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13 results on '"Song, Yan‐Nan"'

6. CARsomes inhibit airway allergic inflammation in mice by inducing antigen‐specific Th2 cell apoptosis

Author

Zhang, Huan‐Ping, primary, Sun, Ying‐Xue, additional, Lin, Zhi, additional, Yang, Gui, additional, Liu, Jiang‐Qi, additional, Mo, Li‐Hua, additional, Geng, Xiao‐Rui, additional, Song, Yan‐Nan, additional, Zeng, Hao‐Tao, additional, Zhao, Miao, additional, Li, Guo‐Shun, additional, Liu, Zhi‐Gang, additional, and Yang, Ping‐Chang, additional

Published
2020
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9. Restoration of immune suppressor function of regulatory B cells collected from patients with allergic rhinitis with Chinese medical formula Yupingfeng San

Author

Zhou, Cai-Jie, Mae, Fei, Liao, Wen-Jing, Song, Li-Juan, Yu, Dian, Song, Yan-Nan, TianYong Hu, Liu, Zhi-Qiang, Liu, Zhi-Gang, Zhang, Xiao-Wen, and Yang, Ping-Chang

Subjects
bacteria, chemical and pharmacologic phenomena, Original Article, biochemical phenomena, metabolism, and nutrition
Abstract

Immune dysregulation, such as defects in immune suppressor function, plays an important role in the pathogenesis of many immune disorders including allergic rhinitis (AR). Some Chinese traditional medical formulae have an immune regulatory function. This study aims to restore the immune suppressor function in regulatory B cells (Bregs) collected from AR patients with a Chinese medical formula, Yupingfeng San (YPFS). In this study, Bregs were isolated from blood samples collected from AR patients and healthy (HA) subjects. The capacity of Breg in suppressing effector T cell (Teff) proliferation was observed in an in vitro experiment to be used as an indicator of immune suppressor function of Breg. The effects of YPFS on promoting Bregs' immune suppressor functions were tested in a cell culture study. The results showed that the number of peripheral Breg in AR patients was not significantly different from that in HA subjects, while the immune suppressor function of AR Breg was compromised. Bcl2L12 expression was higher in AR Bregs than that in HA Bregs. A negative correlation was identified between expression of Bcl2L12 and IL-10 in AR Bregs. Exposure of AR Bregs to YPFS in the culture suppressed the expression of Bcl2L12 and improved their immune suppressor function. In conclusion, YPFS can restore the immune suppressor function of AR Bregs via inhibiting the expression of Bcl2L12. The data suggest that YPFS has the potential to be used in the improvement of immune dysfunction, such as AR.

Published
2019

10. Probiotic extracts ameliorate nasal allergy by inducing interleukin‐35‒producing dendritic cells in mice

Author

Xue, Jin‐Mei, primary, Ma, Fei, additional, An, Yun‐Fang, additional, Suo, Li‐Min, additional, Geng, Xiao‐Rui, additional, Song, Yan‐Nan, additional, Mo, Li‐Hua, additional, Luo, Xiang‐Qian, additional, Zhang, Xiao‐Wen, additional, liu, Da‐Bo, additional, Zhao, Chang‐Qing, additional, and Yang, Ping‐Chang, additional

Published
2019
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13. Restoration of immune suppressor function of regulatory B cells collected from patients with allergic rhinitis with Chinese medical formula Yupingfeng San.

Author

Zhou CJ, Ma F, Liao WJ, Song LJ, Yu D, Song YN, Hu TY, Liu ZQ, Liu ZG, Zhang XW, and Yang PC

Abstract

Immune dysregulation, such as defects in immune suppressor function, plays an important role in the pathogenesis of many immune disorders including allergic rhinitis (AR). Some Chinese traditional medical formulae have an immune regulatory function. This study aims to restore the immune suppressor function in regulatory B cells (Bregs) collected from AR patients with a Chinese medical formula, Yupingfeng San (YPFS). In this study, Bregs were isolated from blood samples collected from AR patients and healthy (HA) subjects. The capacity of Breg in suppressing effector T cell (Teff) proliferation was observed in an in vitro experiment to be used as an indicator of immune suppressor function of Breg. The effects of YPFS on promoting Bregs' immune suppressor functions were tested in a cell culture study. The results showed that the number of peripheral Breg in AR patients was not significantly different from that in HA subjects, while the immune suppressor function of AR Breg was compromised. Bcl2L12 expression was higher in AR Bregs than that in HA Bregs. A negative correlation was identified between expression of Bcl2L12 and IL-10 in AR Bregs. Exposure of AR Bregs to YPFS in the culture suppressed the expression of Bcl2L12 and improved their immune suppressor function. In conclusion, YPFS can restore the immune suppressor function of AR Bregs via inhibiting the expression of Bcl2L12. The data suggest that YPFS has the potential to be used in the improvement of immune dysfunction, such as AR., Competing Interests: None.

Published
2019

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