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1. Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial.

Author

Parra, Edwin, Zhang, Jiexin, Duose, Dzifa, Gonzalez-Kozlova, Edgar, Redman, Mary, Chen, Hong, Manyam, Ganiraju, Kumar, Gayatri, Zhang, Jianhua, Song, Xingzhi, Lazcano, Rossana, Marques-Piubelli, Mario, Laberiano-Fernandez, Caddie, Rojas, Frank, Zhang, Baili, Taing, Len, Jhaveri, Aashna, Geisberg, Jacob, Altreuter, Jennifer, Michor, Franziska, Provencher, James, Yu, Joyce, Cerami, Ethan, Moravec, Radim, Kannan, Kasthuri, Luthra, Rajyalakshmi, Alatrash, Gheath, Huang, Hsin-Hui, Xie, Hui, Patel, Manishkumar, Nie, Kai, Harris, Jocelyn, Argueta, Kimberly, Lindsay, James, Biswas, Roshni, Van Nostrand, Stephen, Kim-Schulze, Seunghee, Gray, Jhanelle, Herbst, Roy, Wistuba, Ignacio, Gettinger, Scott, Kelly, Karen, Bazhenova, Lyudmila, Gnjatic, Sacha, Lee, J, Zhang, Jianjun, and Haymaker, Cara

Subjects
Humans, Nivolumab, Lung Neoplasms, Multiomics, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Immunotherapy, Lung, Epithelial Cells, Ipilimumab, Tumor Microenvironment
Abstract

PURPOSE: Identifying molecular and immune features to guide immune checkpoint inhibitor (ICI)-based regimens remains an unmet clinical need. EXPERIMENTAL DESIGN: Tissue and longitudinal blood specimens from phase III trial S1400I in patients with metastatic squamous non-small cell carcinoma (SqNSCLC) treated with nivolumab monotherapy (nivo) or nivolumab plus ipilimumab (nivo+ipi) were subjected to multi-omics analyses including multiplex immunofluorescence (mIF), nCounter PanCancer Immune Profiling Panel, whole-exome sequencing, and Olink. RESULTS: Higher immune scores from immune gene expression profiling or immune cell infiltration by mIF were associated with response to ICIs and improved survival, except regulatory T cells, which were associated with worse overall survival (OS) for patients receiving nivo+ipi. Immune cell density and closer proximity of CD8+GZB+ T cells to malignant cells were associated with superior progression-free survival and OS. The cold immune landscape of NSCLC was associated with a higher level of chromosomal copy-number variation (CNV) burden. Patients with LRP1B-mutant tumors had a shorter survival than patients with LRP1B-wild-type tumors. Olink assays revealed soluble proteins such as LAMP3 increased in responders while IL6 and CXCL13 increased in nonresponders. Upregulation of serum CXCL13, MMP12, CSF-1, and IL8 were associated with worse survival before radiologic progression. CONCLUSIONS: The frequency, distribution, and clustering of immune cells relative to malignant ones can impact ICI efficacy in patients with SqNSCLC. High CNV burden may contribute to the cold immune microenvironment. Soluble inflammation/immune-related proteins in the blood have the potential to monitor therapeutic benefit from ICI treatment in patients with SqNSCLC.

Published
2024

2. Author Correction: Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma

Author

Zhang, Shaojun, Jiang, Vivian Changying, Han, Guangchun, Hao, Dapeng, Lian, Junwei, Liu, Yang, Cai, Qingsong, Zhang, Rongjia, McIntosh, Joseph, Wang, Ruiping, Dang, Minghao, Dai, Enyu, Wang, Yuanxin, Santos, David, Badillo, Maria, Leeming, Angela, Chen, Zhihong, Hartig, Kimberly, Bigcal, John, Zhou, Jia, Kanagal-Shamanna, Rashmi, Ok, Chi Young, Lee, Hun, Steiner, Raphael E., Zhang, Jianhua, Song, Xingzhi, Nair, Ranjit, Ahmed, Sairah, Rodriquez, Alma, Thirumurthi, Selvi, Jain, Preetesh, Wagner-Bartak, Nicolaus, Hill, Holly, Nomie, Krystle, Flowers, Christopher, Futreal, Andrew, Wang, Linghua, and Wang, Michael

Published
2024
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6. Targeting MCL1-driven anti-apoptotic pathways overcomes blast progression after hypomethylating agent failure in chronic myelomonocytic leukemia

Author

Montalban-Bravo, Guillermo, Thongon, Natthakan, Rodriguez-Sevilla, Juan Jose, Ma, Feiyang, Ganan-Gomez, Irene, Yang, Hui, Kim, Yi June, Adema, Vera, Wildeman, Bethany, Tanaka, Tomoyuki, Darbaniyan, Faezeh, Al-Atrash, Gheath, Dwyer, Karen, Loghavi, Sanam, Kanagal-Shamanna, Rashmi, Song, Xingzhi, Zhang, Jianhua, Takahashi, Koichi, Kantarjian, Hagop, Garcia-Manero, Guillermo, and Colla, Simona

Published
2024
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7. T-prolymphocytic leukemia: TCL1 or MTCP1 rearrangement is not mandatory to establish diagnosis

Author

Fang, Hong, Beird, Hannah C., Wang, Sa A., Ibrahim, Andrew F., Tang, Zhenya, Tang, Guilin, You, M. James, Hu, Shimin, Xu, Jie, Li, Shaoying, Yin, C. Cameron, El Hussein, Siba, Le, Nhi, Futreal, P. Andrew, Bueso-Ramos, Carlos, Thakral, Beenu, Kadia, Tapan M., Thornton, Rebecca, Little, Latasha, Gumbs, Curtis, Song, Xingzhi, Medeiros, L. Jeffrey, and Wang, Wei

Published
2023
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8. Complete loss of TP53 and RB1 is associated with complex genome and low immune infiltrate in pleomorphic rhabdomyosarcoma

Author

Beird, Hannah C., Wu, Chia-Chin, Nakazawa, Michael, Ingram, Davis, Daniele, Joseph R., Lazcano, Rossana, Little, Latasha, Davies, Christopher, Daw, Najat C., Wani, Khalida, Wang, Wei-Lien, Song, Xingzhi, Gumbs, Curtis, Zhang, Jianhua, Rubin, Brian, Conley, Anthony, Flanagan, Adrienne M., Lazar, Alexander J., and Futreal, P. Andrew

Published
2023
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9. Proteogenomic landscape of gastric adenocarcinoma peritoneal metastases

Author

Zhao, Shuangtao, Wang, Ruiping, Song, Shumei, Hao, Dapeng, Han, Guangchun, Song, Xingzhi, Zhang, Jianhua, Pizzi, Melissa Pool, Shanbhag, Namita, Futreal, Andrew, Badgwell, Brian, Harada, Kazuto, Calin, George, Vykoukal, Jody, Yu, Chuan-Yih, Katayama, Hiroyuki, Hanash, Samir M., Wang, Linghua, and Ajani, Jaffer A.

Published
2023
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10. Single cell clonotypic and transcriptional evolution of multiple myeloma precursor disease

Author

Dang, Minghao, Han, Guangchun, Lee, Hans C., Patel, Krina K., Becnel, Melody R., Wang, Ruiping, Thomas, Sheeba K., Hao, Dapeng, Chu, Yanshuo, Weber, Donna M., Lin, Pei, Lutter-Berka, Zuzana, Berrios Nolasco, David A., Huang, Mei, Bansal, Hima, Song, Xingzhi, Zhang, Jianhua, Futreal, Andrew, Moreno Rueda, Luz Yurany, Symer, David E., Green, Michael R., Rojas Hernandez, Cristhiam M., Kroll, Michael, Afshar-Khargan, Vahid, Ndacayisaba, Libere J., Kuhn, Peter, Neelapu, Sattva S., Orlowski, Robert Z., Wang, Linghua, and Manasanch, Elisabet E.

Published
2023
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11. Mechanisms of nuclear content loading to exosomes.

Author

Yokoi, Akira, Villar-Prados, Alejandro, Oliphint, Paul Allen, Zhang, Jianhua, Song, Xingzhi, De Hoff, Peter, Morey, Robert, Liu, Jinsong, Roszik, Jason, Clise-Dwyer, Karen, Burks, Jared K, O'Halloran, Theresa J, Laurent, Louise C, and Sood, Anil K

Subjects
Cell Line, Tumor, Micronuclei, Chromosome-Defective, Humans, Ovarian Neoplasms, DNA Damage, DNA, Female, Exosomes, DNA Copy Number Variations, Tetraspanins, Biomarkers, Tumor, Cell Line, Tumor, Micronuclei, Chromosome-Defective, Biomarkers, Ovarian Cancer, Cancer, Rare Diseases, Genetics, 2.1 Biological and endogenous factors
Abstract

Exosome cargoes are highly varied and include proteins, small RNAs, and genomic DNA (gDNA). The presence of gDNA suggests that different intracellular compartments contribute to exosome loading, resulting in distinct exosome subpopulations. However, the loading of gDNA and other nuclear contents into exosomes (nExo) remains poorly understood. Here, we identify the relationship between cancer cell micronuclei (MN), which are markers of genomic instability, and nExo formation. Imaging flow cytometry analyses reveal that 10% of exosomes derived from cancer cells and

Published
2019

13. Clonal evolution of hematopoietic stem cells after cancer chemotherapy

Author

Uryu, Hidetaka, primary, Saeki, Koichi, additional, Haeno, Hiroshi, additional, Kapadia, Chiraag Deepak, additional, Furudate, Ken, additional, Nangalia, Jyoti, additional, Chapman, Michael Spencer, additional, Zhao, Li, additional, Hsu, Joanne I, additional, Zhao, Chong, additional, Chen, Shujuan, additional, Tanaka, Tomoyuki, additional, Li, Zongrui, additional, Yang, Hui, additional, DiNardo, Courtney, additional, Daver, Naval, additional, Pemmaraju, Naveen, additional, Jain, Nitin, additional, Ravandi, Farhad, additional, Zhang, Jianhua, additional, Song, Xingzhi, additional, Thompson, Erika, additional, Tang, Hongli, additional, Little, Latasha, additional, Gumbs, Curtis, additional, Orlowski, Robert, additional, Qazilbash, Muzaffar, additional, Bhalla, Kapil, additional, Colla, Simona, additional, Kantarjian, Hagop, additional, Shamanna, Rashmi Kanagal, additional, Bueso-Ramos, Carlos, additional, Nakada, Daisuke, additional, Futreal, P Andrew, additional, Shpall, Elizabeth, additional, Goodell, Margaret, additional, Garcia-Manero, Guillermo, additional, and Takahashi, Koichi, additional

Published
2024
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14. Experimental models of undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor

Author

Bhalla, Angela D., Landers, Sharon M., Singh, Anand K., Landry, Jace P., Yeagley, Michelle G., Myerson, Gabryella S. B., Delgado-Baez, Cristian B., Dunnand, Stephanie, Nguyen, Theresa, Ma, Xiaoyan, Bolshakov, Svetlana, Menegaz, Brian A., Lamhamedi-Cherradi, Salah-Eddine, Mao, Xizeng, Song, Xingzhi, Lazar, Alexander J., McCutcheon, Ian E., Slopis, John M., Ludwig, Joseph A., Lev, Dina C., Rai, Kunal, and Torres, Keila E.

Published
2022
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15. Immunogenomic intertumor heterogeneity across primary and metastatic sites in a patient with lung adenocarcinoma

Author

Chen, Runzhe, Li, Jun, Fujimoto, Junya, Hong, Lingzhi, Hu, Xin, Quek, Kelly, Tang, Ming, Mitra, Akash, Behrens, Carmen, Chow, Chi-Wan, Jiang, Peixin, Little, Latasha D., Gumbs, Curtis, Song, Xingzhi, Zhang, Jianhua, Tan, Dongfeng, Heymach, John V., Wistuba, Ignacio, Futreal, P. Andrew, Gibbons, Don L., Byers, Lauren A., Zhang, Jianjun, and Reuben, Alexandre

Published
2022
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16. Metagenomes of rectal swabs in larger, advanced stage cervical cancers have enhanced mucus degrading functionalities and distinct taxonomic structure

Author

Karpinets, Tatiana V., Wu, Xiaogang, Solley, Travis, El Alam, Molly B., Sims, Travis T., Yoshida-Court, Kyoko, Lynn, Erica, Ahmed-Kaddar, Mustapha, Biegert, Greyson, Yue, Jingyan, Song, Xingzhi, Sun, Huandong, Petrosino, Joseph F., Mezzari, Melissa P., Okhuysen, Pablo, Eifel, Patricia J., Jhingran, Anuja, Lin, Lilie L., Schmeler, Kathleen M., Ramondetta, Lois, Ajami, Nadim, Jenq, Robert R., Futreal, Andrew, Zhang, Jianhua, Klopp, Ann H., and Colbert, Lauren E.

Published
2022
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17. Multi-modal molecular programs regulate melanoma cell state

Author

Andrews, Miles C., Oba, Junna, Wu, Chang-Jiun, Zhu, Haifeng, Karpinets, Tatiana, Creasy, Caitlin A., Forget, Marie-Andrée, Yu, Xiaoxing, Song, Xingzhi, Mao, Xizeng, Robertson, A. Gordon, Romano, Gabriele, Li, Peng, Burton, Elizabeth M., Lu, Yiling, Sloane, Robert Szczepaniak, Wani, Khalida M., Rai, Kunal, Lazar, Alexander J., Haydu, Lauren E., Bustos, Matias A., Shen, Jianjun, Chen, Yueping, Morgan, Margaret B., Wargo, Jennifer A., Kwong, Lawrence N., Haymaker, Cara L., Grimm, Elizabeth A., Hwu, Patrick, Hoon, Dave S. B., Zhang, Jianhua, Gershenwald, Jeffrey E., Davies, Michael A., Futreal, P. Andrew, Bernatchez, Chantale, and Woodman, Scott E.

Published
2022
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18. Epstein Barr virus–positive B-cell lymphoma is highly vulnerable to MDM2 inhibitors in vivo

Author

Zhang, Xiaoshan, Zhang, Ran, Ren, Chenghui, Xu, Yi, Wu, Shuhong, Meng, Carrie, Pataer, Apar, Song, Xingzhi, Zhang, Jianhua, Yao, Yixin, He, Hua, Chen, Huiqin, Ma, Wencai, Wang, Jing, Meric-Bernstam, Funda, Champlin, Richard E., Heymach, John V., Rooney, Cliona M., Swisher, Stephen G., Vaporciyan, Ara A., Roth, Jack A., You, M. James, Wang, Michael, and Fang, Bingliang

Published
2022
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19. Supplementary Table 6 from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial

Author

Parra, Edwin Roger, primary, Zhang, Jiexin, primary, Duose, Dzifa Yawa, primary, Gonzalez-Kozlova, Edgar, primary, Redman, Mary W., primary, Chen, Hong, primary, Manyam, Ganiraju C., primary, Kumar, Gayatri, primary, Zhang, Jianhua, primary, Song, Xingzhi, primary, Lazcano, Rossana, primary, Marques-Piubelli, Mario L., primary, Laberiano-Fernandez, Caddie, primary, Rojas, Frank, primary, Zhang, Baili, primary, Taing, Len, primary, Jhaveri, Aashna, primary, Geisberg, Jacob, primary, Altreuter, Jennifer, primary, Michor, Franziska, primary, Provencher, James, primary, Yu, Joyce, primary, Cerami, Ethan, primary, Moravec, Radim, primary, Kannan, Kasthuri, primary, Luthra, Rajyalakshmi, primary, Alatrash, Gheath, primary, Huang, Hsin-Hui, primary, Xie, Hui, primary, Patel, Manishkumar, primary, Nie, Kai, primary, Harris, Jocelyn, primary, Argueta, Kimberly, primary, Lindsay, James, primary, Biswas, Roshni, primary, Van Nostrand, Stephen, primary, Kim-Schulze, Seunghee, primary, Gray, Jhanelle E., primary, Herbst, Roy S., primary, Wistuba, Ignacio I., primary, Gettinger, Scott, primary, Kelly, Karen, primary, Bazhenova, Lyudmila, primary, Gnjatic, Sacha, primary, Lee, J. Jack, primary, Zhang, Jianjun, primary, and Haymaker, Cara, primary

Published
2024
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20. Supplementary Figure 6 from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial

Author

Parra, Edwin Roger, primary, Zhang, Jiexin, primary, Duose, Dzifa Yawa, primary, Gonzalez-Kozlova, Edgar, primary, Redman, Mary W., primary, Chen, Hong, primary, Manyam, Ganiraju C., primary, Kumar, Gayatri, primary, Zhang, Jianhua, primary, Song, Xingzhi, primary, Lazcano, Rossana, primary, Marques-Piubelli, Mario L., primary, Laberiano-Fernandez, Caddie, primary, Rojas, Frank, primary, Zhang, Baili, primary, Taing, Len, primary, Jhaveri, Aashna, primary, Geisberg, Jacob, primary, Altreuter, Jennifer, primary, Michor, Franziska, primary, Provencher, James, primary, Yu, Joyce, primary, Cerami, Ethan, primary, Moravec, Radim, primary, Kannan, Kasthuri, primary, Luthra, Rajyalakshmi, primary, Alatrash, Gheath, primary, Huang, Hsin-Hui, primary, Xie, Hui, primary, Patel, Manishkumar, primary, Nie, Kai, primary, Harris, Jocelyn, primary, Argueta, Kimberly, primary, Lindsay, James, primary, Biswas, Roshni, primary, Van Nostrand, Stephen, primary, Kim-Schulze, Seunghee, primary, Gray, Jhanelle E., primary, Herbst, Roy S., primary, Wistuba, Ignacio I., primary, Gettinger, Scott, primary, Kelly, Karen, primary, Bazhenova, Lyudmila, primary, Gnjatic, Sacha, primary, Lee, J. Jack, primary, Zhang, Jianjun, primary, and Haymaker, Cara, primary

Published
2024
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21. Supplementary Figure 8 from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial

Author

Parra, Edwin Roger, primary, Zhang, Jiexin, primary, Duose, Dzifa Yawa, primary, Gonzalez-Kozlova, Edgar, primary, Redman, Mary W., primary, Chen, Hong, primary, Manyam, Ganiraju C., primary, Kumar, Gayatri, primary, Zhang, Jianhua, primary, Song, Xingzhi, primary, Lazcano, Rossana, primary, Marques-Piubelli, Mario L., primary, Laberiano-Fernandez, Caddie, primary, Rojas, Frank, primary, Zhang, Baili, primary, Taing, Len, primary, Jhaveri, Aashna, primary, Geisberg, Jacob, primary, Altreuter, Jennifer, primary, Michor, Franziska, primary, Provencher, James, primary, Yu, Joyce, primary, Cerami, Ethan, primary, Moravec, Radim, primary, Kannan, Kasthuri, primary, Luthra, Rajyalakshmi, primary, Alatrash, Gheath, primary, Huang, Hsin-Hui, primary, Xie, Hui, primary, Patel, Manishkumar, primary, Nie, Kai, primary, Harris, Jocelyn, primary, Argueta, Kimberly, primary, Lindsay, James, primary, Biswas, Roshni, primary, Van Nostrand, Stephen, primary, Kim-Schulze, Seunghee, primary, Gray, Jhanelle E., primary, Herbst, Roy S., primary, Wistuba, Ignacio I., primary, Gettinger, Scott, primary, Kelly, Karen, primary, Bazhenova, Lyudmila, primary, Gnjatic, Sacha, primary, Lee, J. Jack, primary, Zhang, Jianjun, primary, and Haymaker, Cara, primary

Published
2024
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22. Supplementary Table 3 from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial

Author

Parra, Edwin Roger, primary, Zhang, Jiexin, primary, Duose, Dzifa Yawa, primary, Gonzalez-Kozlova, Edgar, primary, Redman, Mary W., primary, Chen, Hong, primary, Manyam, Ganiraju C., primary, Kumar, Gayatri, primary, Zhang, Jianhua, primary, Song, Xingzhi, primary, Lazcano, Rossana, primary, Marques-Piubelli, Mario L., primary, Laberiano-Fernandez, Caddie, primary, Rojas, Frank, primary, Zhang, Baili, primary, Taing, Len, primary, Jhaveri, Aashna, primary, Geisberg, Jacob, primary, Altreuter, Jennifer, primary, Michor, Franziska, primary, Provencher, James, primary, Yu, Joyce, primary, Cerami, Ethan, primary, Moravec, Radim, primary, Kannan, Kasthuri, primary, Luthra, Rajyalakshmi, primary, Alatrash, Gheath, primary, Huang, Hsin-Hui, primary, Xie, Hui, primary, Patel, Manishkumar, primary, Nie, Kai, primary, Harris, Jocelyn, primary, Argueta, Kimberly, primary, Lindsay, James, primary, Biswas, Roshni, primary, Van Nostrand, Stephen, primary, Kim-Schulze, Seunghee, primary, Gray, Jhanelle E., primary, Herbst, Roy S., primary, Wistuba, Ignacio I., primary, Gettinger, Scott, primary, Kelly, Karen, primary, Bazhenova, Lyudmila, primary, Gnjatic, Sacha, primary, Lee, J. Jack, primary, Zhang, Jianjun, primary, and Haymaker, Cara, primary

Published
2024
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23. Supplementary Figure 1 from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial

Author

Parra, Edwin Roger, primary, Zhang, Jiexin, primary, Duose, Dzifa Yawa, primary, Gonzalez-Kozlova, Edgar, primary, Redman, Mary W., primary, Chen, Hong, primary, Manyam, Ganiraju C., primary, Kumar, Gayatri, primary, Zhang, Jianhua, primary, Song, Xingzhi, primary, Lazcano, Rossana, primary, Marques-Piubelli, Mario L., primary, Laberiano-Fernandez, Caddie, primary, Rojas, Frank, primary, Zhang, Baili, primary, Taing, Len, primary, Jhaveri, Aashna, primary, Geisberg, Jacob, primary, Altreuter, Jennifer, primary, Michor, Franziska, primary, Provencher, James, primary, Yu, Joyce, primary, Cerami, Ethan, primary, Moravec, Radim, primary, Kannan, Kasthuri, primary, Luthra, Rajyalakshmi, primary, Alatrash, Gheath, primary, Huang, Hsin-Hui, primary, Xie, Hui, primary, Patel, Manishkumar, primary, Nie, Kai, primary, Harris, Jocelyn, primary, Argueta, Kimberly, primary, Lindsay, James, primary, Biswas, Roshni, primary, Van Nostrand, Stephen, primary, Kim-Schulze, Seunghee, primary, Gray, Jhanelle E., primary, Herbst, Roy S., primary, Wistuba, Ignacio I., primary, Gettinger, Scott, primary, Kelly, Karen, primary, Bazhenova, Lyudmila, primary, Gnjatic, Sacha, primary, Lee, J. Jack, primary, Zhang, Jianjun, primary, and Haymaker, Cara, primary

Published
2024
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24. Supplementary Table 1 from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial

Author

Parra, Edwin Roger, primary, Zhang, Jiexin, primary, Duose, Dzifa Yawa, primary, Gonzalez-Kozlova, Edgar, primary, Redman, Mary W., primary, Chen, Hong, primary, Manyam, Ganiraju C., primary, Kumar, Gayatri, primary, Zhang, Jianhua, primary, Song, Xingzhi, primary, Lazcano, Rossana, primary, Marques-Piubelli, Mario L., primary, Laberiano-Fernandez, Caddie, primary, Rojas, Frank, primary, Zhang, Baili, primary, Taing, Len, primary, Jhaveri, Aashna, primary, Geisberg, Jacob, primary, Altreuter, Jennifer, primary, Michor, Franziska, primary, Provencher, James, primary, Yu, Joyce, primary, Cerami, Ethan, primary, Moravec, Radim, primary, Kannan, Kasthuri, primary, Luthra, Rajyalakshmi, primary, Alatrash, Gheath, primary, Huang, Hsin-Hui, primary, Xie, Hui, primary, Patel, Manishkumar, primary, Nie, Kai, primary, Harris, Jocelyn, primary, Argueta, Kimberly, primary, Lindsay, James, primary, Biswas, Roshni, primary, Van Nostrand, Stephen, primary, Kim-Schulze, Seunghee, primary, Gray, Jhanelle E., primary, Herbst, Roy S., primary, Wistuba, Ignacio I., primary, Gettinger, Scott, primary, Kelly, Karen, primary, Bazhenova, Lyudmila, primary, Gnjatic, Sacha, primary, Lee, J. Jack, primary, Zhang, Jianjun, primary, and Haymaker, Cara, primary

Published
2024
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25. Supplementary Figure 7 from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial

Author

Parra, Edwin Roger, primary, Zhang, Jiexin, primary, Duose, Dzifa Yawa, primary, Gonzalez-Kozlova, Edgar, primary, Redman, Mary W., primary, Chen, Hong, primary, Manyam, Ganiraju C., primary, Kumar, Gayatri, primary, Zhang, Jianhua, primary, Song, Xingzhi, primary, Lazcano, Rossana, primary, Marques-Piubelli, Mario L., primary, Laberiano-Fernandez, Caddie, primary, Rojas, Frank, primary, Zhang, Baili, primary, Taing, Len, primary, Jhaveri, Aashna, primary, Geisberg, Jacob, primary, Altreuter, Jennifer, primary, Michor, Franziska, primary, Provencher, James, primary, Yu, Joyce, primary, Cerami, Ethan, primary, Moravec, Radim, primary, Kannan, Kasthuri, primary, Luthra, Rajyalakshmi, primary, Alatrash, Gheath, primary, Huang, Hsin-Hui, primary, Xie, Hui, primary, Patel, Manishkumar, primary, Nie, Kai, primary, Harris, Jocelyn, primary, Argueta, Kimberly, primary, Lindsay, James, primary, Biswas, Roshni, primary, Van Nostrand, Stephen, primary, Kim-Schulze, Seunghee, primary, Gray, Jhanelle E., primary, Herbst, Roy S., primary, Wistuba, Ignacio I., primary, Gettinger, Scott, primary, Kelly, Karen, primary, Bazhenova, Lyudmila, primary, Gnjatic, Sacha, primary, Lee, J. Jack, primary, Zhang, Jianjun, primary, and Haymaker, Cara, primary

Published
2024
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26. Data from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial

Author

Parra, Edwin Roger, primary, Zhang, Jiexin, primary, Duose, Dzifa Yawa, primary, Gonzalez-Kozlova, Edgar, primary, Redman, Mary W., primary, Chen, Hong, primary, Manyam, Ganiraju C., primary, Kumar, Gayatri, primary, Zhang, Jianhua, primary, Song, Xingzhi, primary, Lazcano, Rossana, primary, Marques-Piubelli, Mario L., primary, Laberiano-Fernandez, Caddie, primary, Rojas, Frank, primary, Zhang, Baili, primary, Taing, Len, primary, Jhaveri, Aashna, primary, Geisberg, Jacob, primary, Altreuter, Jennifer, primary, Michor, Franziska, primary, Provencher, James, primary, Yu, Joyce, primary, Cerami, Ethan, primary, Moravec, Radim, primary, Kannan, Kasthuri, primary, Luthra, Rajyalakshmi, primary, Alatrash, Gheath, primary, Huang, Hsin-Hui, primary, Xie, Hui, primary, Patel, Manishkumar, primary, Nie, Kai, primary, Harris, Jocelyn, primary, Argueta, Kimberly, primary, Lindsay, James, primary, Biswas, Roshni, primary, Van Nostrand, Stephen, primary, Kim-Schulze, Seunghee, primary, Gray, Jhanelle E., primary, Herbst, Roy S., primary, Wistuba, Ignacio I., primary, Gettinger, Scott, primary, Kelly, Karen, primary, Bazhenova, Lyudmila, primary, Gnjatic, Sacha, primary, Lee, J. Jack, primary, Zhang, Jianjun, primary, and Haymaker, Cara, primary

Published
2024
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27. Supplementary Figure 2 from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial

Author

Parra, Edwin Roger, primary, Zhang, Jiexin, primary, Duose, Dzifa Yawa, primary, Gonzalez-Kozlova, Edgar, primary, Redman, Mary W., primary, Chen, Hong, primary, Manyam, Ganiraju C., primary, Kumar, Gayatri, primary, Zhang, Jianhua, primary, Song, Xingzhi, primary, Lazcano, Rossana, primary, Marques-Piubelli, Mario L., primary, Laberiano-Fernandez, Caddie, primary, Rojas, Frank, primary, Zhang, Baili, primary, Taing, Len, primary, Jhaveri, Aashna, primary, Geisberg, Jacob, primary, Altreuter, Jennifer, primary, Michor, Franziska, primary, Provencher, James, primary, Yu, Joyce, primary, Cerami, Ethan, primary, Moravec, Radim, primary, Kannan, Kasthuri, primary, Luthra, Rajyalakshmi, primary, Alatrash, Gheath, primary, Huang, Hsin-Hui, primary, Xie, Hui, primary, Patel, Manishkumar, primary, Nie, Kai, primary, Harris, Jocelyn, primary, Argueta, Kimberly, primary, Lindsay, James, primary, Biswas, Roshni, primary, Van Nostrand, Stephen, primary, Kim-Schulze, Seunghee, primary, Gray, Jhanelle E., primary, Herbst, Roy S., primary, Wistuba, Ignacio I., primary, Gettinger, Scott, primary, Kelly, Karen, primary, Bazhenova, Lyudmila, primary, Gnjatic, Sacha, primary, Lee, J. Jack, primary, Zhang, Jianjun, primary, and Haymaker, Cara, primary

Published
2024
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28. Supplementary Table 7 from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial

Author

Parra, Edwin Roger, primary, Zhang, Jiexin, primary, Duose, Dzifa Yawa, primary, Gonzalez-Kozlova, Edgar, primary, Redman, Mary W., primary, Chen, Hong, primary, Manyam, Ganiraju C., primary, Kumar, Gayatri, primary, Zhang, Jianhua, primary, Song, Xingzhi, primary, Lazcano, Rossana, primary, Marques-Piubelli, Mario L., primary, Laberiano-Fernandez, Caddie, primary, Rojas, Frank, primary, Zhang, Baili, primary, Taing, Len, primary, Jhaveri, Aashna, primary, Geisberg, Jacob, primary, Altreuter, Jennifer, primary, Michor, Franziska, primary, Provencher, James, primary, Yu, Joyce, primary, Cerami, Ethan, primary, Moravec, Radim, primary, Kannan, Kasthuri, primary, Luthra, Rajyalakshmi, primary, Alatrash, Gheath, primary, Huang, Hsin-Hui, primary, Xie, Hui, primary, Patel, Manishkumar, primary, Nie, Kai, primary, Harris, Jocelyn, primary, Argueta, Kimberly, primary, Lindsay, James, primary, Biswas, Roshni, primary, Van Nostrand, Stephen, primary, Kim-Schulze, Seunghee, primary, Gray, Jhanelle E., primary, Herbst, Roy S., primary, Wistuba, Ignacio I., primary, Gettinger, Scott, primary, Kelly, Karen, primary, Bazhenova, Lyudmila, primary, Gnjatic, Sacha, primary, Lee, J. Jack, primary, Zhang, Jianjun, primary, and Haymaker, Cara, primary

Published
2024
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29. Supplementary Table 4 from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial

Author

Parra, Edwin Roger, primary, Zhang, Jiexin, primary, Duose, Dzifa Yawa, primary, Gonzalez-Kozlova, Edgar, primary, Redman, Mary W., primary, Chen, Hong, primary, Manyam, Ganiraju C., primary, Kumar, Gayatri, primary, Zhang, Jianhua, primary, Song, Xingzhi, primary, Lazcano, Rossana, primary, Marques-Piubelli, Mario L., primary, Laberiano-Fernandez, Caddie, primary, Rojas, Frank, primary, Zhang, Baili, primary, Taing, Len, primary, Jhaveri, Aashna, primary, Geisberg, Jacob, primary, Altreuter, Jennifer, primary, Michor, Franziska, primary, Provencher, James, primary, Yu, Joyce, primary, Cerami, Ethan, primary, Moravec, Radim, primary, Kannan, Kasthuri, primary, Luthra, Rajyalakshmi, primary, Alatrash, Gheath, primary, Huang, Hsin-Hui, primary, Xie, Hui, primary, Patel, Manishkumar, primary, Nie, Kai, primary, Harris, Jocelyn, primary, Argueta, Kimberly, primary, Lindsay, James, primary, Biswas, Roshni, primary, Van Nostrand, Stephen, primary, Kim-Schulze, Seunghee, primary, Gray, Jhanelle E., primary, Herbst, Roy S., primary, Wistuba, Ignacio I., primary, Gettinger, Scott, primary, Kelly, Karen, primary, Bazhenova, Lyudmila, primary, Gnjatic, Sacha, primary, Lee, J. Jack, primary, Zhang, Jianjun, primary, and Haymaker, Cara, primary

Published
2024
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30. Supplementary Figure 5 from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial

Author

Parra, Edwin Roger, primary, Zhang, Jiexin, primary, Duose, Dzifa Yawa, primary, Gonzalez-Kozlova, Edgar, primary, Redman, Mary W., primary, Chen, Hong, primary, Manyam, Ganiraju C., primary, Kumar, Gayatri, primary, Zhang, Jianhua, primary, Song, Xingzhi, primary, Lazcano, Rossana, primary, Marques-Piubelli, Mario L., primary, Laberiano-Fernandez, Caddie, primary, Rojas, Frank, primary, Zhang, Baili, primary, Taing, Len, primary, Jhaveri, Aashna, primary, Geisberg, Jacob, primary, Altreuter, Jennifer, primary, Michor, Franziska, primary, Provencher, James, primary, Yu, Joyce, primary, Cerami, Ethan, primary, Moravec, Radim, primary, Kannan, Kasthuri, primary, Luthra, Rajyalakshmi, primary, Alatrash, Gheath, primary, Huang, Hsin-Hui, primary, Xie, Hui, primary, Patel, Manishkumar, primary, Nie, Kai, primary, Harris, Jocelyn, primary, Argueta, Kimberly, primary, Lindsay, James, primary, Biswas, Roshni, primary, Van Nostrand, Stephen, primary, Kim-Schulze, Seunghee, primary, Gray, Jhanelle E., primary, Herbst, Roy S., primary, Wistuba, Ignacio I., primary, Gettinger, Scott, primary, Kelly, Karen, primary, Bazhenova, Lyudmila, primary, Gnjatic, Sacha, primary, Lee, J. Jack, primary, Zhang, Jianjun, primary, and Haymaker, Cara, primary

Published
2024
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31. Supplementary Table 2 from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial

Author

Parra, Edwin Roger, primary, Zhang, Jiexin, primary, Duose, Dzifa Yawa, primary, Gonzalez-Kozlova, Edgar, primary, Redman, Mary W., primary, Chen, Hong, primary, Manyam, Ganiraju C., primary, Kumar, Gayatri, primary, Zhang, Jianhua, primary, Song, Xingzhi, primary, Lazcano, Rossana, primary, Marques-Piubelli, Mario L., primary, Laberiano-Fernandez, Caddie, primary, Rojas, Frank, primary, Zhang, Baili, primary, Taing, Len, primary, Jhaveri, Aashna, primary, Geisberg, Jacob, primary, Altreuter, Jennifer, primary, Michor, Franziska, primary, Provencher, James, primary, Yu, Joyce, primary, Cerami, Ethan, primary, Moravec, Radim, primary, Kannan, Kasthuri, primary, Luthra, Rajyalakshmi, primary, Alatrash, Gheath, primary, Huang, Hsin-Hui, primary, Xie, Hui, primary, Patel, Manishkumar, primary, Nie, Kai, primary, Harris, Jocelyn, primary, Argueta, Kimberly, primary, Lindsay, James, primary, Biswas, Roshni, primary, Van Nostrand, Stephen, primary, Kim-Schulze, Seunghee, primary, Gray, Jhanelle E., primary, Herbst, Roy S., primary, Wistuba, Ignacio I., primary, Gettinger, Scott, primary, Kelly, Karen, primary, Bazhenova, Lyudmila, primary, Gnjatic, Sacha, primary, Lee, J. Jack, primary, Zhang, Jianjun, primary, and Haymaker, Cara, primary

Published
2024
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32. Supplementary Figure 3 from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial

Author

Parra, Edwin Roger, primary, Zhang, Jiexin, primary, Duose, Dzifa Yawa, primary, Gonzalez-Kozlova, Edgar, primary, Redman, Mary W., primary, Chen, Hong, primary, Manyam, Ganiraju C., primary, Kumar, Gayatri, primary, Zhang, Jianhua, primary, Song, Xingzhi, primary, Lazcano, Rossana, primary, Marques-Piubelli, Mario L., primary, Laberiano-Fernandez, Caddie, primary, Rojas, Frank, primary, Zhang, Baili, primary, Taing, Len, primary, Jhaveri, Aashna, primary, Geisberg, Jacob, primary, Altreuter, Jennifer, primary, Michor, Franziska, primary, Provencher, James, primary, Yu, Joyce, primary, Cerami, Ethan, primary, Moravec, Radim, primary, Kannan, Kasthuri, primary, Luthra, Rajyalakshmi, primary, Alatrash, Gheath, primary, Huang, Hsin-Hui, primary, Xie, Hui, primary, Patel, Manishkumar, primary, Nie, Kai, primary, Harris, Jocelyn, primary, Argueta, Kimberly, primary, Lindsay, James, primary, Biswas, Roshni, primary, Van Nostrand, Stephen, primary, Kim-Schulze, Seunghee, primary, Gray, Jhanelle E., primary, Herbst, Roy S., primary, Wistuba, Ignacio I., primary, Gettinger, Scott, primary, Kelly, Karen, primary, Bazhenova, Lyudmila, primary, Gnjatic, Sacha, primary, Lee, J. Jack, primary, Zhang, Jianjun, primary, and Haymaker, Cara, primary

Published
2024
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33. Supplementary Figure 4 from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial

Author

Parra, Edwin Roger, primary, Zhang, Jiexin, primary, Duose, Dzifa Yawa, primary, Gonzalez-Kozlova, Edgar, primary, Redman, Mary W., primary, Chen, Hong, primary, Manyam, Ganiraju C., primary, Kumar, Gayatri, primary, Zhang, Jianhua, primary, Song, Xingzhi, primary, Lazcano, Rossana, primary, Marques-Piubelli, Mario L., primary, Laberiano-Fernandez, Caddie, primary, Rojas, Frank, primary, Zhang, Baili, primary, Taing, Len, primary, Jhaveri, Aashna, primary, Geisberg, Jacob, primary, Altreuter, Jennifer, primary, Michor, Franziska, primary, Provencher, James, primary, Yu, Joyce, primary, Cerami, Ethan, primary, Moravec, Radim, primary, Kannan, Kasthuri, primary, Luthra, Rajyalakshmi, primary, Alatrash, Gheath, primary, Huang, Hsin-Hui, primary, Xie, Hui, primary, Patel, Manishkumar, primary, Nie, Kai, primary, Harris, Jocelyn, primary, Argueta, Kimberly, primary, Lindsay, James, primary, Biswas, Roshni, primary, Van Nostrand, Stephen, primary, Kim-Schulze, Seunghee, primary, Gray, Jhanelle E., primary, Herbst, Roy S., primary, Wistuba, Ignacio I., primary, Gettinger, Scott, primary, Kelly, Karen, primary, Bazhenova, Lyudmila, primary, Gnjatic, Sacha, primary, Lee, J. Jack, primary, Zhang, Jianjun, primary, and Haymaker, Cara, primary

Published
2024
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34. Supplementary Table 5 from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial

Author

Parra, Edwin Roger, primary, Zhang, Jiexin, primary, Duose, Dzifa Yawa, primary, Gonzalez-Kozlova, Edgar, primary, Redman, Mary W., primary, Chen, Hong, primary, Manyam, Ganiraju C., primary, Kumar, Gayatri, primary, Zhang, Jianhua, primary, Song, Xingzhi, primary, Lazcano, Rossana, primary, Marques-Piubelli, Mario L., primary, Laberiano-Fernandez, Caddie, primary, Rojas, Frank, primary, Zhang, Baili, primary, Taing, Len, primary, Jhaveri, Aashna, primary, Geisberg, Jacob, primary, Altreuter, Jennifer, primary, Michor, Franziska, primary, Provencher, James, primary, Yu, Joyce, primary, Cerami, Ethan, primary, Moravec, Radim, primary, Kannan, Kasthuri, primary, Luthra, Rajyalakshmi, primary, Alatrash, Gheath, primary, Huang, Hsin-Hui, primary, Xie, Hui, primary, Patel, Manishkumar, primary, Nie, Kai, primary, Harris, Jocelyn, primary, Argueta, Kimberly, primary, Lindsay, James, primary, Biswas, Roshni, primary, Van Nostrand, Stephen, primary, Kim-Schulze, Seunghee, primary, Gray, Jhanelle E., primary, Herbst, Roy S., primary, Wistuba, Ignacio I., primary, Gettinger, Scott, primary, Kelly, Karen, primary, Bazhenova, Lyudmila, primary, Gnjatic, Sacha, primary, Lee, J. Jack, primary, Zhang, Jianjun, primary, and Haymaker, Cara, primary

Published
2024
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35. Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform

Author

Jin, Yimei, primary, Miyama, Takahiko, additional, Brown, Alexandria, additional, Hayase, Tomo, additional, Song, Xingzhi, additional, Singh, Anand K., additional, Huang, Licai, additional, Flores, Ivonne I., additional, McDaniel, Lauren K., additional, Glover, Israel, additional, Halsey, Taylor M., additional, Prasad, Rishika, additional, Chapa, Valerie, additional, Ahmed, Saira, additional, Zhang, Jianhua, additional, Rai, Kunal, additional, Peterson, Christine B., additional, Lizee, Gregory, additional, Karmouch, Jennifer, additional, Hayase, Eiko, additional, Molldrem, Jeffrey J., additional, Chang, Chia-Chi, additional, Tsai, Wen-Bin, additional, and Jenq, Robert R., additional

Published
2024
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36. Supplementary File 1 from Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Author

Awad, Dominik, primary, Cao, Pham Hong Anh, primary, Pulliam, Thomas L., primary, Spradlin, Meredith, primary, Subramani, Elavarasan, primary, Tellman, Tristen V., primary, Ribeiro, Caroline F., primary, Muzzioli, Riccardo, primary, Jewell, Brittany E., primary, Pakula, Hubert, primary, Ackroyd, Jeffrey J., primary, Murray, Mollianne M., primary, Han, Jenny J., primary, Leng, Mei, primary, Jain, Antrix, primary, Piyarathna, Badrajee, primary, Liu, Jingjing, primary, Song, Xingzhi, primary, Zhang, Jianhua, primary, Klekers, Albert R., primary, Drake, Justin M., primary, Ittmann, Michael M., primary, Coarfa, Cristian, primary, Piwnica-Worms, David, primary, Farach-Carson, Mary C., primary, Loda, Massimo, primary, Eberlin, Livia S., primary, and Frigo, Daniel E., primary

Published
2024
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37. Supplementary Figures S1-S28 from Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Author

Awad, Dominik, primary, Cao, Pham Hong Anh, primary, Pulliam, Thomas L., primary, Spradlin, Meredith, primary, Subramani, Elavarasan, primary, Tellman, Tristen V., primary, Ribeiro, Caroline F., primary, Muzzioli, Riccardo, primary, Jewell, Brittany E., primary, Pakula, Hubert, primary, Ackroyd, Jeffrey J., primary, Murray, Mollianne M., primary, Han, Jenny J., primary, Leng, Mei, primary, Jain, Antrix, primary, Piyarathna, Badrajee, primary, Liu, Jingjing, primary, Song, Xingzhi, primary, Zhang, Jianhua, primary, Klekers, Albert R., primary, Drake, Justin M., primary, Ittmann, Michael M., primary, Coarfa, Cristian, primary, Piwnica-Worms, David, primary, Farach-Carson, Mary C., primary, Loda, Massimo, primary, Eberlin, Livia S., primary, and Frigo, Daniel E., primary

Published
2024
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38. Data from Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Author

Awad, Dominik, primary, Cao, Pham Hong Anh, primary, Pulliam, Thomas L., primary, Spradlin, Meredith, primary, Subramani, Elavarasan, primary, Tellman, Tristen V., primary, Ribeiro, Caroline F., primary, Muzzioli, Riccardo, primary, Jewell, Brittany E., primary, Pakula, Hubert, primary, Ackroyd, Jeffrey J., primary, Murray, Mollianne M., primary, Han, Jenny J., primary, Leng, Mei, primary, Jain, Antrix, primary, Piyarathna, Badrajee, primary, Liu, Jingjing, primary, Song, Xingzhi, primary, Zhang, Jianhua, primary, Klekers, Albert R., primary, Drake, Justin M., primary, Ittmann, Michael M., primary, Coarfa, Cristian, primary, Piwnica-Worms, David, primary, Farach-Carson, Mary C., primary, Loda, Massimo, primary, Eberlin, Livia S., primary, and Frigo, Daniel E., primary

Published
2024
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39. Supplementary Tables 1-8 from Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Author

Awad, Dominik, primary, Cao, Pham Hong Anh, primary, Pulliam, Thomas L., primary, Spradlin, Meredith, primary, Subramani, Elavarasan, primary, Tellman, Tristen V., primary, Ribeiro, Caroline F., primary, Muzzioli, Riccardo, primary, Jewell, Brittany E., primary, Pakula, Hubert, primary, Ackroyd, Jeffrey J., primary, Murray, Mollianne M., primary, Han, Jenny J., primary, Leng, Mei, primary, Jain, Antrix, primary, Piyarathna, Badrajee, primary, Liu, Jingjing, primary, Song, Xingzhi, primary, Zhang, Jianhua, primary, Klekers, Albert R., primary, Drake, Justin M., primary, Ittmann, Michael M., primary, Coarfa, Cristian, primary, Piwnica-Worms, David, primary, Farach-Carson, Mary C., primary, Loda, Massimo, primary, Eberlin, Livia S., primary, and Frigo, Daniel E., primary

Published
2024
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40. Supplementary File 2 from Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Author

Awad, Dominik, primary, Cao, Pham Hong Anh, primary, Pulliam, Thomas L., primary, Spradlin, Meredith, primary, Subramani, Elavarasan, primary, Tellman, Tristen V., primary, Ribeiro, Caroline F., primary, Muzzioli, Riccardo, primary, Jewell, Brittany E., primary, Pakula, Hubert, primary, Ackroyd, Jeffrey J., primary, Murray, Mollianne M., primary, Han, Jenny J., primary, Leng, Mei, primary, Jain, Antrix, primary, Piyarathna, Badrajee, primary, Liu, Jingjing, primary, Song, Xingzhi, primary, Zhang, Jianhua, primary, Klekers, Albert R., primary, Drake, Justin M., primary, Ittmann, Michael M., primary, Coarfa, Cristian, primary, Piwnica-Worms, David, primary, Farach-Carson, Mary C., primary, Loda, Massimo, primary, Eberlin, Livia S., primary, and Frigo, Daniel E., primary

Published
2024
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41. Intratumoral Microbiome of Adenoid Cystic Carcinomas and Comparison with Other Head and Neck Cancers

Author

Karpinets, Tatiana V., primary, Mitani, Yoshitsugu, additional, Chang, Chia-Chi, additional, Wu, Xiaogang, additional, Song, Xingzhi, additional, Flores, Ivonne I, additional, McDaniel, Lauren K, additional, Hoballah, Yasmine M, additional, Veguilla, Fabiana J, additional, Ferrarotto, Renata, additional, Colbert, Lauren E, additional, Ajami, Nadim J, additional, Jenq, Robert R, additional, Zhang, Jianhua, additional, Futreal, Andrew P, additional, and El-Naggar, Adel K., additional

Published
2024
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42. Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma

Author

Wang, Ruiping, Dang, Minghao, Harada, Kazuto, Han, Guangchun, Wang, Fang, Pool Pizzi, Melissa, Zhao, Meina, Tatlonghari, Ghia, Zhang, Shaojun, Hao, Dapeng, Lu, Yang, Zhao, Shuangtao, Badgwell, Brian D., Murphy, Mariela Blum, Shanbhag, Namita, Estrella, Jeannelyn S., Roy-Chowdhuri, Sinchita, Abdelhakeem, Ahmed Adel Fouad, Wang, Yuanxin, Peng, Guang, Hanash, Samir, Calin, George A., Song, Xingzhi, Chu, Yanshuo, Zhang, Jianhua, Li, Mingyao, Chen, Ken, Lazar, Alexander J., Futreal, Andrew, Song, Shumei, Ajani, Jaffer A., and Wang, Linghua

Subjects
Adenocarcinoma -- Prognosis -- Genetic aspects -- Patient outcomes, Metastasis -- Prognosis -- Genetic aspects -- Patient outcomes, Stomach cancer -- Prognosis -- Genetic aspects -- Patient outcomes, Biological sciences, Health
Abstract

Intratumoral heterogeneity (ITH) is a fundamental property of cancer; however, the origins of ITH remain poorly understood. We performed single-cell transcriptome profiling of peritoneal carcinomatosis (PC) from 15 patients with gastric adenocarcinoma (GAC), constructed a map of 45,048 PC cells, profiled the transcriptome states of tumor cell populations, incisively explored ITH of malignant PC cells and identified significant correlates with patient survival. The links between tumor cell lineage/state compositions and ITH were illustrated at transcriptomic, genotypic, molecular and phenotypic levels. We uncovered the diversity in tumor cell lineage/state compositions in PC specimens and defined it as a key contributor to ITH. Single-cell analysis of ITH classified PC specimens into two subtypes that were prognostically independent of clinical variables, and a 12-gene prognostic signature was derived and validated in multiple large-scale GAC cohorts. The prognostic signature appears fundamental to GAC carcinogenesis and progression and could be practical for patient stratification. Single-cell analysis of gastric cancer samples tracks the cell of origin of metastatic lesions and identifies an independent prognostic signature of the clinical outcome., Author(s): Ruiping Wang [sup.1] , Minghao Dang [sup.1] , Kazuto Harada [sup.2] [sup.12] , Guangchun Han [sup.1] , Fang Wang [sup.3] , Melissa Pool Pizzi [sup.2] , Meina Zhao [sup.2] [...]

Published
2021
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43. Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer

Author

Lee, Sanghoon, Zhao, Li, Rojas, Christine, Bateman, Nicholas W., Yao, Hui, Lara, Olivia D., Celestino, Joseph, Morgan, Margaret B., Nguyen, Tri V., Conrads, Kelly A., Rangel, Kelly M., Dood, Robert L., Hajek, Richard A., Fawcett, Gloria L., Chu, Randy A., Wilson, Katlin, Loffredo, Jeremy L., Viollet, Coralie, Jazaeri, Amir A., Dalgard, Clifton L., Mao, Xizeng, Song, Xingzhi, Zhou, Ming, Hood, Brian L., Banskota, Nirad, Wilkerson, Matthew D., Te, Jerez, Soltis, Anthony R., Roman, Kristin, Dunn, Andrew, Cordover, David, Eterovic, Agda Karina, Liu, Jinsong, Burks, Jared K., Baggerly, Keith A., Fleming, Nicole D., Lu, Karen H., Westin, Shannon N., Coleman, Robert L., Mills, Gordon B., Casablanca, Yovanni, Zhang, Jianhua, Conrads, Thomas P., Maxwell, George L., Futreal, P. Andrew, and Sood, Anil K.

Published
2020
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44. Abstract A029: DDR pathway genes in CRT resistance: Insights from longitudinal whole exome sequencing in cervical cancer

Author

Ehsan, Shafqat F., primary, Wang, Rui, additional, Wu, Xiaogang, additional, Karpinets, Tatiana V., additional, Bronk, Julianna K., additional, Kapadia, Chiraag, additional, Song, Xingzhi, additional, Futreal, Andrew M., additional, Klopp, Ann H., additional, Harris, Tim, additional, Zhang, Jianhua, additional, and Colbert, Lauren E., additional

Published
2024
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45. Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma

Author

Zhang, Shaojun, Jiang, Vivian Changying, Han, Guangchun, Hao, Dapeng, Lian, Junwei, Liu, Yang, Cai, Qingsong, Zhang, Rongjia, McIntosh, Joseph, Wang, Ruiping, Dang, Minghao, Dai, Enyu, Wang, Yuanxin, Santos, David, Badillo, Maria, Leeming, Angela, Chen, Zhihong, Hartig, Kimberly, Bigcal, John, Zhou, Jia, Kanagal-Shamanna, Rashmi, Ok, Chi Young, Lee, Hun, Steiner, Raphael E., Zhang, Jianhua, Song, Xingzhi, Nair, Ranjit, Ahmed, Sairah, Rodriquez, Alma, Thirumurthi, Selvi, Jain, Preetesh, Wagner-Bartak, Nicolaus, Hill, Holly, Nomie, Krystle, Flowers, Christopher, Futreal, Andrew, Wang, Linghua, and Wang, Michael

Published
2021
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46. Author Correction: Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma

Author

Hu, Xin, Fujimoto, Junya, Ying, Lisha, Fukuoka, Junya, Ashizawa, Kazuto, Sun, Wenyong, Reuben, Alexandre, Chow, Chi-Wan, McGranahan, Nicholas, Chen, Runzhe, Hu, Jinlin, Godoy, Myrna C., Tabata, Kazuhiro, Kuroda, Kishio, Shi, Lei, Li, Jun, Behrens, Carmen, Parra, Edwin Roger, Little, Latasha D., Gumbs, Curtis, Mao, Xizeng, Song, Xingzhi, Tippen, Samantha, Thornton, Rebecca L., Kadara, Humam, Scheet, Paul, Roarty, Emily, Ostrin, Edwin Justin, Wang, Xu, Carter, Brett W., Antonoff, Mara B., Zhang, Jianhua, Vaporciyan, Ara A., Pass, Harvey, Swisher, Stephen G., Heymach, John V., Lee, J. Jack, Wistuba, Ignacio I., Hong, Waun Ki, Futreal, P. Andrew, Su, Dan, and Zhang, Jianjun

Published
2021
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47. Author Correction: Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics

Author

Morita, Kiyomi, Wang, Feng, Jahn, Katharina, Hu, Tianyuan, Tanaka, Tomoyuki, Sasaki, Yuya, Kuipers, Jack, Loghavi, Sanam, Wang, Sa A., Yan, Yuanqing, Furudate, Ken, Matthews, Jairo, Little, Latasha, Gumbs, Curtis, Zhang, Jianhua, Song, Xingzhi, Thompson, Erika, Patel, Keyur P., Bueso-Ramos, Carlos E., DiNardo, Courtney D., Ravandi, Farhad, Jabbour, Elias, Andreeff, Michael, Cortes, Jorge, Bhalla, Kapil, Garcia-Manero, Guillermo, Kantarjian, Hagop, Konopleva, Marina, Nakada, Daisuke, Navin, Nicholas, Beerenwinkel, Niko, Futreal, P. Andrew, and Takahashi, Koichi

Published
2021
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48. Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer

Author

Chen, Ming, Chen, Runzhe, Jin, Ying, Li, Jun, Hu, Xin, Zhang, Jiexin, Fujimoto, Junya, Hubert, Shawna M., Gay, Carl M., Zhu, Bo, Tian, Yanhua, McGranahan, Nicholas, Lee, Won-Chul, George, Julie, Hu, Xiao, Chen, Yamei, Wu, Meijuan, Behrens, Carmen, Chow, Chi-Wan, Pham, Hoa H. N., Fukuoka, Junya, Wu, Jia, Parra, Edwin Roger, Little, Latasha D., Gumbs, Curtis, Song, Xingzhi, Wu, Chang-Jiun, Diao, Lixia, Wang, Qi, Cardnell, Robert, Zhang, Jianhua, Wang, Jing, Le, Xiuning, Gibbons, Don L., Heymach, John V., Jack Lee, J., William, Jr, William N., Cheng, Chao, Glisson, Bonnie, Wistuba, Ignacio, Andrew Futreal, P., Thomas, Roman K., Reuben, Alexandre, Byers, Lauren A., and Zhang, Jianjun

Published
2021
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49. Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia

Author

Wang, Feng, Morita, Kiyomi, DiNardo, Courtney D., Furudate, Ken, Tanaka, Tomoyuki, Yan, Yuanqing, Patel, Keyur P., MacBeth, Kyle J., Wu, Bin, Liu, Guowen, Frattini, Mark, Matthews, Jairo A., Little, Latasha D., Gumbs, Curtis, Song, Xingzhi, Zhang, Jianhua, Thompson, Erika J., Kadia, Tapan M., Garcia-Manero, Guillermo, Jabbour, Elias, Ravandi, Farhad, Bhalla, Kapil N., Konopleva, Marina, Kantarjian, Hagop M., Andrew Futreal, P., and Takahashi, Koichi

Published
2021
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50. The histologic phenotype of lung cancers is associated with transcriptomic features rather than genomic characteristics

Author

Tang, Ming, Abbas, Hussein A., Negrao, Marcelo V., Ramineni, Maheshwari, Hu, Xin, Hubert, Shawna Marie, Fujimoto, Junya, Reuben, Alexandre, Varghese, Susan, Zhang, Jianhua, Li, Jun, Chow, Chi-Wan, Mao, Xizeng, Song, Xingzhi, Lee, Won-Chul, Wu, Jia, Little, Latasha, Gumbs, Curtis, Behrens, Carmen, Moran, Cesar, Weissferdt, Annikka, Lee, J. Jack, Sepesi, Boris, Swisher, Stephen, Cheng, Chao, Kurie, Jonathan, Gibbons, Don, Heymach, John V., Wistuba, Ignacio I., Futreal, P. Andrew, Kalhor, Neda, and Zhang, Jianjun

Published
2021
Full Text
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