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Analytic solutions are derived for the problem of scattering of obliquely incident plane waves from a rectangular crack in a fluid-saturated porous solid. The propagation direction and polarization direction of the incident waves can be arbitrary. The solutions are based on expanding the crack opening displacements in terms of Chebyshev functions. Explicit expressions for the frequency-dependent stress intensity factors and scattering far fields are obtained. The poroelastic effects play a key role in determining the crack opening mode by changing the effective normal stress applied on the crack surfaces. Consequently, the dynamic responses of the crack can be quite different from those of conventional dry crack in an elastic solid. The effects of scattered slow-P waves as well as wave-induced crack fluid pressure on the dynamic stress intensity factors are clarified, and a corner effect is observed in the scattering patterns for moderately high frequencies. The comparisons of synthetic seismograms with the elastic model show the slow-P waves can cause significant energy loss and waveform change. This study can be used for fracture analysis of porous media and nondestructive testing for individual hydraulic fractures in reservoirs. [ABSTRACT FROM AUTHOR]

In the aftermath of a hurricane, humanitarian logistics plays a critical role in delivering relief items to the affected areas in a timely fashion. This paper proposes a novel stochastic look-ahead framework that implements a two-stage stochastic programming model in a rolling horizon approach to address the evolving uncertain logistics system state during the post-hurricane humanitarian logistics operations. The two-stage stochastic programming model that executes in this rolling horizon approach is formulated as a mixed-integer programming problem. The model aims to minimize the total cost incurred in the logistics operations, which consist of transportation cost and social cost. The social cost is measured as a function of deprivation for unsatisfied demand. Our extensive numerical results and sensitivity analysis demonstrate the effectiveness of the proposed approach in reducing the total cost incurred during the post-hurricane relief logistics operations compared to the two-stage stochastic programming model implemented in a static fashion. [ABSTRACT FROM AUTHOR]

Crack problems are often reduced to dual integral equations, which can be solved by expanding the displacement integral equation as a series in the form of Chebyshev-like or Jacobi polynomials. Schmidt's multiplying-factor integration method has been one of the most favorable techniques for determining the expansion coefficients by constructing a well-posed system of linear algebraic equations. However, Schmidt's method is less efficient for numerical computation because the matrix elements of the linear equations are evaluated from dual integrals. In this study, we propose a modified method to construct linear equations to efficiently determine the expansion coefficients. The modified technique is developed upon the application of certain multiplying factors to the traction integral equation and then integrating the resulting equation over "source" regions. Such manipulations simplify the matrix elements as single integrals. By carrying out numerical examples, we demonstrate that the technique is not only accurate but also very efficient. In particular, the method only needs approximately 1/5 of the computation time of Schmidt's method. Therefore, this method can be used to replace Schmidt's method and is expected to be very useful in solving crack problems. [ABSTRACT FROM AUTHOR]

In this paper, we consider service applications where drivers serve subscription customers at their homes on a regular basis and at known times. To build trust with customers, the company requires that subscription customers are consistently served by the same driver. In addition to subscription customers, on-demand customers request delivery on a daily basis. For the company, the challenge is to consistently serve the subscription customers while simultaneously maximizing the daily profit from the on-demand customers. We model the problem as a two-stage stochastic decision problem. The first stage determines the assignment of drivers to subscription customers. The second stage is a team-orienteering problem with time windows and mandatory visits by fixed drivers. We present an anticipatory consistent customer assignment policy (ACCA) based on the multiple scenario approach framework. Our computational study shows that ACCA significantly outperforms consistency concepts from the literature, while increasing costs less than 5%. [ABSTRACT FROM AUTHOR]

Understanding the wave propagation in fluid-saturated cracked rocks is important for detecting and characterizing cracked reservoirs and fault zones with applications in geomechanics, hydrogeology, exploration geophysics and reservoir engineering. In sedimentary rocks, microscopic-scale pores are usually filled with fluid. One logical means of modelling the essential features of such rocks is to use poroelasticity theory. But previous models of wave propagation in cracked porous medium are either restricted to low frequencies at which effects of the elastic scattering (scattering into fast- P and S waves via mode conversion at the crack faces) are negligible or to the case that the crack-filling fluid is assumed to be incompressible. To overcome these restrictions, we consider the effects of crack fluid compressibility by extending spring condition into poroelasticity and derive exact solutions of the scattering problem of an incident P wave by a circular crack containing compressible fluid in a porous medium. Based on the solutions, we develop two different effective medium models to estimate frequency-dependent effective velocity and attenuation in a fluid-saturated porous rock with a set of aligned cracks. The mixed-boundary value problem reveals that both the wave-induced fluid flow (WIFF) and elastic wave scattering can cause important velocity dispersion and attenuation. The diffusion-type WIFF dominates the velocity change and attenuation for the low frequency range, while the elastic scattering dominates them for the relatively higher frequency range. The dependences of the P -wave velocity on the crack fluid compressibility are different at different frequencies. For the WIFF-dominated frequency range and Rayleigh-scattering frequency range, the P -wave velocity decreases with the crack fluid compressibility. In contrast, for the Mie scattering frequency range, the opposite occurs (the P -wave velocity increases with the crack fluid compressibility). [ABSTRACT FROM AUTHOR]

In this paper, we propose partition-based decomposition algorithms for solving two-stage stochastic integer program with continuous recourse. The partition-based decomposition method enhance the classical decomposition methods (such as Benders decomposition) by utilizing the inexact cuts (coarse cuts) induced by a scenario partition. Coarse cut generation can be much less expensive than the standard Benders cuts, when the partition size is relatively small compared to the total number of scenarios. We conduct an extensive computational study to illustrate the advantage of the proposed partition-based decomposition algorithms compared with the state-of-the-art approaches. [ABSTRACT FROM AUTHOR]

Hydraulic fractures and preexisting cracks in natural aquifers and hydrocarbon reservoirs are often saturated with fluids. Understanding the elastic wave properties in such a cracked fluid-saturated medium is of importance for many physical and engineering applications such as hydrology, petroleum engineering, oil exploration, induced seismicity, and nuclear waste disposal. In this paper, the scattering of a normally incident longitudinal (P-) wave by a fluid-saturated circular crack in an infinite elastic non-porous matrix is studied. In particular, the mechanism of hydraulic conduction (including the effects of the crack permeability and fluid inertia) inside the crack is incorporated. A semi-analytic solution for this scattering problem is derived. Based on the solution and multiple scattering theorem, an effective medium model is developed to determine the velocity dispersion and attenuation due to wave scattering in an elastic matrix with sparse distribution of aligned cracks. It is shown that the effective P-wave velocity is consistent with Gassmann's theory in the low-frequency limit. The effect of crack permeability on scattering is negligible, but the effect of fluid inertia is important. Specifically, it is found that resonance phenomena can take place inside the cracks at frequencies much lower than the scattering characteristic frequency so that rapid velocity variation can occur at relatively low frequencies. The fluid viscosity plays a damping role in weakening the resonance. The effects of crack thickness and fluid compressibility on scattering dispersion are similar to those in the case of plane-strain (two-dimensional) slit crack. [ABSTRACT FROM AUTHOR]

Humana, a large health care company, has set a goal of 20% improvement in health in the communities it serves by 2020. The metric chosen for the Bold Goal initiative was the HRQOL-4 version of the Centers for Disease Control and Prevention (CDC) Healthy Days survey. This paper presents the methods for measuring progress, reports results for the first year of tracking, and describes Humana's community-based interventions. Across 7 specially designated “Bold Goal” communities, mean unhealthy days declined from 10.98 in 2015 to 10.64 in 2016, which represented a 3.1% relative, or 0.34 absolute, decline. This compares with a 0.17 absolute unhealthy days decline in Humana's national population overall. The paper also describes how additional work identifying associations between social determinants of health (SDOH) and Healthy Days is influencing Humana's strategy. Lastly, a strategy of community engagement is illustrated through 2 case examples: San Antonio and Knoxville. In the San Antonio area, the community in which Humana has been involved the longest, unhealthy days dropped by 9.0% (−0.95 absolute) from a mean 10.52 to 9.57 unhealthy days. In Knoxville, one of the newer areas of engagement, mean unhealthy days declined by 4.8% (−0.61 absolute), representing declines in both physically and mentally unhealthy days. Overall, results are encouraging, and Humana expects declines to accelerate over time as initiatives are launched and scaled in Bold Goal communities. [ABSTRACT FROM AUTHOR]

A mathematical formulation is presented for the dynamic stress intensity factor (mode I) of a permeable penny-shaped crack subjected to a time-harmonic propagating longitudinal wave in an infinite poroelastic solid. In particular, the effect of the wave-induced fluid flow on the dynamic stress intensity factor is analyzed. The Hankel integral transform technique in conjunction with Helmholtz potential theory is used to formulate the mixed boundary-value problem as dual integral equations in the frequency domain. Using appropriate transforms, the dual integral equations can be reduced to a Fredholm integral equation of the second kind. The phenomenon of fluid flow along the crack surface has significant influences upon the frequency-dependent behavior of the dynamic stress intensity factor. The stress intensity factor monotonically decreases with increasing frequency, declining the fastest when the crack radius and the slow wave wavelength are of the same order. Such near-field information is of particular importance in predicting the crack strength subjected to oscillating loads. The characteristic frequency at which the stress intensity factor decays the fastest shifts to higher frequency values when the crack radius decreases. [ABSTRACT FROM AUTHOR]

A mathematical formulation is presented for the dynamic stress intensity factor (mode I) of a finite permeable crack subjected to a time-harmonic propagating longitudinal wave in an infinite poroelastic solid. In particular, the effect of the wave-induced fluid flow due to the presence of a liquid-saturated crack on the dynamic stress intensity factor is analyzed. Fourier sine and cosine integral transforms in conjunction with Helmholtz potential theory are used to formulate the mixed boundary-value problem as dual integral equations in the frequency domain. The dual integral equations are reduced to a Fredholm integral equation of the second kind. It is found that the stress intensity factor monotonically decreases with increasing frequency, decreasing the fastest when the crack width and the slow wave wavelength are of the same order. The characteristic frequency at which the stress intensity factor decays the fastest shifts to higher frequency values when the crack width decreases. [ABSTRACT FROM AUTHOR]

An exact analytical solution is presented for the effective dynamic shear modulus in a heterogeneous fluid-filled poroelastic medium containing spherical inclusions. The complex and frequency-dependent properties of the derived shear modulus are solely caused by the physical mechanism of mesoscopic-scale wave-induced fluid flow whose scale is assumed to be smaller than wavelength but larger than the size of pores. Our model consists of three phases: a spherical inclusion, a shell of matrix material with different mechanical and/or hydraulic properties and an outer region of effective homogeneous medium of infinite extent. This three-phase model represents a self-consistent model or an approximate model of composite having periodically distributed inclusions. The behaviors of both the inclusion and the matrix are described by Biot's equations (1941) with standard conditions of Deresiewicz and Skalak (1963) at the inclusion-matrix interface. The effective medium is regarded as an equivalent elastic or viscoelastic material with complex and frequency-dependent moduli to be determined. The derived effective shear modulus is used to quantify the shear-wave attenuation and velocity dispersion. For the problem of fluid patchy saturation (inclusions with the same solid frame as the matrix but with a different pore fluid from that in the matrix), the gas pocket does not affect the shear attenuation and dispersion characteristic of the water-filled matrix medium at all. For the problem of double porosity structure (inclusions having a different solid frame than the matrix but the same pore fluid as the matrix), with the increase of frequency the heterogeneous medium transitions from a low-frequency state having drained inclusions and drained matrix with no pore pressure difference to a higher-frequency state having undrained inclusions and undrained matrix with no fluid communication at the inclusion's surface. The relaxation frequency at which the maximum value of inverse quality factor occurs moves to frequencies by two orders of magnitude lower if the size of a unit cell increases by one order of magnitude. Stiff inclusions imbedded in a relatively soft matrix can cause significant and observable attenuation at seismic frequency bands, but softer inclusions imbedded in a relatively stiff matrix cause very weak attenuation. The mixed heterogeneity in both the solid frame and pore fluid also has important influences on the frequency-dependent shear wave attenuation. [ABSTRACT FROM AUTHOR]

Human trafficking is a serious crime and violation of human rights that results in numerous harms. Although the phenomenon is not new, scholarship on the issue has grown substantially since the first legal framework was passed in 2000. However, the existing literature has been criticized for its skewed focus on victims, among other things. The dearth of information on traffickers and their operations limits our ability to reduce or prevent perpetration. The current study presents a comprehensive and critical review of the existing literature focused on traffickers to synthesize what is already known and highlight the key gaps. Twenty-nine articles met the inclusion criteria of (1) focusing on traffickers and their operations and (2) relying on data either directly from traffickers or sources that contained detailed information about criminal cases against traffickers. We used an iterative process to identify relevant studies, which included collecting articles of which we were already familiar or were identified in existing reviews, searching their reference lists, and conducting cited-by searches until saturation was reached. Topics found in the extant literature included: characteristics of traffickers, relationships between traffickers and victims, organizational characteristics and networks, operations, connections with other crimes, motivations, perceptions of behavior, and risks associated with trafficking. It concludes with recommendations for future research and a discussion of how bridging gaps in the literature could support more rigorous mathematical modeling that is needed to identify and assess promising perpetration prevention and intervention strategies. [ABSTRACT FROM AUTHOR]

• The exact solutions of wave scattering by a rectangular permeable crack in a fluid-saturated porous medium are derived. • The analytic solutions are used to develop an effective medium model for a porous medium with aligned cracks. • The effects of wave-induced fluid diffusion as well as crack geometry on seismic attenuation and dispersion are shown numerically. • New results are useful for extracting crack information from seismic frequency-dependent signatures with applications in exploration geophysics. It is well known that mesoscopic-scale wave-induced fluid flow (WIFF) between cracks and surrounding porous matrix is one of significant mechanisms in causing seismic dispersion and attenuation. Previous theoretical models that were used to interpret the interaction between cracks and passing waves assumed the cracks to be circular or slit-like. However, in many actual cases, the cracks can have a shape more close to a rectangle. In this paper, we develop an effective medium model to estimate the P-wave attenuation and velocity dispersion in a saturated porous rock containing a random distribution of permeable, aligned, rectangular cracks of infinitesimal thickness. This is done by combining the far-field displacement representation of the solution of a normally incident P wave scattered by a single crack and Foldy's scattering theorem. The effective low-frequency P-wave velocity predicted by the present model is asymptotically consistent with the Gassmann's theory. It is shown that thorough knowledge of the crack shape is important for understanding seismic signatures. Specifically, the WIFF relaxation frequency is mainly determined by the crack intermediate dimension, while it is insensitive to the crack largest dimension. Moreover, P-wave velocity of the rectangular crack model can be quite different from those of the circular crack model and the slit crack model, although the overall frequency-dependent trends of the velocities for different models are very similar. Analogously to the circular crack model and the slit crack model, at the normal incidence of a fast-P wave, the WIFF is found to dominate the wave attenuation and velocity dispersion. These results are helpful to estimate formation parameters from different frequency components of observed seismic data. [ABSTRACT FROM AUTHOR]

Wildfire occurrence and spread are affected by atmospheric and land-cover conditions, and therefore meteorological and land-cover parameters can be used in area burned prediction. We apply three forecast methods, a generalized linear model, regression trees, and neural networks (Levenberg–Marquardt backpropagation) to produce monthly wildfire predictions 1 year in advance. The models are trained using the Global Fire Emissions Database version 4 with small fires (GFEDv4s). Continuous 1-year monthly fire predictions from 2011 to 2015 are evaluated with GFEDs data for 10 major fire regions around the globe. The predictions by the neural network method are superior. The 1-year moving predictions have good prediction skills over these regions, especially over the tropics and the southern hemisphere. The temporal refined index of agreement (IOA) between predictions and GFEDv4s regional burned areas are 0.82, 0.82, 0.8, 0.75, and 0.56 for northern and southern Africa, South America, equatorial Asia and Australia, respectively. The spatial refined IOA for 5-year averaged monthly burned area range from 0.69 in low-fire months to 0.86 in high-fire months over South America, 0.3–0.93 over northern Africa, 0.69–0.93 over southern Africa, 0.47–0.85 over equatorial Asia, and 0.53–0.8 over Australia. For fire regions in the northern temperate and boreal regions, the temporal and spatial IOA between predictions and GFEDv4s data in fire seasons are 0.7–0.79 and 0.24–0.83, respectively. The predictions in high-fire months are better than low-fire months. This study illustrates the feasibility of global fire activity outlook forecasts using a neural network model and the method can be applied to quickly assess the potential effects of climate change on wildfires. [ABSTRACT FROM AUTHOR]

• The mode-I stress intensity factor (SIF) of a periodic array of collinear cracks in a porous medium is investigated. • This paper studies the case of fluid-saturated permeable cracks. • The interacting cracks and crack surficial permeability can significantly affect the magnitude and the frequency-dependent trend of the SIF. The dynamic (frequency-dependent) mode-I stress intensity factor (SIF) is obtained for a porous medium containing an array of equally distributed collinear cracks. Unlike previous work in which the cracks are assumed to be dry and impermeable, this paper studies the case that the crack is fluid-saturated and permeable. The cracks are under the action of a normal incidence of a time-harmonic plane longitudinal (P) wave. The interaction between the collinear cracks and the mechanism of wave-induced fluid flow (scattered slow P wave) can significantly affect the magnitude and frequency-dependent trend of the SIF, in particular at low frequencies. At low frequencies, the magnitude of the SIF increases monotonously with the decreasing distance between the adjacent cracks and can be much larger than that of a single crack, implying that the material strength can be greatly lowered by the interaction of cracks. However, at higher frequencies, the impacts of interacting cracks are negligible. The comparison with the counterpart of dry impermeable cracks reveals that the magnitude of SIF is lower than that of dry impermeable cracks owing to effective normal stress effect. Moreover, unlike the SIF of dry impermeable cracks for which a peak value is observed around elastic wave resonance frequency, the corresponding SIF of fluid-saturated permeable cracks monotonously decreases with the increasing frequency. This frequency-dependent trend is attributed to the conversion of incident energy into the slow P wave. The obtained results reveal significant influences of the presence of pore fluid and interaction of collinear cracks upon the SIF, both magnitudes and frequency-dependent trends. Such information is useful in predicting the fracture strength of saturated porous materials subjected to oscillating loads. [ABSTRACT FROM AUTHOR]

• Analytic solutions of the stress intensity factors (SIFs) of a fluid-saturated permeable crack in a poroelastic material subjected to a time-harmonic elastic wave have been derived. • Insights of effects of incident wave types, material permeability, incident angle and crack surficial permeability on the frequency-dependent behaviors of the SIFs have been obtained through numerical examples. • Because of the wave-induced fluid flow, the crack fluid can significantly change the effective normal stress so that the magnitude of mode-I SIF can be lower than that of a dry impermeable crack. In many practices, cracks are filled with fluid and their background materials can be modelled within the framework of poroelasticity. Understanding the crack-tip mechanical behaviors of such a cracked medium subjected to dynamic loads is of importance for prediction of fracture failure. In this paper, based on Biot's theory of poroelastodynamics, solutions of mode-I and mode-II dynamic stress intensity factors (SIFs) of a Griffith crack are derived for the scattering problem of oblique incidence of in-plane time-harmonic P-SV waves. The crack surfaces are assumed to be permeable, and the crack is saturated by fluid. With the aid of Fourier integral transforms, the problem is reduced to a system of coupled Fredholm integral equations with special emphasis placed on finding the near-field solution. Impacts of incident wave type, material permeability and incident angle on the frequency-dependent behaviors of the SIFs have been shown graphically. It is found that the induced fluid pressure inside the crack can significantly change the effective normal stress so that the magnitude of mode-I SIF is much lower than that of a dry impermeable crack. Furthermore, the diffusion-type fluid flow (scattered slow P wave) can greatly lower the magnitude of mode-I SIF at low frequencies (much smaller than the resonance frequency). The characteristic frequency at which the curves of SIFs decline strongest occurs when the characteristic diffusion length is of the same order of the crack size. The fluid flow can also lower mode-II SIF at low frequencies and the effects are strong in the low permeability case. Specifically, in the case of scattering of SV waves, it is shown that the maximum drop of mode-II SIF in peak with respect to that of the corresponding dry crack in an elastic medium is about 10%. The obtained results reveal significant influences of the presence of pore fluid upon the SIFs, both magnitudes and frequency-dependent trends. Such information is useful in predicting the fracture strength of saturated porous materials subjected to oscillating loads. [ABSTRACT FROM AUTHOR]

In this work, we study the optimal design of two-armed clinical trials to maximize the accuracy of parameter estimation in a statistical model, where the interaction between patient covariates and treatment are explicitly incorporated to enable precision medication decisions. Such a modeling extension leads to significant complexities for the produced optimization problems because they include optimization over design and covariates concurrently. We take a min-max optimization model and minimize (over design) the maximum (over population) variance of the estimated interaction effect between treatment and patient covariates. This results in a min-max bilevel mixed integer nonlinear programming problem, which is notably challenging to solve. To address this challenge, we introduce a surrogate optimization model by approximating the objective function, for which we propose two solution approaches. The first approach provides an exact solution based on reformulation and decomposition techniques. In the second approach, we provide a lower bound for the inner optimization problem and solve the outer optimization problem over the lower bound. We test our proposed algorithms with synthetic and real-world data sets and compare them with standard (re)randomization methods. Our numerical analysis suggests that the proposed approaches provide higher-quality solutions in terms of the variance of estimators and probability of correct selection. We also show the value of covariate information in precision medicine clinical trials by comparing our proposed approaches to an alternative optimal design approach that does not consider the interaction terms between covariates and treatment. Summary of Contribution: Precision medicine is the future of healthcare where treatment is prescribed based on each patient information. Designing precision medicine clinical trials, which are the cornerstone of precision medicine, is extremely challenging because sample size is limited and patient information may be multidimensional. This work proposes a novel approach to optimally estimate the treatment effect for each patient type in a two-armed clinical trial by reducing the largest variance of personalized treatment effect. We use several statistical and optimization techniques to produce efficient solution methodologies. Results have the potential to save countless lives by transforming the design and implementation of future clinical trials to ensure the right treatments for the right patients. Doing so will reduce patient risks and reduce costs in the healthcare system. [ABSTRACT FROM AUTHOR]

The Asian summer monsoon (ASM) affects more than one-third of the world's population due to its close connection with floods, droughts thus water resources in densely populated Asian countries. The effects of aerosols emitted in remote regions on the ASM, in contrast to local emissions, remain largely unclear. Here we demonstrate through a hierarchy of climate models that aerosol emissions from the central African wildfires could strengthen the circulation of the ASM (South Asian Monsoon in particular), increase precipitation over South Asia and reduce precipitation immediately north and south of it. The enhanced latent heating over South Asia provides a critical positive feedback to the initial strengthening of monsoon westerlies associated with wildfire-driven anomalous Rossby wave source. The atmospheric dynamical bridge discovered here effectively connects African biomass burning with hydroclimate variability over East Asia in boreal summer and offers a new source of monsoon predictability across a range of timescales. [ABSTRACT FROM AUTHOR]

Two critical yet frequently conflicting objectives for logistics and transportation service companies are improving customer satisfaction and reducing transportation cost. In particular, given a network of customer requests with preferred service times, it is very challenging to find vehicle routes and service schedules simultaneously that respect all operating constraints and minimize the total transportation and customers' inconvenience costs. In this paper, we introduce the vehicle routing problem with time windows and convex node costs (VRPTW-CNC), in which we model each customer's inconvenience cost as a convex function of the service start time at that customer. The VRPTW-CNC combines and extends both the standard vehicle routing problem with time windows and some previous results on the optimal service scheduling problem over a fixed route. We propose a branch-and-cut-and-price algorithm to solve the VRPTW-CNC with general convex inconvenience cost functions. To solve the pricing problem, our labeling algorithm only generates labels that possibly lead to optimal schedule times over a route, which significantly improves the effectiveness of pricing. Extensive computational results demonstrate the effectiveness of our approach. [ABSTRACT FROM AUTHOR]

In this study, we present a semi-analytical method to simulate the propagation of seismic waves in horizontally stratified double-porosity media. We solve the governing equations in the frequency–wavenumber domain and then compute the time–space domain solutions by Hankel and fast Fourier transforms. We conduct numerical simulations to study the properties of the seismic waves in the double-porosity media. The results show the existence of three P waves, one fast P wave and two slow P waves. The two slow P waves are highly attenuated and can be observed by assuming a low fluid viscosity. By comparing the fast P wave in a single-porosity medium and that in a double-porosity medium, we find that the double-porosity model predicts much higher attenuation of the fast P wave due to the local fluid flow between the background medium and the inclusions. We also study the parameters affecting the attenuation, such as the radius of the spherical inclusions, the viscosity of the pore fluid, the permeability of the background medium and the porosity of the inclusions. Finally, we present a cross-well survey model to investigate the seismic responses in the double-porosity media and compare them with the responses in the single-porosity media. We find that both the amplitude and velocity of the fast P wave decrease with the increase of the volume ratio of the inclusions. [ABSTRACT FROM AUTHOR]

Surgery scheduling is of critical importance, because an operating room (OR) is the major cost generating unit in the hospital. However, schedulers face tremendous challenges brought by case cancellation, which have been observed in most departments. On the other hand, the randomness of surgery duration also has a significant impact on an OR schedule. In this paper, we develop a stochastic integer programming model for multiple ORs that simultaneously considers the uncertainties of case cancellation and surgery duration. We aim at minimizing the costs from the perspectives of both health care providers and patients. The Benders decomposition is used to address the computational complexity. A series of experiments is conducted to show the effectiveness of the proposed model and solution approaches. A case study based on two departments at West China Hospital is carried out, where the total cost can be reduced by approximately 27%. A sensitivity analysis is conducted in the case study, from which we gain managerial insights. Note to Practitioners—The effectiveness and efficiency of operating room (OR) scheduling are highly valued by hospital practitioners, as the OR department is one of the most resource-intensive units in a hospital. The uncertainty of surgery duration and patient cancellation in OR scheduling brings a tremendous challenges to the decision makers. We propose a stochastic integer programming model by taking these uncertain factors into consideration. The proposed model significantly outperforms the current practice according to our case study. We also conduct a sensitivity analysis to obtain managerial insights. The value of stochastic solutions is calculated to show the importance of considering both the uncertain factors. [ABSTRACT FROM AUTHOR]

The pollution-routing problem (PRP) aims to determine a set of routes and speed over each leg of the routes simultaneously to minimize the total operational and environmental costs. A common approach to solve the PRP exactly is through speed discretization, i.e., assuming that speed over each arc is chosen from a prescribed set of values. In this paper, we keep speed as a continuous decision variable within an interval and propose new formulations for the PRP. In particular, we build two mixed-integer convex optimization models for the PRP, by employing tools from disjunctive convex programming. These are the first arc-based formulations for the PRP with continuous speed. We also derive several families of valid inequalities to further strengthen both models. We test the proposed formulations on benchmark instances. Some instances are solved to optimality for the first time. [ABSTRACT FROM AUTHOR]

Golgi Membrane Protein 1 (GOLM1) has been identified as a prime target for cancer therapy because it overexpresses in many solid tumors, increases tumor growth and metastasis and leads to unfavorable survival. Though various approaches including siRNA interference and antibody targeting have been attempted, GOLM1 has remained an un-targetable molecule because of its mainly intracellular location and the lack of domains that could possibly be interfered with by small molecules. Numerous natural anti-tumoral plant substances have been identified, while their possible function on GOLM1 has never been revealed. This is the first report to study the relationship between GOLM1 downregulation and natural anti-tumoral plant substances and the possible mechanism. Among three tested possible migration-inhibiting natural substances (Epigallocatechin gallate (EGCG), Betulinic acid (BA) and Lupeol), EGCG showed the most potent inhibition effect on GOLM1 expression and MDA-MB-231 cell migration. Knocking down GOLM1 expression further increased the EGCG treatment effect. Molecular docking prediction and following experiments suggested that EGCG may inhibit GOLM1 expression and MDA-MB-231 cells migration through HGF/HGFR/AKT/GSK-3/β-catenin/c-Myc signaling pathway. In all, EGCG is the first identified GOLM1 downregulation natural product. Silencing GOLM1 may be a novel mechanism of potentiated anti-cancer migration effects and cytotoxic effect of EGCG. In addition, this study shed a new way for cancer therapy by combination of GOLM1 silencing and EGCG treatment in the future. [Display omitted] [ABSTRACT FROM AUTHOR]

We assess the ability of individual models (single-model ensembles) and the multi-model ensemble (MME) in the European Union-funded ENSEMBLES project to simulate the intraseasonal oscillations (ISOs; specifically in 10-20-day and 30-50-day frequency bands) of the Indian summer monsoon rainfall (ISMR) over the Western Ghats (WG) and the Bay of Bengal (BoB), respectively. This assessment is made on the basis of the dynamical linkages identified from the analysis of observations in a companion study to this work. In general, all models show reasonable skill in simulating the active and break cycles of the 30-50-day ISOs over the Indian summer monsoon region. This skill is closely associated with the proper reproduction of both the northward propagation of the intertropical convergence zone (ITCZ) and the variations of monsoon circulation in this band. However, the models do not manage to correctly simulate the eastward propagation of the 30-50-day ISOs in the western/central tropical Pacific and the eastward extension of the ITCZ in a northwest to southeast tilt. This limitation is closely associated with a limited capacity of models to accurately reproduce the magnitudes of intraseasonal anomalies of both the ITCZ in the Asian tropical summer monsoon regions and trade winds in the tropical Pacific. Poor reproduction of the activity of the western Pacific subtropical high on intraseasonal time scales also amplify this limitation. Conversely, the models make good reproduction of the WG 10-20-day ISOs. This success is closely related to good performance of the models in the representation of the northward propagation of the ITCZ, which is partially promoted by local air-sea interactions in the Indian Ocean in this higher-frequency band. Although the feature of westward propagation is generally represented in the simulated BoB 10-20-day ISOs, the air-sea interactions in the Indian Ocean are spuriously active in the models. This leads to active WG rainfall, which is not present in the observed BoB 10-20-day ISOs. Further analysis indicates that the intraseasonal variability of the ISMR is generally underrepresented in the simulations. Skill of the MME in seasonal ISMR forecasting is strongly dependent on individual model performance. Therefore, in order to improve the model skill with respect to seasonal ISMR forecasting, we suggest it is necessary to better represent the robust dynamical links between the ISOs and the relevant circulation variations, as well as the proportion of intraseasonal variability in the individual models. [ABSTRACT FROM AUTHOR]

Within substations installed with flexible ac transmission systems, the magnetic flux leakage (MFL) generated by air core reactors in static var compensator (SVC) can be very high. To reduce the influence of the high magnetic field, an optimal suppression method is selected based on fuzzy comprehensive evaluation. First, a series of onsite measurements are performed around the reactors in the SVC. From the measurement results, the low-voltage cables, dc system, grounding grid, and magnetic flux density around the air core reactors are seriously affected by the MFL generated by the air core reactors with currents of a few kiloamperes. Then, according to the actual parameters of the air core reactors, a three-dimensional simulation model is constructed using the finite-element method (FEM) to calculate the magnetic flux density and some parameters related to the magnetic field. Moreover, four different suppression methods are proposed to suppress the MFL influence. Due to the multiple aspects affected by MFL, it is always difficult to make a quantitative comparison for the suppression methods based on previous research. For this reason, a fuzzy comprehensive evaluation method based on a linear evaluation model is proposed to quantitatively compare the suppression methods by using the suppression effect value δ. In a comparison of different suppression methods, the aluminum plate shielding with proper parameters has prove to be an optimal method for achieving a comprehensive suppression effect. The modeling and evaluation methods presented in this article are both valuable to solve the complex MFL influence problem in different SVC-based substations. [ABSTRACT FROM AUTHOR]

Cervical spondylotic myelopathy (CSM) is a leading cause of spinal cord dysfunction with few treatment options. Although mitochondrial dynamics are linked to a wide range of pathological changes in neurodegenerative diseases, a connection between aberrant mitochondrial dynamics and CSM remains to be illuminated. In addition, mechanisms underlying the emerging anti-inflammatory and neuroprotective effects of echinacoside (ECH), the main active ingredient of Cistanche salsa , are poorly understood. We hypothesized that excessive mitochondrial fission plays a critical role in regulating inflammatory responses in CSM, and ECH might alleviate such responses by regulating mitochondrial dynamics. To this end, we assessed the effects of ECH and Mdivi-1, a selective inhibitor of dynamin-related protein (Drp1), in a rat model of chronic cervical cord compression and activated BV2 cells. Our results showed that rats with Mdivi-1 intervention had improved motor function compared with vehicle-treated rats. Indeed, Mdivi-1 treatment attenuated pro-inflammatory cytokine expression, as well as activation of the nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, nuclear transcription factor-κB (NF-κB), and Drp1 in lesions. Compared with vehicle-treated rats, compression sites of Mdivi-1-treated animals exhibited elongated mitochondrial morphologies and reduced reactive oxygen species (ROS). Similarly, ECH-treated rats exhibited neurological recovery and suppression of inflammatory response or related signals in the lesion area after treatment. Interestingly, ECH treatment partly reversed aberrant mitochondrial fragmentation and oxidative stress within the lesion area. In vitro data suggested that ECH suppressed activated microglia by modulating activation of the NLRP3 inflammasome and NF-κB signaling. Furthermore, we observed that ECH markedly inhibited Drp1 translocation onto mitochondria, whereby it regulated mitochondrial dynamics and ROS production, which act as regulators of NLRP3 inflammasome activation and NF-κB signaling. Thus, our findings reveal that mitochondrial dynamics modulate inflammatory responses during CSM. Moreover, ECH may attenuate neuroinflammation in rats subjected to chronic cervical cord compression by regulating Drp1-dependent mitochondrial fission and activation of downstream signaling. Image 1 • Chronic compression to cervical cord leads to the mitochondrial fission event in lesion area. • Mitochondrial dynamics modulate inflammatory responses during cervical spondylotic myelopathy. • Echinacoside attenuated inflammatory responses in a rat chronic cervical cord compression model. • Neuroprotective effects of echinacoside may be associated with its role on mitochondrial dynamics and downstream signaling. [ABSTRACT FROM AUTHOR]

Atmospheric transport of black carbon (BC) from surrounding areas has been shown to impact the Tibetan environment, and clarifying the geographical source and receptor regions is crucial for providing guidance for mitigation actions. In this study, 10 trace volatile organic compounds (VOCs) sampled across Tibet are chosen as proxies to diagnose source regions and related transport of pollutants to Tibet. The levels of these VOCs in Tibet are higher than those in the Arctic and Antarctic regions but much lower than those observed at many remote and background sites in Asia. The highest VOC level is observed in the eastern region, followed by the southern region and the northern region. A positive matrix factorization (PMF) model found that three factors—industry, biomass burning, and traffic—present different spatial distributions, which indicates that different zones of Tibet are influenced by different VOC sources. The average age of the air masses in the northern and eastern regions is estimated to be 3.5 and 2.8 days using the ratio of toluene to benzene, respectively, which indicates the foreign transport of VOC species to those regions. Back-trajectory analyses show that the Afghanistan-Pakistan-Tajikistan region, Indo-Gangetic Plain (IGP), and Meghalaya-Myanmar region could transport industrial VOCs to different zones of Tibet from west to east. The agricultural bases in northern India could transport biomass burning-related VOCs to the middle-northern and eastern zones of Tibet. High traffic along the unique national roads in Tibet is associated with emissions from local sources and neighboring areas. Our study proposes international joint-control efforts and targeted actions to mitigate the climatic changes and effects associated with VOCs in Tibet, which is a climate sensitive region and an important source of global water. [ABSTRACT FROM AUTHOR]

We propose two new Lagrangian dual problems for chance-constrained stochastic programs based on relaxing nonanticipativity constraints. We compare the strength of the proposed dual bounds and demonstrate that they are superior to the bound obtained from the continuous relaxation of a standard mixed-integer programming (MIP) formulation. For a given dual solution, the associated Lagrangian relaxation bounds can be calculated by solving a set of single scenario subproblems and then solving a single knapsack problem. We also derive two new primal MIP formulations and demonstrate that for chance-constrained linear programs, the continuous relaxations of these formulations yield bounds equal to the proposed dual bounds. We propose a new heuristic method and two new exact algorithms based on these duals and formulations. The first exact algorithm applies to chance-constrained binary programs, and uses either of the proposed dual bounds in concert with cuts that eliminate solutions found by the subproblems. The second exact method is a branch-and-cut algorithm for solving either of the primal formulations. Our computational results indicate that the proposed dual bounds and heuristic solutions can be obtained efficiently, and the gaps between the best dual bounds and the heuristic solutions are small. [ABSTRACT FROM AUTHOR]