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31. Development of a urine-based metabolomics approach for multi-cancer screening and tumor origin prediction.

Author

Xu, Xinping, Zeng, Chunyan, Qing, Bei, He, Yun, Song, Guodong, Wang, Jiaojiao, Yu, Shuqi, Zhang, Tao, Wei, Qingyan, Liu, Li, Wen, He, Hu, Junyuan, Zhang, Wei, Li, Yan, Chen, Youxiang, and Xia, Zhenkun

Subjects
MEDICAL screening, EARLY detection of cancer, TUMOR markers, STOMACH cancer, LUNG cancer
Abstract

Background: Cancer remains a leading cause of mortality worldwide. A non-invasive screening solution was required for early diagnosis of cancer. Multi-cancer early detection (MCED) tests have been considered to address the challenge by simultaneously identifying multiple types of cancer within a single test using minimally invasive blood samples. However, a multi-cancer screening strategy utilizing urine-based metabolomics has not yet been developed. Methods: We enrolled 911 cancer patients with 548 lung cancer (LC), 177 with gastric cancer (GC), and 186 with colorectal cancer (CRC), alongside 563 individuals with non-cancerous benign diseases and 229 healthy controls (HC) and investigated the metabolic profiles of urine samples. Participants were randomly allocated to discovery and validation cohorts. The discovery cohort was used for identifying multi-cancer and tissue-specific signatures to build the cancer screening and tumor origin prediction models, while the validation cohort was employed for assessing the performance of these models. Results: We identified and annotated a total of 360 metabolites from the urine samples. Using the LASSO regression algorithm, 18 metabolites were characterized as urinary metabolic biomarkers and exhibited excellent discriminative performance between cancer patients and HC with AUC of 0.96 in the validation cohort. In comparison with the performance of traditional tumor markers CEA, the screening model performed higher sensitivity across the cancer stages, with a particularly increase in sensitivity among early-stage cancer patients. Moreover, the screening model also exhibited in high classification of cancers from non-cancerous group, comprising with HC and benign disease participants. Furthermore, two non-overlapping metabolic panels were selected to differentiate LC from Non-LC and GC from CRC with the AUC values of 0.87 and 0.83 in validation cohorts, respectively. Additionally, the model accurately predicted the origin of three lethal cancers: lung, gastric, and colorectal, with an overall accuracy of 0.75. The AUC values for LC, GC, and CRC were 0.88, 0.88, and 0.80, respectively. Discussion: Our study demonstrates the potential of urine-based metabolomics for multi-cancer early detection. The approach offers non-invasive cancer screening, promising widespread implementation in population-based programs for early detection and improved outcomes. Further validation and expansion are needed for broader clinical applicability. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Efficacy and Safety of PL-5 (Peceleganan) Spray for Wound Infections: A Phase IIb Randomized Clinical Trial

Author

Wei, Yating, Wu, Jun, Chen, Yuxin, Fan, Kunwu, Yu, Xuming, Li, Xiaojian, Zhao, Yaohua, Li, Yi, Lv, Guozhong, Song, Guodong, Rong, Xinzhou, Lin, Cai, Wang, Haitao, Chen, Xiaodong, Zhang, Pihong, Han, Chunmao, Zu, Hongxu, Liu, Wenjun, Zhang, Yi, Liu, Chang, Su, Yongtao, Zhang, Baolin, Sun, Bingwei, Wang, Lei, Lai, Wen, Liu, Jinhui, Xia, Chengde, Ji, Geng, Zhu, Feng, Yu, Jia’ao, Ahemaiti, Akebaer, Dong, Hu, and Chen, Mingxia

Published
2023
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48. Measuring the Scientific Impact of Growth Hormone Treatment in Burns: A Bibliometric Analysis Based on CiteSpace.

Author

Shao, Yang, Han, Mei, and Song, Guodong

Subjects
SOMATOTROPIN, BIBLIOMETRICS, METABOLIC regulation, WOUND healing, INFECTION prevention
Abstract

This study utilized CiteSpace software to conduct a bibliometric analysis of the literature related to the use of growth hormones in treating burns. The results showed that the research on this topic has attracted increasing attention from scholars worldwide, with the number of publications increasing annually. The research teams and institutions involved in this field are mainly concentrated in China, followed by the United States, Russia, and other countries. The analysis also revealed the prominent co-cited literature and the most influential authors in the field, such as D. N. Herndon and Y. Li. The main research themes identified in the literature included the effects of growth hormones on wound healing, tissue repair and regeneration, inflammatory responses, and cell proliferation. In addition, the research on the clinical applications of growth hormone in burn treatment has been expanded to include areas such as metabolic regulation, immune function, and the prevention of infections. The findings of this study provide useful insights into the current status and future directions of research in the field of growth hormone treatment of burns. [ABSTRACT FROM AUTHOR]

Published
2024
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