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3. Human vascularized bile duct-on-a chip: a multi-cellular micro-physiological system for studying cholestatic liver disease.

4. Bile formation and secretion: An update.

5. Role of Biliary Organoids in Cholestasis Research and Regenerative Medicine.

6. Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis.

7. Organic Solute Transporter Alpha Deficiency: A Disorder With Cholestasis, Liver Fibrosis, and Congenital Diarrhea.

8. Bile-Derived Organoids From Patients With Primary Sclerosing Cholangitis Recapitulate Their Inflammatory Immune Profile.

9. Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies.

10. Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response.

11. CFTR-associated ligand is a negative regulator of Mrp2 expression.

12. Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid-fed mouse model of cholestasis.

13. A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization.

14. Na(+) /H(+) exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury.

15. Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations.

16. Altered expression and function of canalicular transporters during early development of cholestatic liver injury in Abcb4-deficient mice.

17. All-trans-retinoic acid improves cholestasis in α-naphthylisothiocyanate-treated rats and Mdr2-/- mice.

18. Peroxisome proliferator-activated receptor α activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion.

19. Ostα-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity.

20. Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice.

21. Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion.

22. A C-terminal tyrosine-based motif in the bile salt export pump directs clathrin-dependent endocytosis.

24. Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine.

25. Ostα depletion protects liver from oral bile acid load.

26. Role of breast cancer resistance protein in the adaptive response to cholestasis.

27. Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression.

28. NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function.

29. Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis.

30. The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver disease.

31. Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis.

32. Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression.

33. ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained.

34. Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II.

35. N-Glycosylation of the alpha subunit does not influence trafficking or functional activity of the human organic solute transporter alpha/beta.

36. Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases.

37. Phloracetophenone-induced choleresis in rats is mediated through Mrp2.

38. Nuclear receptors RXRalpha:RARalpha are repressors for human MRP3 expression.

39. Radixin is required to maintain apical canalicular membrane structure and function in rat hepatocytes.

40. Hepatic and extrahepatic synthesis and disposition of dinitrophenyl-S-glutathione in bile duct-ligated rats.

41. Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.

42. Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis.

43. A comparison of gene expression in mouse liver and kidney in obstructive cholestasis utilizing high-density oligonucleotide microarray technology.

44. OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia.

45. Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis.

46. Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat.

47. Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets.

48. Molecular characterization of a multidrug resistance-associated protein, Mrp2, from the little skate.

49. The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type II.

50. Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes.

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