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One of the main challenges in molecular science is to model a chemical complex and predict its thermochemical properties. Various researchers have developed a number of hypothetical techniques in this regard, and one of them is focused on the topological indices. A topological index is a number associated with a molecule's structural graph that is considered to be capable of predicting certain chemical and physical properties of molecules. Degree-based topological indices are one of the groups of topological indices that are crucial in chemical graph theory. Shannon's entropy is a fundamental factor of a subclass of topological indices that measures the structural information of the graphs. In this study, we examine the entropy based on topological indices such as the first and second Zagreb indices, the general Randić index, the harmonic and sum-connectivity index of Hanoi graph. Moreover, we determine a number of multiplicative invariants, and different polynomials for Hanoi graphs with graphical illustrations. [ABSTRACT FROM AUTHOR]

In China, achieving sustainable development goals for PPP projects is an urgent issue. Project governance mechanisms are important to PPP project sustainability, but there are many risk factors in traditional project governance mechanisms. This research focuses on embedding risk governance mechanisms into the traditional project governance system with contract governance mechanisms and relationship governance mechanisms. The main purpose is to reveal the integration of PPP project governance mechanisms and its impact on governance performance and project sustainability, and to propose governance optimization strategies. First, by enriching the understanding of the governance mechanism, governance performance and project sustainability, and improving the measurement scale. Then, by constructing a structural equation model, collecting data through questionnaires, and exploring the effect of the project governance mechanism on project sustainability. (1) The results of direct effect testing show that contractual governance mechanisms, relational governance mechanisms and risk governance mechanisms are positively associated with governance performance, and governance performance is positively associated with project sustainability; (2) the results of mediating effect testing show that interaction of the three governance mechanisms has a positive effect on governance performance. The research results provide a new approach and perspectives for improving project governance mechanisms and achieving sustainable development in the practice of PPP projects. [ABSTRACT FROM AUTHOR]

This article was designed by using a network pharmacological approach to reveal the therapeutic targets and molecular mechanisms of oxyresveratrol (Oxyres) treating colorectal cancer (CRC). Furthermore, several bioinformatic findings would be validated. Pathogenetic targets of CRC and pharmacological targets of Oxyres were identified by web‐available databases. All identifiable biotargets were collected for functional enrichment analyses to reveal the biological processes and signaling pathways of Oxyres treating CRC. In addition, human CRC, non‐CRC samples, and cell line study were used to validate the predictive biotargets of Oxyres treating CRC. In network pharmacological analyses, top therapeutic targets of mitogen‐activated protein kinase 1 (MAPK1), insulin growth factor 1 (IGF1), hematopoietic prostaglandin D synthase (HPGDS), GTPase HRas (HRAS), and cytochrome P450 2C9 (CYP2C9) in Oxyres treating CRC were identified, respectively. As shown in functional analysis, biological processes of Oxyres treating CRC were mainly involved in modulating cell communication, signal transduction, apoptosis, cell motility, cell proliferation, and lipid metabolism. Furthermore, top 10 signaling pathways of Oxyres treating CRC were identified, respectively. In human study, CRC samples resulted in increased neoplastic expressions of Ki‐67, MAPK1, IGF1, characterized with clinical imaging inspection, pathological diagnosis, and altered blood lipids in these CRC cases. In cell culture study, Oxyres‐dosed CRC cells exhibited reduced cell proliferation, promoted cellular apoptosis. Furthermore, significantly decreased proteins of intracellular Ki‐67, MAPK1, and IGF1 were observed in Oxyres‐dosed cells when compared to those in controls. Collectively, anti‐CRC pharmacological activity of Oxyres may be mainly associated with induction of apoptosis and suppression of cell proliferation as revealed in bioinformatic findings. In addition, all core biotargets and molecular mechanisms of Oxyres treating CRC are unveiled respectively. Interestingly, the identifiable MAPK1, IGF1 biotargets may be potential molecules for treating and screening CRC. [ABSTRACT FROM AUTHOR]

Herein, for the first time, we present a novel solution method for controllable synthesis of the overlooked cubic phase Cu 2 GeTe 3 nanocrystals. The resulting Cu 2 GeTe 3 nanocrystals are of high quality with monodispersed size and uniform shape. Optical characterization demonstrates that Cu 2 GeTe 3 nanocrystals have a broad absorption in the visible to near-infrared region. Furthermore, an optoelectronic device based on Cu 2 GeTe 3 nanocrystals exhibits excellent stability, reproducibility and responsivity. The novel synthetic route presented here not only can open a new avenue for fabricating Cu 2 GeTe 3 nanocrystals, especially at the nanoscale, but also may further expand their applications.

We previously demonstrated that human platelets activated with SFLLRN release PAR-1 activation peptide, PAR-1-(1-41), even in the presence of hirudin. This observation suggests that during their activation, platelets generate a protease that activates PAR-1. In this study, PAR-1 and -4 activation peptides were detected 10 s after