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Tooth extraction is one of the most common procedures undertaken in the dental clinic. As with any surgical procedure, even a simple tooth extraction can result in complications. Post extraction complications can be annoying to the patient, thereby causing mild morbidity and have an impact on their quality of life. Complications are wide starting from common ones like alveolitis and root fracture, dry socket, infraction, halitosis, pain, trismus and uncommon ones like displacement of root fragments within the sinus and oral antral fistula. The aim of this study was to evaluate post-extraction complications among patients visiting saveetha dental college. This is a retrospective study. We reviewed patient records and analysed the data of 86000 patients between June 2019 and March 2020. From a pooled sample size of 23000 extractions done during this period, data of patients reporting for post-extraction complications were segregated and analysed. The statistical analysis was done using SPSS Version 20 by IBM. The results were analysed using the chi-square test. In this study, we observed that among a sample of 23000 simple extractions, only 42 patients had reported back with post-extraction complications (0.18%). These complications were more in males than in females. When compared between maxillary and mandibular arch, the mandible had more incidence with 54.16%. The most common complication was dry socket (58.34%). Pain as a complication was more in males than in females. Within the limits of the study, the incidence of post-extraction complication is more in males than females. Higher incidence of complication was seen in a mandibular arch (54.16%) than in maxillary arch (45.84%).

Background Emergence of fluconazole resistance mediated by L321F mutation in the ERG11 gene poses a serious impediment in the candidal treatment process. This leads to the search of novel target proteins to develop newer drugs against fluconazole resistant C. albicans. The present investigation is thus aimed to explore the inhibitory potential of bioactive compounds from A. nilotica against the wild and mutated ERG11 gene of C. albicans. Materials and methods Homology modelling of the wild and mutated ERG11 target gene was done by Modeller 9.2, with SDM I-mutant form of ERG11 together with SAVES server and Ramachandran plot validation. 2D and 3D structures of the bioactive compounds from A. nilotica were optimized by ACD chemsketch. Molinspirational assessments for the molecular properties of the ligands and their drug likeliness were estimated. In silico inhibitory potential of the selected ligands against wild and mutated ERG11 was done by AutoDock 2.0 and was visualized with Accelrys discovery studio tool. Results Apigenin proved to be the best candidate to target mutant ERG11 with a binding energy of −8.33 Kcal/mol followed by catechin with six hydrogen bonds with more drug likeliness. Molinspiration assessments showed zero violations for all the bioactive compounds from A. nilotica and the TPSA scores of the ligands showed the values Conclusion The findings of the study emphasize that kaempferol, apigenin and catechin from A. nilotica seem to possess a promising inhibitory effect against the wild and mutated ERG11 of C. albicans suggesting ERG11 as the best target to combat fluconazole resistant C. albicans with further in vivo validation targeting the same.