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$^{18}$F-Fluoromisonidazole ($^{18}$F-FMISO) is a highly promising positron emission tomography radiopharmaceutical for identifying hypoxic regions in solid tumors. This research employs spatiotemporal multi-scale mathematical modeling to explore how different levels of angiogenesis influence the transport of radiopharmaceuticals within tumors. In this study, two tumor geometries with heterogeneous and uniform distributions of capillary networks were employed to incorporate varying degrees of microvascular density. The synthetic image of the heterogeneous and vascularized tumor was generated by simulating the angiogenesis process. The proposed multi-scale spatiotemporal model accounts for intricate physiological and biochemical factors within the tumor microenvironment, such as the transvascular transport of the radiopharmaceutical agent, its movement into the interstitial space by diffusion and convection mechanisms, and ultimately its uptake by tumor cells. Results showed that both quantitative and semi-quantitative metrics of $^{18}$F-FMISO uptake differ spatially and temporally at different stages during tumor growth. The presence of a high microvascular density in uniformly vascularized tumor increases cellular uptake, as it allows for more efficient release and rapid distribution of radiopharmaceutical molecules. This results in enhanced uptake compared to the heterogeneous vascularized tumor. In both heterogeneous and uniform distribution of microvessels in tumors, the diffusion transport mechanism has a more pronounced than convection. The findings of this study shed light on the transport phenomena behind $^{18}$F-FMISO radiopharmaceutical distribution and its delivery in the tumor microenvironment, aiding oncologists in their routine decision-making processes.

The concept of topological Fano resonance, characterized by an ultrasharp asymmetric line shape, is a promising candidate for robust sensing applications due to its sensitivity to external parameters and immunity to structural disorder. In this study, the vacancy-induced topological Fano resonance in a nanoribbon made up of a hexagonal lattice with armchair sides is examined by introducing several on-site vacancies, which are deliberately created at regular distances, along a zigzag chain that stretches across the width of the ribbon. The presence of the on-site vacancies can create localized energy states within the electronic band structure, leading to the formation of an impurity band, which can result in Fano resonance phenomena by forming a conductivity channel between the edge modes on both armchair sides of the ribbon. Consequently, an ultracompact tunable on-chip integrated topological Fano resonance derived from the graphene-based nanomechanical phononic crystals is proposed. The Fano resonance arises from the interference between topologically protected even and odd edge modes at the interface between trivial and nontrivial insulators in a nanoribbon structure governed by the Kane-Mele model describing the quantum spin Hall effect in hexagonal lattices. The simulation of the topological Fano resonance is performed analytically using the Lippmann-Schwinger scattering formulation. One of the advantages of the present study is that the related calculations are carried out analytically, and in addition to the simplicity and directness, it reproduces the results obtained from the Landauer-B\"{u}ttiker formulation very well both quantitatively and qualitatively. The findings open up possibilities for the design of highly sensitive and accurate robust sensors for detecting extremely tiny forces, masses, and spatial positions.

We investigate the variation of concurrence in a spin-1/2 transverse field XY chain system in an excited state. Initially, we precisely solve the eigenvalue problem of the system Hamiltonian using the fermionization technique. Subsequently, we calculate the concurrence between nearest-neighbor pairs of spins in all excited states with higher energy than the ground state. Below the factorized field, denoted as $h_f=\sqrt{J^2-(J \delta)^2}$, we find no pairwise entanglement between nearest neighbors in excited states. At the factorized field, corresponding to a factorized state, we observe weak concurrence in very low energy states. Beyond $h_f$, the concurrence strengthens, entangling all excited states. The density of entangled states peaks at the center of the excited spectrum. Additionally, the distribution of concurrence reveals that the midpoint of the non-zero concurrence range harbors the most entangled excited states., Comment: 8 pages, 3 figures

In this study, we explore the ground state phase diagram of the spin-1/2 XX chain model, which features $XZY-YZX$ type three-spin interactions (TSI). This model, while seemingly simple, reveals a rich tapestry of quantum behaviors. Our analysis relies on several key metrics. The '$l_1$-norm of coherence' helps us identify coherent states within the phase diagram, which represent states capable of superposition and interference. We employ the 'spin squeezing parameter' to pinpoint unique coherent states characterized by isotropic noise in all directions, making them invaluable for quantum metrology. Additionally, we utilize the 'entanglement entropy' to determine which of these coherent states exhibit entanglement, indicating states that cannot be fully described by local variables. Our research unveils diverse regions within the phase diagram, each characterized by coherent, squeezed, or entangled states, offering insights into the quantum phenomena underling these systems. We also study the critical scaling versus the system size for the mentioned quantities.

We consider an armchair bilayer phosphorene that is connected to two hot and cold leads from both sides and study the thermoelectric properties of such a system with periodic vacancies at the middle of nanoribbon and in the armchair direction. For this purpose, we first analytically show that by creating a vacancy, a localized state is generated around it. Then we demonstrate that in the presence periodic vacancies, a new energy band will be formed in the energy bandstructure, and by changing the distance between the vacancies, the width of the transmission channel and finally the electric power and thermoelectric efficiency can be tuned.

The emergent integrability in a many-body localized (MBL) system can be well characterized by the existence of the complete set of local integrals of motion (LIOMs). Such exactly conserved and exponentially localized operators are often understood as quasiparticle operators which can be expanded in terms of single-particle operators dressed with different numbers of particle-hole pairs. Here, we consider a one-dimensional XXZ spin-$\frac12$ Heisenberg chain in the presence of a random field and try to quantify the corrections needed to be considered in the picture of quasiparticles associated with LIOMs due to the presence of particle-hole excitations. To this end, we explicitly present the multibody expansion of LIOM creation operators of the system in the MBL regime. We analytically obtain the coefficients of this expansion and discuss the effect of higher-order corrections associated with different numbers of particle-hole excitations. Our analysis shows that depending on the localization length of the system, there exist a regime in which the contributions that come from higher-order terms can break down the effective one-particle description of the LIOMs and such quasiparticles become essentially many-body-like.

Many-body localization (MBL) is a novel prototype of ergodicity breaking due to the emergence of local integrals of motion (LIOMs) in a disordered interacting quantum system. To better understand the role played by the existence of such macroscopically LIOMs, we explore and study some of their structural properties across the MBL transition. We first, consider a one-dimensional XXZ spin chain in a disordered magnetic field and introduce and implement a non-perturbative, fast, and accurate method of constructing LIOMs. In contrast to already existing methods, our scheme allows obtaining LIOMs not only in the deep MBL phase but rather, near the transition point too. Then, we take the matrix representation of LIOM operators as an adjacency matrix of a directed graph whose elements describe the connectivity of ordered eigenbasis in the Hilbert-space. Our cluster size analysis for this graph shows that the MBL transition coincides with a percolation transition in the Hilbert-space. By performing finite-size scaling, we compare the critical disorder and correlation exponent $\nu$ both in the presence and absence of interaction. Finally, we also discuss how the distribution of diagonal elements of LIOM operators in a typical cluster signals the transition.

Armchair phosphorene nanoribbons (APNRs) are known to be semiconductors with an indirect bandgap. Here, we propose to introduce new states in the gap of APNRs by creating a periodic structure of vacancies (antidots). Based on the tight-binding model, we show that a periodic array of vacancies or nanopores leads to the formation of an impurity band inside the gap region. We first present an analytical expression for the dispersion relation of an impurity band induced by hybridization of bound states associated with each single vacancy defect. Then, we increase the size of vacancy defects to include a bunch of atoms and theoretically investigate the effect of nanopores size and their spacing on electronic band structure, carrier transmission function, and thermoelectric properties. Our analysis of the power generation rate and thermoelectric efficiency of these structures reveals that an ANPR can be used as a superb thermoelectric power generation module.

The existence of robust chiral edge states in a finite topologically nontrivial chern insulator is a consequence of the bulk-boundary correspondence. In this paper, we present a theoretical framework based on lattice Green's function to study the scattering of such chiral edge electrons by a single localized impurity. To this end, in the first step, we consider the standard topological Haldane model on a honeycomb lattice with strip geometry. We obtain analytical expressions for the wave functions and their corresponding energy dispersion of the low-energy chiral states localized at the edge of the ribbon. Then, we employ the $T$-matrix Lippmann-Schwinger approach to explicitly show the robustness of chiral edge states against the impurity scattering. This backscattering-free process has an interesting property that the transmitted wave function acquires an additional phase factor. Although this additional phase factor does not affect quantum transport through the chiral channel it can carry quantum information. As an example of such quantum information transport, we investigate the entanglement of two magnetic impurities in a chern insulator through the dissipation-less scattering of chiral electrons.

Motivated by recent scanning tunneling microscopy/spectroscopy experiments on probing single vacancies in black phosphorus, we present a theory for Fano antiresonances induced by coupling between vacancy states and edge states of zigzag phosphorene nanoribbons (zPNRs). To this end, in the first step, using the tight-binding Hamiltonian, we obtain an analytic solution on the lattice for the state associated to a single vacancy located in the bulk phosphorene which shows a highly anisotropic localization in real space. For a finite zigzag ribbon, in the absence of particle-hole symmetry, the localized state induced by vacancies can couple to the wave functions of the edge states which results in the formation of a new bound state. The energy of vacancy bound state lies inside the quasi-flat band composed of edge states when the vacancy locates sufficiently far away from the edge. Then, we employ the T-matrix Lippmann-Schwinger approach to obtain an explicit analytical expression for the scattering amplitude of the edge electrons of a zPNR by the presence of a single vacancy which shows a Fano resonance profile with a tunable dip. We demonstrate that varying the position of the vacancy produces substantially different effects on the resonance width, resonance energy position, and the asymmetry parameter of Fano line shape. Furthermore, the validity of the theoretical descriptions is verified numerically by using the Landauer approach.

Transport of the edge-state electrons along zigzag phosphorene nanoribbons in presence of two impurities/vacancies is analytically investigated. Considering the places of the defects, a number of different situations are examined. When both defects are placed on the edge zigzag chain, as is expected, with changing the energy of the traveling electrons the electrical conductance exhibits a resonance behavior. In this case, for two vacancies the observed resonant peaks become extremely sharp. An amazing behavior is seen when the second vacancy is located along an armchair chain while the first is placed at the intersection of the edge zigzag and this armchair chains. In this case, in a considerable range of energy, the conductance is strongly strengthened. In fact the presence of the second vacancy create a shielded region around the first vacancy, consequently, the traveling wave bypasses this region and enhances the conductivity. The analytical results are compared with numerical simulations showing a very good agreement.

In this paper, we investigate how two on-side doped impurities with net magnetic moments in an edge chain of a zigzag phosphorene nanoribbon~(zPNR) can be entangled by scattering of the traveling edge-state electrons. To this end, in the first step, we employ the Lippmann-Schwinger equation as well as the Green's function approach to study the scattering of the free traveling electrons from two magnetic impurities in a one-dimensional tight-binding chain. Then, following the same formalism, that is shown that the behavior of two on-side spin impurities in the edge chain of a zPNR in responding to the scattering of the edge-state traveling electrons is very similar to what happens for the one-dimensional chain. In both cases, considering a known incoming wave state, the reflected and transmitted parts of the final wave state are evaluated analytically. Using the obtained results, the related partial density matrices and the reflection and transmission probabilities are computable. Negativity as a measure of the produced entanglement in the final state is calculated and the results are discussed. Our theoretical model actually proposes a method, which is perhaps experimentally performable to create the entanglement in the state of the impurities.

Zigzag phosphorene nanoribbons have quasi-flat band edge modes entirely detached from the bulk states. We analytically study the electronic transport through such edge states in the presence of a localized defect for semi-infinite and finite ribbons. Using the tight-binding model, we derive analytical expressions for the Green's function and transmission amplitude of both pristine and defective nanoribbons. We find that the transmission of both semi-infinite and finite ribbons is sensitive to the location of a single impurity defect with respect to the edge. By the presence of an impurity on the outermost edge site of the ribbon, the transmission through the edge channel, similar to a one-dimensional chain, strongly suppresses for the entire energy spectrum of the quasi-flat band. In contrast, the transmission of low-energy $(E\approx 0)$ states, is robust as the impurity is moved one position far away from the edge on the same sub-lattice. The analytical calculations are also complemented by exact numerical transport computations using the Landauer approach.