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5. Long-term outcomes of infliximab in a real-world multicenter cohort of patients with acute severe ulcerative colitis

Author

Oh, Shin Ju, Shin, Ga Young, Soh, Hosim, Lee, Jae Gon, Im, Jong Pil, Eun, Chang Soo, Lee, Kang-Moon, Park, Dong Il, Han, Dong Soo, Kim, Hyo Jong, and Lee, Chang Kyun

Subjects
medicine.medical_specialty, medicine.medical_treatment, Cytomegalovirus colitis, RC799-869, Internal medicine, medicine, Colectomy, colitis, ulcerative, business.industry, Hazard ratio, Gastroenterology, Retrospective cohort study, Diseases of the digestive system. Gastroenterology, Inflammatory Bowel Diseases, colectomy, medicine.disease, Ulcerative colitis, Infliximab, Cohort, Medicine, Original Article, infliximab, business, hospitalization, Cohort study, medicine.drug
Abstract

Background/Aims: Infliximab (IFX) has proven effective as rescue therapy in steroid-refractory acute severe ulcerative colitis (ASUC), however, the long-term real-world data are scarce. Our study aimed to assess the long-term treatment outcomes of IFX in a real-life cohort.Methods: We established a multicenter retrospective cohort of hospitalized patients with ASUC, who met Truelove and Witt’s criteria and received intravenous corticosteroid (IVCS) or IFX during index hospitalization between 2006 and 2016 in 5 university hospitals in Korea. The cohort was systematically followed up until colectomy, death or last follow-up visit.Results: A total of 296 patients were followed up for a mean of 68.9 ± 44.0 months. During index hospitalization, 49 patients were treated with IFX; as rescue therapy for IVCS failure in 37 and as first-line medical therapy for ASUC in 12. All patients treated with IFX avoided colectomy during index hospitalization. The cumulative rates of rehospitalization and colectomy were 20.4% and 6.1% at 3 months and 39.6% and 18.8% at the end of follow-up, respectively. Patients treated with IFX presented with significantly shorter colectomy-free survival than IVCS responders (P= 0.04, log-rank test). Both cytomegalovirus colitis and Clostridioides difficile infection (CDI) were the significant predictors of colectomy in the overall study cohort (hazard ratios of 6.57 and 4.61, respectively). There were no fatalities.Conclusions: Our real-world cohort study demonstrated that IFX is an effective therapeutic option in Korean patients with ASUC, irrespective of IFX indication. Aggressive vigilance for cytomegalovirus colitis and CDI is warranted for hospitalized patients with ASUC.

Published
2021

6. Deep learning model for diagnosing gastric mucosal lesions using endoscopic images: development, validation, and method comparison

Author

Nam, Joon Yeul, primary, Chung, Hyung Jin, additional, Choi, Kyu Sung, additional, Lee, Hyuk, additional, Kim, Tae Jun, additional, Soh, Hosim, additional, Kang, Eun Ae, additional, Cho, Soo-Jeong, additional, Ye, Jong Chul, additional, Im, Jong Pil, additional, Kim, Sang Gyun, additional, Kim, Joo Sung, additional, Chung, Hyunsoo, additional, and Lee, Jeong-Hoon, additional

Published
2022
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9. Occult Blood in Feces Is Associated with Increased Risk of Psoriasis.

Author

Lee, Hyun Jung, Han, Kyungdo, Soh, Hosim, Koh, Seong-Joon, Im, Jong Pil, Kim, Joo Sung, Park, Hyo Eun, and Kim, Miri

Subjects
PSORIATIC arthritis, INFLAMMATORY bowel diseases, PSORIASIS, NATIONAL health insurance, FECES, PERIODIC health examinations
Abstract

Background: The fecal immunochemistry test (FIT) has been proposed as a surrogate marker of intestinal inflammation. Psoriasis is a chronic inflammatory skin disease that is linked to underlying systemic inflammatory conditions, including inflammatory bowel disease. Methods: We investigated the association between occult blood in feces and the risk of psoriasis using data from the National Health Insurance System. This study was conducted involving 1,395,147 individuals who underwent health examinations from January 2009 to December 2012 and were followed up until the end of 2017. Results: The incidence of psoriasis (per 1,000 person-years) was 3.76 versus 4.14 (FIT-negative versus FIT-positive group) during a median follow-up of 6.68 years. In the multivariable-adjusted model, the hazard ratios for psoriasis were 1.03 for one positive FIT result, 1.12 for two positive FIT results, and 1.34 for three positive FIT results compared with negative FIT results. Conclusion: The risk of psoriasis was significantly increased in patients with positive FIT results compared to the FIT-negative population. [ABSTRACT FROM AUTHOR]

Published
2022
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13. Occult Blood in Feces Is Associated With an Increased Risk of Ischemic Stroke and Myocardial Infarction: A Nationwide Population Study

Author

Moon, Jung Min, primary, Lee, Hyun Jung, additional, Han, Kyungdo, additional, Kim, Da Hye, additional, Hong, Seung Wook, additional, Soh, Hosim, additional, Park, Seona, additional, Kang, Eun Ae, additional, Lee, Jooyoung, additional, Koh, Seong‐Joon, additional, Im, Jong Pil, additional, and Kim, Joo Sung, additional

Published
2021
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14. A Deep Learning Model for Diagnosing Gastric Mucosal Lesions Using Endoscopic Images: Development, Validation, and Method Comparison

Author

Nam, Joon Yeul, primary, Chung, Hyung Jin, additional, Choi, Kyu Sung, additional, Lee, Hyuk, additional, Han, Seung Jun, additional, Kim, Tae Jun, additional, Soh, Hosim, additional, Kang, Eun Ae, additional, Cho, Soo-Jeong, additional, Ye, Jong Chul, additional, Im, Jong Pil, additional, Kim, Sang Gyun, additional, Kim, Yoon Jun, additional, Kim, Joo Sung, additional, Yoon, Jung-Hwan, additional, Chung, Hyunsoo, additional, and Lee, Jeong-Hoon, additional

Published
2021
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17. Periodontitis combined with smoking increases risk of the ulcerative colitis: A national cohort study

Author

Kang, Eun Ae, primary, Chun, Jaeyoung, additional, Kim, Jee Hyun, additional, Han, Kyungdo, additional, Soh, Hosim, additional, Park, Seona, additional, Hong, Seung Wook, additional, Moon, Jung Min, additional, Lee, Jooyoung, additional, Lee, Hyun Jung, additional, Park, Jun-Beom, additional, Im, Jong Pil, additional, and Kim, Joo Sung, additional

Published
2020
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24. Novel sulfate tablet PBK‐1701TCversusoral sulfate solution for colon cleansing: A randomized phase 3 trial

Author

Yang, Hyo‐Joon, primary, Park, Dong Il, additional, Park, Soo‐Kyung, additional, Lee, Chang Kyun, additional, Kim, Hyo Jong, additional, Oh, Shin Ju, additional, Moon, Jung Rock, additional, Lee, Beom Jae, additional, Koh, Jin Sung, additional, Kim, Hyun Soo, additional, Park, Seon‐Young, additional, Kim, Dong Hyun, additional, Chun, Jaeyoung, additional, Kang, Eun Ae, additional, Kim, Jung, additional, Soh, Hosim, additional, Eun, Chang Soo, additional, Kim, You Sun, additional, and Jeen, Yoon Tae, additional

Published
2019
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28. Mo1661 A RANDOMIZED CONTROLLED TRIAL COMPARING NOVEL ORAL SULFATE TABLETS WITH ORAL SULFATE SOLUTION IN BOWEL CLEANSING BEFORE COLONOSCOPY

Author

Yang, Hyo-Joon, primary, Park, Dongil, additional, Park, Soo-Kyung, additional, Lee, Chang Kyun, additional, Kim, Hyo-Jong, additional, Oh, Shin Ju, additional, Moon, Jung Rock, additional, Lee, Beom Jae, additional, Koh, Jin Sung, additional, Kim, Hyun-Soo, additional, Park, Seon-Young, additional, Kim, Dong Hyun, additional, Chun, Jaeyoung, additional, Kang, Eun Ae, additional, Kim, Jung, additional, Soh, Hosim, additional, Eun, Chang Soo, additional, Kim, You Sun, additional, and Jeen, Yoon Tae, additional

Published
2019
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39. Crohn's disease and ulcerative colitis are associated with different lipid profile disorders: a nationwide population‐based study.

Author

Soh, Hosim, Im, Jong Pil, Han, Kyungdo, Park, Seona, Hong, Seung Wook, Moon, Jeong Min, Kang, Eun Ae, Chun, Jaeyoung, Lee, Hyun Jung, and Kim, Joo Sung

Subjects
*CROHN'S disease, *INFLAMMATORY bowel diseases, *ULCERATIVE colitis, *HIGH density lipoproteins, *BLOOD lipids, *BLOOD cholesterol, *BODY mass index
Abstract

Summary: Background: The relationships between lipid profiles and IBD remain elusive. Aim: To determine the association of IBD with serum lipid profiles. Methods: A nationwide population‐based study was performed using claims data from the Korean National Healthcare Insurance service. A total of 9 706 026 subjects undergoing medical check‐ups in 2009 were enrolled and followed up until 2016. Individuals who developed Crohn's disease (CD) or ulcerative colitis (UC) were identified during follow‐up. Adjusted hazard ratio (aHR) by age, sex, body mass index, cigarette smoking, alcohol drinking, exercise, income and underlying comorbidities was calculated to define the impact of serum lipid profiles on developing IBD. Results: During a median follow‐up of 7.3 years, IBD was detected in 7,058 (0.07%) individuals. Compared with the highest quartile of serum total cholesterol (TC) levels, lower TC levels were associated with higher incidence of CD (aHR: Q1, 2.52; Q2, 1.52; Q3, 1.27), but not UC. Lower serum LDL‐C levels were associated with higher incidence of CD (aHR: Q1, 1.92; Q2, 1.47; Q3, 1.22), but not UC. Moreover, lower serum HDL‐C levels were associated with higher incidence of CD (aHR: Q1, 2.49; Q2, 1.90; Q3, 1.43), but not UC. In contrast, lower serum triglyceride levels were associated with higher incidence of UC (aHR: Q1, 1.22; Q2, 1.19; Q3, 1.19), but not CD. Conclusions: Low serum TC, LDL‐C and HDL‐C levels were associated with CD. Low serum triglyceride levels were related to UC. [ABSTRACT FROM AUTHOR]

Published
2020
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40. Increased risk of idiopathic pulmonary fibrosis in inflammatory bowel disease: A nationwide study.

Author

Kim, Jihye, Chun, Jaeyoung, Lee, Changhyun, Han, Kyungdo, Choi, Seungho, Lee, Jooyoung, Soh, Hosim, Choi, Kookhwan, Park, Seona, Kang, Eun Ae, Lee, Hyun Jung, Im, Jong Pil, and Kim, Joo Sung

Subjects
INTERNATIONAL Statistical Classification of Diseases & Related Health Problems, INFLAMMATORY bowel diseases, CROHN'S disease, NATIONAL health insurance, REPORTING of diseases, ULCERATIVE colitis, IDIOPATHIC pulmonary fibrosis
Abstract

Background and Aim: The relationship between inflammatory bowel disease (IBD) and idiopathic pulmonary fibrosis (IPF) remains unclear. We evaluated the risk for developing IPF in patients with IBD using a nationwide population‐based study. Methods: Using claims data from the National Health Insurance service in Korea, patients with IBD, including Crohn's disease (CD) and ulcerative colitis (UC), were identified through both the 10th revision of the International Statistical Classification of Diseases and Related Health Problems and rare and intractable disease program codes from January 2010 to December 2013. We compared 38 921 IBD patients with age‐matched and sex‐matched individuals without IBD in a ratio of 1:3. Patients with newly diagnosed IPF were identified by both the 10th revision of the International Statistical Classification of Diseases and Related Health Problems and rare and intractable disease registration codes. Results: During a mean 4.9‐year follow‐up, the incidence of IPF in patients with IBD was 33.21 per 100 000 person‐years. The overall risk of IPF was significantly higher in IBD patients than in non‐IBD controls (hazard ratio [HR], 1.62; 95% confidence interval [CI], 1.20–2.20; P = 0.003). In patients with CD, the incidence (per 100 000 person‐years) of IPF was 26.04; in controls, the incidence was 9.15 (HR, 2.89; 95% CI, 1.46–5.72; P = 0.002). The incidence of IPF in patients with UC tended to be higher than in controls (36.66 vs 26.54 per 100 000 person‐years; 95% CI, 0.99–1.99; HR, 1.41; P = 0.066). The risk of developing IPF in patients with IBD was higher in male patients than in female patients (P = 0.093 in CD; P = 0.147 in UC by interaction analysis). Conclusions: Patients with IBD, especially CD, have an increased risk of developing IPF. [ABSTRACT FROM AUTHOR]

Published
2020
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41. Novel sulfate tablet PBK‐1701TC versus oral sulfate solution for colon cleansing: A randomized phase 3 trial.

Author

Yang, Hyo‐Joon, Park, Dong Il, Park, Soo‐Kyung, Lee, Chang Kyun, Kim, Hyo Jong, Oh, Shin Ju, Moon, Jung Rock, Lee, Beom Jae, Koh, Jin Sung, Kim, Hyun Soo, Park, Seon‐Young, Kim, Dong Hyun, Chun, Jaeyoung, Kang, Eun Ae, Kim, Jung, Soh, Hosim, Eun, Chang Soo, Kim, You Sun, and Jeen, Yoon Tae

Subjects
COLON (Anatomy), SULFATES, BODY mass index, CONFIDENCE intervals, SALINE waters
Abstract

Background and Aim: PBK‐1701TC is a novel sulfate tablet‐based that contains 320 mg of simethicone and delivers 90% of the salt and water delivered by oral sulfate solution (OSS) preparation. This study evaluated the efficacy, safety, and tolerability of PBK‐1701TC compared with OSS in bowel preparation for colonoscopy. Methods: This randomized, multicenter, phase 3 non‐inferiority trial included adults aged 19 years or older with a body mass index of 19–30 kg/m2 undergoing colonoscopy at five university hospitals in Korea. The primary efficacy endpoint was successful bowel‐cleansing rate, defined as Harefield Cleansing Scale grade A or B as evaluated by blinded central readers. Secondary endpoints included the presence of residual air bubbles. Adverse events and laboratory evaluations were monitored to assess safety. Tolerability was assessed via participant interview. Results: Overall, 235 participants were randomized, and 224 were included in the per‐protocol analysis (PBK, 112; OSS, 112). Successful bowel cleansing was achieved for 95.5% (107/112) in the PBK group, which was non‐inferior to the OSS group (98.2%, 110/112) with a difference of −2.7% (one sided 97.5% confidence limit, −8.1%). The participants in the PBK group had fewer intraluminal bubbles (0.9% vs 81.3%, P < 0.001) and reported a lower incidence of nausea and vomiting, with better acceptance, taste, and willingness to repeat the regimen than those in the OSS group (all P < 0.05). Conclusion: The novel sulfate tablet, PBK‐1701TC, was non‐inferior to OSS with respect to bowel‐cleansing efficacy and exhibited better safety and tolerability in adults undergoing colonoscopy. [ABSTRACT FROM AUTHOR]

Published
2020
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