1. Humoral immunogenicity assessment after receiving three types of SARS-CoV-2 vaccine.
- Author
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Najafi, Niloofar, Soleimanjahi, Hoorieh, Moghaddam-Banaem, Lida, Raoufy, Mohammad Reza, Shahali, Shadab, Kazemnejad, Anoshirvan, and Nasiri, Zeynab
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COVID-19 vaccines , *IMMUNE response , *IMMUNOGLOBULINS , *VACCINE effectiveness , *VACCINE immunogenicity , *ANTIBODY titer - Abstract
Several vaccines have been developed against SARS-CoV-2 and subsequently approved by national/international regulators. Detecting specific antibodies after vaccination enables us to evaluate the vaccine's effectiveness. We conducted a prospective longitudinal study among members of Tarbiat Modares University of Tehran, Iran, from 4 September 2021 until 29 December 2021. We aimed to compare the humoral immunogenicity of 3 vaccine types. Participants consisted of 462 adults. Anti-SARS-CoV-2 receptor-binding domain [RBD] IgG titer was compared in 3 groups, each vaccinated by available vaccines in Iran at the time: Oxford/AstraZeneca, COVIran Barekat, and Sinopharm. The median IgG titer was: 91.2, 105.6, 224.0 BAU/ml for Sinopharm, COVIran Barekat and Oxford/AstraZeneca respectively after the first dose; 195.2, 192.0, 337.6 BAU/ml after the second one. We also analyzed the frequency of antibody presence in each vaccine group, in the same order the results were 59.0%, 62.6% and 89.4% after the first dose and 92.1%,89.5% and 98.9% after the second. The comparison of results demonstrated that AstraZeneca vaccine is a superior candidate vaccine for COVID-19 vaccination out of the three. Our data also demonstrated statistically significant higher antibody titer among recipients with an infection history. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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