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514 results on '"Song, Guosheng"'

7. Dynamic hierarchical ligand anisotropy for competing macrophage regulation in vivo

Author

Kim, Kanghyeon, Min, Sunhong, Thangam, Ramar, Tag, Kyong-Ryol, Lee, Hyun-Jeong, Heo, Jeongyun, Jung, Hwapyung, Swe, Thet Thet, Zare, Iman, Song, Guosheng, Najafabadi, Alireza Hassani, Lee, Junmin, Jung, Hyun-Do, Kim, Jong Seung, Hur, Sunghoon, Song, Hyun-Cheol, Park, Sung-Gyu, Zhang, Kunyu, Zhao, Pengchao, Bian, Liming, Kim, Se Hoon, Yoon, Juyoung, Ahn, Jae-Pyoung, Kim, Hong-Kyu, and Kang, Heemin

Published
2025
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11. Photonic control of ligand nanospacing in self-assembly regulates stem cell fate

Author

Lee, Sungkyu, Yoo, Jounghyun, Bae, Gunhyu, Thangam, Ramar, Heo, Jeongyun, Park, Jung Yeon, Choi, Honghwan, Kim, Chowon, An, Jusung, Kim, Jungryun, Mun, Kwang Rok, Shin, Seungyong, Zhang, Kunyu, Zhao, Pengchao, Kim, Yuri, Kang, Nayeon, Han, Seong-Beom, Kim, Dahee, Yoon, Jiwon, Kang, Misun, Kim, Jihwan, Yang, Letao, Karamikamkar, Solmaz, Kim, Jinjoo, Zhu, Yangzhi, Najafabadi, Alireza Hassani, Song, Guosheng, Kim, Dong-Hwee, Lee, Ki-Bum, Oh, Soong Ju, Jung, Hyun-Do, Song, Hyun-Cheol, Jang, Woo Young, Bian, Liming, Chu, Zhiqin, Yoon, Juyoung, Kim, Jong Seung, Zhang, Yu Shrike, Kim, Yongju, Jang, Ho Seong, Kim, Sehoon, and Kang, Heemin

Published
2024
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22. Bright sub-20 nm cathodoluminescent nanoprobes for multicolor electron microscopy

Author

Prigozhin, Maxim B., Maurer, Peter C., Courtis, Alexandra M., Liu, Nian, Wisser, Michael D., Siefe, Chris, Tian, Bining, Chan, Emory, Song, Guosheng, Fischer, Stefan, Aloni, Shaul, Ogletree, D. Frank, Barnard, Edward S., Joubert, Lydia-Marie, Rao, Jianghong, Alivisatos, A. Paul, Macfarlane, Roger M., Cohen, Bruce E., Cui, Yi, Dionne, Jennifer A., and Chu, Steven

Subjects
Condensed Matter - Materials Science, Physics - Biological Physics, Physics - Optics
Abstract

Electron microscopy (EM) has been instrumental in our understanding of biological systems ranging from subcellular structures to complex organisms. Although EM reveals cellular morphology with nanoscale resolution, it does not provide information on the location of proteins within a cellular context. An EM-based bioimaging technology capable of localizing individual proteins and resolving protein-protein interactions with respect to cellular ultrastructure would provide important insights into the molecular biology of a cell. Here, we report on the development of luminescent nanoprobes potentially suitable for labeling biomolecules in a multicolor EM modality. In this approach, the labels are based on lanthanide-doped nanoparticles that emit light under electron excitation in a process known as cathodoluminescence (CL). Our results suggest that the optimization of nanoparticle composition, synthesis protocols and electron imaging conditions could enable high signal-to-noise localization of biomolecules with a sub-20-nm resolution, limited only by the nanoparticle size. In ensemble measurements, these luminescent labels exhibit narrow spectra of nine distinct colors that are characteristic of the corresponding rare-earth dopant type.

Published
2018
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23. Bright sub-20-nm cathodoluminescent nanoprobes for electron microscopy

Author

Prigozhin, Maxim B, Maurer, Peter C, Courtis, Alexandra M, Liu, Nian, Wisser, Michael D, Siefe, Chris, Tian, Bining, Chan, Emory, Song, Guosheng, Fischer, Stefan, Aloni, Shaul, Ogletree, D Frank, Barnard, Edward S, Joubert, Lydia-Marie, Rao, Jianghong, Alivisatos, A Paul, Macfarlane, Roger M, Cohen, Bruce E, Cui, Yi, Dionne, Jennifer A, and Chu, Steven

Subjects
Biological Sciences, Engineering, Nanotechnology, Bioengineering, Generic health relevance, Fluorescent Dyes, Microscopy, Electron, Transmission, Nanoparticles, cond-mat.mtrl-sci, physics.bio-ph, physics.optics, Nanoscience & Nanotechnology
Abstract

Electron microscopy has been instrumental in our understanding of complex biological systems. Although electron microscopy reveals cellular morphology with nanoscale resolution, it does not provide information on the location of different types of proteins. An electron-microscopy-based bioimaging technology capable of localizing individual proteins and resolving protein-protein interactions with respect to cellular ultrastructure would provide important insights into the molecular biology of a cell. Here, we synthesize small lanthanide-doped nanoparticles and measure the absolute photon emission rate of individual nanoparticles resulting from a given electron excitation flux (cathodoluminescence). Our results suggest that the optimization of nanoparticle composition, synthesis protocols and electron imaging conditions can lead to sub-20-nm nanolabels that would enable high signal-to-noise localization of individual biomolecules within a cellular context. In ensemble measurements, these labels exhibit narrow spectra of nine distinct colours, so the imaging of biomolecules in a multicolour electron microscopy modality may be possible.

Published
2019

30. Simultaneous In Vivo Imaging of Neutrophil Elastase and Oxidative Stress in Atherosclerotic Plaques Using a Unimolecular Photoacoustic Probe.

Author

Ma, Yuan, Cao, Hui, Chen, Baode, Xu, Xinyu, Zhang, Qingpeng, Chen, Haoming, Zhang, Xiao‐Bing, and Song, Guosheng

Subjects
LEUKOCYTE elastase, PHOTOINDUCED electron transfer, ATHEROSCLEROTIC plaque, ACOUSTIC imaging, OXIDATIVE stress
Abstract

Atherosclerosis, a major global health concern with high morbidity and mortality rates, involves complex interactions of chronic inflammation, oxidative stress, and proteolytic enzymes. Conventional imaging methods struggle to capture the dynamic biochemical processes in atherosclerotic plaques. Here, we introduce a novel unimolecular photoacoustic probe (UMAPP) designed with specific binding sites for neutrophil elastase (NE) and the redox pair O2⋅−/GSH, enabling real‐time monitoring of oxidative stress and activated neutrophils in plaques. UMAPP, comprising a boron‐dipyrromethene (BODIPY) core linked to a hydrophilic NE‐cleavable tetrapeptide and dual oxidative stress‐responsive catechol moieties, facilitates NE‐mediated modulation of photoinduced electron transfer impacting photoacoustic intensity at 685 nm (PA685). Furthermore, oxidation and reduction of catechol groups by O2⋅− and GSH induce reversible, ratiometric changes in the photoacoustic spectrum (PA745/PA685 ratio). Initial UMAPP applications successfully distinguished atherosclerotic and healthy mice, evaluated pneumonia's effect on plaque composition and verified the probe's effectiveness in drug‐treatment studies by detecting molecular alterations before visible histopathological changes. The integrated molecular imaging capabilities of UMAPP offer promising advancements in atherosclerosis diagnosis and management, enabling early and accurate identification of vulnerable plaques. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Imaging-guided companion diagnostics in radiotherapy by monitoring APE1 activity with afterglow and MRI imaging.

Author

Yue, Renye, Li, Zhe, Liu, Huiyi, Wang, Youjuan, Li, Yuhang, Yin, Rui, Yin, Baoli, Qian, Haisheng, Kang, Heemin, Zhang, Xiaobing, and Song, Guosheng

Subjects
COMPANION diagnostics, MAGNETIC resonance imaging, RADIATION doses, DOSE-response relationship (Radiation), RADIOTHERAPY, CONTRAST-enhanced magnetic resonance imaging, CONTRAST media
Abstract

Companion diagnostics using biomarkers have gained prominence in guiding radiotherapy. However, biopsy-based techniques fail to account for real-time variations in target response and tumor heterogeneity. Herein, we design an activated afterglow/MRI probe as a companion diagnostics tool for dynamically assessing biomarker apurinic/apyrimidinic endonuclease 1(APE1) during radiotherapy in vivo. We employ ultrabright afterglow nanoparticles and ultrasmall FeMnOx nanoparticles as dual contrast agents, significantly broadening signal change range and enhancing the sensitivity of APE1 imaging (limit of detection: 0.0092 U/mL in afterglow imaging and 0.16 U/mL in MRI). We devise longitudinally and transversely subtraction-enhanced imaging (L&T-SEI) strategy to markedly enhance MRI contrast and signal-to-noise ratio between tumor and normal tissue of living female mice. The combined afterglow and MRI facilitate both anatomical and functional imaging of APE1 activity. This probe enables correlation of afterglow and MRI signals with APE1 expression, radiation dosage, intratumor ROS, and DNA damage, enabling early prediction of radiotherapy outcomes (as early as 3 h), significantly preceding tumor size reduction (6 days). By monitoring APE1 levels, this probe allows for early and sensitive detection of liver organ injury, outperforming histopathological analysis. Furthermore, MRI evaluates APE1 expression in radiation-induced abscopal effects provides insights into underlying mechanisms, and supports the development of treatment protocols. Companion diagnostics using biomarkers are promising for guiding radiotherapy, but biopsy-based techniques normally fail to detect real-time variations in target response and tumor heterogeneity. Herein, the authors report an activated afterglow/MRI probe as a companion diagnostics tool for dynamically assessing biomarker apurinic/apyrimidinic endonuclease 1(APE1) during radiotherapy in vivo. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Renal clearable magnetic nanoparticles for magnetic resonance imaging and guided therapy.

Author

Zhang, Qinpeng, Yin, Rui, Guan, Guoqiang, Liu, Huiyi, and Song, Guosheng

Abstract

Magnetic resonance imaging (MRI) is a non‐invasive, radiation‐free imaging technique widely used for disease detection and therapeutic evaluation due to its infinite penetration depth. Magnetic nanoparticles (MNPs) have unique magnetic and physicochemical properties, making them ideal as contrast agents for MRI. However, the in vivo toxicity of MNPs, resulting from metal ion leakage and long‐term accumulation in the reticuloendothelial system (RES), limits their clinical application. To overcome these challenges, there is considerable interest in the development of renal‐clearable MNPs that can be completely cleared through the kidney, reducing retention time and potential toxic risks. In this review, we provide an overview of recent advancements in the development of renal‐clearable MNPs for disease imaging and treatment. We discuss the factors influencing renal clearance, summarize the types of renal‐clearable MNPs, their synthesis methods, and biomedical applications. This review aims to offer comprehensive information for the design and clinical translation of renal‐clearable MNPs. This article is categorized under:Nanotechnology Approaches to Biology > Nanoscale Systems in BiologyDiagnostic Tools > Biosensing [ABSTRACT FROM AUTHOR]

Published
2024
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