// Jing Sui 1 , Si-Yi Xu 1 , Jiali Han 2 , Song-Ru Yang 3 , Cheng-Yun Li 1 , Li-Hong Yin 1 , Yue-Pu Pu 1 and Ge-Yu Liang 1 1 Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, P.R. China 2 Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA 3 Department of Thoracic Surgery, Nanjing Chest Hospital, Nanjing, P.R. China Correspondence to: Ge-Yu Liang, email: lianggeyu@163.com Keywords: lncRNA, ceRNA network, LUSC, prognostic biomarker Received: May 23, 2017 Accepted: June 28, 2017 Published: July 27, 2017 ABSTRACT Accumulating evidence shows the important role of long non-coding RNAs (lncRNAs) in competing endogenous RNA (ceRNA) networks for predicting survival in tumor patients. However, prognostic biomarkers for lung squamous cell carcinoma (LUSC) are still lacking. The objective of this study is to identify a lncRNA signature for evaluation of overall survival (OS) in 474 LUSC patients from The Cancer Genome Atlas (TCGA) database. A total of 474 RNA sequencing profiles in LUSC patients with clinical data were obtained, providing a large sample of RNA sequencing data, and 83 LUSC-specific lncRNAs, 26 miRNAs, and 85 mRNAs were identified to construct the ceRNA network (fold change>2, P