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To evaluate a software simulating perfused liver volume from virtual selected embolization points on proximal enhanced cone-beam CT (CBCT) liver angiography data set by using selective CBCT as reference standard.Seventy-eight selective/proximal CBCT couples in 46 patients referred for intra-arterial liver treatment at two recruiting centers were retrospectively included. A reference selective volume (RSV) was calculated from the selective CBCT by manual segmentation and was used as a reference standard. The Virtual Perfusion Volume (VPV) was then obtained using Liver ASSIST Virtual Parenchyma software on proximal CBCT angiography using the same injection point as for selective CBCT. RSV and VPV were then compared as absolute, relative, and signed volumetric errors (ABSThe software was technically successful in automatically computing VPV in 74/78 cases (94.8%).On the 74 analyzed couples, median RSV was not significantly different from VPV (394 cc [196 - 640cc] and 391 cc [192 - 620cc] respectively, p=0.435).Median ABSPerfusion hepatic volumes simulated on proximal enhanced CBCT using the virtual parenchyma software are numerically and spatially similar to those manually obtained on selective CBCT.