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18 results on '"Song, Hong Chuan"'

5. Resorcylic Acid Lactones Produced by an Endophytic Penicillium ochrochloron Strain from Kadsura angustifolia.

Author

Song, Hong Chuan, Qin, Dan, Liu, Hai Yang, Dong, Jin Yan, You, Chuan, and Wang, Yu Meng

Subjects
*MEDICINAL plants, *LACTONES, *MOLECULAR structure, *CHROMATOGRAPHIC analysis, *CELL lines, *SPECTRUM analysis
Abstract

Four new β -resorcylic acid lactones, including penochrochlactone A (2), 4-O-desmethyl-aigialomycin B (4), and penochrochlactones C and D (5 and 6), two compounds isolated from a natural source for the first time, 5 α , 6 β -acetonide-aigialomycin B (1) and penochrochlactone B (3), together with six known compounds, aigialomycin F (7), aigialomycins A, B, and D (8 – 10), zeaenol (11), and oxozeaenol (12), were isolated from a mycelial solid culture of the endophytic fungus Penicillium ochrochloron SWUKD4.1850 from the medicinal plant Kadsura angustifolia by sequential purification over silica gel, Sephadex LH-20 column chromatography, and preparative HPLC. Their structures were elucidated by extensive spectroscopic analysis and chemical conversions. In addition, all the new compounds were evaluated for their cytotoxic and antibacterial activities in vitro. Penochrochlactone C (5) displayed moderate cytotoxicity against the HeLa tumor cell line with an IC50 value of 9.70 µM. In the antibacterial assays, compounds 4 – 6 exhibited moderate activities against Staphylococcus aureus, Bacillus subtilis, Escherichia coli , and Pseudomonas aeruginosa with MIC values between 9.7 and 32.0 µg/mL. [ABSTRACT FROM AUTHOR]

Published
2021
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16. Microbiological transformation of the triterpene nigranoic acid by the freshwater fungus Dictyosporium heptasporum.

Author

Sun, Rong, Song, Hong-Chuan, Yang, Yu-Hong, Yang, Pan, Yang, Dong-Yan, Shen, Kai-Ze, Xu, Yao-Bo, Gao, Yan-Xiu, Chen, Ye-Gao, and Dong, Jin-Yan

Abstract

The microbiological transformation of the triterpene nigranoic acid (3,4-secocycloarta-4(28),24(Z)-diene-3,26-dioic acid) (1) to 3,4-secocycloarta-4(28),17(20),24(Z)-triene-7β-hydroxy-16β,26-lactone-3-oic acid (2) and 3,4-secocycloarta-4(28),17(20)(Z),24(Z)-triene-7β-hydroxy-16β-methoxy-3,26-dioic acid (3) by the freshwater fungus Dictyosporium heptasporum YMF1.01213 has been demonstrated. The structures of the biotransformation products were determined by spectroscopic and MS analyses. Compound 2, characterized by the presence of a formed C-16/C-26 ester bridge, provided a novel nine-membered lactone ring structural skeleton for 3,4-secocycloartane triterpenoid derivatives. In addition, Compounds 1–3 exhibited weak anti-HIV activity in vitro. Compounds 2 and 3 were reported for the first time as natural product derivatives. [ABSTRACT FROM AUTHOR]

Published
2013
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18. Ymf 1029A-E, preussomerin analogues from the fresh-water-derived fungus YMF 1.01029.

Author

Dong JY, Song HC, Li JH, Tang YS, Sun R, Wang L, Zhou YP, Wang LM, Shen KZ, Wang CR, and Zhang KQ

Subjects
Animals, Antinematodal Agents chemistry, Antinematodal Agents pharmacology, Epoxy Compounds chemistry, Epoxy Compounds pharmacology, Fresh Water microbiology, Heterocyclic Compounds, 4 or More Rings chemistry, Heterocyclic Compounds, 4 or More Rings pharmacology, Inhibitory Concentration 50, Ivermectin analogs & derivatives, Ivermectin pharmacology, Molecular Structure, Nematoda drug effects, Trees microbiology, Antinematodal Agents isolation & purification, Epoxy Compounds isolation & purification, Fungi chemistry, Heterocyclic Compounds, 4 or More Rings isolation & purification
Abstract

Five new preussomerin analogues, ymf 1029A (1), B (2), C (3), D (4), and E (5), were isolated from the liquid cultures of an unidentified freshwater fungus YMF 1.01029, along with four known compounds, preussomerin C (6), preussomerin D (7), (4RS)-4,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one (8), and 4,6,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one (9). The structures of new metabolites were determined by analysis of NMR and MS data and by analogy with the data for the known bis-spirobisnaphthalene preussomerins. In vitro immersion experiments showed that these metabolites displayed weak nematicidal activity against Bursaphelenchus xylophilus, while compound 7 was the most potent. This is the first report of these compounds, which antagonize the Bursaphelenchus xylophilus nematode.

Published
2008
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