Search

Your search keyword '"Song, Kyuyoung"' showing total 312 results
Start Over Author "Song, Kyuyoung"
312 results on '"Song, Kyuyoung"'

2. Sex-Dimorphic Analyses Identify Novel and Sex-Specific Genetic Associations in Inflammatory Bowel Disease.

Author

Khrom, Michelle, Li, Dalin, Naito, Takeo, Lee, Ho-Su, Botwin, Gregory, Potdar, Alka, Boucher, Gabrielle, Yang, Shaohong, Mengesha, Emebet, Dube, Shishir, Song, Kyuyoung, McGovern, Dermot, and Haritunians, Talin

Subjects
genetics, inflammatory bowel disease, sex dimorphic, Humans, Female, Male, Genetic Predisposition to Disease, Inflammatory Bowel Diseases, Crohn Disease, Colitis, Ulcerative, Sex Characteristics, Genome-Wide Association Study
Abstract

BACKGROUND: Sex is an integral variable often overlooked in complex disease genetics. Differences between sexes have been reported in natural history, disease complications, and age of onset in inflammatory bowel disease (IBD). While association studies have identified >230 IBD loci, there have been a limited number of studies investigating sex differences underlying these genetic associations. METHODS: We report the first investigation of sex-dimorphic associations via meta-analysis of a sex-stratified association study (34 579 IBD cases, 39 125 controls). In addition, we performed chromosome (chr) X-specific analyses, considering models of X inactivation (XCI) and XCI escape. Demographic and clinical characteristics were also compared between sexes. RESULTS: We identified significant differences between sexes for disease location and perianal complication in Crohns disease and disease extent in ulcerative colitis. We observed genome-wide-significant sex-dimorphic associations (P

Published
2023

4. Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome

Author

Barry, Alexandra, McNulty, Michelle T., Jia, Xiaoyuan, Gupta, Yask, Debiec, Hanna, Luo, Yang, Nagano, China, Horinouchi, Tomoko, Jung, Seulgi, Colucci, Manuela, Ahram, Dina F., Mitrotti, Adele, Sinha, Aditi, Teeninga, Nynke, Jin, Gina, Shril, Shirlee, Caridi, Gianluca, Bodria, Monica, Lim, Tze Y., Westland, Rik, Zanoni, Francesca, Marasa, Maddalena, Turudic, Daniel, Giordano, Mario, Gesualdo, Loreto, Magistroni, Riccardo, Pisani, Isabella, Fiaccadori, Enrico, Reiterova, Jana, Maringhini, Silvio, Morello, William, Montini, Giovanni, Weng, Patricia L., Scolari, Francesco, Saraga, Marijan, Tasic, Velibor, Santoro, Domenica, van Wijk, Joanna A. E., Milošević, Danko, Kawai, Yosuke, Kiryluk, Krzysztof, Pollak, Martin R., Gharavi, Ali, Lin, Fangmin, Simœs e Silva, Ana Cristina, Loos, Ruth J. F., Kenny, Eimear E., Schreuder, Michiel F., Zurowska, Aleksandra, Dossier, Claire, Ariceta, Gema, Drozynska-Duklas, Magdalena, Hogan, Julien, Jankauskiene, Augustina, Hildebrandt, Friedhelm, Prikhodina, Larisa, Song, Kyuyoung, Bagga, Arvind, Cheong, II, Hae, Ghiggeri, Gian Marco, Vachvanichsanong, Prayong, Nozu, Kandai, Lee, Dongwon, Vivarelli, Marina, Raychaudhuri, Soumya, Tokunaga, Katsushi, Sanna-Cherchi, Simone, Ronco, Pierre, Iijima, Kazumoto, and Sampson, Matthew G.

Published
2023
Full Text
View/download PDF

5. Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries

Author

Liu, Zhanju, Liu, Ruize, Gao, Han, Jung, Seulgi, Gao, Xiang, Sun, Ruicong, Liu, Xiaoming, Kim, Yongjae, Lee, Ho-Su, Kawai, Yosuke, Nagasaki, Masao, Umeno, Junji, Tokunaga, Katsushi, Kinouchi, Yoshitaka, Masamune, Atsushi, Shi, Wenzhao, Shen, Chengguo, Guo, Zhenglin, Yuan, Kai, Zhu, Shu, Li, Dalin, Liu, Jianjun, Ge, Tian, Cho, Judy, Daly, Mark J., McGovern, Dermot P. B., Ye, Byong Duk, Song, Kyuyoung, Kakuta, Yoichi, Li, Mingsong, and Huang, Hailiang

Published
2023
Full Text
View/download PDF

6. Transethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals not only shared but also ethnicity-specific disease associations.

Author

Degenhardt, Frauke, Mayr, Gabriele, Wendorff, Mareike, Boucher, Gabrielle, Ellinghaus, Eva, Ellinghaus, David, ElAbd, Hesham, Rosati, Elisa, Hübenthal, Matthias, Juzenas, Simonas, Abedian, Shifteh, Vahedi, Homayon, Thelma, B, Yang, Suk-Kyun, Ye, Byong, Cheon, Jae, Datta, Lisa, Daryani, Naser, Ellul, Pierre, Esaki, Motohiro, Fuyuno, Yuta, McGovern, Dermot, Haritunians, Talin, Hong, Myhunghee, Juyal, Garima, Jung, Eun, Kubo, Michiaki, Kugathasan, Subra, Lenz, Tobias, Leslie, Stephen, Malekzadeh, Reza, Midha, Vandana, Motyer, Allan, Ng, Siew, Okou, David, Raychaudhuri, Soumya, Schembri, John, Schreiber, Stefan, Song, Kyuyoung, Sood, Ajit, Takahashi, Atsushi, Torres, Esther, Umeno, Junji, Alizadeh, Behrooz, Weersma, Rinse, Wong, Sunny, Yamazaki, Keiko, Karlsen, Tom, Rioux, John, Brant, Steven, and Franke, Andre

Subjects
Alleles, Cohort Studies, Colitis, Ulcerative, Ethnicity, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, HLA Antigens, HLA-DQ Antigens, HLA-DRB1 Chains, Haplotypes, Humans, Linkage Disequilibrium, Peptides, Polymorphism, Single Nucleotide, Protein Binding
Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gut. Genetic association studies have identified the highly variable human leukocyte antigen (HLA) region as the strongest susceptibility locus for IBD and specifically DRB1*01:03 as a determining factor for ulcerative colitis (UC). However, for most of the association signal such as delineation could not be made because of tight structures of linkage disequilibrium within the HLA. The aim of this study was therefore to further characterize the HLA signal using a transethnic approach. We performed a comprehensive fine mapping of single HLA alleles in UC in a cohort of 9272 individuals with African American, East Asian, Puerto Rican, Indian and Iranian descent and 40 691 previously analyzed Caucasians, additionally analyzing whole HLA haplotypes. We computationally characterized the binding of associated HLA alleles to human self-peptides and analyzed the physicochemical properties of the HLA proteins and predicted self-peptidomes. Highlighting alleles of the HLA-DRB1*15 group and their correlated HLA-DQ-DR haplotypes, we not only identified consistent associations (regarding effects directions/magnitudes) across different ethnicities but also identified population-specific signals (regarding differences in allele frequencies). We observed that DRB1*01:03 is mostly present in individuals of Western European descent and hardly present in non-Caucasian individuals. We found peptides predicted to bind to risk HLA alleles to be rich in positively charged amino acids. We conclude that the HLA plays an important role for UC susceptibility across different ethnicities. This research further implicates specific features of peptides that are predicted to bind risk and protective HLA proteins.

Published
2021

7. HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis

Author

Akar, Alaa, Flemming, Cornelius, Felix, Flomm, Flosbach, Markus, Jäger, Julia, Jeromin, Niklas, Jung, Johannes, Ohms, Mareike, Reinshagen, Konrad, Rische, Johann, Sagebiel, Adrian, Sandfort, Deborah, Steinert, Fenja, Tomuschat, Christian, Wesche, Jasmin, Shifteh Abedian, Abraham, Clara, Achkar, Jean-Paul, Ahmad, Tariq, Alberts, Rudi, Alizadeh, Behrooz, Amininejad, Leila, Ananthakrishnan, Ashwin N., Andersen, Vibeke, Anderson, Carl A., Andrews, Jane M., Annese, Vito, Aumais, Guy, Baidoo, Leonard, Baldassano, Robert N., Bampton, Peter A., Barclay, Murray, Barrett, Jeffrey C., Bethge, Johannes, Bewshea, Claire, Bis, Joshua C., Bitton, Alain, BK, Thelma, Boucher, Gabrielle, Brain, Oliver, Brand, Stephan, Brant, Steven R., Cheon, Jae Hee, Chew, Angela, Cho, Judy H., Cleynen, Isabelle, Cohain, Ariella, Cooney, Rachel, Croft, Anthony, Daly, Mark J., D'Amato, Mauro, Danese, Silvio, Daryani, Naser Ebrahim, Datta, Lisa Wu, Degenhardt, Frauke, Denapiene, Goda, Denson, Lee A., Devaney, Kathy L., Dewit, Olivier, D'Inca, Renata, Drummond, Hazel E., Dubinsky, Marla, Duerr, Richard H., Edwards, Cathryn, Ellinghaus, David, Ellul, Pierre, Esaki, Motohiro, Essers, Jonah, Ferguson, Lynnette R., Festen, Eleonora A., Fleshner, Philip, Florin, Tim, Franchimont, Denis, Franke, Andre, Fuyuno, Yuta, Gearry, Richard, Georges, Michel, Gieger, Christian, Glas, Jürgen, Goyette, Philippe, Green, Todd, Griffiths, Anne M., Guthery, Stephen L., Hakonarson, Hakon, Halfvarson, Jonas, Hanigan, Katherine, Haritunians, Talin, Hart, Ailsa, Hawkey, Chris, Hayward, Nicholas K., Hedl, Matija, Henderson, Paul, Hold, Georgina L., Hong, Myhunghee, Hu, Xinli, Huang, Hailiang, Hugot, Jean-Pierre, Hui, Ken Y., Imielinski, Marcin, Jazayeri, Omid, Jonaitis, Laimas, Jostins, Luke, Juyal, Garima, Chandra Juyal, Ramesh, Kalla, Rahul, Karlsen, Tom H., Kennedy, Nicholas A., Khan, Mohammed Azam, Kim, Won Ho, Kitazono, Takanari, Kiudelis, Gediminas, Kubo, Michiaki, Kugathasan, Subra, Kupcinskas, Limas, Lamb, Christopher A., de Lange, Katrina M., Latiano, Anna, Laukens, Debby, Lawrance, Ian C., Lee, James C., Lees, Charlie W., Leja, Marcis, Lewis, Nina, Van Limbergen, Johan, Lionetti, Paolo, Liu, Jimmy Z., Louis, Edouard, Luo, Yang, Mahy, Gillian, Malekzadeh, Masoud Mohammad, Malekzadeh, Reza, Mansfield, John, Marriott, Suzie, Massey, Dunecan, Mathew, Christopher G., Matsui, Toshiyuki, McGovern, Dermot P.B., van der Meulen, Andrea, Midha, Vandana, Milgrom, Raquel, Mirzaei, Samaneh, Mitrovic, Mitja, Montgomery, Grant W., Mowat, Craig, Müller, Christoph, Newman, William G., Ng, Aylwin, Ng, Siew C., Evelyn Ng, Sok Meng, Nikolaus, Susanna, Ning, Kaida, Nöthen, Markus, Oikonomou, Ioannis, Okou, David, Orchard, Timothy R., Palmieri, Orazio, Parkes, Miles, Phillips, Anne, Ponsioen, Cyriel Y., Potocnik, Urõs, Poustchi, Hossein, Prescott, Natalie J., Proctor, Deborah D., Radford-Smith, Graham, Rahier, Jean- Francois, Regueiro, Miguel, Reinisch, Walter, Rieder, Florian, Rioux, John D., Roberts, Rebecca, Rogler, Gerhard, Russell, Richard K., Sanderson, Jeremy D., Sans, Miquel, Satsangi, Jack, Schadt, Eric E., Scharl, Michael, Schembri, John, Schreiber, Stefan, Schumm, L. Philip, Scott, Regan, Seielstad, Mark, Shah, Tejas, Sharma, Yashoda, Silverberg, Mark S., Simmons, Alison, Simms, Lisa A., Singh, Abhey, Skieceviciene, Jurgita, van Sommeren, Suzanne, Song, Kyuyoung, Sood, Ajit, Spain, Sarah L., Steinhart, A. Hillary, Stempak, Joanne M., Stronati, Laura, Sung, Joseph J.Y., Targan, Stephan R., Taylor, Kirstin M., Theatre, Emilie, Torkvist, Leif, Torres, Esther A., Tremelling, Mark, Uhlig, Holm H., Umeno, Junji, Vahedi, Homayon, Vasiliauskas, Eric, Velde, Anje ter, Ventham, Nicholas T., Vermeire, Severine, Verspaget, Hein W., De Vos, Martine, Walters, Thomas, Wang, Kai, Wang, Ming-Hsi, Weersma, Rinse K., Wei, Zhi, Whiteman, David, Wijmenga, Cisca, Wilson, David C., Winkelmann, Juliane, Wong, Sunny H., Xavier, Ramnik J., Yamazaki, Keiko, Yang, Suk-Kyun, Ye, Byong Duk, Zeissig, Sebastian, Zhang, Bin, Zhang, Clarence K., Zhang, Hu, Zhang, Wei, Zhao, Hongyu, Zhao, Zhen Z., Baumdick, Martin E., Niehrs, Annika, Schwerk, Maria, Hinrichs, Ole, Jordan-Paiz, Ana, Padoan, Benedetta, Wegner, Lucy H.M., Schloer, Sebastian, Zecher, Britta F., Malsy, Jakob, Joshi, Vinita R., Illig, Christin, Schröder-Schwarz, Jennifer, Möller, Kimberly J., Martin, Maureen P., Yuki, Yuko, Ozawa, Mikki, Sauter, Jürgen, Schmidt, Alexander H., Perez, Daniel, Giannou, Anastasios D., Carrington, Mary, Davis, Randall S., Schumacher, Udo, Sauter, Guido, Huber, Samuel, Puelles, Victor G., Melling, Nathaniel, Altfeld, Marcus, and Bunders, Madeleine J.

Published
2023
Full Text
View/download PDF

8. Immunochip Meta-Analysis of Inflammatory Bowel Disease Identifies Three Novel Loci and Four Novel Associations in Previously Reported Loci

Author

Hong, Myunghee, Ye, Byong Duk, Yang, Suk-Kyun, Jung, Seulgi, Lee, Ho-Su, Kim, Byoung Mok, Bin Lee, Soo, Hong, Jeonghoon, Baek, Jiwon, Park, Sang Hyoung, Han, Buhm, Li, Yi, Liu, Wenting, Haritunians, Talin, Taylor, Kent D, Rotter, Jerome I, Bang, So-Young, Kim, Tae-Hwan, McGovern, Dermot PB, Liu, Jianjun, and Song, Kyuyoung

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Inflammatory Bowel Disease, Digestive Diseases, Autoimmune Disease, Genetics, Crohn's Disease, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Oral and gastrointestinal, Asian People, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Inflammatory Bowel Diseases, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Myosins, NF-KappaB Inhibitor alpha, Nerve Tissue Proteins, Nuclear Proteins, Phosphoproteins, Polymorphism, Single Nucleotide, Proteasome Endopeptidase Complex, Protein Phosphatase 2, Protein Serine-Threonine Kinases, Repressor Proteins, Republic of Korea, Ribonuclease P, Tetraspanins, Trans-Activators, White People, Inflammatory bowel disease, meta-analysis, trans-ethnic, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background and aimsRecent meta-analysis of genome-wide association studies have identified over 241 inflammatory bowel disease susceptibility loci. However, the known variants only account for a fraction of inflammatory bowel disease heritability. To identify additional susceptibility loci, we performed a trans-ethnic meta-analysis as well as an Asian-specific meta-analysis, using all published Immunochip association results of inflammatory bowel disease.MethodsAn inverse-variance fixed-effects meta-analysis was carried out across Korean and East Asian Immunochip datasets of 4156 cases and 4904 controls [Asian ancestry]. A trans-ethnic meta-analysis of inflammatory bowel disease was performed together with the European datasets of 38 155 cases and 48 485 controls genotyped on the immunochip using a Bayesian approach, Meta-Analysis of Trans-ethnic Association studies [MANTRA].ResultsWe identified seven novel associations, including three novel susceptibility loci at MYO10-BASP1, PPP2R3C/KIAA0391/PSMA6/NFKB1A and LRRK1 as well as four novel secondary associations within previously known loci at NCF4, TSPAN32, CIITA and VANGL2. The new loci further implicate alterations in B cell biology in Crohn's disease pathogenesis. The effects of five loci were universal across European and Asian ancestries, whereas the NCF4 and CIITA loci showed significant heterogeneity between European and East Asian populations. In addition, 103 previously known IBD loci showed supporting evidence of association with nominal significance [p < 0.05] in Asians.ConclusionsOur findings of new loci not previously associated with IBD support the importance of studying inflammatory bowel disease genetics in diverse populations.

Published
2018

9. Immunochip Analysis Identification of 6 Additional Susceptibility Loci for Crohn's Disease in Koreans

Author

Yang, Suk-Kyun, Hong, Myunghee, Choi, Hyunchul, Zhao, Wanting, Jung, Yusun, Haritunians, Talin, Ye, Byong Duk, Kim, Kyung-Jo, Park, Sang Hyoung, Lee, Inchul, Kim, Won Ho, Cheon, Jae Hee, Kim, Young-Ho, Jang, Byung Ik, Kim, Hyun-Soo, Choi, Jai Hyun, Koo, Ja Seol, Lee, Ji Hyun, Jung, Sung-Ae, Shin, Hyoung Doo, Kang, Daehee, Youn, Hee-Shang, Taylor, Kent D, Rotter, Jerome I, Liu, Jianjun, McGovern, Dermot PB, and Song, Kyuyoung

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Inflammatory Bowel Disease, Human Genome, Autoimmune Disease, Crohn's Disease, Genetics, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Adolescent, Adult, Asian People, Biomarkers, Case-Control Studies, Cohort Studies, Crohn Disease, Female, Follow-Up Studies, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Odds Ratio, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Prognosis, Young Adult, Crohn's disease, genetics, ImmunoChip, Korean, Gastroenterology & Hepatology, Clinical sciences
Abstract

BackgroundCrohn's disease (CD) is an intractable inflammatory bowel disease of unknown cause. Recent genome-wide association studies of CD in Korean and Japanese populations suggested marginal sharing of susceptibility loci between Caucasian and Asian populations. As the 7 identified loci altogether explain 5.31% of the risk for CD, the objective of this study was to identify additional CD susceptibility loci in the Korean population.MethodsUsing the ImmunoChip custom single-nucleotide polymorphism array designed for dense genotyping of 186 loci identified through GWAS, we analyzed 722 individuals with CD and 461 controls for 96,048 SNP markers in the discovery stage, followed by validation in an additional 948 affected individuals and 977 controls.ResultsWe confirmed 6 previously reported loci in Caucasian: GPR35 at 2q37 (rs3749172; P = 5.30 × 10, odds ratio [OR] = 1.45), ZNF365 at 10q21 (rs224143; P = 2.20 × 10, OR = 1.38), ZMIZ1 at 10q22 (rs1250569; P = 3.05 × 10, OR = 1.30), NKX2-3 at 10q24 (rs4409764; P = 7.93 × 10, OR = 1.32), PTPN2 at 18p11 (rs514000; P = 9.00 × 10, OR = 1.33), and USP25 at 21q11 (rs2823256; P = 2.49 × 10, OR = 1.35), bringing the number of known CD loci (including 3 in the HLA) in Koreans to 15. The 6 additional loci increased the total genetic variance for CD risk from 5.31% to 7.27% in Koreans.ConclusionsAlthough the different genetic backgrounds of CD between Asian and Western countries has been well established for the major susceptibility genes, our findings of overlapping associations offer new insights into the genetic architecture of CD.

Published
2015

10. Transcriptomic Profiling and Cellular Composition of Creeping Fat in Crohn's disease.

Author

Kim, Kyuwon, Park, Sojung, Lee, Yoonho, Baek, Jiwon, Kim, Yongjae, Hwang, Sung Wook, Lee, Jong Lyul, Park, Sang Hyoung, Yang, Suk-Kyun, Han, Buhm, Song, Kyuyoung, Yoon, Yong Sik, Lee, Ho-Su, and Ye, Byong Duk

Abstract

Background and Aims Creeping fat [CF] is a poorly understood feature of Crohn's disease [CD], characterized by the wrapping of mesenteric adipose tissue [MAT] around the inflamed intestine. The aim of this study was to investigate the transcriptional profile and compositional features of CF. Methods We collected 59 MAT samples: 23 paired samples from patients with CD (CF [CD-CF] and MAT around the uninflamed intestine [CD-MAT]) and 13 MAT samples from non-CD patients [Con-MAT]. Differentially expressed gene [DEG], functional pathway, cell deconvolution, and gene co-expression network analyses were performed. Results By comparing three different MAT samples, we identified a total of 529 DEGs [|log2FoldChange| > 1.5; false discovery rate < 0.05]. Of these, 323 genes showed an incremental pattern from Con-MAT to CD-MAT, and to CD-CF, while 105 genes displayed a decremental pattern. Genes with an incremental pattern were related to immune cell responses, including B- and T-cell activation, while genes with a decremental pattern were involved in cell trafficking and migration. Cell deconvolution analysis revealed significant changes in cellular composition between the CD-CF and Con-MAT groups, with increased proportions of B-cells/plasma cells [ p  = 1.16 × 10−4], T-cells [ p  = 3.66 × 10−3], and mononuclear phagocytes [ p  = 3.53 × 10−2] in the CD-CF group. In contrast, only the B-cell/plasma cell component showed a significant increase [ p  = 1.62 × 10−2] in the CD-MAT group compared to Con-MAT. Conclusion The distinct transcriptional profiles and altered cellular components of each MAT found in our study provide insight into the mechanisms behind CF and highlight its possible role in the pathogenesis of CD. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

12. Transcriptomic Profiling and Cellular Composition of Creeping Fat in Crohn’s disease

Author

Kim, Kyuwon, primary, Park, Sojung, additional, Lee, Yoonho, additional, Baek, Jiwon, additional, Kim, Yongjae, additional, Hwang, Sung Wook, additional, Lee, Jong Lyul, additional, Park, Sang Hyoung, additional, Yang, Suk-Kyun, additional, Han, Buhm, additional, Song, Kyuyoung, additional, Yoon, Yong Sik, additional, Lee, Ho-Su, additional, and Ye, Byong Duk, additional

Published
2023
Full Text
View/download PDF

13. Exome sequencing in Asian populations identifies rare deficient SMPD1 alleles that increase risk of Parkinson's disease

Author

Chew, Elaine GY, primary, Liu, Zhehao, additional, Li, Zheng, additional, Chung, Sun Ju, additional, Lian, Michelle M, additional, Tandiono, Moses, additional, Ng, Ebonne Y, additional, Tan, Louis CS, additional, Chng, Wee Ling, additional, Tan, Tiak Ju, additional, Peh, Esther KL, additional, Ho, Ying Swan, additional, Chen, Xiao Yin, additional, Lim, Erin YT, additional, Chang, Chu Hua, additional, Leong, Jonavan J, additional, Heng, Yue Jing, additional, Peh, Ting Xuan, additional, Chan, Ling-Ling, additional, Chao, Yinxia, additional, Au, Wing-Lok, additional, Prakash, Kumar M, additional, Lim, Jia Lun, additional, Tay, Yi Wen, additional, Mok, Vincent, additional, Chan, Anne YY, additional, Lin, Juei-Jueng, additional, Jeon, Beom S, additional, Song, Kyuyoung, additional, Tham, Clement CY, additional, Pang, Chi Pui, additional, Ahn, Jeeyun, additional, Park, Kyu Hyung, additional, Wiggs, Janey L, additional, Aung, Tin, additional, Tan, Ai-Huey, additional, Ahmad Annuar, Azlina, additional, Makarious, Mary B, additional, Blauwendraat, Cornelis, additional, Nalls, Mike A, additional, Robak, Laurie A, additional, Alcalay, Roy N, additional, Gan-Or, Ziv, additional, Lim, Shen-Yang, additional, Khor, Chiea-Chuen, additional, Tan, Eng-King, additional, Wang, Zhenxun, additional, and Foo, Jia Nee, additional

Published
2023
Full Text
View/download PDF

14. CFH and VIPR2 as susceptibility loci in choroidal thickness and pachychoroid disease central serous chorioretinopathy

Author

Nagahama Study Group, Hosoda, Yoshikatsu, Yoshikawa, Munemitsu, Miyake, Masahiro, Tabara, Yasuharu, Ahn, Jeeyun, Woo, Se Joon, Honda, Shigeru, Sakurada, Yoichi, Shiragami, Chieko, Nakanishi, Hideo, Oishi, Akio, Ooto, Sotaro, Miki, Akiko, Iida, Tomohiro, Iijima, Hiroyuki, Nakamura, Makoto, Khor, Chiea Chuen, Wong, Tien Yin, Song, Kyuyoung, Park, Kyu Hyung, Yamada, Ryo, Matsuda, Fumihiko, Tsujikawa, Akitaka, and Yamashiro, Kenji

Published
2018

16. Case–case genome-wide association analysis identifying genetic loci with divergent effects on Crohn’s disease and ulcerative colitis

Author

Jung, Seulgi, primary, Kim, Yongjae, additional, Park, Dohoon, additional, Lee, Yoonho, additional, Park, Sojung, additional, Baek, Jiwon, additional, Hwang, Sung Wook, additional, Park, Sang Hyoung, additional, Yang, Suk-Kyun, additional, Ye, Byong Duk, additional, Han, Buhm, additional, Song, Kyuyoung, additional, and Lee, Ho-Su, additional

Published
2022
Full Text
View/download PDF

17. Multi-population genome-wide association study implicates both immune and non-immune factors in the etiology of pediatric steroid sensitive nephrotic syndrome

Author

Barry, Alexandra, primary, McNulty, Michelle T., additional, Jia, Xiaoyuan, additional, Gupta, Yask, additional, Debiec, Hanna, additional, Luo, Yang, additional, Nagano, China, additional, Horinouchi, Tomoko, additional, Jung, Seulgi, additional, Colucci, Manuela, additional, Ahram, Dina F., additional, Mitrotti, Adele, additional, Sinha, Aditi, additional, Teeninga, Nynke, additional, Jin, Gina, additional, Shril, Shirlee, additional, Caridi, Gianluca, additional, Bodria, Monica, additional, Lim, Tze Y, additional, Westland, Rik, additional, Zanoni, Francesca, additional, Marasa, Maddalena, additional, Turudic, Daniel, additional, Giordano, Mario, additional, Gesualdo, Loreto, additional, Magistroni, Riccardo, additional, Pisani, Isabella, additional, Fiaccadori, Enrico, additional, Reiterova, Jana, additional, Maringhini, Silvio, additional, Morello, William, additional, Montini, Giovanni, additional, Weng, Patricia L., additional, Scolari, Francesco, additional, Saraga, Marijan, additional, Tasic, Velibor, additional, Santoro, Domenica, additional, van Wijk, Joanna A.E., additional, Milošević, Danko, additional, Kawai, Yosuke, additional, Kiryluk, Krzysztof, additional, Pollak, Martin R., additional, Gharavi, Ali, additional, Lin, Fangmin, additional, Simœs e Silva, Ana Cristina, additional, Loos, Ruth J.F., additional, Kenny, Eimear E., additional, Schreuder, Michiel F., additional, Zurowska, Aleksandra, additional, Dossier, Claire, additional, Ariceta, Gema, additional, Drozynska-Duklas, Magdalena, additional, Hogan, Julien, additional, Jankauskiene, Augustina, additional, Hildebrandt, Friedhelm, additional, Prikhodina, Larisa, additional, Song, Kyuyoung, additional, Bagga, Arvind, additional, Cheong, Hae Il, additional, Ghiggeri, Gian Marco, additional, Vachvanichsanong, Prayong, additional, Nozu, Kandai, additional, Vivarelli, Marina, additional, Raychaudhuri, Soumya, additional, Tokunaga, Katsushi, additional, Sanna-Cherchi, Simone, additional, Ronco, Pierre, additional, Iijima, Kazumoto, additional, and Sampson, Matthew G., additional

Published
2022
Full Text
View/download PDF

19. Identification of shared loci associated with both Crohn’s disease and leprosy in East Asians

Author

Jung, Seulgi, primary, Park, Dohoon, additional, Lee, Ho-Su, additional, Kim, Yongjae, additional, Baek, Jiwon, additional, Hwang, Sung Wook, additional, Park, Sang Hyoung, additional, Yang, Suk-Kyun, additional, Ye, Byong Duk, additional, Han, Buhm, additional, Sun, Yonghu, additional, Liu, Hong, additional, Zhang, Furen, additional, Liu, Jianjun, additional, and Song, Kyuyoung, additional

Published
2022
Full Text
View/download PDF

20. Tu1841 NOVEL CLINICAL ASSOCIATIONS WITH SEROLOGY IN A TRANSANCESTRY CROHN'S DISEASE (CD) COHORT HIGHLIGHTING POPULATION HOMOGENEITY AND HETEROGENEITY

Author

Dube, Shishir, Li, Dalin, Haritunians, Talin, Yang, Shaohong, Braun, Jonathan G., Debbas, Philip, Dutra-Clarke, Rhiannon, Targan, Stephan, Venkateswaran, Suresh, Beecham, Ashley H., Gomez, Lissette, Quintero, Maria Alejandra, Leavitt, James S., Deshpande, Amar R., Kerman, David H., Proksell, Siobhan, McCauley, Jacob L., Damas, Oriana M., Yang, Suk-Kyun, Song, Kyuyoung, Hwang, Sung W., Park, Sang Hyoung, Lee, Ho-Su, Abreu, Maria T., Ahmad, Tariq, Kugathasan, Subra, Torres, Esther A., Ye, Byong Duk, and Mcgovern, Dermot P.B.

Published
2024
Full Text
View/download PDF

21. Genome-wide association study of Parkinson’s disease in East Asians

Author

Foo, Jia Nee, Tan, Louis C., Irwan, Ishak D., Au, Wing-Lok, Low, Hui Qi, Prakash, Kumar-M., Ahmad-Annuar, Azlina, Bei, Jinxin, Chan, Anne YY, Chen, Chiung Mei, Chen, Yi-Chun, Chung, Sun Ju, Deng, Hao, Lim, Shen-Yang, Mok, Vincent, Pang, Hao, Pei, Zhong, Peng, Rong, Shang, Hui-Fang, Song, Kyuyoung, Tan, Ai Huey, Wu, Yih-Ru, Aung, Tin, Cheng, Ching-Yu, Chew, Fook Tim, Chew, Soo-Hong, Chong, Siow-Ann, Ebstein, Richard P., Lee, Jimmy, Saw, Seang-Mei, Seow, Adeline, Subramaniam, Mythily, Tai, E-Shyong, Vithana, Eranga N., Wong, Tien-Yin, Heng, Khai Koon, Meah, Wee-Yang, Khor, Chiea Chuen, Liu, Hong, Zhang, Furen, Liu, Jianjun, and Tan, Eng-King

Published
2017
Full Text
View/download PDF

31. Analysis of non-synonymous-coding variants of Parkinsonʼs disease-related pathogenic and susceptibility genes in East Asian populations

Author

Foo, Jia Nee, Tan, Louis C., Liany, Herty, Koh, Tat Hung, Irwan, Ishak D., Ng, Yen Yek, Ahmad-Annuar, Azlina, Au, Wing-Lok, Aung, Tin, Chan, Anne Y.Y., Chong, Siow-Ann, Chung, Sun Ju, Jung, Yusun, Khor, Chiea Chuen, Kim, Juyeon, Lee, Jimmy, Lim, Shen-Yang, Mok, Vincent, Prakash, Kumar-M., Song, Kyuyoung, Tai, E.-Shyong, Vithana, Eranga N., Wong, Tien-Yin, Tan, Eng-King, and Liu, Jianjun

Published
2014
Full Text
View/download PDF

32. Genome-wide association study of Crohnʼs disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations

Author

Yang, Suk-Kyun, Hong, Myunghee, Zhao, Wanting, Jung, Yusun, Baek, Jiwon, Tayebi, Naeimeh, Kim, Kyung Mo, Ye, Byong Duk, Kim, Kyung-Jo, Park, Sang Hyoung, Lee, Inchul, Lee, Eun-Ju, Kim, Won Ho, Cheon, Jae Hee, Kim, Young-Ho, Jang, Byung Ik, Kim, Hyun-Soo, Choi, Jai Hyun, Koo, Ja Seol, Lee, Ji Hyun, Jung, Sung-Ae, Lee, Yeoun Joo, Jang, Joo Young, Shin, Hyoung Doo, Kang, Daehee, Youn, Hee-Shang, Liu, Jianjun, and Song, Kyuyoung

Published
2014
Full Text
View/download PDF

34. 1237 SEROLOGICAL DIFFERENCES IN AN INFLAMMATORY BOWEL DISEASE (IBD) TRANS-ANCESTRY COHORT HIGHLIGHTING POPULATION HETEROGENEITY

Author

Dube, Shishir, Li, Dalin, Haritunians, Talin, Yang, Shaohong, Braun, Jonathan G., Debbas, Philip, Dutra-Clarke, Rhiannon, Targan, Stephan, Ahmad, Tariq, Venkateswaran, Suresh, Kugathasan, Subra, Beecham, Ashley H., Gomez, Lissette, Quintero, Maria, Leavitt, James S., Deshpande, Amar R., Kerman, David H., Proksell, Siobhan, McCauley, Jacob L., Damas, Oriana M., Abreu, Maria T., Torres, Esther A., Yang, Suk-Kyun, Song, Kyuyoung, Hwang, Sung W., Park, Sang Hyoung, Lee, Ho-Su, Ye, Byong Duk, and Mcgovern, Dermot P.B.

Published
2023
Full Text
View/download PDF

37. Fine-scale map of Encyclopedia of DNA elements regions in the Korean population

Author

Yoo, Yeon-Kyeong, Ke, Xiayi, Hong, Sungwoo, Jang, Hye-Yoon, Park, Kyunghee, Kim, Sook, Ahn, TaeJin, Lee, Yeun-Du, Song, Okryeol, Rho, Na-Young, Lee, Moon Sue, Lee, Yeon-Su, Kim, Jaeheup, Kim, Young J., Yang, Jun-Mo, Song, Kyuyoung, Kimm, Kyuchan, Weir, Bruce, Cardon, Lon R., Lee, Jong-Eun, and Hwang, Jung-Joo

Subjects
Genetic variation -- Research, Genetic polymorphisms -- Research, Genotype -- Research, Biological sciences
Abstract

The International HapMap Project aims to generate detailed human genome variation maps by densely genotyping single-nucleotide polymorphisms (SNPs) in CEPH, Chinese, Japanese, and Yoruba samples. This will undoubtedly become an important facility for genetic studies of diseases and complex traits in the four populations. To address how the genetic information contained in such variation maps is transferable to other populations, the Korean government, industries, and academics have launched the Korean HapMap project to genotype high-density Encyclopedia of DNA Elements (ENCODE) regions in 90 Korean individuals. Here we show that the LD pattern, block structure, haplotype diversity, and recombination rate are highly concordant between Korean and the two HapMap Asian samples, particularly Japanese. The availability of information from both Chinese and Japanese samples helps to predict more accurately the possible performance of HapMap markers in Korean disease-gene studies. Tagging SNPs selected from the two HapMap Asian maps, especially the Japanese map, were shown to be very effective for Korean samples. These results demonstrate that the HapMap variation maps are robust in related populations and will serve as an important resource for the studies of the Korean population in particular.

Published
2006

38. Interpretation of XIAP Variants of Uncertain Significance in Paediatric Patients with Refractory Crohn’s Disease

Author

Chang, Iksoo, primary, Park, Seongjun, additional, Lee, Hye-Jin, additional, Kim, Inki, additional, Park, Sojung, additional, Ahn, Mi Kyoung, additional, Lee, Juhwan, additional, Kang, Mooseok, additional, Baek, In-Jeoung, additional, Sung, Young Hoon, additional, Pack, Chan-Gi, additional, Kang, Hyo-jeong, additional, Lee, Kunsong, additional, Im, Ho Joon, additional, Seo, Eul Ju, additional, Kim, Kyung Mo, additional, Yang, Suk-Kyun, additional, Song, Kyuyoung, additional, and Oh, Seak Hee, additional

Published
2021
Full Text
View/download PDF

43. Identification of Risk Loci for Parkinson Disease in Asians and Comparison of Risk Between Asians and Europeans

Author

Foo, Jia Nee, primary, Chew, Elaine Guo Yan, additional, Chung, Sun Ju, additional, Peng, Rong, additional, Blauwendraat, Cornelis, additional, Nalls, Mike A., additional, Mok, Kin Y., additional, Satake, Wataru, additional, Toda, Tatsushi, additional, Chao, Yinxia, additional, Tan, Louis C. S., additional, Tandiono, Moses, additional, Lian, Michelle M., additional, Ng, Ebonne Y., additional, Prakash, Kumar-M., additional, Au, Wing-Lok, additional, Meah, Wee-Yang, additional, Mok, Shi Qi, additional, Annuar, Azlina Ahmad, additional, Chan, Anne Y. Y., additional, Chen, Ling, additional, Chen, Yongping, additional, Jeon, Beom S., additional, Jiang, Lulu, additional, Lim, Jia Lun, additional, Lin, Juei-Jueng, additional, Liu, Chunfeng, additional, Mao, Chengjie, additional, Mok, Vincent, additional, Pei, Zhong, additional, Shang, Hui-Fang, additional, Shi, Chang-He, additional, Song, Kyuyoung, additional, Tan, Ai Huey, additional, Wu, Yih-Ru, additional, Xu, Yu-ming, additional, Xu, Renshi, additional, Yan, Yaping, additional, Yang, Jing, additional, Zhang, BaoRong, additional, Koh, Woon-Puay, additional, Lim, Shen-Yang, additional, Khor, Chiea Chuen, additional, Liu, Jianjun, additional, and Tan, Eng-King, additional

Published
2020
Full Text
View/download PDF

44. Expression Quantitative Trait Loci (eQTL) Mapping in Korean Patients With Crohn’s Disease and Identification of Potential Causal Genes Through Integration With Disease Associations

Author

Jung, Seulgi, primary, Liu, Wenting, additional, Baek, Jiwon, additional, Moon, Jung Won, additional, Ye, Byong Duk, additional, Lee, Ho-Su, additional, Park, Sang Hyoung, additional, Yang, Suk-Kyun, additional, Han, Buhm, additional, Liu, Jianjun, additional, and Song, Kyuyoung, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results