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11. Brain computer interface with P300-Speller: usability for disabled patients with Amyotrophic Lateral Sclerosis

Author

Guy, Violaine, Soriani, M. H., Bruno, Mariane, Papadopoulo, Théodore, Desnuelle, Claude, Clerc, Maureen, Centre de Référence Maladies Neuromusculaires et SLA, hôpital Archet 1, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Computational Imaging of the Central Nervous System (ATHENA), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), and Clerc, Maureen

Subjects
[SDV] Life Sciences [q-bio], AAC system, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, [SDV]Life Sciences [q-bio], [SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, P300 Speller, BCI, ALS
Abstract

International audience; ObjectivesAmyotrophic Lateral Sclerosis (ALS), a progressive neurodegenerative disease, restricts patients’ communication capacity a few years after onset. Promising proof-of-concept of Brain-Computer Interface (BCI) has already been demonstrated in ALS and locked-in patients, mostly in pre-clinical studies or only on few patients, but performance was estimated not yet high enough to support adoption by people with physical limitation of speech. Here, a visual BCI device is evaluated in a clinical study to test if disabled patients with multiple deficiencies related to ALS would be able to use BCI to communicate in a daily environment. MethodsAfter clinical evaluation of physical, cognitive and language capacities, 20 patients with ALS were included. The BCI P300 speller system consisted of an EEG acquisition connected to real-time processing software, and separate keyboard display control software. It was equipped with original features such as optimal stopping of flashes and word prediction.The study consisted of two 3-block sessions (copy spelling, free spelling and free use) using the system in several modes of operation in view of evaluating its usability through its effectiveness, efficiency and satisfaction. ResultsEffectiveness is evidenced as 100% of participants successfully achieved all spelling tasks. Efficiency is supported considering over 95% of correct symbols were selected by 65% of participants. The average number of correct symbols/min ranged from 3.6 (without word prediction) to 5.04 (with word prediction). Participants expressed satisfaction with an average score of 8.7/10 on a Visual Analog Scale assessing comfort, ease of use and utility. Patients quickly learned how to operate this system which did not require much learning effort. ConclusionWord prediction and optimal stopping of flashes improve information transfer rate and make BCI competitive with alternative communication systems such as eye trackers. Remaining requirements to improve the device for a suitable ergonomic use are currently in progress.

Published
2017

12. Effective metropolitan governance is not an outcome just from a law making process. The Italian case

Author

Pioletti, Maurizio, Soriani, M. a. u. r. i. z. i. o., and Stefano

Subjects
Territorial, Delrio law, or intermunicipal cooperation, Delrio law, Polycentric metropolitan governance, Metropolitan institution, Territorial, or intermunicipal cooperation, Strategic development projects , Business community, Metropolitan institution, Strategic development projects, Business community, Polycentric metropolitan governance
Published
2016

14. 6 min walking test 12 month changes in DMD: Correlation with genotype

Author

Pane, M., Mazzone, E., Soriani, M. P., Scalise, R., Berardinelli, A., Messina, Sonia, Torrente, Y., D’Amico, A., Doglio, L., Viaggiano, E., D’Ambrosio, P., Cavallaro, F., Frosoni, S., Bello, L., De Sanctis, R., Fanelli, L., Rolle, E., Bianco, F., Magri, F., Vita, Gianluca, Motta, M. C., Donati, M. A., Mongini, T., Pini, A., Battini, R., Pegoraro, E., Previtali, S., Napoletano, S., Bruno, C., Politano, L., Comi, G. P., Bertini, E., and Mercuri, E.

Published
2013

15. H-1, C-13 and N-15 assignment of the GNA1946 outer membrane lipoprotein from Neisseria meningitidis

Author

Neumoin, A., Leonchiks, A., Petit, P., Vuillard, L., Pizza, M., Soriani, M., Boelens, R., Bonvin, A. M. J. J., Sub NMR Spectroscopy, and NMR Spectroscopy

Subjects
Liporotein, Antigen, Pathogenic bacteria, Meningitis, Nmr
Abstract

GNA1946 (Genome-derived Neisseria Antigen 1946) is a highly conserved exposed outer membrane lipoprotein from Neisseria meningitidis bacteria of 287 amino acid length (31 kDa). Although the structure of NMB1946 has been solved recently by X-Ray crystallography, understanding the behaviour of GNA1946 in aqueuos solution is highly relevant for the discovery of the antigenic determinants of the protein that will possibly lead to a more efficient vaccine development against virulent serogroup B strain of N.meningitidis. Here we report almost complete H-1, C-13 and N-15 resonance assignments of GNA1946 (residues 10-287) in aqueous buffer solution.

Published
2011

16. NMR resonance assignments of NarE, a putative ADP-ribosylating toxin from Neisseria meningitidis

Author

Carlier, L.P.A., Köhler, Christian, Veggi, D., Pizza, M., Soriani, M., Boelens, R., Bonvin, A.M.J.J., NMR Spectroscopy, Sub NMR Spectroscopy, Equipe de Chimie Organique et Biologie Structurale (ECOBS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU), Université Pierre et Marie Curie - Paris 6 (UPMC), NMR Spectroscopy, and Sub NMR Spectroscopy

Subjects
030303 biophysics, Bacterial Toxins, Molecular Sequence Data, ADP Ribose Transferases, Biology, Neisseria meningitidis, medicine.disease_cause, Biochemistry, Protein Structure, Secondary, Article, 03 medical and health sciences, chemistry.chemical_compound, Structural Biology, medicine, NarE, Meningitis, Amino Acid Sequence, Peptide sequence, Nuclear Magnetic Resonance, Biomolecular, 030304 developmental biology, 0303 health sciences, Adenosine Diphosphate Ribose, Adenosine diphosphate ribose, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Nuclear magnetic resonance spectroscopy, NMR, Heteronuclear molecule, chemistry, ADP ribosylation, ADP-ribosylation, Pathogenic bacteria, Target protein
Abstract

International audience; NarE is a 16 kDa protein identified from Neisseria meningitidis, one of the bacterial pathogens responsible for meningitis. NarE belongs to the ADP-ribosyltransferase family and catalyses the transfer of ADP-ribose moieties to arginine residues in target protein acceptors. Many pathogenic bacteria utilize ADP-ribosylating toxins to modify and alter essential functions of eukaryotic cells. NarE was proposed to bind iron through a Fe-S center which is supposed to be implied in catalysis. We have produced and purified uniformly labeled (15)N- and (15)N/(13)C-NarE and assigned backbone and side-chain resonances using multidimensional heteronuclear NMR spectroscopy. These assignments provide the starting point for the three-dimensional structure determination of NarE and the characterization of the role of the Fe-S center in the catalytic mechanism.

Published
2011
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18. [Internet and amyotrophic lateral sclerosis treatment: What is wrong?]

Author

Meininger, V., Antoine, J.-C., Arne-Bes, M. C., Broussolle, E., Bruneteau, G., Camdessanche, J. P., Camu, W., Carluer, L., Cintas, P., Clavelou, Pierre, Corcia, P., Couratier, Philippe, Danel-Brunaud, V., Desnuelle, C., Destée, A., Dib, M., Fleury, M.-C., Furby, A., Giroud, M., Gonzales, J., Guy, N., Kolev, I., Lacomblez, Lucette, Lardillier-Noel, D., Le Forestier, N., Maugin, D., Nicolas, G., Pittion, S., Pouget, Jean, Pradat, P. F., Rousso, E., Salachas, F., Soriani, M. H., Tranchant, C., Vandenberghe, N., Verschueren, A., Viader, F., Vial, C., Service de Neurologie [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale et Comparée (NETEC), and Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Université de Limoges (UNILIM)

Subjects
Internet, United States Food and Drug Administration, Amyotrophic Lateral Sclerosis, Drug Evaluation, Preclinical, Lithium Compounds, Humans, Intercellular Signaling Peptides and Proteins, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Insulin-Like Growth Factor I, Drug Approval, United States, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2009
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25. GP-2 is the major ATP-binding protein of pig pancreatic zymogen granule membranes

Author

Soriani M and Freiburghaus Au

Subjects
Enzyme Precursors, Hepatology, Chemistry, Swine, Endocrinology, Diabetes and Metabolism, Binding protein, Membrane Proteins, Zymogen granule, Cytoplasmic Granules, Endocrinology, Membrane, Adenosine Triphosphate, Biochemistry, Internal Medicine, Animals, Carrier Proteins, Pancreas
Published
1997

26. The structure of fragment B of FdeC (Factor Adherece E. coli), a novel broadly conserved E. coli adhesin, with structural homology to invasin and intimin

Author

Spraggon, G., primary, Nesta, B., additional, Alteri, C., additional, Gomes Moriel, D., additional, Rosini, R., additional, Veggi, D., additional, Smith, S., additional, Bertoldi, I., additional, Pastorello, I., additional, Ferlenghi, I., additional, Fontana, M.R., additional, Frankel, G., additional, Mobley, H.L.T., additional, Rappuli, R., additional, Pizza, M., additional, Serino, L., additional, and Soriani, M., additional

Published
2012
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40. H, C and N assignment of the GNA1946 outer membrane lipoprotein from Neisseria meningitidis.

Author

Neumoin, A., Leonchiks, A., Petit, P., Vuillard, L., Pizza, M., Soriani, M., Boelens, R., and Bonvin, A.

Abstract

GNA1946 (Genome-derived Neisseria Antigen 1946) is a highly conserved exposed outer membrane lipoprotein from Neisseria meningitidis bacteria of 287 amino acid length (31 kDa). Although the structure of NMB1946 has been solved recently by X-Ray crystallography, understanding the behaviour of GNA1946 in aqueuos solution is highly relevant for the discovery of the antigenic determinants of the protein that will possibly lead to a more efficient vaccine development against virulent serogroup B strain of N.meningitidis. Here we report almost complete H, C and N resonance assignments of GNA1946 (residues 10-287) in aqueous buffer solution. [ABSTRACT FROM AUTHOR]

Published
2011
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42. Direct and indirect modulation of ornithine decarboxylase and cyclooxygenase by UVB radiation in human skin cells.

Author

Soriani, M, Luscher, P, and Tyrrell, RM

Abstract

Exposure to solar ultraviolet (UV) B radiation is responsible for skin inflammation and tumour progression. Cyclooxygenase and ornithine decarboxylase are believed to be involved in such processes since they participate in the synthesis of mediators of inflammation and cell differentiation, respectively. We have investigated the in vitro modulation of expression of such genes by UVB radiation in different skin cell lines. We have observed that accumulation of ornithine decarboxylase mRNA is unaffected by even high UVB doses in both human epidermal keratinocytes and dermal fibroblasts, whereas cyclooxygenase-2 levels were significantly up-regulated by low UVB doses in KB human epidermoid keratinocytes. Depletion of total intracellular glutathione levels in KB cells amplified the activation, revealing a role for an oxidative component of UVB in modulating cyclooxygenase gene expression. Transfer of medium from UVB irradiated keratinocytes to fibroblasts resulted in a significant activation of cyclooxygenase expression and activity, while ornithine decarboxylase levels were unaffected. We conclude that UVB radiation can activate cyclooxygenase gene expression in human skin cells both by direct activation pathways or indirectly by inducing a paracrine mechanism. [ABSTRACT FROM PUBLISHER]

Published
1999
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46. Direct and indirect modulation of ornithine decarboxylase and cyclooxygenase by UVB radiation in human skin cells

Author

Luscher, P., Tyrrell, R., and Soriani, M.

Abstract

Exposure to solar ultraviolet (UV) B radiation is responsible for skin inflammation and tumour progression. Cyclooxygenase and ornithine decarboxylase are believed to be involved in such processes since they participate in the synthesis of mediators of inflammation and cell differentiation, respectively. We have investigated the in vitro modulation of expression of such genes by UVB radiation in different skin cell lines. We have observed that accumulation of ornithine decarboxylase mRNA is unaffected by even high UVB doses in both human epidermal keratinocytes and dermal fibroblasts, whereas cyclooxygenase-2 levels were significantly up-regulated by low UVB doses in KB human epidermoid keratinocytes. Depletion of total intracellular glutathione levels in KB cells amplified the activation, revealing a role for an oxidative component of UVB in modulating cyclooxygenase gene expression. Transfer of medium from UVB irradiated keratinocytes to fibroblasts resulted in a significant activation of cyclooxygenase expression and activity, while ornithine decarboxylase levels were unaffected. We conclude that UVB radiation can activate cyclooxygenase gene expression in human skin cells both by direct activation pathways or indirectly by inducing a paracrine mechanism.

Published
1999

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