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1. Vaccination induces broadly neutralizing antibody precursors to HIV gp41

Author

Schiffner, Torben, Phung, Ivy, Ray, Rashmi, Irimia, Adriana, Tian, Ming, Swanson, Olivia, Lee, Jeong Hyun, Lee, Chang-Chun D., Marina-Zárate, Ester, Cho, So Yeon, Huang, Jiachen, Ozorowski, Gabriel, Skog, Patrick D., Serra, Andreia M., Rantalainen, Kimmo, Allen, Joel D., Baboo, Sabyasachi, Rodriguez, Oscar L., Himansu, Sunny, Zhou, Jianfu, Hurtado, Jonathan, Flynn, Claudia T., McKenney, Katherine, Havenar-Daughton, Colin, Saha, Swati, Shields, Kaitlyn, Schultze, Steven, Smith, Melissa L., Liang, Chi-Hui, Toy, Laura, Pecetta, Simone, Lin, Ying-Cing, Willis, Jordan R., Sesterhenn, Fabian, Kulp, Daniel W., Hu, Xiaozhen, Cottrell, Christopher A., Zhou, Xiaoya, Ruiz, Jennifer, Wang, Xuesong, Nair, Usha, Kirsch, Kathrin H., Cheng, Hwei-Ling, Davis, Jillian, Kalyuzhniy, Oleksandr, Liguori, Alessia, Diedrich, Jolene K., Ngo, Julia T., Lewis, Vanessa, Phelps, Nicole, Tingle, Ryan D., Spencer, Skye, Georgeson, Erik, Adachi, Yumiko, Kubitz, Michael, Eskandarzadeh, Saman, Elsliger, Marc A., Amara, Rama R., Landais, Elise, Briney, Bryan, Burton, Dennis R., Carnathan, Diane G., Silvestri, Guido, Watson, Corey T., Yates, III, John R., Paulson, James C., Crispin, Max, Grigoryan, Gevorg, Ward, Andrew B., Sok, Devin, Alt, Frederick W., Wilson, Ian A., Batista, Facundo D., Crotty, Shane, and Schief, William R.

Published
2024
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2. Author Correction: Vaccination induces broadly neutralizing antibody precursors to HIV gp41

Author

Schiffner, Torben, Phung, Ivy, Ray, Rashmi, Irimia, Adriana, Tian, Ming, Swanson, Olivia, Lee, Jeong Hyun, Lee, Chang-Chun D., Marina-Zárate, Ester, Cho, So Yeon, Huang, Jiachen, Ozorowski, Gabriel, Skog, Patrick D., Serra, Andreia M., Rantalainen, Kimmo, Allen, Joel D., Baboo, Sabyasachi, Rodriguez, Oscar L., Himansu, Sunny, Zhou, Jianfu, Hurtado, Jonathan, Flynn, Claudia T., McKenney, Katherine, Havenar-Daughton, Colin, Saha, Swati, Shields, Kaitlyn, Schultze, Steven, Smith, Melissa L., Liang, Chi-Hui, Toy, Laura, Pecetta, Simone, Lin, Ying-Cing, Willis, Jordan R., Sesterhenn, Fabian, Kulp, Daniel W., Hu, Xiaozhen, Cottrell, Christopher A., Zhou, Xiaoya, Ruiz, Jennifer, Wang, Xuesong, Nair, Usha, Kirsch, Kathrin H., Cheng, Hwei-Ling, Davis, Jillian, Kalyuzhniy, Oleksandr, Liguori, Alessia, Diedrich, Jolene K., Ngo, Julia T., Lewis, Vanessa, Phelps, Nicole, Tingle, Ryan D., Spencer, Skye, Georgeson, Erik, Adachi, Yumiko, Kubitz, Michael, Eskandarzadeh, Saman, Elsliger, Marc A., Amara, Rama R., Landais, Elise, Briney, Bryan, Burton, Dennis R., Carnathan, Diane G., Silvestri, Guido, Watson, Corey T., Yates, III, John R., Paulson, James C., Crispin, Max, Grigoryan, Gevorg, Ward, Andrew B., Sok, Devin, Alt, Frederick W., Wilson, Ian A., Batista, Facundo D., Crotty, Shane, and Schief, William R.

Published
2024
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3. Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies

Author

Joyce, Collin, Murrell, Sasha, Murrell, Ben, Omorodion, Oluwarotimi, Ver, Lorena S, Carrico, Nancy, Bastidas, Raiza, Nedellec, Rebecca, Bick, Michael, Woehl, Jordan, Zhao, Fangzhu, Burns, Alison, Barman, Shawn, Appel, Michael, Ramos, Alejandra, Wickramasinghe, Lalinda, Eren, Kemal, Vollbrecht, Thomas, Smith, Davey M, Pond, Sergei L Kosakovsky, McBride, Ryan, Worth, Charli, Batista, Facundo, Sok, Devin, Network, The IAVI Protocol C Investigators The IAVI African HIV Research, Poignard, Pascal, Briney, Bryan, Wilson, Ian A, Landais, Elise, and Burton, Dennis R

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, HIV/AIDS, Biotechnology, Vaccine Related, Infectious Diseases, Vaccine Related (AIDS), Prevention, Immunization, Infection, Good Health and Well Being, Humans, Broadly Neutralizing Antibodies, HIV Antibodies, HIV Infections, Epitopes, Dermatitis, HIV-1, IAVI Protocol C Investigators & The IAVI African HIV Research Network, Microbiology, Virology, Medical microbiology
Abstract

Vaccination strategies aimed at maturing broadly neutralizing antibodies (bnAbs) from naïve precursors are hindered by unusual features that characterize these Abs, including insertions and deletions (indels). Longitudinal studies of natural HIV infection cases shed light on the complex processes underlying bnAb development and have suggested a role for superinfection as a potential enhancer of neutralization breadth. Here we describe the development of a potent bnAb lineage that was elicited by two founder viruses to inform vaccine design. The V3-glycan targeting bnAb lineage (PC39-1) was isolated from subtype C-infected IAVI Protocol C elite neutralizer, donor PC39, and is defined by the presence of multiple independent insertions in CDRH1 that range from 1-11 amino acids in length. Memory B cell members of this lineage are predominantly atypical in phenotype yet also span the class-switched and antibody-secreting cell compartments. Development of neutralization breadth occurred concomitantly with extensive recombination between founder viruses before each virus separated into two distinct population "arms" that evolved independently to escape the PC39-1 lineage. Ab crystal structures show an extended CDRH1 that can help stabilize the CDRH3. Overall, these findings suggest that early exposure of the humoral system to multiple related Env molecules could promote the induction of bnAbs by focusing Ab responses to conserved epitopes.

Published
2023

4. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

Author

Rogers, Thomas F, Zhao, Fangzhu, Huang, Deli, Beutler, Nathan, Burns, Alison, He, Wan-Ting, Limbo, Oliver, Smith, Chloe, Song, Ge, Woehl, Jordan, Yang, Linlin, Abbott, Robert K, Callaghan, Sean, Garcia, Elijah, Hurtado, Jonathan, Parren, Mara, Peng, Linghang, Ramirez, Sydney, Ricketts, James, Ricciardi, Michael J, Rawlings, Stephen A, Wu, Nicholas C, Yuan, Meng, Smith, Davey M, Nemazee, David, Teijaro, John R, Voss, James E, Wilson, Ian A, Andrabi, Raiees, Briney, Bryan, Landais, Elise, Sok, Devin, Jardine, Joseph G, and Burton, Dennis R

Subjects
Vaccine Related, Pneumonia & Influenza, Prevention, Pneumonia, Infectious Diseases, Emerging Infectious Diseases, Biodefense, Biotechnology, Lung, Immunization, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Good Health and Well Being, Adult, Angiotensin-Converting Enzyme 2, Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Antibody Affinity, Antibody Specificity, Betacoronavirus, Binding Sites, COVID-19, Cell Line, Coronavirus Infections, Disease Models, Animal, Epitopes, Female, Humans, Immunization, Passive, Male, Mesocricetus, Middle Aged, Neutralization Tests, Pandemics, Peptidyl-Dipeptidase A, Pneumonia, Viral, Protein Domains, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Viral Load, Virus Replication, COVID-19 Serotherapy, General Science & Technology
Abstract

Countermeasures to prevent and treat coronavirus disease 2019 (COVID-19) are a global health priority. We enrolled a cohort of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-recovered participants, developed neutralization assays to investigate antibody responses, adapted our high-throughput antibody generation pipeline to rapidly screen more than 1800 antibodies, and established an animal model to test protection. We isolated potent neutralizing antibodies (nAbs) to two epitopes on the receptor binding domain (RBD) and to distinct non-RBD epitopes on the spike (S) protein. As indicated by maintained weight and low lung viral titers in treated animals, the passive transfer of a nAb provides protection against disease in high-dose SARS-CoV-2 challenge in Syrian hamsters. The study suggests a role for nAbs in prophylaxis, and potentially therapy, of COVID-19. The nAbs also define protective epitopes to guide vaccine design.

Published
2020

5. Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model

Author

Rogers, Thomas F, Zhao, Fangzhu, Huang, Deli, Beutler, Nathan, Burns, Alison, He, Wan-Ting, Limbo, Oliver, Smith, Chloe, Song, Ge, Woehl, Jordan, Yang, Linlin, Abbott, Robert K, Callaghan, Sean, Garcia, Elijah, Hurtado, Jonathan, Parren, Mara, Peng, Linghang, Ricketts, James, Ricciardi, Michael J, Rawlings, Stephen A, Smith, Davey M, Nemazee, David, Teijaro, John R, Voss, James E, Andrabi, Raiees, Briney, Bryan, Landais, Elise, Sok, Devin, Jardine, Joseph G, and Burton, Dennis R

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Vaccine Related, Pneumonia & Influenza, Prevention, Infectious Diseases, Emerging Infectious Diseases, Lung, Pneumonia, Biotechnology, Immunization, Biodefense, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Good Health and Well Being
Abstract

The development of countermeasures to prevent and treat COVID-19 is a global health priority. In under 7 weeks, we enrolled a cohort of SARS-CoV-2-recovered participants, developed neutralization assays to interrogate serum and monoclonal antibody responses, adapted our high throughput antibody isolation, production and characterization pipeline to rapidly screen over 1000 antigen-specific antibodies, and established an animal model to test protection. We report multiple highly potent neutralizing antibodies (nAbs) and show that passive transfer of a nAb provides protection against high-dose SARS-CoV-2 challenge in Syrian hamsters. The study suggests a role for nAbs in prophylaxis, and potentially therapy, of COVID-19. The nAbs define protective epitopes to guide vaccine design.

Published
2020

6. Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways

Author

Zhao, Fangzhu, Keating, Celina, Ozorowski, Gabriel, Shaabani, Namir, Francino-Urdaniz, Irene M., Barman, Shawn, Limbo, Oliver, Burns, Alison, Zhou, Panpan, Ricciardi, Michael J., Woehl, Jordan, Tran, Quoc, Turner, Hannah L., Peng, Linghang, Huang, Deli, Nemazee, David, Andrabi, Raiees, Sok, Devin, Teijaro, John R., Whitehead, Timothy A., Ward, Andrew B., Burton, Dennis R., and Jardine, Joseph G.

Published
2022
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7. Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

Author

Zhao, Fangzhu, Berndsen, Zachary T., Pedreño-Lopez, Nuria, Burns, Alison, Allen, Joel D., Barman, Shawn, Lee, Wen-Hsin, Chakraborty, Srirupa, Gnanakaran, Sandrasegaram, Sewall, Leigh M., Ozorowski, Gabriel, Limbo, Oliver, Song, Ge, Yong, Peter, Callaghan, Sean, Coppola, Jessica, Weisgrau, Kim L., Lifson, Jeffrey D., Nedellec, Rebecca, Voigt, Thomas B., Laurino, Fernanda, Louw, Johan, Rosen, Brandon C., Ricciardi, Michael, Crispin, Max, Desrosiers, Ronald C., Rakasz, Eva G., Watkins, David I., Andrabi, Raiees, Ward, Andrew B., Burton, Dennis R., and Sok, Devin

Published
2022
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8. Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein

Author

van Schooten, Jelle, Farokhi, Elinaz, Schorcht, Anna, van den Kerkhof, Tom L. G. M., Gao, Hongmei, van der Woude, Patricia, Burger, Judith A., Meesters, Tim G. Rijkhold, Bijl, Tom, Ghalaiyini, Riham, Turner, Hannah L., Dorning, Jessica, van Schaik, Barbera D. C., van Kampen, Antoine H. C., Labranche, Celia C., Stanfield, Robyn L., Sok, Devin, Montefiori, David C., Burton, Dennis R., Seaman, Michael S., Ozorowski, Gabriel, Wilson, Ian A., Sanders, Rogier W., Ward, Andrew B., and van Gils, Marit J.

Published
2022
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10. Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

Author

Foss, Stian, primary, Sakya, Siri A., additional, Aguinagalde, Leire, additional, Lustig, Marta, additional, Shaughnessy, Jutamas, additional, Cruz, Ana Rita, additional, Scheepmaker, Lisette, additional, Mathiesen, Line, additional, Ruso-Julve, Fulgencio, additional, Anthi, Aina Karen, additional, Gjølberg, Torleif Tollefsrud, additional, Mester, Simone, additional, Bern, Malin, additional, Evers, Mitchell, additional, Bratlie, Diane B., additional, Michaelsen, Terje E., additional, Schlothauer, Tilman, additional, Sok, Devin, additional, Bhattacharya, Jayanta, additional, Leusen, Jeanette, additional, Valerius, Thomas, additional, Ram, Sanjay, additional, Rooijakkers, Suzan H. M., additional, Sandlie, Inger, additional, and Andersen, Jan Terje, additional

Published
2024
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11. Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins

Author

Khalek, Irene S., primary, Senji Laxme, R. R., additional, Nguyen, Yen Thi Kim, additional, Khochare, Suyog, additional, Patel, Rohit N., additional, Woehl, Jordan, additional, Smith, Jessica M., additional, Saye-Francisco, Karen, additional, Kim, Yoojin, additional, Misson Mindrebo, Laetitia, additional, Tran, Quoc, additional, Kędzior, Mateusz, additional, Boré, Evy, additional, Limbo, Oliver, additional, Verma, Megan, additional, Stanfield, Robyn L., additional, Menzies, Stefanie K., additional, Ainsworth, Stuart, additional, Harrison, Robert A., additional, Burton, Dennis R., additional, Sok, Devin, additional, Wilson, Ian A., additional, Casewell, Nicholas R., additional, Sunagar, Kartik, additional, and Jardine, Joseph G., additional

Published
2024
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12. Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire

Author

Altman, Pilar X., primary, Ozorowski, Gabriel, additional, Stanfield, Robyn L., additional, Haakenson, Jeremy, additional, Appel, Michael, additional, Parren, Mara, additional, Lee, Wen-Hsin, additional, Sang, Huldah, additional, Woehl, Jordan, additional, Saye-Francisco, Karen, additional, Joyce, Collin, additional, Song, Ge, additional, Porter, Katelyn, additional, Landais, Elise, additional, Andrabi, Raiees, additional, Wilson, Ian A., additional, Ward, Andrew B., additional, Mwangi, Waithaka, additional, Smider, Vaughn V., additional, Burton, Dennis R., additional, and Sok, Devin, additional

Published
2024
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13. Diverse competitor B cell responses to a germline-targeting priming immunogen in human Ig loci transgenic mice

Author

Schiffner, Torben, primary, Palser, Anne, additional, Jardine, Joseph G., additional, Liguori, Alessia, additional, Menis, Sergey, additional, Raemisch, Sebastian, additional, Hu, Xiaozhen, additional, Kulp, Daniel W., additional, Wang, Xiaoning, additional, Diedrich, Jolene K., additional, Groschel, Bettina, additional, Kalyuzhniy, Oleksandr, additional, Tingle, Ryan, additional, Le, Khoa, additional, Georgeson, Erik, additional, Adachi, Yumiko, additional, Kubitz, Michael, additional, Landais, Elise, additional, Yates, John R., additional, Paulson, James C., additional, Sok, Devin, additional, Kellam, Paul, additional, and Schief, William R., additional

Published
2024
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14. Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller

Author

Freund, Natalia T, Wang, Haoqing, Scharf, Louise, Nogueira, Lilian, Horwitz, Joshua A, Bar-On, Yotam, Golijanin, Jovana, Sievers, Stuart A, Sok, Devin, Cai, Hui, Cesar Lorenzi, Julio C, Halper-Stromberg, Ariel, Toth, Ildiko, Piechocka-Trocha, Alicja, Gristick, Harry B, van Gils, Marit J, Sanders, Rogier W, Wang, Lai-Xi, Seaman, Michael S, Burton, Dennis R, Gazumyan, Anna, Walker, Bruce D, West, Anthony P, Bjorkman, Pamela J, and Nussenzweig, Michel C

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Vaccine Related, Infectious Diseases, Prevention, Vaccine Related (AIDS), HIV/AIDS, Biotechnology, Immunization, Aetiology, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Animals, Antibodies, Neutralizing, B-Lymphocytes, Cohort Studies, Crystallography, X-Ray, Epitopes, HEK293 Cells, HIV Antibodies, HIV Infections, HIV-1, HLA-B Antigens, HLA-B27 Antigen, Humans, Mice, Mice, Transgenic, Neutralization Tests, Viral Load, Viremia, env Gene Products, Human Immunodeficiency Virus, Biological Sciences, Medical and Health Sciences, Medical biotechnology, Biomedical engineering
Abstract

Some HIV-1-infected patients develop broad and potent HIV-1 neutralizing antibodies (bNAbs) that when passively transferred to mice or macaques can treat or prevent infection. However, bNAbs typically fail to neutralize coexisting autologous viruses due to antibody-mediated selection against sensitive viral strains. We describe an HIV-1 controller expressing HLA-B57*01 and HLA-B27*05 who maintained low viral loads for 30 years after infection and developed broad and potent serologic activity against HIV-1. Neutralization was attributed to three different bNAbs targeting nonoverlapping sites on the HIV-1 envelope trimer (Env). One of the three, BG18, an antibody directed against the glycan-V3 portion of Env, is the most potent member of this class reported to date and, as revealed by crystallography and electron microscopy, recognizes HIV-1 Env in a manner that is distinct from other bNAbs in this class. Single-genome sequencing of HIV-1 from serum samples obtained over a period of 9 years showed a diverse group of circulating viruses, 88.5% (31 of 35) of which remained sensitive to at least one of the temporally coincident autologous bNAbs and the individual's serum. Thus, bNAb-sensitive strains of HIV-1 coexist with potent neutralizing antibodies that target the virus and may contribute to control in this individual. When administered as a mix, the three bNAbs controlled viremia in HIV-1YU2-infected humanized mice. Our finding suggests that combinations of bNAbs may contribute to control of HIV-1 infection.

Published
2017

15. Cost-effectiveness of broadly neutralizing antibodies for infant HIV prophylaxis in settings with high HIV burdens: a simulation modeling study

Author

Alba, Christopher, primary, Malhotra, Shelly, additional, Horsfall, Stephanie, additional, Barnhart, Matthew E., additional, Bekker, Adrie, additional, Chapman, Katerina, additional, Cunningham, Coleen K., additional, Fast, Patricia E., additional, Fouda, Genevieve G., additional, Freedberg, Kenneth A., additional, Goga, Ameena, additional, Ghazaryan, Lusine R., additional, Leroy, Valériane, additional, Mann, Carlyn, additional, McCluskey, Margaret M., additional, McFarland, Elizabeth J., additional, Muturi-Kioi, Vincent, additional, Permar, Sallie R., additional, Shapiro, Roger, additional, Sok, Devin, additional, Stranix-Chibanda, Lynda, additional, Weinstein, Milton C., additional, Ciaranello, Andrea L., additional, and Dugdale, Caitlin M., additional

Published
2023
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16. Neutralization diversity of HIV-1 Indian subtype C envelopes obtained from cross sectional and followed up individuals against broadly neutralizing monoclonal antibodies having distinct gp120 specificities

Author

Mullick, Ranajoy, Sutar, Jyoti, Hingankar, Nitin, Deshpande, Suprit, Thakar, Madhuri, Sahay, Seema, Ringe, Rajesh P., Mukhopadhyay, Sampurna, Patil, Ajit, Bichare, Shubhangi, Murugavel, Kailapuri G., Srikrishnan, Aylur K., Goyal, Rajat, Sok, Devin, and Bhattacharya, Jayanta

Published
2021
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17. The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2

Author

Huang, Ruiqi, primary, Warner Jenkins, Gabrielle, additional, Kim, Yunjeong, additional, Stanfield, Robyn L., additional, Singh, Amrinder, additional, Martinez-Yamout, Maria, additional, Kroon, Gerard J., additional, Torres, Jonathan L., additional, Jackson, Abigail M., additional, Kelley, Abigail, additional, Shaabani, Namir, additional, Zeng, Baisen, additional, Bacica, Michael, additional, Chen, Wen, additional, Warner, Christopher, additional, Radoicic, Jasmina, additional, Joh, Joongho, additional, Dinali Perera, Krishani, additional, Sang, Huldah, additional, Kim, Tae, additional, Yao, Jianxiu, additional, Zhao, Fangzhu, additional, Sok, Devin, additional, Burton, Dennis R., additional, Allen, Jeff, additional, Harriman, William, additional, Mwangi, Waithaka, additional, Chung, Donghoon, additional, Teijaro, John R., additional, Ward, Andrew B., additional, Dyson, H. Jane, additional, Wright, Peter E., additional, Wilson, Ian A., additional, Chang, Kyeong-Ok, additional, McGregor, Duncan, additional, and Smider, Vaughn V., additional

Published
2023
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18. Broadening a SARS-CoV-1–neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution

Author

Zhao, Fangzhu, primary, Yuan, Meng, additional, Keating, Celina, additional, Shaabani, Namir, additional, Limbo, Oliver, additional, Joyce, Collin, additional, Woehl, Jordan, additional, Barman, Shawn, additional, Burns, Alison, additional, Tran, Quoc, additional, Zhu, Xueyong, additional, Ricciardi, Michael, additional, Peng, Linghang, additional, Smith, Jessica, additional, Huang, Deli, additional, Briney, Bryan, additional, Sok, Devin, additional, Nemazee, David, additional, Teijaro, John R., additional, Wilson, Ian A., additional, Burton, Dennis R., additional, and Jardine, Joseph G., additional

Published
2023
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21. Ancestral SARS-CoV-2-Driven Antibody Repertoire Diversity in an Unvaccinated Individual Correlates with Expanded Neutralization Breadth

Author

Deshpande, Suprit, primary, Ansari, Mohammed Yousuf, additional, Sutar, Jyoti, additional, Das, Payel, additional, Hingankar, Nitin, additional, Mukherjee, Sohini, additional, Jayal, Priyanka, additional, Singh, Savita, additional, Anantharaj, Anbalagan, additional, Singh, Janmejay, additional, Chattopadhyay, Souvick, additional, Raghavan, Sreevatsan, additional, Gosain, Mudita, additional, Chauhan, Supriya, additional, Shrivas, Shweta, additional, Prasad, Chaman, additional, Chauhan, Sangeeta, additional, Sharma, Neha, additional, Jana, Pradipta, additional, Thiruvengadam, Ramachandran, additional, Kshetrapal, Pallavi, additional, Wadhwa, Nitya, additional, Das, Bhabatosh, additional, Batra, Gaurav, additional, Medigeshi, Guruprasad, additional, Sok, Devin, additional, Bhatnagar, Shinjini, additional, Garg, Pramod Kumar, additional, and Bhattacharya, Jayanta, additional

Published
2023
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22. Efficient isolation of rare B cells using next-generation antigen barcoding

Author

Hurtado, Jonathan, primary, Flynn, Claudia, additional, Lee, Jeong Hyun, additional, Salcedo, Eugenia C., additional, Cottrell, Christopher A., additional, Skog, Patrick D., additional, Burton, Dennis R., additional, Nemazee, David, additional, Schief, William R., additional, Landais, Elise, additional, Sok, Devin, additional, and Briney, Bryan, additional

Published
2023
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23. Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice

Author

Sok, Devin, Briney, Bryan, Jardine, Joseph G., Kulp, Daniel W., Menis, Sergey, Pauthner, Matthias, Wood, Andrew, Lee, E-Chiang, Le, Khoa M., Jones, Meaghan, Ramos, Alejandra, Kalyuzhniy, Oleksandr, Adachi, Yumiko, Kuhitz, Michael, MacPherson, Skye, Bradley, Allan, Friedrich, Glenn A., Schief, William R., and Burton, Dennis R.

Published
2016

24. Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus

Author

Liu, Jinyan, Ghneim, Khader, Sok, Devin, Bosche, William J., Li, Yuan, Chipriano, Elizabeth, Berkemeier, Brian, Oswald, Kelli, Borducchi, Erica, Cabral, Crystal, Peter, Lauren, Brinkman, Amanda, Shetty, Mayuri, Jimenez, Jessica, Mondesir, Jade, Lee, Benjamin, Giglio, Patricia, Chandrashekar, Abishek, Abbink, Peter, Colantonio, Arnaud, Gittens, Courtney, Baker, Chantelle, Wagner, Wendeline, Lewis, Mark G., Li, Wenjun, Sekaly, Rafick-Pierre, Lifson, Jeffrey D., Burton, Dennis R., and Barouch, Dan H.

Published
2016

25. HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

Author

Jardine, Joseph G., Kulp, Daniel W., Havenar-Daughton, Colin, Sarkar, Anita, Briney, Bryan, Sok, Devin, Sesterhenn, Fabian, Ereño-Orbea, June, Kalyuzhniy, Oleksandr, Deresa, Isaiah, Hu, Xiaozhen, Spencer, Skye, Jones, Meaghan, Georgeson, Erik, Adachi, Yumiko, Kubitz, Michael, deCamp, Allan C., Julien, Jean-Philippe, Wilson, Ian A., Burton, Dennis R., Crotty, Shane, and Schief, William R.

Published
2016

26. Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

Author

Bornholdt, Zachary A., Turner, Hannah L., Murin, Charles D., Li, Wen, Sok, Devin, Souders, Colby A., Piper, Ashley E., Goff, Arthur, Shamblin, Joshua D., Wollen, Suzanne E., Sprague, Thomas R., Fusco, Marnie L., Pommert, Kathleen B. J., Cavacini, Lisa A., Smith, Heidi L., Klempner, Mark, Reimann, Keith A., Krauland, Eric, Gerngross, Tillman U., Wittrup, Karl D., Saphire, Erica Ollmann, Burton, Dennis R., Glass, Pamela J., Ward, Andrew B., and Walker, Laura M.

Published
2016

27. Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques

Author

Magnani, Diogo M., Rogers, Thomas F., Beutler, Nathan, Ricciardi, Michael J., Bailey, Varian K., Gonzalez-Nieto, Lucas, Briney, Bryan, Sok, Devin, Le, Khoa, Strubel, Alexander, Gutman, Martin J., Pedreño-Lopez, Núria, Grubaugh, Nathan D., Silveira, Cassia G. T., Maxwell, Helen S., Domingues, Aline, Martins, Mauricio A., Lee, David E., Okwuazi, Erica E., Jean, Sherrie, Strobert, Elizabeth A., Chahroudi, Ann, Silvestri, Guido, Vanderford, Thomas H., Kallas, Esper G., Desrosiers, Ronald C., Bonaldo, Myrna C., Whitehead, Stephen S., Burton, Dennis R., and Watkins, David I.

Published
2017
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28. Complementary antibody lineages achieve neutralization breadth in an HIV-1 infected elite neutralizer

Author

van Schooten, Jelle, primary, Schorcht, Anna, additional, Farokhi, Elinaz, additional, Umotoy, Jeffrey C., additional, Gao, Hongmei, additional, van den Kerkhof, Tom L. G. M., additional, Dorning, Jessica, additional, Rijkhold Meesters, Tim G., additional, van der Woude, Patricia, additional, Burger, Judith A., additional, Bijl, Tom, additional, Ghalaiyini, Riham, additional, Torrents de la Peña, Alba, additional, Turner, Hannah L., additional, Labranche, Celia C., additional, Stanfield, Robyn L., additional, Sok, Devin, additional, Schuitemaker, Hanneke, additional, Montefiori, David C., additional, Burton, Dennis R., additional, Ozorowski, Gabriel, additional, Seaman, Michael S., additional, Wilson, Ian A., additional, Sanders, Rogier W., additional, Ward, Andrew B., additional, and van Gils, Marit J., additional

Published
2022
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29. Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows

Author

Sok, Devin, Le, Khoa M., Vadnais, Melissa, Saye-Francisco, Karen L., Jardine, Joseph G., Torres, Jonathan L., Berndsen, Zachary T., Kong, Leopold, Stanfield, Robyn, Ruiz, Jennifer, Ramos, Alejandra, Liang, Chi-Hui, Chen, Patricia L., Criscitiello, Michael F., Mwangi, Waithaka, Wilson, Ian A., Ward, Andrew B., Smider, Vaughn V., and Burton, Dennis R.

Subjects
Immunogenetics -- Research, Cows (Cattle) -- Genetic aspects, HIV antibodies -- Research, Immunologic research, Animal vaccination -- Methods, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Devin Sok [1, 2, 3, 4]; Khoa M. Le [1, 2, 3, 4]; Melissa Vadnais [5]; Karen L. Saye-Francisco [1, 2, 3]; Joseph G. Jardine [1, 2, 3]; Jonathan [...]

Published
2017
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30. Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice

Author

Melzi, Eleonora, primary, Willis, Jordan R., additional, Ma, Krystal M., additional, Lin, Ying-Cing, additional, Kratochvil, Sven, additional, Berndsen, Zachary T., additional, Landais, Elise A., additional, Kalyuzhniy, Oleksandr, additional, Nair, Usha, additional, Warner, John, additional, Steichen, Jon M., additional, Kalyuzhniy, Anton, additional, Le, Amber, additional, Pecetta, Simone, additional, Perez, Manfredo, additional, Kirsch, Kathrin, additional, Weldon, Stephanie R., additional, Falcone, Samantha, additional, Himansu, Sunny, additional, Carfi, Andrea, additional, Sok, Devin, additional, Ward, Andrew B., additional, Schief, William R., additional, and Batista, Facundo D., additional

Published
2022
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31. Ancestral SARS-CoV-2 driven antibody repertoire diversity in an unvaccinated individual correlates with expanded neutralization breadth

Author

Deshpande, Suprit, primary, Ansari, Mohammed Yousuf, additional, Sutar, Jyoti, additional, Das, Payel, additional, Hingankar, Nitin, additional, Mukherjee, Sohini, additional, Jayal, Priyanka, additional, Singh, Savita, additional, Anantharaj, Anbalagan, additional, Singh, Janmejay, additional, Chattopadhyay, Souvick, additional, Raghavan, Sreevatsan, additional, Gosain, Mudita, additional, Chauhan, Supriya, additional, Shrivas, Shweta, additional, Prasad, Chaman, additional, Chauhan, Sangeeta, additional, Sharma, Neha, additional, Jana, Pradipta, additional, Thiruvengadam, Ramachandran, additional, Kshetrapal, Pallavi, additional, Wadhwa, Nitya, additional, Das, Bhabatosh, additional, Batra, Gaurav, additional, Medigeshi, Guruprasad, additional, Sok, Devin, additional, Bhatnagar, Shinjini, additional, Garg, Pramod Kumar, additional, and Bhattacharya, Jayanta, additional

Published
2022
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33. HIV-1 neutralizing antibodies induced by native-like envelope trimers

Author

Sanders, Rogier W., van Gils, Marit J., Derking, Ronald, Sok, Devin, Ketas, Thomas J., Burger, Judith A., Ozorowski, Gabriel, Cupo, Albert, Simonich, Cassandra, Goo, Leslie, Arendt, Heather, Kim, Helen J., Lee, Jeong Hyun, Pugach, Pavel, Williams, Melissa, Debnath, Gargi, Moldt, Brian, van Breemen, Mariëlle J., Isik, Gözde, Medina-Ramírez, Max, Back, Jaap Willem, Koff, Wayne C., Julien, Jean-Philippe, Rakasz, Eva G., Seaman, Michael S., Guttman, Miklos, Lee, Kelly K., Klasse, Per Johan, LaBranche, Celia, Schief, William R., Wilson, Ian A., Overbaugh, Julie, Burton, Dennis R., Ward, Andrew B., Montefiori, David C., Dean, Hansi, and Moore, John P.

Published
2015

35. Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge

Author

Julg, Boris, Tartaglia, Lawrence J., Keele, Brandon F., Wagh, Kshitij, Pegu, Amarendra, Sok, Devin, Abbink, Peter, Schmidt, Stephen D., Wang, Keyun, Chen, Xuejun, Gordon Joyce, M., Georgiev, Ivelin S., Choe, Misook, Kwong, Peter D., Doria-Rose, Nicole A., Le, Khoa, Louder, Mark K., Bailer, Robert T., Moore, Penny L., Korber, Bette, Seaman, Michael S., Abdool Karim, Salim S., Morris, Lynn, Koup, Richard A., Mascola, John R., Burton, Dennis R., and Barouch, Dan H.

Published
2017
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37. Fully synthetic platform to rapidly generate tetravalent bispecific nanobody-based immunoglobulins.

Author

Mindrebo, Laetitia Misson, Hejun Liu, Ozorowski, Gabriel, Quoc Tran, Woehl, Jordan, Khalek, Irene, Smith, Jessica M., Barman, Shawn, Fangzhu Zhao, Keating, Celina, Limbo, Oliver, Verma, Megan, Jingjia Liu, Stanfield, Robyn L., Xueyong Zhu, Turner, Hannah L., Sok, Devin, Po-Ssu Huang, Burton, Dennis R., and Ward, Andrew B.

Subjects
IMMUNOGLOBULINS, BISPECIFIC antibodies, SARS-CoV-2, MODULAR design, ANTIGENS
Abstract

Nanobodies bind a target antigen with a kinetic profile similar to a conventional antibody, but exist as a single heavy chain domain that can be readily multimerized to engage antigen via multiple interactions. Presently, most nanobodies are produced by immunizing camelids; however, platforms for animal-free production are growing in popularity. Here, we describe the development of a fully synthetic nanobody library based on an engineered human VH3-23 variable gene and a multispecific antibody-like format designed for biparatopic target engagement. To validate our library, we selected nanobodies against the SARS-CoV-2 receptor-binding domain and employed an on-yeast epitope binning strategy to rapidly map the specificities of the selected nanobodies. We then generated antibody-like molecules by replacing the VH and VL domains of a conventional antibody with two different nanobodies, designed as a molecular clamp to engage the receptor-binding domain biparatopically. The resulting bispecific tetra-nanobody immunoglobulins neutralized diverse SARS-CoV-2 variants with potencies similar to antibodies isolated from convalescent donors. Subsequent biochemical analyses confirmed the accuracy of the on-yeast epitope binning and structures of both individual nanobodies, and a tetra-nanobody immunoglobulin revealed that the intended mode of interaction had been achieved. This overall workflow is applicable to nearly any protein target and provides a blueprint for a modular workflow for the development of multispecific molecules. [ABSTRACT FROM AUTHOR]

Published
2023
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40. A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 Delta variant

Author

Hingankar, Nitin, primary, Deshpande, Suprit, additional, Das, Payel, additional, Rizvi, Zaigham Abbas, additional, Wibmer, Constantinos Kurt, additional, Mashilo, Poppy, additional, Ansari, Mohammed Yousuf, additional, Burns, Alison, additional, Barman, Shawn, additional, Zhao, Fangzhu, additional, Mukherjee, Sohini, additional, Torres, Jonathan L., additional, Chattopadhyay, Souvick, additional, Mehdi, Farha, additional, Sutar, Jyoti, additional, Rathore, Deepak Kumar, additional, Pargai, Kamal, additional, Singh, Janmejay, additional, Sonar, Sudipta, additional, Jakhar, Kamini, additional, Dandotiya, Jyotsna, additional, Bhattacharyya, Sankar, additional, Mani, Shailendra, additional, Samal, Sweety, additional, Singh, Savita, additional, Kshetrapal, Pallavi, additional, Thiruvengadam, Ramachandran, additional, Batra, Gaurav, additional, Medigeshi, Guruprasad, additional, Ward, Andrew B., additional, Bhatnagar, Shinjini, additional, Awasthi, Amit, additional, Sok, Devin, additional, and Bhattacharya, Jayanta, additional

Published
2022
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41. Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

Author

Jardine, Joseph, Julien, Jean-Philippe, Menis, Sergey, Ota, Takayuki, Kalyuzhniy, Oleksandr, McGuire, Andrew, Sok, Devin, Huang, Po-Ssu, MacPherson, Skye, Jones, Meaghan, Nieusma, Travis, Mathison, John, Baker, David, Ward, Andrew B., Burton, Dennis R., Stamatatos, Leonidas, Nemazee, David, Wilson, Ian A., and Schief, William R.

Published
2013
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44. Highly mutated antibodies capable of neutralizing N276 glycan-deficient HIV after a single immunization with an Env trimer

Author

Lee, Jeong Hyun, primary, Nakao, Catherine, additional, Appel, Michael, additional, Le, Amber, additional, Landais, Elise, additional, Kalyuzhniy, Oleksandr, additional, Hu, Xiaozhen, additional, Liguori, Alessia, additional, Mullen, Tina-Marie, additional, Groschel, Bettina, additional, Abbott, Robert K., additional, Sok, Devin, additional, Schief, William R., additional, and Crotty, Shane, additional

Published
2022
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45. From structure to sequence: Antibody discovery using cryoEM

Author

Antanasijevic, Aleksandar, primary, Bowman, Charles A., additional, Kirchdoerfer, Robert N., additional, Cottrell, Christopher A., additional, Ozorowski, Gabriel, additional, Upadhyay, Amit A., additional, Cirelli, Kimberly M., additional, Carnathan, Diane G., additional, Enemuo, Chiamaka A., additional, Sewall, Leigh M., additional, Nogal, Bartek, additional, Zhao, Fangzhu, additional, Groschel, Bettina, additional, Schief, William R., additional, Sok, Devin, additional, Silvestri, Guido, additional, Crotty, Shane, additional, Bosinger, Steven E., additional, and Ward, Andrew B., additional

Published
2022
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46. Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape

Author

Zhao, Fangzhu, primary, Keating, Celina, additional, Ozorowski, Gabriel, additional, Shaabani, Namir, additional, Francino-Urdaniz, Irene M., additional, Barman, Shawn, additional, Limbo, Oliver, additional, Burns, Alison, additional, Zhou, Panpan, additional, Ricciardi, Michael, additional, Woehl, Jordan, additional, Tran, Quoc, additional, Turner, Hannah L, additional, Peng, Linghang, additional, Huang, Deli, additional, Nemazee, David, additional, Andrabi, Raiees, additional, Sok, Devin, additional, Teijaro, John R, additional, Whitehead, Timothy A, additional, Ward, Andrew B, additional, Burton, Dennis, additional, and Jardine, Joseph G, additional

Published
2022
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48. An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability

Author

van Gils, Marit J., van den Kerkhof, Tom L. G. M., Ozorowski, Gabriel, Cottrell, Christopher A., Sok, Devin, Pauthner, Matthias, Pallesen, Jesper, de Val, Natalia, Yasmeen, Anila, de Taeye, Steven W., Schorcht, Anna, Gumbs, Stephanie, Johanna, Inez, Saye-Francisco, Karen, Liang, Chi-Hui, Landais, Elise, Nie, Xiaoyan, Pritchard, Laura K., Crispin, Max, Kelsoe, Garnett, Wilson, Ian A., Schuitemaker, Hanneke, Klasse, Per Johan, Moore, John P., Burton, Dennis R., Ward, Andrew B., and Sanders, Rogier W.

Published
2016
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49. A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 delta variant

Author

Hingankar, Nitin, primary, Deshpande, Suprit, additional, Das, Payel, additional, Rizvi, Zaigham Abbas, additional, Burns, Alison, additional, Barman, Shawn, additional, Zhao, Fangzhu, additional, Ansari, Mohammed Yousuf, additional, Mukherjee, Sohini, additional, Torres, Jonathan L., additional, Chattopadhyay, Souvick, additional, Mehdi, Farha, additional, Sutar, Jyoti, additional, Rathore, Deepak Kumar, additional, Pargai, Kamal, additional, Singh, Janmejay, additional, Sonar, Sudipta, additional, Jakhar, Kamini, additional, Bhattacharyya, Sankar, additional, Mani, Shailendra, additional, Singh, Savita, additional, Dandotiya, Jyotsna, additional, Kshetrapal, Pallavi, additional, Thiruvengadam, Ramachandran, additional, Batra, Gaurav, additional, Medigeshi, Guruprasad R, additional, Ward, Andrew, additional, Bhatnagar, Shinjini, additional, Awasthi, Amit, additional, Sok, Devin, additional, and Bhattacharya, Jayanta, additional

Published
2021
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50. Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

Author

Zhao, Fangzhu, primary, Berndsen, Zachary T., additional, Pedreño-Lopez, Nuria, additional, Burns, Alison, additional, Allen, Joel D., additional, Barman, Shawn, additional, Lee, Wen-Hsin, additional, Chakraborty, Srirupa, additional, Gnanakaran, Sandrasegaram, additional, Sewall, Leigh M., additional, Ozorowski, Gabriel, additional, Limbo, Oliver, additional, Song, Ge, additional, Yong, Peter, additional, Callaghan, Sean, additional, Weisgrau, Kim L., additional, Lifson, Jeffrey D., additional, Nedellec, Rebecca, additional, Voigt, Thomas B, additional, Laurino, Fernanda, additional, Louw, Johan, additional, Rosen, Brandon C., additional, Ricciardi, Michael, additional, Crispin, Max, additional, Desrosiers, Ronald C., additional, Rakasz, Eva G., additional, Watkins, David I., additional, Andrabi, Raiees, additional, Ward, Andrew B., additional, Burton, Dennis R., additional, and Sok, Devin, additional

Published
2021
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