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185 results on '"Son, Seung-Myoung"'

4. Gastric Metastasis Mimicking Early Gastric Cancer from Invasive Ductal Carcinoma of the Breast: Case Report and Literature Review.

Author

Yoo, Kwon Cheol, Kim, Dae Hoon, Park, Sungmin, Yun, HyoYung, Ryu, Dong Hee, Lee, Jisun, and Son, Seung-Myoung

Subjects
LOBULAR carcinoma, LITERATURE reviews, DUCTAL carcinoma, CANCER invasiveness, STOMACH cancer, METASTASIS
Abstract

Backgound and Objectives: Gastric metastasis from invasive ductal breast cancer (BC) is rare. It mainly occurs in patients with lobular BC. The occurrence of multiple metastases is typically observed several years after the primary diagnosis. Endoscopic findings of gastric metastasis of the BC were usually the linitis plastic type. Case presentation: A 72-year-old women who underwent right modified radical mastectomy (MRM) 10 month ago was referred after being diagnosed with early gastric cancer (EGC) during systemic chemotherapy. EGC type I was found at gastric fundus, and pathologic finding showed poorly differentiated adenocarcinoma. Metachronous double primary tumor EGC was considered. Management and Outcome: A laparoscopic total gastrectomy was performed, and postoperative pathology revealed submucosa invasion and two lymph node metastases. A pathologic review that focused on immunohistochemical studies of selected antibodies such as GATA binding protein 3 (GATA3), gross cystic disease fluid protein-15 (GCDFP-15), cytokeratin 7 (CK7) was performed again, comparing previous results. As a result, gastric metastasis from BC was diagnosed. After totally laparoscopic total gastrectomy, palliative first-line chemotherapy with paclitaxel/CDDP was performed. Two months after gastrectomy, she was diagnosed with para-aortic lymph node metastasis and multiple bone metastases. She expired six months after gastrectomy. Conclusions: Gastric metastasis from invasive ductal carcinoma of the breast, which is clinically manifested as EGC, is a very rare condition. If there is a history of BC, careful pathological review will be required. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Vasomotion in human arteries and their regulations based on ion channel regulations: 10 years study

Author

Kim, Dae Hoon, primary, Choi, Jin Young, additional, Kim, Su Mi, additional, Son, Seung‐Myoung, additional, Choi, Song‐Yi, additional, Koo, Beommo, additional, Rah, Cheong‐Sil, additional, Nam, Ji Hyun, additional, Ju, Moon Jin, additional, Lee, Jong Sung, additional, You, Ra Young, additional, Hong, Seung Hwa, additional, Lee, Junyoung, additional, Bae, Jang‐Whan, additional, Kim, Chan Hyung, additional, Choi, Woong, additional, Kim, Hun Sik, additional, Xu, Wen‐Xie, additional, Lee, Sang Jin, additional, Kim, Young Chul, additional, and Yun, Hyo‐Yung, additional

Published
2023
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18. pSlug S158 Immunohistochemistry is Useful in Grading Meningioma.

Author

Woo, Chang Gok, Son, Seung-Myoung, Kim, Eung-Gook, and Lee, Ok-Jun

Subjects
*MENINGIOMA, *IMMUNOHISTOCHEMISTRY, *TUMOR grading, *MITOSIS, *TRANSCRIPTION factors
Abstract

Snail family transcriptional repressor 2 (SNAI2, Slug) is a transcription factor that belong to the Slug/Snail superfamily. Site specific phosphorylation of slug (pSlugS158) is detected during the M phase, and thus, this phosphorylated protein is considered a novel marker for detecting mitotic figures. Herein, we investigated whether the detection of mitosis using pSlugS158 expression can be used in the histological grading of meningioma. We performed immunohistochemistry for pSlugS158 and PHH3 in tissue samples of 61 patients with meningioma and examined the association between mitotic counts using pSlugS158 and recurrence-free survival (RFS). The nuclear expression of pSlugS158 was observed in the cell with mitotic figures. Tumor grading based on pSlugS158 was significantly associated with the RFS (p <.001). It can be concluded that pSlugS158 is a useful and practical marker to detect mitosis and seems to be reliable for the counting of mitoses in histological grading of meningioma. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Diagnostic Value of Ascitic Tumor Markers for Gastric Cancer-associated Malignant Ascites

Author

Yang, Yaewon, primary, Kim, Hong Jun, additional, Go, Se-il, additional, Bae, Woo Kyun, additional, Song, Eun-Kee, additional, Byeon, Seonggyu, additional, Kim, Hee Kyung, additional, Jeong, Yusook, additional, Kwon, Jihyun, additional, Lee, Ki Hyeong, additional, Chae, Hee Bok, additional, Son, Seung-Myoung, additional, Kim, Dae Hoon, additional, Yun, Hyo Yung, additional, and Han, Hye Sook, additional

Published
2022
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36. pSlugS158 immunohistochemistry is a novel promising mitotic marker for FFPE samples: a pilot study.

Author

Woo, Chang Gok, Son, Seung-Myoung, Lim, Young Hyun, Lee, Dakeun, Park, Jung-Jin, Kim, Eung-Gook, Shin, Eun-Young, and Lee, Ok-Jun

Abstract

Slug is a transcription factor belonging to the slug/snail superfamily. The protein is involved in embryonic development and epithelial-mesenchymal transition of tumors. Slug is also under temporal regulation during cell cycle. Here, we examined relationship between pSlugS158 (site-specific phosphorylation) and the cell cycle, and checked whether its phosphorylation level reflects mitotic activity in tissue specimens. Cell cycle analysis was performed after cell synchronization. To evaluate pSlugS158 identifying mitotic figures, we performed immunohistochemistry (IHC) for pSlugS158 in various formalin-fixed paraffin-embedded tissues; in addition, mitotic counts were compared with those in sections stained with hematoxylin and eosin (HE) and IHC for PHH3, a mitotic marker. We found that the level of pSlugS158 protein increased specifically at M phase and decreased at the G1/S phases in vitro. In almost all tested tissues, nuclear stain of pSlugS158 was identified in the cell with mitotic figures. There was no significant difference in mitotic counts between HE- and pSlugS158-stained sections. In conclusion, pSlugS158 may be a novel and practical immunohistochemical marker for detecting mitotic figures in human tissues. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Primary merkel cell carcinoma of the oral mucosa: a case report with review of literature

Author

Son, Seung-Myoung, Woo, Chang Gok, Kim, Kyoung Won, Lee, Ho-Chang, and Lee, Ok-Jun

Subjects
Case Report
Abstract

We present a case of primary Merkel cell carcinoma in the oral mucosa of a 60-year-old man. The patient underwent incisional biopsy of the tumor. Histologically, the tumor was composed of small monotonous cells in a solid sheet-like and single-cell row growth pattern. Immunohistochemically, tumor cells were positive for pan-cytokeratin, CD56, and synaptophysin, and negative for leukocyte common antigen, vimentin, S-100 protein, HMB-45, and thyroid transcription factor 1. Cytokeratin 20 staining showed a paranuclear dot-like pattern in tumor cells. Therefore, the diagnosis of Merkel cell carcinoma was made. The patient received chemotherapy with etoposide and cisplatin followed by 62 Gy radiation in 31 fractions over seven weeks. Follow-up brain CT scans after three and five months showed complete remission of the mass and enlarged lymph node. He is currently doing well with no evidence of recurrence. The present case is the first report of Merkel cell carcinoma arising in the buccal vestibule.The patient is currently doing well with no evidence of recurrence at six months.

Published
2017

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