29 results on '"Sondey, Christopher"'
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2. Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity
3. Discovery and characterization of novel peptide inhibitors of the NRF2/MAFG/DNA ternary complex for the treatment of cancer
4. Establishing and Validating Cellular Functional Target Engagement Assay for Selective IRAK4 Inhibitor Discovery
5. Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α
6. Abstract 3938: Discovery of a novel small molecule inhibitor of the YAP1/TAZ-TEAD transcriptional complex
7. sj-pdf-1-jbx-10.1177_24725552211021074 – Supplemental material for Establishing and Validating Cellular Functional Target Engagement Assay for Selective IRAK4 Inhibitor Discovery
8. Antidiabetic Properties of the Histamine H3 Receptor Protean Agonist Proxyfan
9. Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5)
10. MALDI–tandem mass spectrometry imaging of astemizole and its primary metabolite in rat brain sections
11. Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors
12. Initial optimization and series evolution of diaminopyrimidine inhibitors of interleukin-1 receptor associated kinase 4
13. Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4
14. Fused bicycles as arylketone bioisosteres leading to potent, orally active thiadiazole H3 antagonists
15. Synthesis and structure–activity relationship (SAR) study of 4-azabenzoxazole analogues as H3 antagonists
16. Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors
17. Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation
18. Discovery of a series of potent arylthiadiazole H 3 antagonists
19. The Discovery of N-((2H-Tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): A Potent and Selective Glucagon Receptor Antagonist
20. Synthesis and structure–activity relationships of 2-(1,4′-bipiperidin-1′-yl)thiazolopyridine as H 3 receptor antagonists
21. Discovery of a Potent Thiadiazole Class of Histamine H3 Receptor Antagonist for the Treatment of Diabetes
22. Discovery of a series of potent arylthiadiazole H3 antagonists
23. Synthesis and structure–activity relationships of 2-(1,4′-bipiperidin-1′-yl)thiazolopyridine as H3 receptor antagonists
24. Carbon and nitrogen fluxes in a closed seawater facility
25. The Discovery of N-((2H-Tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide(SCH 900822): A Potent and Selective Glucagon Receptor Antagonist.
26. Synthesis and structure–activity relationship (SAR) study of 4-azabenzoxazole analogues as H3 antagonists
27. Discovery of a series of potent arylthiadiazole H3 antagonists
28. Synthesis and structure–activity relationships of 2-(1,4′-bipiperidin-1′-yl)thiazolopyridine as H3 receptor antagonists
29. Activation of Hepatocyte Growth Factor/MET Signaling as a Mechanism of Acquired Resistance to a Novel YAP1/TEAD Small Molecule Inhibitor.
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