofares, Khaled, Braverman, Itzhak, Brozek-Madry, Eliza, Byaruhanga, Richard, Callejas, Claudio, Carrie, Sean, Caulley, Lisa, Chussi, Desderius, de Corso, Eugenio, Coste, Andre, El Hadi, Usama, Elfarouk, Ahmed, Eloy, Philippe, Farrokhi, Shokrollah, Felisati, Giovanni, Ferrari, Michel, Fishchuk, Roman, Grayson, Jessica, Goncalves, Paulo, Grdinic, Boris, Grgic, Velimir, Hamizan, Aneeza, Heinichen, Julio, Husain, Salina, Ing Ping, Tang, Ivaska, Justinas, Jakimovska, Frodita, Jovancevic, Ljiljana, Kakande, Emily, Kamel, Reda, Karpischenko, Sergei, Kariyawasam, Harsha, Kawauchi, Hideyuki, Kjeldsen, Anette, Klimek, Ludger, Krzeski, Antoni, Kopacheva Barsova, Gabriela, Wam Kim, Sung, Lal, Devyani, Letort, José, Lopatin, Andrey, Mahdjoubi, Abdelhak, Mesbahi, Alireza, Netkovski, Jane, Nyenbue Tshipukane, Dieudonné, Obando-Valverde, Andrés, Okano, Mitsuhiro, Onerci111, Metin, Ong, Yew Kwang, Orlandi, Richard, Otori, Nobuyoshi, Ouennoughy, Kheir, Ozkan, Muge, Peric, Aleksandar, Plzak, Jan, Prokopakis, Emmanuel, Prepageran, Nerayanan, Psaltis, Alkis, Pugin, Benoit, Raftopulos, Marco, Rombaux, Philippe, Riechelmann, Herbert, Sahtout, Semia, Sarafoleanu, Caius-Codrut, Searyoh, Kafui, Rhee, Chae-Seo, Shi, Jianbo, Shkoukani, Mahdi, Shukuryan, Arthur, Sicak, Marian, Smyth, David, Snidvongs, Kornkiat, Soklic Kosak, Tanja, Stjärne, Pär, Sutikno, Budi, Steinsvåg, Sverre, Tantilipikorn, Pongsakorn, Thanaviratananich, Sanguansak, Tran, Thuy, Urbancic, Jure, Valiulis, Arunas, Vasquez de Aparicio, Carolina, Vicheva, Dilyana, Virkkula, Paula, Vicente, Gil, Voegels, Richard, Wagenmann, Martin, Wardani, Retno, Welge-Lussen, Antje, Witterick, Ian, Wright, Erin, Zabolotniy, Dmytro, Zsolt, Bella, Zwetsloot, Casper, HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, University of Helsinki, Korva-, nenä- ja kurkkutautien klinikka, HUS Head and Neck Center, uBibliorum, Faculteit Medische Wetenschappen/UMCG, Fokkens, Wytske J., UCL - (MGD) Service d'oto-rhino-laryngologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service d'oto-rhino-laryngologie, Ear, Nose and Throat, and AII - Inflammatory diseases

Subjects
Adult, medicine.medical_specialty, Evidence-based practice, Rhinosinusitis, MEDLINE, Therapeutics, PLACEBO-CONTROLLED TRIAL, 03 medical and health sciences, 0302 clinical medicine, Nasal Polyps, QUALITY-OF-LIFE, Diagnosis, paranasal sinus diseases, nasal polyps, therapeutics, diagnosis, asthma, prevention, control, Paranasal Sinus Diseases, Humans, Medicine, Nasal polyps, ENDOSCOPIC-SINUS-SURGERY, 3125 Otorhinolaryngology, ophthalmology, Sinusitis, Prevention and Control, Child, 030223 otorhinolaryngology, Intensive care medicine, UPPER RESPIRATORY-TRACT, TERM-FOLLOW-UP, Rhinitis, Science & Technology, business.industry, General Medicine, Guideline, Evidence-based medicine, RANDOMIZED CONTROLLED-TRIAL, medicine.disease, ACUTE MAXILLARY SINUSITIS, Asthma, 3. Good health, Integrated care, CHURG-STRAUSS-SYNDROME, Otorhinolaryngology, Acute Disease, Chronic Disease, Position paper, PRIMARY CILIARY DYSKINESIA, Human medicine, business, ALLERGIC FUNGAL RHINOSINUSITIS, Life Sciences & Biomedicine
Abstract

The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012. The core objective of the EPOS2020 guideline is to provide revised, up-to-date and clear evidence-based recommendations and integrated care pathways in ARS and CRS. EPOS2020 provides an update on the literature published and studies undertaken in the eight years since the EPOS2012 position paper was published and addresses areas not extensively covered in EPOS2012 such as paediatric CRS and sinus surgery. EPOS2020 also involves new stakeholders, including pharmacists and patients, and addresses new target users who have become more involved in the management and treatment of rhinosinusitis since the publication of the last EPOS document, including pharmacists, nurses, specialised care givers and indeed patients themselves, who employ increasing self-management of their condition using over the counter treatments. The document provides suggestions for future research in this area and offers updated guidance for definitions and outcome measurements in research in different settings. EPOS2020 contains chapters on definitions and classification where we have defined a large number of terms and indicated preferred terms. A new classification of CRS into primary and secondary CRS and further division into localized and diffuse disease, based on anatomic distribution is proposed. There are extensive chapters on epidemiology and predisposing factors, inflammatory mechanisms, (differential) diagnosis of facial pain, allergic rhinitis, genetics, cystic fibrosis, aspirin exacerbated respiratory disease, immunodeficiencies, allergic fungal rhinosinusitis and the relationship between upper and lower airways. The chapters on paediatric acute and chronic rhinosinusitis are totally rewritten. All available evidence for the management of acute rhinosinusitis and chronic rhinosinusitis with or without nasal polyps in adults and children is systematically reviewed and integrated care pathways based on the evidence are proposed. Despite considerable increases in the amount of quality publications in recent years, a large number of practical clinical questions remain. It was agreed that the best way to address these was to conduct a Delphi exercise . The results have been integrated into the respective sections. Last but not least, advice for patients and pharmacists and a new list of research needs are included. The full document can be downloaded for free on the website of this journal: http://www.rhinologyjournal.com. ispartof: RHINOLOGY vol:58 issue:Suppl S29 pages:I-+ ispartof: location:Netherlands status: published

Published
2020

45. Biologics for chronic rhinosinusitis

Author

Chong, Lee-Yee, primary, Piromchai, Patorn, additional, Sharp, Steve, additional, Snidvongs, Kornkiat, additional, Philpott, Carl, additional, Hopkins, Claire, additional, and Burton, Martin J, additional

Published
2020
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47. Biologics for chronic rhinosinusitis

Author

Chong, Lee-Yee, primary, Piromchai, Patorn, additional, Sharp, Steve, additional, Snidvongs, Kornkiat, additional, Philpott, Carl, additional, Hopkins, Claire, additional, and Burton, Martin J, additional

Published
2019
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48. Intranasal corticosteroids for non-allergic rhinitis

Author

Segboer, Christine, primary, Gevorgyan, Artur, additional, Avdeeva, Klementina, additional, Chusakul, Supinda, additional, Kanjanaumporn, Jesada, additional, Aeumjaturapat, Songklot, additional, Reeskamp, Laurens F, additional, Snidvongs, Kornkiat, additional, and Fokkens, Wytske, additional

Published
2019
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