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20 results on '"Song, Guang-Qi"'

6. microRNA-106b-5p Promotes Cell Growth and Sensitizes Chemosensitivity to Sorafenib by Targeting the BTG3/Bcl-xL/p27 Signaling Pathway in Hepatocellular Carcinoma

Author

Enkhnaran, Bilegsaikhan, primary, Zhang, Guang-Cong, additional, Zhang, Ning-Ping, additional, Liu, Hai-Ning, additional, Wu, Hao, additional, Xuan, Shi, additional, Yu, Xiang-Nan, additional, Song, Guang-Qi, additional, Shen, Xi-Zhong, additional, Zhu, Ji-Min, additional, Liu, Xiu-Ping, additional, and Liu, Tao-Tao, additional

Published
2022
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7. Additional file 4 of Tumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages

Author

Sun, Jia-Lei, Zhang, Ning-Ping, Xu, Ru-Chen, Zhang, Guang-Cong, Liu, Zhi-Yong, Abuduwaili, Weinire, Wang, Fu, Yu, Xiang-Nan, Shi, Xuan, Song, Guang-Qi, Wu, Hao, Liu, Tao-Tao, Shen, Xi-Zhong, Deng, Bin, Weng, Shu-Qiang, Dong, Ling, and Zhu, Ji-Min

Abstract

Additional file 4: Table S1. List of primers used for qPCR analysis in this study.

Published
2021
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8. Additional file 1 of Tumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages

Author

Sun, Jia-Lei, Zhang, Ning-Ping, Xu, Ru-Chen, Zhang, Guang-Cong, Liu, Zhi-Yong, Abuduwaili, Weinire, Wang, Fu, Yu, Xiang-Nan, Shi, Xuan, Song, Guang-Qi, Wu, Hao, Liu, Tao-Tao, Shen, Xi-Zhong, Deng, Bin, Weng, Shu-Qiang, Dong, Ling, and Zhu, Ji-Min

Abstract

Additional file 1: Figure S1. Iron deprivation drives the immunosuppressive polarization of macrophages. (A) Cell viability was measured in BMDMs and PMs with indicated treatment by CCK-8 assay. (B) The mRNA expression of M1 signature genes in PMs with indicated treatment using qPCR. The fold changes in expression level relative to control were expressed as 2−ΔΔCt. (C) The mRNA expression of M2 signature genes in RAW264.7 cells with indicated treatment using qPCR. The fold changes in expression level relative to control were expressed as 2−ΔΔCt. (D–G) The surface expression of CD206 and PD-L1 with indicated treatment in RAW264.7 cells using FACS. The results were shown as relative fold changes in MFI of CD206 and PD-L1 normalized to their corresponding controls. All data are representative of three independent experiments and presented as mean ± SD. *p

Published
2021
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9. Additional file 3 of Tumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages

Author

Sun, Jia-Lei, Zhang, Ning-Ping, Xu, Ru-Chen, Zhang, Guang-Cong, Liu, Zhi-Yong, Abuduwaili, Weinire, Wang, Fu, Yu, Xiang-Nan, Shi, Xuan, Song, Guang-Qi, Wu, Hao, Liu, Tao-Tao, Shen, Xi-Zhong, Deng, Bin, Weng, Shu-Qiang, Dong, Ling, and Zhu, Ji-Min

Abstract

Additional file 3: Figure S3. Iron deprivation drives macrophage M2 polarization through induction of Hif-1α. (A, B) The mRNA expression of Hif-1α and Hif-2α in PMs with indicated treatment using qPCR. The fold changes in expression level relative to control were expressed as 2−ΔΔCt. (C) The protein expression of HIF-2α in PMs with indicated treatment was detected by Western blot. (D) The mRNA expression of Arg1, Vegfa, and Pd-l1 by qPCR in BMDMs with either Hif-2α knockdown or its control counterpart upon indicated treatment. The fold changes in expression level relative to control were expressed as 2−ΔΔCt. (E) The concentration of lactate in the supernatants of Hepa1-6/shNT and Hepa1-6/shTfrc cells was measured by lactate assay kit.

Published
2021
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10. Additional file 2 of Tumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages

Author

Sun, Jia-Lei, Zhang, Ning-Ping, Xu, Ru-Chen, Zhang, Guang-Cong, Liu, Zhi-Yong, Abuduwaili, Weinire, Wang, Fu, Yu, Xiang-Nan, Shi, Xuan, Song, Guang-Qi, Wu, Hao, Liu, Tao-Tao, Shen, Xi-Zhong, Deng, Bin, Weng, Shu-Qiang, Dong, Ling, and Zhu, Ji-Min

Abstract

Additional file 2: Figure S2. Tumor cells fail to educate macrophages toward an iron-releasing phenotype but instead an iron starvation response. (A) The mRNA expression of Tfrc, Fth1, and SLC40A1 in PMs co-cultured with indicated cells or DMEM alone using qPCR. The fold changes in expression level relative to control were expressed as 2−ΔΔCt. (B) Heat map of iron metabolism-related genes in THP-1 monocyte-derived macrophages based on RNA-seq data from GSE159254. (C) BMDMs and Hepa1-6 cells in the co-culture system were allowed to grow in DMEM media containing 50 ng/mL FITC-labeled holo-transferrin, and then in vitro holo-transferrin uptake assay was performed. BMDMs were collected 2 h later, and the MFI of FITC-transferrin was measured by FACS. All data are representative of three independent experiments and presented as mean ± SD. *p

Published
2021
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12. microRNA-106b-5p Promotes Cell Growth and Sensitizes Chemosensitivity to Sorafenib by Targeting the BTG3/Bcl-xL/p27 Signaling Pathway in Hepatocellular Carcinoma

Author

Bilegsaikhan, Enkhnaran, primary, Zhang, Ning-Ping, additional, Zhang, Guang-Cong, additional, Liu, Hai-Ning, additional, Wu, Hao, additional, Shi, Xuan, additional, Yu, Xiang-Nan, additional, Song, Guang-Qi, additional, Shen, Xi-Zhong, additional, Liu, Xiu-Ping, additional, Zhu, Ji-Min, additional, and Liu, Tao-Tao, additional

Published
2020
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13. Upregulated calcium‐binding tyrosine phosphorylation‐regulated protein‐a/b regulates cell proliferation and apoptosis and predicts poor prognosis in hepatocellular carcinoma

Author

Yu, Xiang‐Nan, primary, Guo, Hong‐Ying, additional, Liu, Tao‐Tao, additional, Zhang, Guang‐Cong, additional, Zhu, Hai‐Rong, additional, Shi, Xuan, additional, Song, Guang‐Qi, additional, Jiang, Xue‐Mei, additional, Huang, Xiao‐Xi, additional, Weng, Shu‐Qiang, additional, Dong, Ling, additional, Shen, Xi‐Zhong, additional, Huang, Yang‐Qing, additional, and Zhu, Ji‐Min, additional

Published
2019
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14. Comprehensive analysis of long non‑coding RNA‑messenger RNA‑microRNA co‑expression network identifies cell cycle‑related lncRNA in hepatocellular carcinoma

Author

Zhu, Hai‑Rong, primary, Yu, Xiang‑Nan, additional, Zhang, Guang‑Cong, additional, Shi, Xuan, additional, Bilegsaikhan, Enkhnaran, additional, Guo, Hong‑Ying, additional, Liu, Li‑Li, additional, Cai, Yu, additional, Song, Guang‑Qi, additional, Liu, Tao‑Tao, additional, Dong, Ling, additional, Janssen, Harry, additional, Weng, Shu‑Qiang, additional, Wu, Jian, additional, Shen, Xi‑Zhong, additional, and Zhu, Ji‑Min, additional

Published
2019
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16. microRNA-19a-3p promotes tumor metastasis and chemoresistance through the PTEN/Akt pathway in hepatocellular carcinoma

Author

Jiang, Xue-Mei, primary, Yu, Xiang-Nan, additional, Liu, Tao-Tao, additional, Zhu, Hai-Rong, additional, Shi, Xuan, additional, Bilegsaikhan, Enkhnaran, additional, Guo, Hong-Ying, additional, Song, Guang-Qi, additional, Weng, Shu-Qiang, additional, Huang, Xiao-Xi, additional, Dong, Ling, additional, Janssen, Harry L.A., additional, Shen, Xi-Zhong, additional, and Zhu, Ji-Min, additional

Published
2018
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19. The production of a cloned Chinese Taihu piglet by somatic cell nuclear transfer.

Author

Song Guang-qi, Wen Jiang, Li Zhan-jun, Wang Ling-yan, Yin Yu-peng, Guan Ji-yu, Tang Bo, Xie Guang-hong, Sun Bo-xing, Guo Chang-ming, Deng Xu-ming, Ouyang Hong-sheng, Lai Liang-xue, and Li Zi-yi

Abstract

The article presents a study which aims to clone Chinese Taihu piglet through somatic nuclear cell nuclear transfer (SCNT). It reports that the first cloned pig through SCNT was in 2000 but efficiency is still low. Successful cloning of Chinese Taihu pig by fetal fibroblast of the pigs was conducted where modified Taihu pigs with high productivity or human disease models will be based.

Published
2009

20. Pre-mRNA processing factor 19 functions in DNA damage repair and radioresistance by modulating cyclin D1 in hepatocellular carcinoma.

Author

Yu XN, Zhang GC, Liu HN, Zhu JM, Liu TT, Song GQ, Dong L, Yin J, and Shen XZ

Abstract

Pre-mRNA processing factor 19 (PRP19) is elevated in hepatocellular carcinoma (HCC); however, little is known about its function in DNA damage repair in HCC. In this study, analysis of The Cancer Genome Atlas data and our tumor models after ionizing radiation (IR) treatment indicated that increased expression of PRP19 was positively correlated with DNA damage repair. Gain of PRP19 expression induced by plasmids resulted in decreases in apoptosis and double-strand breaks (DSBs), and an increase in cell survival after IR. Loss of PRP19 expression induced by small interfering RNAs resulted in the accumulation of apoptosis and DSBs, and a decrease in cell survival. Mechanistically, the effect of PRP19 on DNA damage repair was mediated by the modulation of cyclin D1 expression in HCC. PRP19 controlled the translation of cyclin D1 by modulating eukaryotic initiation factor 4E. PRP19 affected the DNA damage repair ability of cyclin D1 by interacting with the WD40 domain. The combination of PRP19 and cyclin D1 was more valuable than each single marker for predicting the prognosis of patients. Taken together, the present results demonstrate that PRP19 promotes DNA damage repair by modulating cyclin D1 expression and function, thereby contributing to the radioresistance in HCC., Competing Interests: The authors declare no competing interests., (© 2021 The Authors.)

Published
2021
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