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8. Micosi profonde

Author

Sorice, F., Castagnari, Luigi, and Contini, Carlo

Published
2000

12. Scabbia

Author

Sorice, F and Contini, Carlo

Subjects
scabbia
Published
2000

13. Hib-EuroSud'95: The south exists

Author

Barquet, N Aristegui, J RuizContreras, J HernandezSampelayo, T Sorice, F Fara, GM Vierucci, A Kattamis, C and Valente, P

Published
1996

14. A controlled trial of nevirapine plus zidovudine versus zidovudine alone in p24 antigenaemic HIV-infected patients. The Dutch-Italian-Australian Nevirapine Study Group

Author

Carr, A., Vella, S., de Jong, M. D., Sorice, F., Imrie, A., Boucher, C. A., Cooper, D. A., and Other departments

Subjects
immune system diseases, virus diseases
Abstract

OBJECTIVES: Nevirapine is a non-nucleoside reverse transcriptase inhibitor of HIV-1 which exhibits synergy in vitro with zidovudine (ZDV) and also is active against ZDV-resistant HIV. We evaluated the activity and safety of nevirapine in combination with ZDV in patients receiving long-term ZDV therapy. METHODS: We conducted a randomized, open-label, controlled 28-week study of nevirapine (200 mg daily for 2 weeks followed by 200 mg twice daily for 26 weeks) and continued ZDV (500-600 mg daily) versus continued ZDV alone in 49 HIV-1 p24 antigenaemic patients with CD4+ lymphocyte counts

Published
1996

17. Intrathecal synthesis of interleukin-2 and soluble IL-2 receptor in asymptomatic HIV-1 seropositive individuals. Correlation with local production of specific IgM and IgG antibodies

Author

Ciardi, Maria Rosa, Sharief, Mk, Noori, Ma, Thompson, Ej, Salotti, A, Rossi, F, Vullo, V, Catania, S, Sorice, F, and Cirelli, A.

Subjects
Adult, Male, Adolescent, Enzyme-Linked Immunosorbent Assay, Receptors, Interleukin-2, Middle Aged, Immunoglobulin M, Spinal Cord, Immunoglobulin G, HIV Seropositivity, HIV-1, Humans, Interleukin-2, Female
Abstract

The relationship between the interleukin-2 (IL-2) system and the humoral response against human immunodeficiency virus type-I (HIV-1) is important in understanding the immune reaction before the development of AIDS. Levels of IL-2 and soluble IL-2 receptor (sIL-2R) in serum and cerebrospinal fluid (CSF) samples from 31 asymptomatic HIV-1 seropositive individuals were measured and correlated with levels of anti-1 IgG and IgM antibodies. High IL-2 levels were detected in the CSF of 20 (65%) subjects, 18 (90%) of whom had evidence of intrathecal synthesis of HIV-1-specific IgM antibodies. Similarly, IgG antibodies were detected in 10 subjects who had elevated IL-2 levels in the CSF. Moreover, intrathecal levels of IL-2 and sIL-2R correlated with intrathecal synthesis of both IgG and IgM antibodies. Local release of IL-2 seems to play an important role in the initiation of the antibody response against HIV-1 in early stages of infection and may be utilised in devising effective therapeutic strategies.

Published
1993

24. Evaluation of vaginal microflora in patients infected with HIV

Author

Maria Teresa Mascellino, Iona E, Iegri F, Catania S, Trinchieri V, Oliva P, Amenta L, Revérberi L, and Sorice F

Subjects
hiv infection, Acquired Immunodeficiency Syndrome, complications, Bacteria, microbiology, Vaginal Diseases, acquired immunodeficiency syndrome, aids, aids-related complex, bacteria, bacterial infections, candidiasis, complications/microbiology, female, genital tract infections, growth /&/ development, hiv infections, humans, microorganisms, vagina, vaginal diseases, vulvovaginal, HIV Infections, Bacterial Infections, AIDS-Related Complex, Vagina, Humans, Female, Candidiasis, Vulvovaginal
Abstract

HIV infection is thought to exacerbate the virulence of normal saprophytic vaginal microflora. We studied the vaginal ecosystem of HIV patients to detect the quantitative and qualitative variation of vaginal microorganisms. 15 patients (5 with AIDS and 10 with ARC) were investigated. Vaginal candidiasis was more frequent in this group than in the control groups. Gardnerella was present in 60% of patients generally in association with anaerobic bacteria and Mycoplasma. Among anaerobia, Bacteroides sp and other Gram-negative rods were the most common bacteria. Neisseria gonorrhoeae was absent in all patients tested. Chlamydia trachomatis was recovered in two out of the 15 HIV-positive patients. Aerobic Gram-negative flora was 100-fold that of the control group and anaerobic Gram-negative flora 10-fold.

Published
1991

33. Clinical Results of a Multicenter Study with Sulbactam/Ampicillin for the Treatment of Patients with Lower Respiratory and Urinary Tract Infections

Author

De Simone, C., primary, Chiodo, F., additional, Delia, S., additional, Pastore, G., additional, Scalise, G., additional, Sorice, F., additional, Tonietti, G., additional, Zanussi, C., additional, Paoloni, M., additional, Gargiulo, M., additional, Lambert Gardini, S., additional, Giacometti, A., additional, Tzantzoglou, S., additional, Trinchieri, V., additional, and D’Annibali, E., additional

Published
1991
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37. Influence of ofloxacin, norfloxacin, nalidixic acid, pyromidic acid and pipemidic acid on human γ-interferon production and blastogenesis.

Author

De Simone, C., Baldinelli, L., Ferrazzi, M., De Santis, S., Pugnaloni, L., and Sorice, F.

Abstract

Several new quinolone derivatives were investigated for their influence on human lymphocyte blastogenesis and γ-interferon production following concanavalin A stimulation. All the antimicrobials induced inhibition of lymphocyte DNA synthesis. The γ-interferon measurements showed that nalidixic acid and norfloxacin have a negative influence on lymphokine poduction and release. [ABSTRACT FROM PUBLISHER]

Published
1986

38. Clinical and immunological assessment in HIV+ subjects receiving inosine-pranobex. A randomised, multicentric study.

Author

Simone, C., Albertini, F., Almaviva, M., Angarano, G., Chiodo, F., Costigliola, P., Delia, S., Ferlini, A., Gritti, F., Mazzarello, G., Milazzo, F., Montroni, M., Narciso, P., Pastore, G., Raise, E., Santini, G., Sorice, F., Terragna, A., Visco, G., and Vullo, V.

Abstract

Inosine-pranobex (methisoprinol, isoprinosine; INPX) is the p-acetamidobenzoic salt of N,N-dimethylamino-2-propanol and inosine in a 3:1 molar ratio. In early studies, INPX was found to partially inhibit human immunodeficiency virus (HIV) and to increase the immunocompetence of HIV-infected subjects in vitro. We report the results of a randomised, multicentric clinical trial carried out on 553 HIV+ patients. 261 individuals were treated with INPX (two 500 mg tablets every 6 h for 3 months) and the remaining 292 constituted the untreated control group. INPX treatment was associated with a slightly improved clinical condition or with a trend in that direction, as compared to the untreated group. A preservation of the CD4/CD8 cell ratio values, a decrease in the CD8+ cells and an increase in the Leu 2-7+ cell number better than in the untreated individuals was also observed in the patients taking INPX. No serious or adverse effects of INPX have been observed. [ABSTRACT FROM AUTHOR]

Published
1989
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41. Human eosinophils and parasitic diseases II. Characterization of two cell fractions isolated at different densities.

Author

Desimone, C., Donell, G., Mell, D., Rosati, F., and Sorice, F.

Subjects
EOSINOPHILS, KILLER cells, LEUCOCYTES, SILICON compounds, COMMUNICABLE diseases, MEDICAL parasitology
Abstract

A new procedure. based on centrifugation through multiple discontinuous gradients of polyvinylpyrrolidone-coated silica particles has been developed for the separation of almost pure cosinophils from blood samples of healthy donors. When this technique is employed for the purification of cosinophils from the peripheral blood of patients with parasilic diseases. two cell fractions almost pure in cosinophil granulocytes are harvested at different densities. Preliminary results, concerning the characterization of these cell Fractions, indicate that in the terms of detectable membrane receptors and K cell activity. two distinct cosinophil suhpopulations can be recognized. [ABSTRACT FROM AUTHOR]

Published
1982

42. Human eosinophils and parasitic diseases: light and electron microscopy evidence of interaction with sheep erythrocyte.

Author

de Simone, C., Donelli, G., Meli, D., Rosati, F., and Sorice, F.

Subjects
PARASITIC diseases, EOSINOPHIL disorders, ERYTHROCYTES, ELECTRON microscopy, MEDICAL parasitology, BLOOD cells
Abstract

The aim of this study was to investigate the possible formation of spontaneous rosettes between human eosinophils and sheep erythrocytes. In patients with parasitic diseases a percentage of 15.7±C) (range 6-23%), ensinophils were able to form rosettes. Each rosette showed as few as four to eight erythrocytes attached per eosinophil. Two types of interaction were observed at the electron microscope: point attachments and large surface contacts. In patients with non-parasite induced eosinophilia the formation of rosettes is decidedly below the above-mentioned percentage (<2%) or totally absent. It follows that during parasitic infections with blood eosinophilia, whatever the mechanism responsible, the formation of spontaneous rosettes could be of diagnostic significance and might reflect qualitative or quantitative modifications in the eosinophil population. [ABSTRACT FROM AUTHOR]

Published
1980

46. Human Amoebiasis: The Interaction of Lymphocyte Surface-Bound Immune Complexes and Pmns Impairs T Cell Proliferative Responses to E. Histolytica Mitogen

Author

De Simone, C., Delia, S., Meco, L. Di, Mastroianni, C., Mastropietro, C., Vullo, V., and Sorice, F.

Abstract

In some of the sera from patients with amoebiasis circulating immune complexes are present which are thought to interact with lymphoid cells, enabling them to elicit a burst of oxygen consumption in PMNs. The intensity of chemiluminescence is related to the presence of C3+ and Fc IgG+ cells in the lymphoid cell suspensions employed. The generation and release of highly reactive oxygen derivatives from PMNs impair T lymphocyte proliferative responses to the E. histolytica mitogen. The Authors suggest that one of the mechanisms by which circulating immune complexes present in the sera of patients with amoebiasis may interfere with T cell-mediated immune responses, is through their binding to the surface of the C3+, Fc IgG+ cells with subsequent stimulation of the PMN oxidative metabolism.

Published
1985
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47. Detection and partial characterization of circulating immune complexes in hydatid disease

Author

D'Amelio, R, Pontesilli, O, Palmisano, L, Pezzella, M, Vullo, V, Delia, S, De Rose, F, Sorice, F, and Aiuti, F

Abstract

Thirty sera from eight patients with disseminated or localized hydatid disease have been examined for the presence of circulating immune complexes (CICs) by the conglutinin-binding assay and for immunoglobulin levels. The highest levels of CICs were of the immunoglobulin A (IgA) class, with lower values of IgG-CIC and IgM-CIC; these results did not correlate, except for IgG, with the free immunoglobulin levels. Efforts to identify parasitic antigen(s) involved in the CIC formation with different methods have been unsuccessful. In the follow-up of each patient, CIC appeared to be better correlated to clinical conditions than to hemagglutination titers. We have concluded that the presence of CIC in hydatid disease is probably an expression of B-cell polyclonal activation and that these complexes are valuable in the clinical monitoring of the disease.

Published
1983
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