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Objective: In modern healthcare, accurately predicting diseases is a crucial matter. This study introduces a novel approach using graph neural networks (GNNs) and a Graph Transformer (GT) to predict the incidence of heart failure (HF) on a patient similarity graph at the next hospital visit. Materials and Methods: We used electronic health records (EHR) from the MIMIC-III dataset and applied the K-Nearest Neighbors (KNN) algorithm to create a patient similarity graph using embeddings from diagnoses, procedures, and medications. Three models - GraphSAGE, Graph Attention Network (GAT), and Graph Transformer (GT) - were implemented to predict HF incidence. Model performance was evaluated using F1 score, AUROC, and AUPRC metrics, and results were compared against baseline algorithms. An interpretability analysis was performed to understand the model's decision-making process. Results: The GT model demonstrated the best performance (F1 score: 0.5361, AUROC: 0.7925, AUPRC: 0.5168). Although the Random Forest (RF) baseline achieved a similar AUPRC value, the GT model offered enhanced interpretability due to the use of patient relationships in the graph structure. A joint analysis of attention weights, graph connectivity, and clinical features provided insight into model predictions across different classification groups. Discussion and Conclusion: Graph-based approaches such as GNNs provide an effective framework for predicting HF. By leveraging a patient similarity graph, GNNs can capture complex relationships in EHR data, potentially improving prediction accuracy and clinical interpretability.

Every year, humanity loses about 1.5 million persons due to diabetic disease. Therefore continuous monitoring of diabetes is highly needed, but the conventional approach, i.e., fingertip pricking, causes mental and physical pain to the patient. This work introduces painless and cheaper non-invasive blood glucose level monitoring, Exploiting the advancement and huge progress in deep learning to develop a hybrid convolution neural network (CNN) - gate recurrent unit (GRU) network to hit the targeted system, The proposed system deploys CNN for extracting spatial patterns in the photoplethysmogram (PPG) signal and GRU is used for detecting the temporal patterns. The performance of the proposed system achieves a Mean Absolute Error (MAE) of 2.96 mg/dL, a mean square error (MSE) of 15.53 mg/dL, a root mean square Error (RMSE) of 3.94 mg/dL, and a coefficient of determination ($R^2$ score) of 0.97 on the test dataset. According to the Clarke Error Grid analysis, 100% of points fall within the clinically acceptable zone (Class A)

Millimeter-wave refracting telescopes targeting the degree-scale structure of the cosmic microwave background (CMB) have recently grown to diffraction-limited apertures of over 0.5 meters. These instruments are entirely housed in vacuum cryostats to support their sub-kelvin bolometric detectors and to minimize radiative loading from thermal emission due to absorption loss in their transmissive optical elements. The large vacuum window is the only optical element in the system at ambient temperature, and therefore minimizing loss in the window is crucial for maximizing detector sensitivity. This motivates the use of low-loss polymer materials and a window as thin as practicable. However, the window must simultaneously meet the requirement to keep sufficient vacuum, and therefore must limit gas permeation and remain mechanically robust against catastrophic failure under pressure. We report on the development of extremely thin composite polyethylene window technology that meets these goals. Two windows have been deployed for two full observing seasons on the BICEP3 and BA150 CMB telescopes at the South Pole. On BICEP3, the window has demonstrated a 6% improvement in detector sensitivity., Comment: 20 pages, 12 figures, 4 tables

We introduce a family of boundary conditions and point constraints for conformal immersions that increase the controllability of surfaces defined as minimizers of conformal variational problems. Our free boundary conditions fix the metric on the boundary, up to a global scale, and admit a discretization compatible with discrete conformal equivalence. We also introduce constraints on the conformal scale factor, enforcing rigidity of the geometry in regions of interest, and describe how in the presence of point constraints the conformal class encodes knot points of the spline that can be directly manipulated. To control the tangent planes, we introduce flux constraints balancing the internal material stresses. The collection of these point constraints provide intuitive controls for exploring a subspace of conformal immersions interpolating a fixed set of points in space. We demonstrate the applicability of our framework to geometric modeling, mathematical visualization, and form finding., Comment: to appear in Differential Geom. Appl., 26 pages

We propose a novel dust battery mechanism for generating seed magnetic fields in the early universe, in which charged dust grains are radiatively accelerated, inducing strong electric currents that subsequently generate magnetic fields. Our analysis demonstrates that this process is effective even at very low metallicities (approximately $ \sim 10^{-5} Z_\odot$), and capable of producing seed fields with significant amplitudes of $B \sim \rm \mu G$ around luminous sources over timescales of years to Myr and across spatial scales ranging from au to kpc. Crucially, we find that this mechanism is generically $\sim10^8$ times more effective than the radiatively-driven electron battery or Biermann battery in relatively cool gas ($\ll 10^{5}\,$K), including both neutral and ionized gas. Furthermore, our results suggest that, to first order, dissipation effects do not appear to significantly impede this process, and that it can feasibly generate coherent seed fields on macroscopically large ISM scales (much larger than turbulent dissipation scales or electron mean-free-paths in the ISM). These seed fields could then be amplified by subsequent dynamo actions to the observed magnetic fields in galaxies. Additionally, we propose a sub-grid model for integration into cosmological simulations, and the required electric-field expressions for magnetohydrodynamic-particle-in-a-cell (MHD-PIC) simulations that explicitly model dust dynamics. Finally, we explore the broad applicability of this mechanism across different scales and conditions, emphasizing its robustness compared to other known battery mechanisms., Comment: 19 pages, 2 figures, 1 appendix. Submitted to ApJ

We use a custom-made calibrator to measure individual detectors' polarization angles of BICEP3, a small aperture telescope observing the cosmic microwave background (CMB) at 95GHz from the South Pole. We describe our calibration strategy and the statistical and systematic uncertainties associated with the measurement. We reach an unprecedented precision for such measurement on a CMB experiment, with a repeatability for each detector pair of $0.02\deg$. We show that the relative angles measured using this method are in excellent agreement with those extracted from CMB data. Because the absolute measurement is currently limited by a systematic uncertainty, we do not derive cosmic birefringence constraints from BICEP3 data in this work. Rather, we forecast the sensitivity of BICEP3 sky maps for such analysis. We investigate the relative contributions of instrument noise, lensing, and dust, as well as astrophysical and instrumental systematics. We also explore the constraining power of different angle estimators, depending on analysis choices. We establish that the BICEP3 2-year dataset (2017--2018) has an on-sky sensitivity to the cosmic birefringence angle of $\sigma = 0.078\deg$, which could be improved to $\sigma = 0.055\deg$ by adding all of the existing BICEP3 data (through 2023). Furthermore, we emphasize the possibility of using the BICEP3 sky patch as a polarization calibration source for CMB experiments, which with the present data could reach a precision of $0.035\deg$. Finally, in the context of inflation searches, we investigate the impact of detector-to-detector variations in polarization angles as they may bias the tensor-to-scalar ratio r. We show that while the effect is expected to remain subdominant to other sources of systematic uncertainty, it can be reliably calibrated using polarization angle measurements such as the ones we present in this paper., Comment: 29 Pages, 17 Figures, 6 Tables, as submitted to PRD

The BICEP3 and BICEP Array polarimeters are small-aperture refracting telescopes located at the South Pole designed to measure primordial gravitational wave signatures in the Cosmic Microwave Background (CMB) polarization, predicted by inflation. Constraining the inflationary signal requires not only excellent sensitivity, but also careful control of instrumental systematics. Both instruments use antenna-coupled orthogonally polarized detector pairs, and the polarized sky signal is reconstructed by taking the difference in each detector pair. As a result, the differential response between detectors within a pair becomes an important systematic effect we must control. Additionally, mapping the intensity and polarization response in regions away from the main beam can inform how sidelobe levels affect CMB measurements. Extensive calibration measurements are taken in situ every austral summer for control of instrumental systematics and instrument characterisation. In this work, we detail the set of beam calibration measurements that we conduct on the BICEP receivers, from deep measurements of main beam response to polarized beam response and sidelobe mapping. We discuss the impact of these measurements for instrumental systematics studies and design choices for future CMB receivers., Comment: 13 pages, 7 figures, 1 table, Proceedings paper SPIE 2024

Daily activity monitoring systems used in households provide vital information for health status, particularly with aging residents. Multiple approaches have been introduced to achieve such goals, typically obtrusive and non-obtrusive. Amongst the obtrusive approaches are the wearable devices, and among the non-obtrusive approaches are the movement detection systems, including motion sensors and thermal sensor arrays (TSAs). TSA systems are advantageous when preserving a person's privacy and picking his precise spatial location. In this study, human daily living activities were monitored day and night, constructing the corresponding activity time series and spatial probability distribution and employing a TSA system. The monitored activities are classified into two categories: sleeping and daily activity. Results showed the possibility of distinguishing between classes regardless of day and night. The obtained sleep activity duration was compared with previous research using the same raw data. Results showed that the duration of sleep activity, on average, was 9 hours/day, and daily life activity was 7 hours/day. The person's spatial probability distribution was determined using the bivariate distribution for the monitored location. In conclusion, the results showed that sleeping activity was dominant. Our study showed that TSAs were the optimum choice when monitoring human activity. Our proposed approach tackled limitations encountered by previous human activity monitoring systems, such as preserving human privacy while knowing his precise spatial location.

Mid-infrared (MIR) spectroscopy is a powerful technique employed for a variety of applications, including gas sensing, industrial inspection, astronomy, surveillance, and imaging. Thin-film narrowband interference filters, targeted to specific absorption bands of target molecules, are commonly deployed for cost-effective MIR sensing systems. These devices require complex and time-consuming fabrication processes. Also, their customization on the micro-scale for emerging miniaturized applications is challenging. Plasmonic nanostructure arrays operating in reflection and transmission modes have been developed for MIR. However, they experience undesirable characteristics, such as broad spectra and low reflection/transmission efficiencies. All-dielectric metasurfaces have low intrinsic losses and have emerged as a substitute for plasmonic metasurfaces in MIR spectroscopy. Nevertheless, they typically operate only in reflection mode. In this work, we present a hybrid metal-dielectric metasurface for MIR spectroscopy operating in transmission mode. The metasurface is composed of germanium (Ge) atop aluminum (Al) cylinders, and we show that the transmission response arises because of the hybridization of modes arising from the Ge and the Al structures. The presented metasurface has a high transmission efficiency of 80 % at $\lambda = 2.6\ \mu\text{m}$, and a narrow full-width-at-half-maximum of $0.4\ \mu\text{m}$. We show numerical simulations, successful fabrication using a straightforward fabrication method, and deployment as the in-line optical filter in a CO$_2$ gas detection with a limit of detection of ~0.04% (a few hundred ppm). Our work demonstrates the potential for hybrid metasurfaces as in-line gas sensing optical filters in MIR spectroscopy.

Measurements of B-mode polarization in the CMB sourced from primordial gravitational waves would provide information on the energy scale of inflation and its potential form. To achieve these goals, one must carefully characterize the Galactic foregrounds, which can be distinguished from the CMB by conducting measurements at multiple frequencies. BICEP Array is the latest-generation multi-frequency instrument of the BICEP/Keck program, which specifically targets degree-scale primordial B-modes in the CMB. In its final configuration, this telescope will consist of four small-aperture receivers, spanning frequency bands from 30 to 270 GHz. The 220/270 GHz receiver designed to characterize Galactic dust is currently undergoing commissioning at Stanford University and is scheduled to deploy to the South Pole during the 2024--2025 austral summer. Here, we will provide an overview of this high-frequency receiver and discuss the integration status and test results as it is being commissioned.

Numerous stars exhibit surprisingly large variations in their refractory element abundances, often interpreted as signatures of planetary ingestion events. In this study, we propose that differences in the dust-to-gas ratio near stars during their formation can produce similar observational signals. We investigate this hypothesis using a suite of radiation-dust-magnetohydrodynamic STARFORGE simulations of star formation. Our results show that the distribution of refractory abundance variations ($\rm \Delta [X/H]$) has extended tails, with about 10-30% of all stars displaying variations around $\sim$0.1 dex. These variations are comparable to the accretion of $2-5 \rm M_\oplus$ of planetary material into the convective zones of Sun-like stars. The width of the distributions increases with the incorporation of more detailed dust physics, such as radiation pressure and back-reaction forces, as well as with larger dust grain sizes and finer resolutions. Furthermore, our simulations reveal no correlation between $\rm \Delta [X/H]$ and stellar separations, suggesting that dust-to-gas fluctuations likely occur on scales smaller than those of wide binaries. These findings highlight the importance of considering dust dynamics as a potential source of the observed chemical enrichment in stars., Comment: 10 pages, 3 figures. Submitted to ApJL

Anonymity is an important principle online. However, malicious actors have long used misleading identities to conduct fraud, spread disinformation, and carry out other deceptive schemes. With the advent of increasingly capable AI, bad actors can amplify the potential scale and effectiveness of their operations, intensifying the challenge of balancing anonymity and trustworthiness online. In this paper, we analyze the value of a new tool to address this challenge: "personhood credentials" (PHCs), digital credentials that empower users to demonstrate that they are real people -- not AIs -- to online services, without disclosing any personal information. Such credentials can be issued by a range of trusted institutions -- governments or otherwise. A PHC system, according to our definition, could be local or global, and does not need to be biometrics-based. Two trends in AI contribute to the urgency of the challenge: AI's increasing indistinguishability from people online (i.e., lifelike content and avatars, agentic activity), and AI's increasing scalability (i.e., cost-effectiveness, accessibility). Drawing on a long history of research into anonymous credentials and "proof-of-personhood" systems, personhood credentials give people a way to signal their trustworthiness on online platforms, and offer service providers new tools for reducing misuse by bad actors. In contrast, existing countermeasures to automated deception -- such as CAPTCHAs -- are inadequate against sophisticated AI, while stringent identity verification solutions are insufficiently private for many use-cases. After surveying the benefits of personhood credentials, we also examine deployment risks and design challenges. We conclude with actionable next steps for policymakers, technologists, and standards bodies to consider in consultation with the public., Comment: 63 pages, 7 figures, 5 tables; minor additions to acknowledgments and wording changes for clarity; corrected typo

To address the rural broadband challenge and to leverage the unique opportunities that rural regions provide for piloting advanced wireless applications, we design and implement the ARA wireless living lab for research and innovation in rural wireless systems and their applications in precision agriculture, community services, and so on. ARA focuses on the unique community, application, and economic context of rural regions, and it features the first-of-its-kind, real-world deployment of long-distance, high-capacity wireless x-haul and access platforms across a rural area of diameter over 30 km. With both software-defined radios and programmable COTS systems and through effective orchestration of these wireless resources with fiber as well as compute resources embedded end-to-end across user equipment, base stations, edge, and cloud, ARA offers programmability, performance, robustness, and heterogeneity at the same time, thus enabling rural-focused co-evolution of wireless and applications while helping advance the frontiers of wireless systems in domains such as O-RAN, NextG, and agriculture applications. Here we present the design principles and implementation strategies of ARA, characterize its performance and heterogeneity, and highlight example wireless and application experiments uniquely enabled by ARA., Comment: 17 pages, 18 figures

The dust grain size distribution (GSD) likely varies significantly across star-forming environments in the Universe, but its impact on star formation remains unclear. This ambiguity arises because the GSD interacts non-linearly with processes like heating, cooling, radiation, and chemistry, which have competing effects and varying environmental dependencies. Processes such as grain coagulation, expected to be efficient in dense star-forming regions, reduce the abundance of small grains and increase that of larger grains. Motivated by this, we investigate the effects of similar GSD variations on the thermochemistry and evolution of giant molecular clouds (GMCs) using magnetohydrodynamic simulations spanning a range of cloud masses and grain sizes, which explicitly incorporate the dynamics of dust grains within the full-physics framework of the \SF project. We find that grain size variations significantly alter GMC thermochemistry: with the leading-order effect is that larger grains, under fixed dust mass, GSD dynamic range, and dust-to-gas ratio, result in lower dust opacities. This reduced opacity permits ISRF and internal radiation photons to penetrate more deeply. This leads to rapid gas heating and inhibited star formation. Star formation efficiency is highly sensitive to grain size, with an order of magnitude reduction when grain size dynamic range increases from $10^{-3}$-0.1 $\rm\mu m$ to 0.1-10 $\rm\mu m$. Additionally, warmer gas suppresses low-mass star formation, and decreased opacities result in a greater proportion of gas in diffuse ionized structures., Comment: 13 pages, 5 figures, submitted to ApJ

In task-oriented conversational AI evaluation, unsupervised methods poorly correlate with human judgments, and supervised approaches lack generalization. Recent advances in large language models (LLMs) show robust zeroshot and few-shot capabilities across NLP tasks. This paper explores using LLMs for automated dialogue quality evaluation, experimenting with various configurations on public and proprietary datasets. Manipulating factors such as model size, in-context examples, and selection techniques, we examine "chain-of-thought" (CoT) reasoning and label extraction procedures. Our results show that (1) larger models yield more accurate dialogue labels; (2) algorithmic selection of in-context examples outperforms random selection; (3) CoT reasoning where an LLM is asked to provide justifications before outputting final labels improves performance; and (4) fine-tuned LLMs outperform out-of-the-box ones. Our results indicate that LLMs that are suitably fine-tuned and have sufficient reasoning capabilities can be leveraged for automated dialogue evaluation.

Stars form within dense cores composed of both gas and dust within molecular clouds. However, despite the crucial role that dust plays in the star formation process, its dynamics is frequently overlooked, with the common assumption being a constant, spatially uniform dust-to-gas ratio and grain size spectrum. In this study, we introduce a set of radiation-dust-magnetohydrodynamic simulations of star forming molecular clouds from the {\small STARFORGE} project. These simulations expand upon the earlier radiation MHD models, which included cooling, individual star formation, and feedback. Notably, they explicitly address the dynamics of dust grains, considering radiation, drag, and Lorentz forces acting on a diverse size spectrum of live dust grains. We find that once stars exceed a certain mass threshold ($\sim 2 M_{\odot}$), their emitted radiation can evacuate dust grains from their vicinity, giving rise to a dust-suppressed zone of size $\sim 100$ AU. This removal of dust, which interacts with gas through cooling, chemistry, drag, and radiative transfer, alters the gas properties in the region. Commencing during the early accretion stages and preceding the Main-sequence phase, this process results in a mass-dependent depletion in the accreted dust-to-gas (ADG) mass ratio within both the circumstellar disc and the star. We predict massive stars ($\gtrsim 10 M_{\odot}$) would exhibit ADG ratios that are approximately one order of magnitude lower than that of their parent clouds. Consequently, stars, their discs, and circumstellar environments would display notable deviations in the abundances of elements commonly associated with dust grains, such as carbon and oxygen., Comment: 14 pages, 9 figures, submitted to ApJ

The BICEP/$\textit{Keck}$ (BK) series of cosmic microwave background (CMB) polarization experiments has, over the past decade and a half, produced a series of field-leading constraints on cosmic inflation via measurements of the "B-mode" polarization of the CMB. Primordial B modes are directly tied to the amplitude of primordial gravitational waves (PGW), their strength parameterized by the tensor-to-scalar ratio, $r$, and thus the energy scale of inflation. Having set the most sensitive constraints to-date on $r$, $\sigma(r)=0.009$ ($r_{0.05}<0.036, 95\%$ C.L.) using data through the 2018 observing season ("BK18"), the BICEP/$\textit{Keck}$ program has continued to improve its dataset in the years since. We give a brief overview of the BK program and the "BK18" result before discussing the program's ongoing efforts, including the deployment and performance of the $\textit{Keck Array}$'s successor instrument, BICEP Array, improvements to data processing and internal consistency testing, new techniques such as delensing, and how those will ultimately serve to allow BK reach $\sigma(r) \lesssim 0.003$ using data through the 2027 observing season., Comment: 9 pages, 5 figures. Contribution to the 2024 Cosmology session of the 58th Rencontres de Moriond

The magnetohydrodynamics (MHD) equations plus 'non-ideal' (Ohmic, Hall, ambipolar) resistivities are widely used to model weakly-ionized astrophysical systems. We show that if gradients in the magnetic field become too steep, the implied charge drift speeds become much faster than microphysical signal speeds, invalidating the assumptions used to derive both the resistivities and MHD equations themselves. Generically this situation will excite microscale instabilities that suppress the drift and current. We show this could be relevant at low ionization fractions especially if Hall terms appear significant, external forces induce supersonic motions, or dust grains become a dominant charge carrier. Considering well-established treatments of super-thermal drifts in laboratory, terrestrial, and Solar plasmas as well as conduction and viscosity models, we generalize a simple prescription to rectify these issues, where the resistivities are multiplied by a correction factor that depends only on already-known macroscopic quantities. This is generalized for multi-species and weakly-ionized systems, and leaves the equations unchanged in the drift limits for which they are derived, but restores physical behavior (driving the system back towards slow drift by diffusing away small-scale gradients in the magnetic field) if the limits are violated. This has important consequences: restoring intuitive behaviors such as the system becoming hydrodynamic in the limit of zero ionization; suppressing magnetic structure on scales below a critical length which can comparable to circumstellar disk sizes; limiting the maximum magnetic amplification; and suppressing the effects of the Hall term in particular. This likely implies that the Hall term does not become dynamically important under most conditions of interest in these systems., Comment: 16 pages, 4 figures. Submitted to the Open Journal of Astrophysics. Comments welcome

We demonstrate a wide-band diplexed focal plane suitable for observing low-frequency foregrounds that are important for cosmic microwave background polarimetry. The antenna elements are composed of slotted bowtie antennas with 60% bandwidth that can be partitioned into two bands. Each pixel is composed of two interleaved 12$\times$12 pairs of linearly polarized antenna elements forming a phased array, designed to synthesize a symmetric beam with no need for focusing optics. The signal from each antenna element is captured in-phase and uniformly weighted by a microstrip summing tree. The antenna signal is diplexed into two bands through the use of two complementary, six-pole Butterworth filters. This filter architecture ensures a contiguous impedance match at all frequencies, and thereby achieves minimal reflection loss between both bands. Subsequently, out-of-band rejection is increased with a bandpass filter and the signal is then deposited on a transition-edge sensor bolometer island. We demonstrate the performance of this focal plane with two distinct bands, 30 and 40 GHz, each with a bandwidth of $\sim$20 and 15 GHz, respectively. The unequal bandwidths between the two bands are caused by an unintentional shift in diplexer frequency from its design values. The end-to-end optical efficiency of these detectors are relatively modest, at 20-30%, with an efficiency loss due to an unknown impedance mismatch in the summing tree. Far-field beam maps show good optical characteristics with edge pixels having no more than $\sim$ 5% ellipticity and $\sim$10-15% peak-to-peak differences for A-B polarization pairs., Comment: 17 pages, 13 figures. Accepted for publication in ApJS

Clinical trials are pivotal in the drug discovery process to determine the safety and efficacy of a drug candidate. The high failure rates of these trials are attributed to deficiencies in clinical model development and protocol design. Improvements in the clinical drug design process could therefore yield significant benefits for all stakeholders involved. This paper examines the current challenges faced in clinical trial design and optimization, reviews established classical computational approaches, and introduces quantum algorithms aimed at enhancing these processes. Specifically, the focus is on three critical aspects: clinical trial simulations, site selection, and cohort identification. This study aims to provide a comprehensive framework that leverages quantum computing to innovate and refine the efficiency and effectiveness of clinical trials.

In-Memory Computing (IMC) introduces a new paradigm of computation that offers high efficiency in terms of latency and power consumption for AI accelerators. However, the non-idealities and defects of emerging technologies used in advanced IMC can severely degrade the accuracy of inferred Neural Networks (NN) and lead to malfunctions in safety-critical applications. In this paper, we investigate an architectural-level mitigation technique based on the coordinated action of multiple checksum codes, to detect and correct errors at run-time. This implementation demonstrates higher efficiency in recovering accuracy across different AI algorithms and technologies compared to more traditional methods such as Triple Modular Redundancy (TMR). The results show that several configurations of our implementation recover more than 91% of the original accuracy with less than half of the area required by TMR and less than 40% of latency overhead., Comment: This paper will be presented at 29th IEEE European Test Symposium 2024 (ETS) 2024