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17 results on '"Solovyeva, Svetlana N."'

1. Some outcomes and a hypothetical mechanism of combined lead and benzo(a)pyrene intoxication, and its alleviation with a complex of bioprotectors

Author

Minigalieva, Ilzira A., Shtin, Tatiana N., Makeyev, Oleg H., Panov, Vladimir G., Privalova, Larisa I., Gurvic, Vladimir B., Sutunkova, Marina P., Bushueva, Tatiana V., Sakhautdinova, Renata R., Klinova, Svetlana V., Solovyeva, Svetlana N., Chernyshov, Ivan N., Shuman, Eugene A., Korotkov, Artem A., and Katsnelson, Boris A.

Published
2020
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4. A paradoxical response of the rat organism to long-term inhalation of silica-containing submicron (predominantly nanoscale) particles of a collected industrial aerosol at realistic exposure levels

Author

Sutunkova, Marina P., Solovyeva, Svetlana N., Katsnelson, Boris A., Gurvich, Vladimir B., Privalova, Larisa I., Minigalieva, Ilzira A., Slyshkina, Tatyana V., Valamina, Irene E., Makeyev, Oleg H., Shur, Vladimir Ya., Zubarev, Ilya V., Kuznetsov, Dmitry K., and Shishkina, Ekaterina V.

Published
2017
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10. General toxic and cardiovascular toxic impact of cadmium oxide nanoparticles

Author

Klinova, Svetlana V., primary, Minigalieva, Ilzira A., additional, Katsnelson, Boris A., additional, Solovyeva, Svetlana N., additional, Privalova, Larisa I., additional, Gurvich, Vladimir B., additional, Ryabova, Iuliia V., additional, Chernyshov, Ivan N., additional, Bushueva, Tatiana V., additional, Sakhautdinova, Renata R., additional, Shur, Vladimir Ya., additional, Shishkina, Ekaterina V., additional, and Sutunkova, Marina P., additional

Published
2021
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11. Looking for the LOAEL or NOAEL Concentration of Nickel-Oxide Nanoparticles in a Long-Term Inhalation Exposure of Rats

Author

Katsnelson, Boris A., primary, Chernyshov, Ivan N., additional, Solovyeva, Svetlana N., additional, Minigalieva, Ilzira A., additional, Gurvich, Vladimir B., additional, Valamina, Irene E., additional, Makeyev, Oleg H., additional, Sahautdinova, Renata R., additional, Privalova, Larisa I., additional, Tsaregorodtseva, Anastasia E., additional, Korotkov, Artem V., additional, Shuman, Eugene A., additional, Panov, Vladimir G., additional, and Sutunkova, Marina P., additional

Published
2021
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12. An overview of experiments with lead-containing nanoparticles performed by the Ekaterinburg nanotoxicological research team

Author

Minigaliyeva, Ilzira A., primary, Sutunkova, Marina P., additional, Gurvich, Vladimir B., additional, Bushueva, Tatiana V., additional, Klinova, Svetlana V., additional, Solovyeva, Svetlana N., additional, Chernyshov, Ivan N., additional, Valamina, Irene E., additional, Shur, Vladimir Y., additional, Shishkina, Ekaterina V., additional, Makeyev, Oleg H., additional, Panov, Vladimir G., additional, Privalova, Larisa I., additional, and Katsnelson, Boris A., additional

Published
2020
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14. Combined Subchronic Toxicity of Aluminum (III), Titanium (IV) and Silicon (IV) Oxide Nanoparticles and Its Alleviation with a Complex of Bioprotectors

Author

Minigalieva, Ilzira A., Katsnelson, Boris A., Privalova, Larisa I., Sutunkova, Marina P., Gurvich, Vladimir B., Shur, Vladimir Y., Shishkina, Ekaterina V., Valamina, Irene E., Makeyev, Oleg H., Panov, Vladimir G., Varaksin, Anatoly N., Bushueva, Tatiana V., Sakhautdinova, Renata R., Klinova, Svetlana V., Solovyeva, Svetlana N., Meshtcheryakova, Ekaterina Y., Minigalieva, Ilzira A., Katsnelson, Boris A., Privalova, Larisa I., Sutunkova, Marina P., Gurvich, Vladimir B., Shur, Vladimir Y., Shishkina, Ekaterina V., Valamina, Irene E., Makeyev, Oleg H., Panov, Vladimir G., Varaksin, Anatoly N., Bushueva, Tatiana V., Sakhautdinova, Renata R., Klinova, Svetlana V., Solovyeva, Svetlana N., and Meshtcheryakova, Ekaterina Y.

Published
2018

15. Combined Subchronic Toxicity of Aluminum (III), Titanium (IV) and Silicon (IV) Oxide Nanoparticles and Its Alleviation with a Complex of Bioprotectors

Author

Minigalieva, Ilzira A., primary, Katsnelson, Boris A., additional, Privalova, Larisa I., additional, Sutunkova, Marina P., additional, Gurvich, Vladimir B., additional, Shur, Vladimir Y., additional, Shishkina, Ekaterina V., additional, Valamina, Irene E., additional, Makeyev, Oleg H., additional, Panov, Vladimir G., additional, Varaksin, Anatoly N., additional, Bushueva, Tatiana V., additional, Sahautdinova, Renata R., additional, Klinova, Svetlana V., additional, Solovyeva, Svetlana N., additional, and Meshtcheryakova, Ekaterina Y., additional

Published
2018
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16. Toxic Effects of Low-Level Long-Term Inhalation Exposures of Rats to Nickel Oxide Nanoparticles.

Author

Sutunkova, Marina P., Solovyeva, Svetlana N., Minigalieva, Ilzira A., Gurvich, Vladimir B., Saatkhudinova, Renata R., Klinova, Svetlana V., Privalova, Larisa I., Katsnelson, Boris A., Valamina, Irene E., Makeyev, Oleg H., Tsaregorodtseva, Anastasia E., Korotkov, Artem V., Shuman, Eugene A., Shur, Vladimir Ya., Shishkina, Ekaterina V., and Zubarev, Ilya V.

Subjects
*NICKEL oxide, *NANOPARTICLES, *TOXICOLOGY of poisonous gases, *GENETIC toxicology, *DNA, *MICE
Abstract

Rats were exposed to nickel oxide nanoparticles (NiO-NP) inhalation at 0.23 ± 0.01 mg/m3 for 4 h a day 5 times a week for up to 10 months. The rat organism responded to this impact with changes in cytological and some biochemical characteristics of the bronchoalveolar lavage fluid along with a paradoxically little pronounced pulmonary pathology associated with a rather low chronic retention of nanoparticles in the lungs. There were various manifestations of systemic toxicity, including damage to the liver and kidneys; a likely allergic syndrome as indicated by some cytological signs; transient stimulation of erythropoiesis; and penetration of nickel into the brain from the nasal mucous membrane along the olfactory pathway. Against a picture of mild to moderate chronic toxicity of nickel, its in vivo genotoxic effect assessed by the degree of DNA fragmentation in nucleated blood cells (the RAPD test) was pronounced, tending to increasing with the length of the exposure period. When rats were given orally, in parallel with the toxic exposure, a set of innocuous substances with differing mechanisms of expected bioprotective action, the genotoxic effect of NiO-NPs was found to be substantially attenuated. [ABSTRACT FROM AUTHOR]

Published
2019
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17. Combined Subchronic Toxicity of Aluminum (III), Titanium (IV) and Silicon (IV) Oxide Nanoparticles and Its Alleviation with a Complex of Bioprotectors.

Author

Minigalieva IA, Katsnelson BA, Privalova LI, Sutunkova MP, Gurvich VB, Shur VY, Shishkina EV, Valamina IE, Makeyev OH, Panov VG, Varaksin AN, Bushueva TV, Sakhautdinova RR, Klinova SV, Solovyeva SN, and Meshtcheryakova EY

Subjects
Aluminum chemistry, Animals, Injections, Intraperitoneal, Male, Metal Nanoparticles administration & dosage, Metal Nanoparticles chemistry, Pectins administration & dosage, Protective Agents administration & dosage, Rats, Silicon chemistry, Titanium chemistry, Vitamins administration & dosage, Metal Nanoparticles toxicity, Toxicity Tests, Subchronic
Abstract

Stable suspensions of metal/metalloid oxide nanoparticles (MeO-NPs) obtained by laser ablation of 99.99% pure elemental aluminum, titanium or silicon under a layer of deionized water were used separately, or in three binary combinations, or in a ternary combination to induce subchronic intoxications in rats. To this end, the MeO-NPs were repeatedly injected intraperitoneally (i.p.) 18 times during 6 weeks before measuring a large number of functional, biochemical, morphological and cytological indices for the organism's status. In many respects, the Al₂O₃-NP was found to be the most toxic species alone and the most dangerous component of the combinations studied. Mathematical modeling with the help of the Response Surface Methodology showed that, as well as in the case of any other binary toxic combinations previously investigated by us, the organism's response to a simultaneous exposure to any two of the MeO-NP species under study was characterized by a complex interaction between all possible types of combined toxicity (additivity, subadditivity or superadditivity of unidirectional action and different variants of opposite effects) depending on which outcome this type was estimated for and on effect and dose levels. With any third MeO-NP species acting in the background, the type of combined toxicity displayed by the other two remained virtually the same or changed significantly, becoming either more or less unfavorable. Various harmful effects produced by the (Al₂O₃-NP + TiO₂-NP + SiO₂-NP)-combination, including its genotoxicity, were substantially attenuated by giving the rats per os during the entire exposure period a complex of innocuous bioactive substances expected to increase the organism's antitoxic resistance., Competing Interests: The authors declare no conflict of interest.

Published
2018
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