Objectives: To evaluate whether education, occupation and overqualification (defined as having a level of educational attainment higher than the skill level required for an occupation) are associated with risk of all-cause and cardiovascular disease (CVD) mortality. Method: A prospective study of the association between overqualification and all-cause and CVD mortality was undertaken in the Canadian Census Mortality Follow-up study (1991-2001), a 15% sample of Canadian adults who completed the 1991 census long-form questionnaire (n=1,091,800, 39% women, baseline age 35-64 years). Education, occupation and all confounders (age, income adequacy, marital status, years since immigration, ethnicity, Aboriginal origins, province of residence, and community size) were measured at study baseline, with subsequent follow-up for mortality. Results: Sex-specific age-adjusted Cox proportional hazards models showed an inverse association between education and all-cause mortality (women: hazard ratio (HR)=1.55, 95% confidence interval (CI): 1.45-1.66; men: HR=1.94, 95% CI: 1.87-2.01, for Conclusions: Increasingly, Canadians are pursuing high levels of education; however, the occupational distribution in the labour market has not changed to the same extent. Results from this study suggest that the resulting increase in workers who are overqualified for their occupation will not lead to increased all-cause or CVD mortality. Key words: Canada/epidemiology; socioeconomic factors; mortality; cardiovascular diseases Objectifs : Determiner si l'instruction, la profession et la surqualification (definie comme le fait d'avoir un niveau d'instruction superieur au niveau de competence exige pour une profession) sont associees au risque de mortalite toutes causes confondues et de mortalite due aux maladies cardiovasculaires (MCV). Methode : Une etude prospective de l'association entre la surqualification et la mortalite toutes causes confondues et due aux MCV a ete menee dans l'Etude canadienne de suivi de la mortalite selon le recensement (1991-2001), un echantillon de 15 % des Canadiens d'age adulte ayant rempli le questionnaire complet du Recensement de 1991 (n=1 091 800, 39 % de femmes, 35 a 64 ans au debut de l'etude). L'instruction, la profession et tous les facteurs confusionnels (age, niveau adequat du revenu, etat matrimonial, annees depuis l'immigration, ethnicite, origines autochtones, province de residence et taille de la communaute) ont ete mesures au debut de l'etude, et un suivi ulterieur a ete fait pour la mortalite. Resultats : Des modeles des risques proportionnels de Cox rajustes selon l'age et le sexe ont montre une association inverse entre l'instruction et la mortalite toutes causes confondues (femmes : coefficient de danger (CD)=1,55, intervalle de confiance (IC) de 95% : 1,45-1,66; hommes : CD=1,94, IC de 95% : 1,87-2,01, Conclusions : De plus en plus, les Canadiens font des etudes poussees, mais la repartition professionnelle sur le marche du travail n'a pas change dans la meme proportion. D'apres les resultats de notre etude, l'augmentation des travailleurs surqualifies pour leur profession n'entrainera pas de hausse de la mortalite toutes causes confondues ni de la mortalite due aux MCV. Mots cles : Canada/epidemiologie; facteurs socioeconomiques; mortalite; maladies cardiovasculaires, There is strong evidence demonstrating an inverse association between socio-economic position (SEP) and mortality. (1) In epidemiologic studies, SEP is typically measured as education, occupation or income. (2) These indicators [...]