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1. Comparative effects of glucagon-like peptide-1 receptors agonists, 4-dipeptidyl peptidase inhibitors, and metformin on metabolic syndrome

Author: Bouzas, Cristina, Pastor, Rosario, Garcia, Silvia, Monserrat-Mesquida, Margalida, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Goday, Albert, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Fernández-Barceló, Olga, Vioque, Jesús, Romaguera, Dora, Lopez-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Lluís, Riquelme-Gallego, Blanca, Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodriguez, Miguel, Matía, Pilar, Vidal, Josep, Cardenas-Salas, Jersy-Jair, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Manzanares, Josep M., Gonzalez-Monge, Inmaculada, Muñoz, Miguel-Ángel, Martinez-Urbistondo, Diego, Tojal-Sierra, Lucas, Muñoz-Bravo, Carlos, Miralles-Gisbert, Salvador, Martin, Marian, García-Ríos, Antonio, Castro-Barquero, Sara, Fernández-García, José Carlos, Santos-Lozano, José Manuel, Basterra-Gortari, F. Javier, Gutiérrez-Carrasquilla, Liliana, Guillem-Saiz, Patricia, Satorres, Alba, Abete, Itziar, Sorto-Sanchez, Carolina, Díez-Espino, Javier, Babio, Nancy, Fitó, Montse, and Tur, Josep A.
Published: 2023
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2. Polyphenol intake and cardiovascular risk in the PREDIMED-Plus trial. A comparison of different risk equations

Author: Rubín-García, María, Vitelli-Storelli, Facundo, Toledo, Estefanía, Castro-Barquero, Sara, Tresserra-Rimbau, Anna, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Hernáez, Álvaro, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Bernal-López, M. Rosa, Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Álvarez-Álvarez, Laura, Pintó, Xavier, Gaforio, José J., Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emili, Gea, Alfredo, Manzanares, José María, Sorlí, Jose V., Schröder, Helmut, Abete, Itziar, Tojal-Sierra, Lucas, Crespo-Oliva, Edelys, González-Botella, Andrés, Rayó, Elena, García-Rios, Antonio, Gómez-Pérez, Ana María, Santos-Lozano, José Manuel, Bartolomé Resano, Rafael, Murphy, Michelle M., Ortega-Azorin, Carolina, Medrano, Casimira, Zulet, María Ángeles, Sorto-Sanchez, Carolina, Babio, Nancy, Fitó, Montserrat, Lamuela-Raventós, Rosa María, and Martín-Sánchez, Vicente
Published: 2022
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3. Ingesta de polifenoles y riesgo cardiovascular en el ensayo PREDIMED-Plus. Una comparación de diferentes ecuaciones de riesgo

Author: Rubín-García, María, Vitelli-Storelli, Facundo, Toledo, Estefanía, Castro-Barquero, Sara, Tresserra-Rimbau, Anna, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Hernáez, Álvaro, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Bernal-López, M. Rosa, Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Álvarez-Álvarez, Laura, Pintó, Xavier, Gaforio, José J., Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emili, Gea, Alfredo, Manzanares, José María, Sorlí, Jose V., Schröder, Helmut, Abete, Itziar, Tojal-Sierra, Lucas, Crespo-Oliva, Edelys, González-Botella, Andrés, Rayó, Elena, García-Rios, Antonio, Gómez-Pérez, Ana María, Santos-Lozano, José Manuel, Bartolomé Resano, Rafael, Murphy, Michelle M., Ortega-Azorin, Carolina, Medrano, Casimira, Zulet, María Ángeles, Sorto-Sanchez, Carolina, Babio, Nancy, Fitó, Monstserrat, Lamuela-Raventós, Rosa María, and Martín-Sánchez, Vicente
Published: 2022
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4. Pro-vegetarian food patterns and cardiometabolic risk in the PREDIMED-Plus study: a cross-sectional baseline analysis

Author: Oncina-Cánovas, Alejandro, Vioque, Jesús, González-Palacios, Sandra, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Zomeño, Dolores, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Bernal-Lopez, Rosa M., Lapetra, José, Serra-Majem, J. Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emili, Toledo, Estefanía, Babio, Nancy, Sorli, Jose V., Schröder, Helmut, Zulet, María Angeles, Sorto-Sánchez, Carolina, Barón-López, Francisco Javier, Compañ-Gabucio, Laura, Morey, Marga, García-Ríos, Antonio, Casas, Rosa, Gómez-Pérez, Ana María, Santos-Lozano, José Manuel, Vázquez-Ruiz, Zenaida, Nishi, Stephanie K., Asensio, Eva M., Soldevila, Núria, Abete, Itziar, Goicolea-Güemez, Leire, Buil-Cosiales, Pilar, García-Gavilán, Jesús F., Canals, Erik, Torres-Collado, Laura, and García-de-la-Hera, Manuela
Published: 2022
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5. Association between ankle-brachial index and cognitive function in participants in the PREDIMED-Plus study: cross-sectional assessment

Author: López, Meritxell, Ríos, Angel, Romaguera, Dora, Martínez-González, Miguel Ángel, Fernández-Aranda, Fernando, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Vioque, Jesús, Alonso-Gómez, Ángel M., Crespo-Oliva, Edelys, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., García-Ríos, Antonio, Bueno-Cavanillas, Aurora, Gaforio, José J., Matía-Martín, Pilar, Daimiel, Lidia, Sánchez-Rodríguez, Rubén, Vidal, Josep, Sanz-Martínez, Enrique, Ros, Emilio, Toledo, Estefanía, Barrubés, Laura, Barragán, Rocío, de la Torre, Rafael, Fiol, Miquel, González-Palacios, Sandra, Sorto-Sánchez, Carolina, Martín-Ruiz, María Victoria, Zulet, María Ángeles, Díaz-Collado, Fátima, Casas, Rosa, Fernández-García, José Carlos, Santos-Lozano, José Manuel, Mallorqui-Bagué, Nuria, Argelich, Emma, Lecea, Óscar, Paz-Graniel, Indira, Sorlí, José V., Cuenca, Aida, Munuera, Susana, Hernándis-Marsán, María Vicenta, Vaquero-Luna, Jessica, Ruiz-Canela, Miguel, Camacho-Barcia, Lucía, Jiménez-Murcia, Susana, Castañer, Olga, and Yáñez, Aina M.
Published: 2021
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6. Asociación entre índice tobillo-brazo y rendimiento cognitivo en participantes del estudio PREDIMED-Plus: estudio transversal

Author: López, Meritxell, Ríos, Angel, Romaguera, Dora, Martínez-González, Miguel Ángel, Fernández-Aranda, Fernando, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Vioque, Jesús, Alonso-Gómez, Ángel M., Crespo-Oliva, Edelys, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., García-Ríos, Antonio, Bueno-Cavanillas, Aurora, Gaforio, José J., Matía-Martín, Pilar, Daimiel, Lidia, Sánchez-Rodríguez, Rubén, Vidal, Josep, Sanz-Martínez, Enrique, Ros, Emilio, Toledo, Estefanía, Barrubés, Laura, Barragán, Rocío, de la Torre, Rafael, Fiol, Miquel, González-Palacios, Sandra, Sorto-Sánchez, Carolina, Martín-Ruiz, María Victoria, Zulet, María Ángeles, Díaz-Collado, Fátima, Casas, Rosa, Fernández-García, José Carlos, Santos-Lozano, José Manuel, Mallorqui-Bagué, Nuria, Argelich, Emma, Lecea, Óscar, Paz-Graniel, Indira, Sorlí, José V., Cuenca, Aida, Munuera, Susana, Hernándis-Marsán, María Vicenta, Vaquero-Luna, Jessica, Ruiz-Canela, Miguel, Camacho-Barcia, Lucía, Jiménez-Murcia, Susana, Castañer, Olga, and Yáñez, Aina M.
Published: 2021
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7. Desired weight loss and its association with health, health behaviors and perceptions in an adult population with weight excess: One-year follow-up

Author: Bouzas, Cristina, Bibiloni, Maria del Mar, Garcia, Silvia, Mateos, David, Martínez-González, Miguel Ángel, 1957, Salas Salvadó, Jordi, Corella Piquer, Dolores, Goday Arnó, Albert, Martínez, J. Alfredo, 1957, Alonso Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, Lopez Miranda, José, Estruch Riba, Ramon, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, Riquelme Gallego, Blanca, Martín Sánchez, Vicente, Pintó Sala, Xavier, Gaforio, José J., Matía Martín, Pilar, Vidal i Cortada, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros Rahola, Emilio, Pascual Roquet Jalmar, Elena, Babio, Nancy, Gonzalez Monge, Inmaculada, Castañer, Olga, Abete, Itziar, Sorto Sánchez, Carolina, Benavente Marín, Juan Carlos, Torres Collado, Laura, Martin, Marian, García Ríos, Antonio, Castro Barquero, Sara, Fernández García, José C., Santos Lozano, José Manuel, Fernandez Lazaro, Cesar I., Salas Huetos, Albert, Guillem Saiz, Patricia, Zomeño, María Dolores, Zulet, M. Ángeles, Goikoetxea Bahon, Amaia, Gea, Alfredo, Nishi, Stephanie K., Schröder, Helmut, 1958, Tur, Josep A., and The PREDIMED-plus Investigators
Subjects: Síndrome metabòlica, Weight loss, Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, desired weight loss, Metabolic syndrome, Hàbits sanitaris, Aprimament, Clinical trials, Mediterranean diet, PREDIMED-plus trial, Health behavior, health perception, Food Science, Assaigs clínics
Abstract: Background: Metabolic syndrome (MetS) worsens quality of life and increases mortality. Dissatisfaction with weight in patients with MetS may modify the effect of lifestyle interventions to achieve changes in health-related behaviors. Objective: To assess 1-year changes in cardiovascular risk scores, self-perceived general health and health-related behaviors according to observed changes in desired weight loss during the first year of intervention in a large cardiovascular prevention trial. Design: Prospective analysis of the PREDIMED-PLUS trial, including 5,499 adults (55-75 years old) with overweight or obesity at baseline. Methods: The desired weight loss was the difference between ideal and measured weight. Tertiles of change in desired weight loss (1 year vs. baseline) were defined by the following cut-off points: >= 0.0 kg (T1, n = 1,638); 0.0 to -4.0 kg (T2, n = 1,903), European Research Council (ERC) European Commission 20132018 340918, Spanish government, ISCIII, through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund PI13/00673 PI13/00492 PI13/00272 PI13/01123 PI13/00462 PI13/00233 PI13/02184 PI13/00728 PI13/01090 PI13/01056 PI14/01722 PI14/00636 PI14/00618 PI14/00696 PI14/01206 PI14/01919, Especial Action Project entitled: Implementacion y evaluacion de una intervencion intensive sobre la actividad fisica Cohorte PREDIMED-Plus grant, Recercaixa Grant 2013ACUP00194, Junta de Andalucia PI0458/2013 PS0358/2016 PI0137/2018, Center for Forestry Research & Experimentation (CIEF), European Commission PROMETEO/2017/017 European Cooperation in Science and Technology (COST) European Commission CA16112, Balearic Islands Health Research Institute (IDISBA), European Commission CIBEROBN CB06/03 CB12/03 European Commission European Commission Joint Research Centre EAT2BENICE_H2020_SFS2016, Fundacio La Marato TV3 201630.10, Fernando Tarongi Bauza Grant, 'Spanish government, ISCIII, through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund' PI17/00855 PI17/01347 PI17/00525 PI17/01827 PI17/00532 PI17/00215 PI17/01441 PI17/00508 PI17/01732 PI17/00926 PI19/00957 PI19/00386 PI19/00309 PI19/01032 PI19/00576 PI19/00017, the Spanish government, ISCIII, through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund PI14/00853 PI14/01374 PI14/00972 PI14/00728 PI14/01471 PI16/00473 PI16/00662 PI16/01873 PI16/01094 PI16/00501 PI16/00533 PI16/00381 PI16/00366 PI16/01522 PI16/01120 PI17/00764 PI17/01183 PI19/01226, "Spanish government, ISCIII, through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund" PI19/00781 PI19/01560 PI19/01332 PI20/01802 PI20/00138 PI20/01532 PI20/00456 PI20/00339 PI20/00557 PI20/00886 PI20/01158
Published: 2022

8. Dietary diversity and depression: cross-sectional and longitudinal analyses in Spanish adult population with metabolic syndrome. Findings from PREDIMED-Plus trial

Author: Cano-Ibáñez, Naomi, primary, Serra-Majem, Lluis, additional, Martín-Peláez, Sandra, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Lassale, Camille, additional, Martínez, Jose Alfredo, additional, Alonso-Gómez, Ángel M, additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Gómez-Pérez, Ana María, additional, Lapetra, José, additional, Fernández-Aranda, Fernando, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A, additional, Cubelos, Naiara, additional, Pintó, Xavier, additional, Gaforio, José Juan, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Calderón, Cristina, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Gea, Alfredo, additional, Babio, Nancy, additional, Gimenez-Alba, Ignacio Manuel, additional, Zomeño-Fajardo, María Dolores, additional, Abete, Itziar, additional, Tojal Sierra, Lucas, additional, Romero-Galisteo, Rita P, additional, García de la Hera, Manoli, additional, Martín-Padillo, Marian, additional, García-Ríos, Antonio, additional, Casas, Rosa M, additional, Fernández-García, JC, additional, Santos-Lozano, José Manuel, additional, Toledo, Estefanía, additional, Becerra-Tomas, Nerea, additional, Sorli, Jose V, additional, Schröder, Helmut, additional, Zulet, María A, additional, Sorto-Sánchez, Carolina, additional, Diez-Espino, Javier, additional, Gómez-Martínez, Carlos, additional, Fitó, Montse, additional, and Sánchez-Villegas, Almudena, additional
Published: 2022
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9. Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk

Author: Medicina, Medikuntza, Valle Hita, Cristina, Díaz López, Andrés, Becerra Tomás, Andrea, Martínez González, Miguel Ángel, Ruiz García, Verónica, Corella, Dolores, Goday, Albert, Martínez Hernández, J. Alfredo, Alonso Gómez, Ángel María, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, Cano Ibáñez, Noemí, Tur, Josep A., Rubín García, María, Pintó, Xabier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Mas Fontao, Sebastián, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Sorlí, José V., Roca, C., Abete, Itziar, Moreno Rodríguez, Anai, Crespo Oliva, Edelys, Candela García, Inmaculada, Morey, Margarita, García Ríos, Antonio, Casas, Rosa, Fernández García, José Carlos, Santos Lozano, José Manuel, Díez Espino, Javier, Ortega Azorín, Carolina, Comas, M., Zulet, M. Ángeles, Sorto Sánchez, Carolina, Ruiz Canela, Miguel, Fitó, Montse, Salas Salvadó, Jordi, Babio, Nancy, Medicina, Medikuntza, Valle Hita, Cristina, Díaz López, Andrés, Becerra Tomás, Andrea, Martínez González, Miguel Ángel, Ruiz García, Verónica, Corella, Dolores, Goday, Albert, Martínez Hernández, J. Alfredo, Alonso Gómez, Ángel María, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, Cano Ibáñez, Noemí, Tur, Josep A., Rubín García, María, Pintó, Xabier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Mas Fontao, Sebastián, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Sorlí, José V., Roca, C., Abete, Itziar, Moreno Rodríguez, Anai, Crespo Oliva, Edelys, Candela García, Inmaculada, Morey, Margarita, García Ríos, Antonio, Casas, Rosa, Fernández García, José Carlos, Santos Lozano, José Manuel, Díez Espino, Javier, Ortega Azorín, Carolina, Comas, M., Zulet, M. Ángeles, Sorto Sánchez, Carolina, Ruiz Canela, Miguel, Fitó, Montse, Salas Salvadó, Jordi, and Babio, Nancy
Abstract: Purpose To assess the association between three different a priori dietary patterns adherence (17-item energy reduced-Mediterranean Diet (MedDiet), Trichopoulou-MedDiet and Dietary Approach to Stop Hypertension (DASH)), as well as the Protein Diet Score and kidney function decline after one year of follow-up in elderly individuals with overweight/obesity and metabolic syndrome (MetS). Methods We prospectively analyzed 5675 participants (55-75 years) from the PREDIMED-Plus study. At baseline and at one year, we evaluated the creatinine-based estimated glomerular filtration rate (eGFR) and food-frequency questionnaires-derived dietary scores. Associations between four categories (decrease/maintenance and tertiles of increase) of each dietary pattern and changes in eGFR (ml/min/1.73m(2)) or >= 10% eGFR decline were assessed by fitting multivariable linear or logistic regression models, as appropriate. Results Participants in the highest tertile of increase in 17-item erMedDiet Score showed higher upward changes in eGFR (beta: 1.87 ml/min/1.73m(2); 95% CI: 1.00-2.73) and had lower odds of >= 10% eGFR decline (OR: 0.62; 95% CI: 0.47-0.82) compared to individuals in the decrease/maintenance category, while Trichopoulou-MedDiet and DASH Scores were not associated with any renal outcomes. Those in the highest tertile of increase in Protein Diet Score had greater downward changes in eGFR (beta: - 0.87 ml/min/1.73m(2); 95% CI: - 1.73 to - 0.01) and 32% higher odds of eGFR decline (OR: 1.32; 95% CI: 1.00-1.75). Conclusions Among elderly individuals with overweight/obesity and MetS, only higher upward change in the 17-item erMedDiet score adherence was associated with better kidney function after one year. However, increasing Protein Diet Score appeared to have an adverse impact on kidney health. Trial Registration Number: ISRCTN89898870 (Data of registration: 2014).
Published: 2022

10. Pro‑vegetarian food patterns and cardiometabolic risk in the PREDIMED‑Plus study: a cross‑sectional baseline analysis

Author: Universidad de Sevilla. Departamento de Medicina, Oncina Cánovas, Alejadro, Vioque, Jesús, González Palacios, Sandra, Delgado Rodríguez, Miguel, Sorto Sánchez, Carolina, Santos Lozano, José Manuel, García de la Hera, Manuela, Universidad de Sevilla. Departamento de Medicina, Oncina Cánovas, Alejadro, Vioque, Jesús, González Palacios, Sandra, Delgado Rodríguez, Miguel, Sorto Sánchez, Carolina, Santos Lozano, José Manuel, and García de la Hera, Manuela
Abstract: Purpose We explored the cross-sectional association between the adherence to three diferent provegetarian (PVG) food patterns defned as general (gPVG), healthful (hPVG) and unhealthful (uPVG), and the cardiometabolic risk in adults with metabolic syndrome (MetS) of the PREDIMED-Plus randomized intervention study. Methods We performed a cross-sectional analysis of baseline data from 6439 participants of the PREDIMED-Plus rand omized intervention study. The gPVG food pattern was built by positively scoring plant foods (vegetables/fruits/legumes/ grains/potatoes/nuts/olive oil) and negatively scoring, animal foods (meat and meat products/animal fats/eggs/fsh and seafood/dairy products). The hPVG and uPVG were generated from the gPVG by adding four new food groups (tea and cof fee/fruit juices/sugar-sweetened beverages/sweets and desserts), splitting grains and potatoes and scoring them diferently. Multivariable-adjusted robust linear regression using MM-type estimator was used to assess the association between PVG food patterns and the standardized Metabolic Syndrome score (MetS z-score), a composed index that has been previously used to ascertain the cardiometabolic risk, adjusting for potential confounders. Results A higher adherence to the gPVG and hPVG was associated with lower cardiometabolic risk in multivariable models. The regression coefcients for 5th vs. 1st quintile were − 0.16 (95% CI: − 0.33 to 0.01) for gPVG (p trend: 0.015), and − 0.23 (95% CI: − 0.41 to − 0.05) for hPVG (p trend: 0.016). In contrast, a higher adherence to the uPVG was associated with higher cardiometabolic risk, 0.21 (95% CI: 0.04 to 0.38) (p trend: 0.019). Conclusion Higher adherence to gPVG and hPVG food patterns was generally associated with lower cardiovascular risk, whereas higher adherence to uPVG was associated to higher cardiovascular risk.
Published: 2022

11. Pro‑vegetarian food patterns and cardiometabolic risk in the PREDIMED‑Plus study: a cross‑sectional baseline analysis

Author: Oncina Cánovas, Alejadro, Vioque, Jesús, González Palacios, Sandra, Delgado Rodríguez, Miguel, Sorto Sánchez, Carolina, Santos Lozano, José Manuel, García de la Hera, Manuela, and Universidad de Sevilla. Departamento de Medicina
Subjects: Dietary food patterns, Metabolic syndrome, Pro-vegetarian, Cardiometabolic risk
Abstract: Purpose We explored the cross-sectional association between the adherence to three diferent provegetarian (PVG) food patterns defned as general (gPVG), healthful (hPVG) and unhealthful (uPVG), and the cardiometabolic risk in adults with metabolic syndrome (MetS) of the PREDIMED-Plus randomized intervention study. Methods We performed a cross-sectional analysis of baseline data from 6439 participants of the PREDIMED-Plus rand omized intervention study. The gPVG food pattern was built by positively scoring plant foods (vegetables/fruits/legumes/ grains/potatoes/nuts/olive oil) and negatively scoring, animal foods (meat and meat products/animal fats/eggs/fsh and seafood/dairy products). The hPVG and uPVG were generated from the gPVG by adding four new food groups (tea and cof fee/fruit juices/sugar-sweetened beverages/sweets and desserts), splitting grains and potatoes and scoring them diferently. Multivariable-adjusted robust linear regression using MM-type estimator was used to assess the association between PVG food patterns and the standardized Metabolic Syndrome score (MetS z-score), a composed index that has been previously used to ascertain the cardiometabolic risk, adjusting for potential confounders. Results A higher adherence to the gPVG and hPVG was associated with lower cardiometabolic risk in multivariable models. The regression coefcients for 5th vs. 1st quintile were − 0.16 (95% CI: − 0.33 to 0.01) for gPVG (p trend: 0.015), and − 0.23 (95% CI: − 0.41 to − 0.05) for hPVG (p trend: 0.016). In contrast, a higher adherence to the uPVG was associated with higher cardiometabolic risk, 0.21 (95% CI: 0.04 to 0.38) (p trend: 0.019). Conclusion Higher adherence to gPVG and hPVG food patterns was generally associated with lower cardiovascular risk, whereas higher adherence to uPVG was associated to higher cardiovascular risk.
Published: 2022

12. Association between the Prime Diet Quality Score and depressive symptoms in a Mediterranean population with metabolic syndrome. Cross-sectional and 2-year follow-up assessment from PREDIMED-PLUS study

Author: Cano-Ibáñez, Naomi, primary, Serra-Majem, Lluis, additional, Martín-Peláez, Sandra, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella Piquer, Maria Dolores, additional, Lassale, Camille, additional, Martínez Hernandez, José Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque Lopez, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Gómez-Pérez, Ana María, additional, Santos-Lozano, José Manuel, additional, Fernández-Aranda, Fernando, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín, Vicente, additional, Pintó Sala, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía Martín, Pilar, additional, Vidal, Josep, additional, Cárdenas, Jersy J., additional, Daimiel Ruiz, Lidia, additional, Ros, Emilio, additional, Buil-Cosiales, Pilar, additional, Becerra-Tomás, Nerea, additional, Saiz, Carmen, additional, Muñoz-Perez, Miguel-Ángel, additional, Abete, Itziar, additional, Tojal-Sierra, Lucas, additional, Fernández-Barceló, Olga, additional, Bernabé-Casanova, Andrea, additional, Konieczna, Jadwiga, additional, García-Ríos, Antonio, additional, Casas, Rosa, additional, Bernal-López, Maria Rosa, additional, Lapetra, José, additional, Toledo, Estefanía, additional, Gómez-Martínez, Carlos, additional, Coltell, Oscar, additional, Malcampo-Manrúbia, Mireia, additional, Zulet, María Angeles, additional, Sorto-Sánchez, Carolina, additional, Gea, Alfredo, additional, Hernández-Fleta, José Luis, additional, Castañer Niño, Olga, additional, and Sánchez-Villegas, Almudena, additional
Published: 2021
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13. Pro-vegetarian food patterns and cardiometabolic risk in the PREDIMED-Plus study: a cross-sectional baseline analysis

Author: Oncina-Cánovas, Alejandro, primary, Vioque, Jesús, additional, González-Palacios, Sandra, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Zomeño, Dolores, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Bernal-Lopez, Rosa M., additional, Lapetra, José, additional, Serra-Majem, J. Luís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín-Sánchez, Vicente, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emili, additional, Toledo, Estefanía, additional, Babio, Nancy, additional, Sorli, Jose V., additional, Schröder, Helmut, additional, Zulet, María Angeles, additional, Sorto-Sánchez, Carolina, additional, Barón-López, Francisco Javier, additional, Compañ-Gabucio, Laura, additional, Morey, Marga, additional, García-Ríos, Antonio, additional, Casas, Rosa, additional, Gómez-Pérez, Ana María, additional, Santos-Lozano, José Manuel, additional, Vázquez-Ruiz, Zenaida, additional, Nishi, Stephanie K., additional, Asensio, Eva M., additional, Soldevila, Núria, additional, Abete, Itziar, additional, Goicolea-Güemez, Leire, additional, Buil-Cosiales, Pilar, additional, García-Gavilán, Jesús F., additional, Canals, Erik, additional, Torres-Collado, Laura, additional, and García-de-la-Hera, Manuela, additional
Published: 2021
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14. Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial

Author: Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, European Research Council, Junta de Andalucía, Generalitat Valenciana, Díaz-López, Andrés, Becerra-Tomás, Nerea, Ruiz, Verónica, Toledo, Estefanía, Babio, Nancy, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, López-Miranda, José, Cano-Ibáñez, Naomi, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Paz, José Antonio de, Vidal, Josep, Vázquez, Clotilde, Ruiz-Canela, Miguel, Bulló, Mònica, Sorlí, Jose V., Goday, Albert, Fiol, Miquel, García de la Hera, Manuela, Tojal-Sierra, Lucas, Pérez-Farinós, Napoleón, Zulet, M. Ángeles, Sánchez-Villegas, Almudena, Sacanella, Emilio, Fernandez-Garcia, José Carlos, Santos-Lozano, José Manuel, Gimenez-Gracia, Miquel, Bibiloni, Maria del Mar, Díez-Espino, Javier, Ortega-Azorín, Carolina, Castañer, Olga, Morey, Marga, Torres-Collado, Laura, Sorto-Sánchez, Carolina, Muñoz, Miguel Ángel, Ros, Emilio, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, European Research Council, Junta de Andalucía, Generalitat Valenciana, Díaz-López, Andrés, Becerra-Tomás, Nerea, Ruiz, Verónica, Toledo, Estefanía, Babio, Nancy, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, López-Miranda, José, Cano-Ibáñez, Naomi, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Paz, José Antonio de, Vidal, Josep, Vázquez, Clotilde, Ruiz-Canela, Miguel, Bulló, Mònica, Sorlí, Jose V., Goday, Albert, Fiol, Miquel, García de la Hera, Manuela, Tojal-Sierra, Lucas, Pérez-Farinós, Napoleón, Zulet, M. Ángeles, Sánchez-Villegas, Almudena, Sacanella, Emilio, Fernandez-Garcia, José Carlos, Santos-Lozano, José Manuel, Gimenez-Gracia, Miquel, Bibiloni, Maria del Mar, Díez-Espino, Javier, Ortega-Azorín, Carolina, Castañer, Olga, Morey, Marga, Torres-Collado, Laura, Sorto-Sánchez, Carolina, Muñoz, Miguel Ángel, Ros, Emilio, Martínez-González, Miguel Ángel, and Salas-Salvadó, Jordi
Abstract: Introduction: Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedDiet) plus increased physical activity (PA) on renal function. Methods: Randomized controlled "PREvención con DIeta MEDiterránea-Plus"(PREDIMED-Plus) trial is conducted in 23 Spanish centers comprising 208 primary care clinics. Overweight/obese (n = 6,719) adults aged 55-75 years with metabolic syndrome were randomly assigned (1:1) to an intensive weight-loss lifestyle intervention with an erMedDiet, PA promotion, and behavioral support (intervention) or usual-care advice to adhere to an energy-unrestricted MedDiet (control) between September 2013 and December 2016. The primary outcome was 1-year change in estimated glomerular filtration rate (EGFR). Secondary outcomes were changes in urine albumin-to-creatinine ratio (UACR), incidence of moderately/severely impaired EGFR (<60 mL/min/1.73 m2) and micro-to macroalbuminuria (UACR ≥30 mg/g), and reversion of moderately (45 to <60 mL/min/1.73 m2) to mildly impaired GFR (60 to <90 mL/min/1.73 m2) or micro-to macroalbuminuria. Results: After 1 year, EGFR declined by 0.66 and 1.25 mL/min/1.73 m2 in the intervention and control groups, respectively (mean difference, 0.58 mL/min/1.73 m2; 95% CI: 0.15-1.02). There were no between-group differences in mean UACR or micro-to macroalbuminuria changes. Moderately/severely impaired EGFR incidence and reversion of moderately to mildly impaired GFR were 40% lower (HR 0.60; 0.44-0.82) and 92% higher (HR 1.92; 1.35-2.73), respectively, in the intervention group. Conclusions: The PREDIMED-Plus lifestyle intervention approach may preserve renal function and delay CKD progression in overweight/obese adults.
Published: 2021

15. The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

Author: Marcos-Delgado, Alba, primary, Fernández-Villa, Tania, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Castañer, Olga, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J, additional, Lapetra, José, additional, Serra-Majem, J. LLuís, additional, García-Molina, Laura, additional, Tur, Josep A., additional, de Paz, José Antonio, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Babio, Nancy, additional, Gimenez-Alba, Ignacio M, additional, Toledo, Estefanía, additional, Zomeño, María Dolores, additional, Zulet, M. A., additional, Vaquero-Luna, Jessica, additional, Pérez-López, Jessica, additional, Pastor-Morel, Ana, additional, Galmes-Panades, Aina M, additional, García-Rios, Antonio, additional, Casas, Rosa, additional, Bernal-López, María Rosa, additional, Santos-Lozano, José Manuel, additional, Becerra-Tomás, Nerea, additional, Ortega-Azorin, Carolina, additional, Vázquez-Ruiz, Zenaida, additional, Pérez-Vega, Karla Alejandra, additional, Abete, Itziar, additional, Sorto-Sánchez, Carolina, additional, Palau-Galindo, Antoni, additional, Galilea-Zabalza, Iñigo, additional, Muñoz-Martínez, Júlia, additional, and Martín, Vicente, additional
Published: 2020
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16. Leisure-Time Physical Activity, Sedentary Behaviour and Diet Quality are Associated with Metabolic Syndrome Severity: The PREDIMED-Plus Study

Author: Gallardo-Alfaro, Laura, primary, Bibiloni, Maria del Mar, additional, Mascaró, Catalina M., additional, Montemayor, Sofía, additional, Ruiz-Canela, Miguel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Martínez, J. Alfredo, additional, Serra-Majem, Lluís, additional, Estruch, Ramon, additional, Fernández-García, José Carlos, additional, Lapetra, José, additional, Pintó, Xavier, additional, García Ríos, Antonio, additional, Bueno-Cavanillas, Aurora, additional, Gaforio, José J., additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Micó-Pérez, Rafael M., additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Fernandez-Lázaro, Cesar Ignacio, additional, Becerra-Tomás, Nerea, additional, Gimenez-Alba, Ignacio Manuel, additional, Zomeño, María Dolors, additional, Konieczna, Jadwiga, additional, Compañ-Gabucio, Laura, additional, Tojal-Sierra, Lucas, additional, Pérez-López, Jéssica, additional, Zulet, M. Ángeles, additional, Casañas-Quintana, Tamara, additional, Castro-Barquero, Sara, additional, Gómez-Pérez, Ana María, additional, Santos-Lozano, José Manuel, additional, Galera, Ana, additional, Basterra-Gortari, F. Javier, additional, Basora, Josep, additional, Saiz, Carmen, additional, Pérez-Vega, Karla Alejandra, additional, Galmés-Panadés, Aina M., additional, Tercero-Maciá, Cristina, additional, Sorto-Sánchez, Carolina, additional, Sayón-Orea, Carmen, additional, García-Gavilán, Jesús, additional, Muñoz-Martínez, Júlia, additional, and Tur, Josep A., additional
Published: 2020
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17. Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study

Author: Castro Barquero, Sara, Tresserra Rimbau, Anna, Vitelli Storelli, Facundo, Doménech, Mónica, Salas Salvadó, Jordi, Martín Sánchez, Vicente, Rubín García, María, Buil Cosiales, Pilar, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso Gómez, Ángel María, Wärnberg, Julia, Martínez, José Alfredo, Serra Majem, Lluís, Tinahones, Francisco José, Lapetra, José, Pintó, Xavier, Tur, Josep Antonio, García Rios, Antonio, García Molina, Laura, Delgado Rodríguez, Miguel, Matía Martín, María Del Pilar, Daimiel, Lidia, Vidal, Josep, Vázquez, Clotilde, Cofán, Montserrat, Romanos Nanclares, Andrea, Becerra Tomas, Nerea, Barragan, Rocio, Castañer, Olga, Konieczna, Jadwiga, González Palacios, Sandra, Sorto Sánchez, Carolina, Pérez López, Jessica, Zulet, María Ángeles, Bautista Castaño, Inmaculada, Casas, Rosa, Gómez Pérez, Ana María, Santos Lozano, José Manuel, Rodríguez Sánchez, María Ángeles, Julibert, Alicia, Martín Calvo, Nerea, Hernández Alonso, Pablo, Sorlí, José V, Sanllorente, Albert, Galmés Panadés, Aina María, Cases Pérez, Eugenio, Goicolea Güemez, Leire, Ruiz Canela, Miguel, Babio, Nancy, Hernáez, Álvaro, Lamuela Raventós, Rosa María, Estruch, Ramon, Castro Barquero, Sara, Tresserra Rimbau, Anna, Vitelli Storelli, Facundo, Doménech, Mónica, Salas Salvadó, Jordi, Martín Sánchez, Vicente, Rubín García, María, Buil Cosiales, Pilar, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso Gómez, Ángel María, Wärnberg, Julia, Martínez, José Alfredo, Serra Majem, Lluís, Tinahones, Francisco José, Lapetra, José, Pintó, Xavier, Tur, Josep Antonio, García Rios, Antonio, García Molina, Laura, Delgado Rodríguez, Miguel, Matía Martín, María Del Pilar, Daimiel, Lidia, Vidal, Josep, Vázquez, Clotilde, Cofán, Montserrat, Romanos Nanclares, Andrea, Becerra Tomas, Nerea, Barragan, Rocio, Castañer, Olga, Konieczna, Jadwiga, González Palacios, Sandra, Sorto Sánchez, Carolina, Pérez López, Jessica, Zulet, María Ángeles, Bautista Castaño, Inmaculada, Casas, Rosa, Gómez Pérez, Ana María, Santos Lozano, José Manuel, Rodríguez Sánchez, María Ángeles, Julibert, Alicia, Martín Calvo, Nerea, Hernández Alonso, Pablo, Sorlí, José V, Sanllorente, Albert, Galmés Panadés, Aina María, Cases Pérez, Eugenio, Goicolea Güemez, Leire, Ruiz Canela, Miguel, Babio, Nancy, Hernáez, Álvaro, Lamuela Raventós, Rosa María, and Estruch, Ramon
Abstract: Dietary polyphenol intake is associated with improvement of metabolic disturbances. The aims of the present study are to describe dietary polyphenol intake in a population with metabolic syndrome (MetS) and to examine the association between polyphenol intake and the components of MetS. This cross-sectional analysis involved 6633 men and women included in the PREDIMED (PREvención con DIeta MEDiterranea-Plus) study. The polyphenol content of foods was estimated from the Phenol-Explorer 3.6 database. The mean of total polyphenol intake was 846 ± 318 mg/day. Except for stilbenes, women had higher polyphenol intake than men. Total polyphenol intake was higher in older participants (>70 years of age) compared to their younger counterparts. Participants with body mass index (BMI) >35 kg/m2 reported lower total polyphenol, flavonoid, and stilbene intake than those with lower BMI. Total polyphenol intake was not associated with a better profile concerning MetS components, except for high-density lipoprotein cholesterol (HDL-c), although stilbenes, lignans, and other polyphenols showed an inverse association with blood pressure, fasting plasma glucose, and triglycerides. A direct association with HDL-c was found for all subclasses except lignans and phenolic acids. To conclude, in participants with MetS, higher intake of several polyphenol subclasses was associated with a better profile of MetS components, especially HDL-c., European Commission, Ministerio de Ciencia, Innovación y Universidades (España)/Fondo Europeo de Desarrollo Regional, Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional, Junta de Andalucía, Generalitat Valenciana, Depto. de Medicina, Fac. de Medicina, TRUE, pub
Published: 2020

18. The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

Author: Marcos Delgado, Alba, Fernández Villa, Tania, Martínez González, Miguel Ángel, Salas Salvadó, Jordi, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Lapetra, José, Serra Majem, J. LLuís, García-Molina, Laura, Tur, Josep A., De Paz, José Antonio, Pintó, Xavier, Delgado Rodríguez, Miguel, Matía Martín, María Del Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Babio, Nancy, Gimenez Alba, Ignacio M., Toledo, Estefanía, Zomeño, María Dolores, Zulet, María Ángeles, Vaquero Luna, Jessica, Pérez López, Jessica, Pastor Morel, Ana, Galmes Panades, Aina M., García Rios, Antonio, Casas, Rosa, Bernal López, María Rosa, Santos Lozano, José Manuel, Becerra Tomás, Nerea, Ortega Azorín, Carolina, Vázquez Ruiz, Zenaida, Pérez Vega, Karla Alejandra, Abete, Itziar, Sorto Sánchez, Carolina, Palau Galindo, Antoni, Galilea Zabalza, Iñigo, Muñoz Martínez, Júlia, Martín, Vicente, Marcos Delgado, Alba, Fernández Villa, Tania, Martínez González, Miguel Ángel, Salas Salvadó, Jordi, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Lapetra, José, Serra Majem, J. LLuís, García-Molina, Laura, Tur, Josep A., De Paz, José Antonio, Pintó, Xavier, Delgado Rodríguez, Miguel, Matía Martín, María Del Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Babio, Nancy, Gimenez Alba, Ignacio M., Toledo, Estefanía, Zomeño, María Dolores, Zulet, María Ángeles, Vaquero Luna, Jessica, Pérez López, Jessica, Pastor Morel, Ana, Galmes Panades, Aina M., García Rios, Antonio, Casas, Rosa, Bernal López, María Rosa, Santos Lozano, José Manuel, Becerra Tomás, Nerea, Ortega Azorín, Carolina, Vázquez Ruiz, Zenaida, Pérez Vega, Karla Alejandra, Abete, Itziar, Sorto Sánchez, Carolina, Palau Galindo, Antoni, Galilea Zabalza, Iñigo, Muñoz Martínez, Júlia, and Martín, Vicente
Abstract: The main objective of this study was to examine the relationship between the level of physical activity (PA) and the degree of obesity with health-related quality of life (HRQoL) in individuals with metabolic syndrome (MetS) who participated in the Predimed-Plus study. A total of 6875 subjects between 55 and 75 years of age with MetS were selected and randomized in 23 Spanish centers. Subjects were classified according to categories of body mass index (BMI). PA was measured with the validated Registre Gironí del Cor (REGICOR) questionnaire and subjects were classified according to their PA level (light, moderate, vigorous) and the HRQoL was measured with the validated short-form 36 (SF-36) questionnaire. By using the ANOVA model, we found a positive and statistically significant association between the level of PA and the HRQoL (aggregated physical and mental dimensions p < 0.001), but a negative association with higher BMI in aggregated physical dimensions p < 0.001. Furthermore, women obtained lower scores compared with men, more five points in all fields of SF-36. Therefore, it is essential to promote PA and body weight control from primary care consultations to improve HRQoL, paying special attention to the differences that sex incurs., European Commission, Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional, Junta de Andalucía, Generalitat Valenciana, Depto. de Medicina, Fac. de Medicina, TRUE, pub
Published: 2020

19. Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study

Author: Castro-Barquero, Sara, Tresserra-Rimbau, Anna, Vitelli-Storelli, Facundo, Doménech, Mónica, Salas-Salvadó, Jordi, Martín-Sánchez, Vicente, Rubín-García, María, Buil-Cosiales, Pilar, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel María, Wärnberg, Julia, Martínez, José Alfredo, Serra-Majem, Luís, Tinahones, Francisco José, Lapetra, José, Pintó, Xavier, Tur, Josep Antonio, Garcia-Rios, Antonio, García-Molina, Laura, Delgado-Rodriguez, Miguel, Matía Martín, Pilar, Daimiel, Lidia, Vidal, Josep, Vázquez, Clotilde, Cofán, Montserrat, Romanos-Nanclares, Andrea, Becerra-Tomas, Nerea, Barragan, Rocio, Castañer, Olga, Konieczna, Jadwiga, González-Palacios, Sandra, Sorto-Sánchez, Carolina, Pérez-López, Jessica, Zulet, María Angeles, Bautista-Castaño, Inmaculada, Casas, Rosa, Gómez-Perez, Ana María, Santos-Lozano, José Manuel, Rodríguez-Sanchez, María Ángeles, Julibert, Alicia, Martín-Calvo, Nerea, Hernández-Alonso, Pablo, Sorlí, José V, Sanllorente, Albert, Galmés-Panadés, Aina María, Cases-Pérez, Eugenio, Goicolea-Güemez, Leire, Ruiz-Canela, Miguel, Babio, Nancy, Hernáez, Álvaro, Lamuela-Raventós, Rosa María, Estruch, Ramon, Castro-Barquero, Sara, Tresserra-Rimbau, Anna, Vitelli-Storelli, Facundo, Doménech, Mónica, Salas-Salvadó, Jordi, Martín-Sánchez, Vicente, Rubín-García, María, Buil-Cosiales, Pilar, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel María, Wärnberg, Julia, Martínez, José Alfredo, Serra-Majem, Luís, Tinahones, Francisco José, Lapetra, José, Pintó, Xavier, Tur, Josep Antonio, Garcia-Rios, Antonio, García-Molina, Laura, Delgado-Rodriguez, Miguel, Matía Martín, Pilar, Daimiel, Lidia, Vidal, Josep, Vázquez, Clotilde, Cofán, Montserrat, Romanos-Nanclares, Andrea, Becerra-Tomas, Nerea, Barragan, Rocio, Castañer, Olga, Konieczna, Jadwiga, González-Palacios, Sandra, Sorto-Sánchez, Carolina, Pérez-López, Jessica, Zulet, María Angeles, Bautista-Castaño, Inmaculada, Casas, Rosa, Gómez-Perez, Ana María, Santos-Lozano, José Manuel, Rodríguez-Sanchez, María Ángeles, Julibert, Alicia, Martín-Calvo, Nerea, Hernández-Alonso, Pablo, Sorlí, José V, Sanllorente, Albert, Galmés-Panadés, Aina María, Cases-Pérez, Eugenio, Goicolea-Güemez, Leire, Ruiz-Canela, Miguel, Babio, Nancy, Hernáez, Álvaro, Lamuela-Raventós, Rosa María, and Estruch, Ramon
Abstract: Dietary polyphenol intake is associated with improvement of metabolic disturbances. The aims of the present study are to describe dietary polyphenol intake in a population with metabolic syndrome (MetS) and to examine the association between polyphenol intake and the components of MetS. This cross-sectional analysis involved 6633 men and women included in the PREDIMED (PREvención con DIeta MEDiterranea-Plus) study. The polyphenol content of foods was estimated from the Phenol-Explorer 3.6 database. The mean of total polyphenol intake was 846 ± 318 mg/day. Except for stilbenes, women had higher polyphenol intake than men. Total polyphenol intake was higher in older participants (>70 years of age) compared to their younger counterparts. Participants with body mass index (BMI) >35 kg/m2 reported lower total polyphenol, flavonoid, and stilbene intake than those with lower BMI. Total polyphenol intake was not associated with a better profile concerning MetS components, except for high-density lipoprotein cholesterol (HDL-c), although stilbenes, lignans, and other polyphenols showed an inverse association with blood pressure, fasting plasma glucose, and triglycerides. A direct association with HDL-c was found for all subclasses except lignans and phenolic acids. To conclude, in participants with MetS, higher intake of several polyphenol subclasses was associated with a better profile of MetS components, especially HDL-c., Unión Europea. FP7, Ministerio de Ciencia e Innovación (MICINN)/FEDER, Instituto de Salud Carlos III (ISCIII)/FEDER, Instituto de Salud Carlos III (ISCIII)/FEDER, Instituto de Salud Carlos III (ISCIII)/FEDER, Junta de Andalucía, Generalitat Valenciana, Depto. de Medicina, Fac. de Medicina, TRUE, pub
Published: 2020

20. The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

Author: Marcos-Delgado, Alba, Fernández-Villa, Tania, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Lapetra, José, Serra-Majem, J. LLuís, García-Molina, Laura, Tur, Josep A., de Paz, José Antonio, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Babio, Nancy, Gimenez-Alba, Ignacio M, Toledo, Estefanía, Zomeño, María Dolores, Zulet, M. A., Vaquero-Luna, Jessica, Pérez-López, Jessica, Pastor-Morel, Ana, Galmes-Panades, Aina M, García-Rios, Antonio, Casas, Rosa, Bernal-López, María Rosa, Santos-Lozano, José Manuel, Becerra-Tomás, Nerea, Ortega-Azorin, Carolina, Vázquez-Ruiz, Zenaida, Pérez-Vega, Karla Alejandra, Abete, Itziar, Sorto-Sánchez, Carolina, Palau-Galindo, Antoni, Galilea-Zabalza, Iñigo, Muñoz-Martínez, Júlia, Martín, Vicente, Marcos-Delgado, Alba, Fernández-Villa, Tania, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Lapetra, José, Serra-Majem, J. LLuís, García-Molina, Laura, Tur, Josep A., de Paz, José Antonio, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Babio, Nancy, Gimenez-Alba, Ignacio M, Toledo, Estefanía, Zomeño, María Dolores, Zulet, M. A., Vaquero-Luna, Jessica, Pérez-López, Jessica, Pastor-Morel, Ana, Galmes-Panades, Aina M, García-Rios, Antonio, Casas, Rosa, Bernal-López, María Rosa, Santos-Lozano, José Manuel, Becerra-Tomás, Nerea, Ortega-Azorin, Carolina, Vázquez-Ruiz, Zenaida, Pérez-Vega, Karla Alejandra, Abete, Itziar, Sorto-Sánchez, Carolina, Palau-Galindo, Antoni, Galilea-Zabalza, Iñigo, Muñoz-Martínez, Júlia, and Martín, Vicente
Abstract: The main objective of this study was to examine the relationship between the level of physical activity (PA) and the degree of obesity with health-related quality of life (HRQoL) in individuals with metabolic syndrome (MetS) who participated in the Predimed-Plus study. A total of 6875 subjects between 55 and 75 years of age with MetS were selected and randomized in 23 Spanish centers. Subjects were classified according to categories of body mass index (BMI). PA was measured with the validated Registre Gironí del Cor (REGICOR) questionnaire and subjects were classified according to their PA level (light, moderate, vigorous) and the HRQoL was measured with the validated short-form 36 (SF-36) questionnaire. By using the ANOVA model, we found a positive and statistically significant association between the level of PA and the HRQoL (aggregated physical and mental dimensions p < 0.001), but a negative association with higher BMI in aggregated physical dimensions p < 0.001. Furthermore, women obtained lower scores compared with men, more five points in all fields of SF-36. Therefore, it is essential to promote PA and body weight control from primary care consultations to improve HRQoL, paying special attention to the differences that sex incurs., Unión Europea. FP7, Instituto de Salud Carlos III (ISCIII) / FEDER, Instituto de Salud Carlos III (ISCIII)/FEDER, Instituto de Salud Carlos III (ISCIII) / FEDER, Junta de Andalucía, Generalitat Valenciana, Depto. de Medicina, Fac. de Medicina, TRUE, pub
Published: 2020

21. The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

Author: Medicina, Medikuntza, Marcos Delgado, Alba, Fernández Villa, Tania, Martínez González, Miguel Ángel, Salas Salvadó, Jordi, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso Gómez, Ángel María, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, García Molina, Laura, Tur, Josep A., De Paz, José Antonio, Pintó, Xavier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Babio, Nancy, Giménez Alba, Ignacio M, Toledo, Estefanía, Zomeño, María Dolores, Zulet, M. Ángeles, Vaquero Luna, Jessica, Pérez López, Jessica, Pastor Morel, Ana, Galmes Panades, Aina María, García Ríos, Antonio, Casas, Rosa, Bernal López, María Rosa, Santos Lozano, José Manuel, Becerra Tomás, Nerea, Ortega Azorín, Carolina, Vázquez Ruiz, Zenaida, Pérez Vega, Karla Alejandra, Abete, Itziar, Sorto Sánchez, Carolina, Palau Galindo, Antoni, Galilea Zabalza, Iñigo, Muñoz Martínez, Júlia, Martín, Vicente, Medicina, Medikuntza, Marcos Delgado, Alba, Fernández Villa, Tania, Martínez González, Miguel Ángel, Salas Salvadó, Jordi, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso Gómez, Ángel María, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, García Molina, Laura, Tur, Josep A., De Paz, José Antonio, Pintó, Xavier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Babio, Nancy, Giménez Alba, Ignacio M, Toledo, Estefanía, Zomeño, María Dolores, Zulet, M. Ángeles, Vaquero Luna, Jessica, Pérez López, Jessica, Pastor Morel, Ana, Galmes Panades, Aina María, García Ríos, Antonio, Casas, Rosa, Bernal López, María Rosa, Santos Lozano, José Manuel, Becerra Tomás, Nerea, Ortega Azorín, Carolina, Vázquez Ruiz, Zenaida, Pérez Vega, Karla Alejandra, Abete, Itziar, Sorto Sánchez, Carolina, Palau Galindo, Antoni, Galilea Zabalza, Iñigo, Muñoz Martínez, Júlia, and Martín, Vicente
Abstract: The main objective of this study was to examine the relationship between the level of physical activity (PA) and the degree of obesity with health-related quality of life (HRQoL) in individuals with metabolic syndrome (MetS) who participated in the Predimed-Plus study. A total of 6875 subjects between 55 and 75 years of age with MetS were selected and randomized in 23 Spanish centers. Subjects were classified according to categories of body mass index (BMI). PA was measured with the validated Registre Gironí del Cor (REGICOR) questionnaire and subjects were classified according to their PA level (light, moderate, vigorous) and the HRQoL was measured with the validated short-form 36 (SF-36) questionnaire. By using the ANOVA model, we found a positive and statistically significant association between the level of PA and the HRQoL (aggregated physical and mental dimensions p < 0.001), but a negative association with higher BMI in aggregated physical dimensions p < 0.001. Furthermore, women obtained lower scores compared with men, more five points in all fields of SF-36. Therefore, it is essential to promote PA and body weight control from primary care consultations to improve HRQoL, paying special attention to the differences that sex incurs.
Published: 2020

22. The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

Author: Instituto de Salud Carlos III, European Research Council, European Commission, Junta de Andalucía, Generalitat Valenciana, Generalitat de Catalunya, Ministerio de Ciencia, Innovación y Universidades (España), Marcos-Delgado, Alba, Fernández-Villa, Tania, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, García-Molina, Laura, Tur, Josep A., Paz, José Antonio de, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Babio, Nancy, Gimenez-Alba, Ignacio M, Toledo, Estefanía, Zomeño Fajardo, Maria Dolores, Zulet, M. Ángeles, Vaquero-Luna, Jessica, Pérez-López, Jessica, Pastor-Morel, Ana, Galmés-Panadés, Aina M., Garcia-Rios, Antonio, Casas, Rosa, Bernal-López, María Rosa, Santos-Lozano, José Manuel, Becerra-Tomás, Nerea, Ortega-Azorín, Carolina, Vázquez-Ruiz, Zenaida, Pérez-Vega, Karla-Alejandra, Abete, Itziar, Sorto-Sánchez, Carolina, Palau-Galindo, Antoni, Galilea-Zabalza, Íñigo, Muñoz-Martínez, Julia, Martín, Vicente, Instituto de Salud Carlos III, European Research Council, European Commission, Junta de Andalucía, Generalitat Valenciana, Generalitat de Catalunya, Ministerio de Ciencia, Innovación y Universidades (España), Marcos-Delgado, Alba, Fernández-Villa, Tania, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, García-Molina, Laura, Tur, Josep A., Paz, José Antonio de, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Babio, Nancy, Gimenez-Alba, Ignacio M, Toledo, Estefanía, Zomeño Fajardo, Maria Dolores, Zulet, M. Ángeles, Vaquero-Luna, Jessica, Pérez-López, Jessica, Pastor-Morel, Ana, Galmés-Panadés, Aina M., Garcia-Rios, Antonio, Casas, Rosa, Bernal-López, María Rosa, Santos-Lozano, José Manuel, Becerra-Tomás, Nerea, Ortega-Azorín, Carolina, Vázquez-Ruiz, Zenaida, Pérez-Vega, Karla-Alejandra, Abete, Itziar, Sorto-Sánchez, Carolina, Palau-Galindo, Antoni, Galilea-Zabalza, Íñigo, Muñoz-Martínez, Julia, and Martín, Vicente
Abstract: The main objective of this study was to examine the relationship between the level of physical activity (PA) and the degree of obesity with health-related quality of life (HRQoL) in individuals with metabolic syndrome (MetS) who participated in the Predimed-Plus study. A total of 6875 subjects between 55 and 75 years of age with MetS were selected and randomized in 23 Spanish centers. Subjects were classified according to categories of body mass index (BMI). PA was measured with the validated Registre Gironí del Cor (REGICOR) questionnaire and subjects were classified according to their PA level (light, moderate, vigorous) and the HRQoL was measured with the validated short-form 36 (SF-36) questionnaire. By using the ANOVA model, we found a positive and statistically significant association between the level of PA and the HRQoL (aggregated physical and mental dimensions p < 0.001), but a negative association with higher BMI in aggregated physical dimensions p < 0.001. Furthermore, women obtained lower scores compared with men, more five points in all fields of SF-36. Therefore, it is essential to promote PA and body weight control from primary care consultations to improve HRQoL, paying special attention to the differences that sex incurs
Published: 2020

23. Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study

Author: Castro-Barquero, Sara, primary, Tresserra-Rimbau, Anna, additional, Vitelli-Storelli, Facundo, additional, Doménech, Mónica, additional, Salas-Salvadó, Jordi, additional, Martín-Sánchez, Vicente, additional, Rubín-García, María, additional, Buil-Cosiales, Pilar, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel, additional, Wärnberg, Julia, additional, Martínez, José, additional, Serra-Majem, Luís, additional, Tinahones, Francisco, additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep, additional, Garcia-Rios, Antonio, additional, García-Molina, Laura, additional, Delgado-Rodriguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Cofán, Montserrat, additional, Romanos-Nanclares, Andrea, additional, Becerra-Tomas, Nerea, additional, Barragan, Rocio, additional, Castañer, Olga, additional, Konieczna, Jadwiga, additional, González-Palacios, Sandra, additional, Sorto-Sánchez, Carolina, additional, Pérez-López, Jessica, additional, Zulet, María, additional, Bautista-Castaño, Inmaculada, additional, Casas, Rosa, additional, Gómez-Perez, Ana, additional, Santos-Lozano, José, additional, Rodríguez-Sanchez, María, additional, Julibert, Alicia, additional, Martín-Calvo, Nerea, additional, Hernández-Alonso, Pablo, additional, Sorlí, José, additional, Sanllorente, Albert, additional, Galmés-Panadés, Aina, additional, Cases-Pérez, Eugenio, additional, Goicolea-Güemez, Leire, additional, Ruiz-Canela, Miguel, additional, Babio, Nancy, additional, Hernáez, Álvaro, additional, Lamuela-Raventós, Rosa, additional, and Estruch, Ramon, additional
Published: 2020
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24. Total and Subtypes of Dietary Fat Intake and Its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk

Author: Julibert, Alicia, primary, Bibiloni, Maria, additional, Bouzas, Cristina, additional, Martínez-González, Miguel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Zomeño, Maria, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel, additional, Wärnberg, Julia, additional, Martínez, J., additional, Serra-Majem, Luís, additional, Estruch, Ramon, additional, Tinahones, Francisco, additional, Lapetra, José, additional, Pintó, Xavier, additional, Lopez-Miranda, José, additional, García-Molina, Laura, additional, Gaforio, José, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Martín-Sánchez, Vicente, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emili, additional, Toledo, Estefanía, additional, Becerra-Tomás, Nerea, additional, Pórtoles, Olga, additional, Pérez-Vega, Karla, additional, Fiol, Miquel, additional, Torres-Collado, Laura, additional, Tojal-Sierra, Lucas, additional, Carabaño-Moral, Rosa, additional, Abete, Itziar, additional, Sanchez-Villegas, Almudena, additional, Casas, Rosa, additional, Bernal-López, María, additional, Santos-Lozano, José, additional, Galera, Ana, additional, Ugarriza, Lucía, additional, Ruiz-Canela, Miguel, additional, Babio, Nancy, additional, Coltell, Oscar, additional, Schröder, Helmut, additional, Konieczna, Jadwiga, additional, Orozco-Beltrán, Domingo, additional, Sorto-Sánchez, Carolina, additional, Eguaras, Sonia, additional, Barrubés, Laura, additional, Fitó, Montserrat, additional, Tur, Josep, additional, and Investigators, PREDIMED-PLUS, additional
Published: 2019
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25. The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

Author: Medicina Preventiva, Marcos Delgado, Alba, Fernández Villa, Tania, Martínez González, Miguel Ángel, Salas Salvadó, Jordi, Corella, Dolores, Castañer, Olga, Martínez, José Alfredo, Alonso Gómez, Ángel María, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco José, Lapetra, José, Serra Majem, J. Lluís, García Molina, Laura, Tur, Josep Antoni, Paz Fernández, José Antonio de, Pintó, Xavier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Babio, Nancy, Giménez Alba, Ignacio Manuel, Toledo, Estefanía, Zomeño, María Dolores, Zulet, Marian A., Vaquero Luna, Jessica, Pastor Morel, Ana, Galmés Panadés, Aina María, García Ríos, Antonio, Casas, Rosa, Bernal López, María Rosa, Santos Lozano, José Manuel, Becerra Tomás, Nerea, Ortega Azorín, Carolina, Vázquez Ruiz, Zenaida, Pérez Vega, Karla Alejandra, Abete, Itziar, Sorto Sánchez, Carolina, Palau Galindo, Antoni, Galilea Zabalza, Íñigo, Muñoz Martínez, Julia, Martín Sánchez, Vicente, Medicina Preventiva, Marcos Delgado, Alba, Fernández Villa, Tania, Martínez González, Miguel Ángel, Salas Salvadó, Jordi, Corella, Dolores, Castañer, Olga, Martínez, José Alfredo, Alonso Gómez, Ángel María, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco José, Lapetra, José, Serra Majem, J. Lluís, García Molina, Laura, Tur, Josep Antoni, Paz Fernández, José Antonio de, Pintó, Xavier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Babio, Nancy, Giménez Alba, Ignacio Manuel, Toledo, Estefanía, Zomeño, María Dolores, Zulet, Marian A., Vaquero Luna, Jessica, Pastor Morel, Ana, Galmés Panadés, Aina María, García Ríos, Antonio, Casas, Rosa, Bernal López, María Rosa, Santos Lozano, José Manuel, Becerra Tomás, Nerea, Ortega Azorín, Carolina, Vázquez Ruiz, Zenaida, Pérez Vega, Karla Alejandra, Abete, Itziar, Sorto Sánchez, Carolina, Palau Galindo, Antoni, Galilea Zabalza, Íñigo, Muñoz Martínez, Julia, and Martín Sánchez, Vicente
Abstract: [EN] The main objective of this study was to examine the relationship between the level of physical activity (PA) and the degree of obesity with health-related quality of life (HRQoL) in individuals with metabolic syndrome (MetS) who participated in the Predimed-Plus study. A total of 6875 subjects between 55 and 75 years of age with MetS were selected and randomized in 23 Spanish centers. Subjects were classified according to categories of body mass index (BMI). PA was measured with the validated Registre Gironi del Cor (REGICOR) questionnaire and subjects were classified according to their PA level (light, moderate, vigorous) and the HRQoL was measured with the validated short-form 36 (SF-36) questionnaire. By using the ANOVA model, we found a positive and statistically significant association between the level of PA and the HRQoL (aggregated physical and mental dimensions p < 0.001), but a negative association with higher BMI in aggregated physical dimensions p < 0.001. Furthermore, women obtained lower scores compared with men, more five points in all fields of SF-36. Therefore, it is essential to promote PA and body weight control from primary care consultations to improve HRQoL, paying special attention to the differences that sex incurs.

26. Impact of mediterranean diet promotion on environmental sustainability: a longitudinal analysis

Author: Tecnologia de los Alimentos, Álvarez Fernández, Laura, Vitelli Storelli, Facundo Ezequiel, Rubín García, María, Oricheta García, María Silvia, Bouzas, Cristina, Ruiz Canela, Miguel, Corella, Dolores, Corella, D., Salas Savadó, Jordi, Fitõ, Montserrat, Martínez, Jose Alfredo, Tojal-sierra, Lucas, Wärnberg, Julia, Vioque, Jesus L., Romaguera, D., López Miranda, José, Estruch, Ramón Sarrate, Tinahones, Francisco J., Santos Lozano, José Manuel, Serra Majem, Lluis I, Bueno Cavanillas, Aurora, Martín Sánchez, Vicente, García Fernández, María del Camino, Esteve-luque, Virginia, Delgado-rodríquez, Miguel, Torrego-ellacuría, Macarena, Vidal Cortada, Josep Rafael Cuauhtémoc Acoltzi, Arancio Prieto, Lucía, Daimiel, L. A., Casas, Rosa, García-arellano, Ana, Shyam, Sangeetha, González, José Ignacio, Castañer, Olga, García Ríos, Antonio, Ortiz Díaz, F., Fernández, A. C., Sánchez-villegas, Almudena, Morey, Marga, Cano-ibáñez, Naomi, Sorto Sánchez, Carolina, Bernal López, María Rosa, Bes-rastrollo, Maira, Nishi, Stephanie K., Coltell, Oscar, Zomeño, María Dolores, Peã±a-orihuela, Patricia Judith, Aparicio, D. V., Zulet, María A, Vázquez, Z., Babio, Nancy Elvira, Pérez, Karla Alejandra, Tur, Josep Antoni, Tecnologia de los Alimentos, Álvarez Fernández, Laura, Vitelli Storelli, Facundo Ezequiel, Rubín García, María, Oricheta García, María Silvia, Bouzas, Cristina, Ruiz Canela, Miguel, Corella, Dolores, Corella, D., Salas Savadó, Jordi, Fitõ, Montserrat, Martínez, Jose Alfredo, Tojal-sierra, Lucas, Wärnberg, Julia, Vioque, Jesus L., Romaguera, D., López Miranda, José, Estruch, Ramón Sarrate, Tinahones, Francisco J., Santos Lozano, José Manuel, Serra Majem, Lluis I, Bueno Cavanillas, Aurora, Martín Sánchez, Vicente, García Fernández, María del Camino, Esteve-luque, Virginia, Delgado-rodríquez, Miguel, Torrego-ellacuría, Macarena, Vidal Cortada, Josep Rafael Cuauhtémoc Acoltzi, Arancio Prieto, Lucía, Daimiel, L. A., Casas, Rosa, García-arellano, Ana, Shyam, Sangeetha, González, José Ignacio, Castañer, Olga, García Ríos, Antonio, Ortiz Díaz, F., Fernández, A. C., Sánchez-villegas, Almudena, Morey, Marga, Cano-ibáñez, Naomi, Sorto Sánchez, Carolina, Bernal López, María Rosa, Bes-rastrollo, Maira, Nishi, Stephanie K., Coltell, Oscar, Zomeño, María Dolores, Peã±a-orihuela, Patricia Judith, Aparicio, D. V., Zulet, María A, Vázquez, Z., Babio, Nancy Elvira, Pérez, Karla Alejandra, and Tur, Josep Antoni
Abstract: [EN]This article aims to estimate the differences in environmental impact (greenhouse gas [GHG] emissions, land use, energy used, acidification and potential eutrophication) after one year of promoting a Mediterranean diet (MD). Methods Baseline and 1-year follow-up data from 5800 participants in the PREDIMED-Plus study were used. Each participant's food intake was estimated using validated semi-quantitative food frequency questionnaires, and the adherence to MD using the Dietary Score. The influence of diet on environmental impact was assessed through the EAT-Lancet Commission tables. The influence of diet on environmental impact was assessed through the EAT-Lancet Commission tables. The association between MD adherence and its environmental impact was calculated using adjusted multivariate linear regression models.

27. Dietary diversity and depression: cross-sectional and longitudinal analyses in Spanish adult population with metabolic syndrome. Findings from PREDIMED-Plus trial.

Author: Cano-Ibáñez N, Serra-Majem L, Martín-Peláez S, Martínez-González MÁ, Salas-Salvadó J, Corella D, Lassale C, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, López-Miranda J, Estruch R, Gómez-Pérez AM, Lapetra J, Fernández-Aranda F, Bueno-Cavanillas A, Tur JA, Cubelos N, Pintó X, Gaforio JJ, Matía-Martín P, Vidal J, Calderón C, Daimiel L, Ros E, Gea A, Babio N, Gimenez-Alba IM, Zomeño-Fajardo MD, Abete I, Tojal Sierra L, Romero-Galisteo RP, García de la Hera M, Martín-Padillo M, García-Ríos A, Casas RM, Fernández-García JC, Santos-Lozano JM, Toledo E, Becerra-Tomas N, Sorli JV, Schröder H, Zulet MA, Sorto-Sánchez C, Diez-Espino J, Gómez-Martínez C, Fitó M, and Sánchez-Villegas A
Abstract: Objective: To examine the cross-sectional and longitudinal (2-year follow-up) associations between dietary diversity (DD) and depressive symptoms., Design: An energy-adjusted dietary diversity score (DDS) was assessed using a validated FFQ and was categorised into quartiles (Q). The variety in each food group was classified into four categories of diversity (C). Depressive symptoms were assessed with Beck Depression Inventory-II (Beck II) questionnaire and depression cases defined as physician-diagnosed or Beck II >= 18. Linear and logistic regression models were used., Setting: Spanish older adults with metabolic syndrome (MetS)., Participants: A total of 6625 adults aged 55-75 years from the PREDIMED-Plus study with overweight or obesity and MetS., Results: Total DDS was inversely and statistically significantly associated with depression in the cross-sectional analysis conducted; OR Q4 v . Q1 = 0·76 (95 % CI (0·64, 0·90)). This was driven by high diversity compared to low diversity (C3 v . C1) of vegetables (OR = 0·75, 95 % CI (0·57, 0·93)), cereals (OR = 0·72 (95 % CI (0·56, 0·94)) and proteins (OR = 0·27, 95 % CI (0·11, 0·62)). In the longitudinal analysis, there was no significant association between the baseline DDS and changes in depressive symptoms after 2 years of follow-up, except for DD in vegetables C4 v . C1 = ( β = 0·70, 95 % CI (0·05, 1·35))., Conclusions: According to our results, DD is inversely associated with depressive symptoms, but eating more diverse does not seem to reduce the risk of future depression. Additional longitudinal studies (with longer follow-up) are needed to confirm these findings.
Published: 2023
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28. Association between the Prime Diet Quality Score and depressive symptoms in a Mediterranean population with metabolic syndrome. Cross-sectional and 2-year follow-up assessment from PREDIMED-PLUS study.

Author: Cano-Ibáñez N, Serra-Majem L, Martín-Peláez S, Martínez-González MÁ, Salas-Salvadó J, Corella Piquer MD, Lassale C, Martínez Hernandez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque Lopez J, Romaguera D, López-Miranda J, Estruch R, Gómez-Pérez AM, Santos-Lozano JM, Fernández-Aranda F, Bueno-Cavanillas A, Tur JA, Martín V, Pintó Sala X, Delgado-Rodríguez M, Matía Martín P, Vidal J, Cárdenas JJ, Daimiel Ruiz L, Ros E, Buil-Cosiales P, Becerra-Tomás N, Saiz C, Muñoz-Perez MÁ, Abete I, Tojal-Sierra L, Fernández-Barceló O, Bernabé-Casanova A, Konieczna J, García-Ríos A, Casas R, Bernal-López MR, Lapetra J, Toledo E, Gómez-Martínez C, Coltell O, Malcampo-Manrúbia M, Zulet MA, Sorto-Sánchez C, Gea A, Hernández-Fleta JL, Castañer Niño O, and Sánchez-Villegas A
Subjects: Humans, Aged, Depression epidemiology, Cross-Sectional Studies, Follow-Up Studies, Diet, Metabolic Syndrome, Diet, Mediterranean
Abstract: The burden of depression is increasing worldwide, specifically in older adults. Unhealthy dietary patterns may partly explain this phenomenon. In the Spanish PREDIMED-Plus study, we explored (1) the cross-sectional association between the adherence to the Prime Diet Quality Score (PDQS), an a priori-defined high-quality food pattern, and the prevalence of depressive symptoms at baseline (cross-sectional analysis) and (2) the prospective association of baseline PDQS with changes in depressive symptomatology after 2 years of follow-up. After exclusions, we assessed 6612 participants in the cross-sectional analysis and 5523 participants in the prospective analysis. An energy-adjusted high-quality dietary score (PDQS) was assessed using a validated FFQ. The cross-sectional association between PDQS and the prevalence of depression or presence of depressive symptoms and the prospective changes in depressive symptoms were evaluated through multivariable regression models (logistic and linear models and mixed linear-effects models). PDQS was inversely associated with depressive status in the cross-sectional analysis. Participants in the highest quintile of PDQS (Q5) showed a significantly reduced odds of depression prevalence as compared to participants in the lowest quartile of PDQS (Q1) (OR (95 %) CI = 0·82 (0·68, 0·98))). The baseline prevalence of depression decreased across PDQS quintiles ( P for trend = 0·015). A statistically significant association between PDQS and changes in depressive symptoms after 2-years follow-up was found ( β (95 %) CI = -0·67 z-score (-1·17, -0·18). A higher PDQS was cross-sectionally related to a lower depressive status. Nevertheless, the null finding in our prospective analysis raises the possibility of reverse causality. Further prospective investigation is required to ascertain the association between PDQS and changes in depressive symptoms along time.
Published: 2022
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29. Desired weight loss and its association with health, health behaviors and perceptions in an adult population with weight excess: One-year follow-up.

Author: Bouzas C, Bibiloni MDM, Garcia S, Mateos D, Martínez-González MÁ, Salas-Salvadó J, Corella D, Goday A, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, Lopez-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem L, Riquelme-Gallego B, Martín-Sánchez V, Pintó X, Gaforio JJ, Matía P, Vidal J, Vázquez C, Daimiel L, Ros E, Pascual-Roquet-Jalmar E, Babio N, Gonzalez-Monge I, Castañer O, Abete I, Sorto-Sánchez C, Carlos Benavente-Marín J, Torres-Collado L, Martin M, García-Ríos A, Castro-Barquero S, Fernández-García JC, Santos-Lozano JM, Fernandez-Lazaro CI, Salas-Huetos A, Guillem-Saiz P, Zomeño MD, Ángeles Zulet M, Goikoetxea-Bahon A, Gea A, Nishi SK, Schröder H, and Tur JA
Abstract: Background: Metabolic syndrome (MetS) worsens quality of life and increases mortality. Dissatisfaction with weight in patients with MetS may modify the effect of lifestyle interventions to achieve changes in health-related behaviors., Objective: To assess 1-year changes in cardiovascular risk scores, self-perceived general health and health-related behaviors according to observed changes in desired weight loss during the first year of intervention in a large cardiovascular prevention trial., Design: Prospective analysis of the PREDIMED-PLUS trial, including 5,499 adults (55-75 years old) with overweight or obesity at baseline., Methods: The desired weight loss was the difference between ideal and measured weight. Tertiles of change in desired weight loss (1 year vs. baseline) were defined by the following cut-off points: ≥0.0 kg (T1, n = 1,638); 0.0 to -4.0 kg (T2, n = 1,903); ≤-4.0 kg (T3, n = 1,958). A food frequency questionnaire assessed diet and the Minnesota-REGICOR questionnaire assessed physical activity. The Framingham equation assessed cardiovascular risks. The changes in the severity of MetS were also assessed. The Beck Depression Inventory assessed depressive symptoms and the SF-36 assessed health-related quality of life. Data were analyzed using general linear models., Results: BMI decreased at T2 and T3 (T1: 0.3, T2: -0.7, T3: -1.9). The most significant improvement in diet quality was observed at T3. Cardiovascular risk decreased at T2 and T3. Mean reductions in MetS severity score were: -0.02 at T1, -0.39 at T2 and -0.78 at T3. The perception of physical health increases in successive tertiles., Conclusions: In older adults with MetS, more ambitious desired weight loss goals were associated with improvements in diet, cardiovascular health and perceived physical health during the first year of a healthy lifestyle intervention programme. Weight dissatisfaction needs to be considered by health professionals., Clinical Trial Registration: http://www.isrctn.com/ISRCTN89898870, identifier 89898870., Competing Interests: Author JS-S reports serving on the board of and receiving grant support through his institution from the International Nut and Dried Fruit Council, and Eroski Foundation. Reports serving in the Executive Committee of the Instituto Danone Spain and on the Scientific Committee of the Danone International Institute. He has received research support from the Patrimonio Comunal Olivarero, Spain and Borges S.A., Spain. Reports receiving consulting fees or travel expenses from Danone; Eroski Foundation; Instituto Danone—Spain; and Abbot Laboratories. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer MM-A declared a shared affiliation with the author BR-G to the handling editor at the time of review., (Copyright © 2022 Bouzas, Bibiloni, Garcia, Mateos, Martínez-González, Salas-Salvadó, Corella, Goday, Martínez, Alonso-Gómez, Wärnberg, Vioque, Romaguera, Lopez-Miranda, Estruch, Tinahones, Lapetra, Serra-Majem, Riquelme-Gallego, Martín-Sánchez, Pintó, Gaforio, Matía, Vidal, Vázquez, Daimiel, Ros, Pascual-Roquet-Jalmar, Babio, Gonzalez-Monge, Castañer, Abete, Sorto-Sánchez, Carlos Benavente-Marín, Torres-Collado, Martin, García-Ríos, Castro-Barquero, Fernández-García, Santos-Lozano, Fernandez-Lazaro, Salas-Huetos, Guillem-Saiz, Zomeño, Ángeles Zulet, Goikoetxea-Bahon, Gea, Nishi, Schröder, Tur and the PREDIMED-Plus investigators.)
Published: 2022
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30. Effect of changes in adherence to Mediterranean diet on nutrient density after 1-year of follow-up: results from the PREDIMED-Plus Study.

Author: Cano-Ibáñez N, Bueno-Cavanillas A, Martínez-González MÁ, Salas-Salvadó J, Corella D, Freixer GL, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X, Tur JA, García-Ríos A, García-Molina L, Delgado-Rodríguez M, Matía-Martín P, Daimiel L, Martín-Sánchez V, Vidal J, Vázquez C, Ros E, Bartolomé-Resano J, Palau-Galindo A, Portoles O, Torres L, Miquel-Fiol, Sánchez MTC, Sorto-Sánchez C, Moreno-Morales N, Abete I, Álvarez-Pérez J, Sacanella E, Bernal-López MR, Santos-Lozano JM, Fanlo-Maresma M, Bouzas C, Razquin C, Becerra-Tomás N, Ortega-Azorin C, LLimona R, Morey M, Román-Maciá J, Goicolea-Güemez L, Vázquez-Ruiz Z, Barrubés L, Fitó M, and Gea A
Subjects: Aged, Cardiovascular Diseases complications, Cardiovascular Diseases prevention & control, Female, Follow-Up Studies, Humans, Male, Metabolic Syndrome complications, Metabolic Syndrome prevention & control, Middle Aged, Obesity complications, Obesity prevention & control, Overweight complications, Overweight prevention & control, Risk Factors, Spain, Time Factors, Cardiovascular Diseases diet therapy, Diet, Mediterranean, Metabolic Syndrome diet therapy, Nutritional Status, Obesity diet therapy, Overweight diet therapy
Abstract: Background: The prevalence of overweight/obesity and related manifestations such as metabolic syndrome (MetS) is increasing worldwide. High energy density diets, usually with low nutrient density, are among the main causes. Some high-quality dietary patterns like the Mediterranean diet (MedDiet) have been linked to the prevention and better control of MetS. However, it is needed to show that nutritional interventions promoting the MedDiet are able to improve nutrient intake., Objective: To assess the effect of improving MedDiet adherence on nutrient density after 1 year of follow-up at the PREDIMED-Plus trial., Methods: We assessed 5777 men (55-75 years) and women (60-75 years) with overweight or obesity and MetS at baseline from the PREDIMED-Plus trial. Dietary changes and MedDiet adherence were evaluated at baseline and after 1 year. The primary outcome was the change in nutrient density (measured as nutrient intake per 1000 kcal). Multivariable-adjusted linear regression models were fitted to analyse longitudinal changes in adherence to the MedDiet and concurrent changes in nutrient density., Results: During 1-year follow-up, participants showed improvements in nutrient density for all micronutrients assessed. The density of carbohydrates (- 9.0%), saturated fatty acids (- 10.4%) and total energy intake (- 6.3%) decreased. These changes were more pronounced in the subset of participants with higher improvements in MedDiet adherence., Conclusions: The PREDIMED-Plus dietary intervention, based on MedDiet recommendations for older adults, maybe a feasible strategy to improve nutrient density in Spanish population at high risk of cardiovascular disease with overweight or obesity.
Published: 2020
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30 results on '"Sorto Sánchez, Carolina"'

1. Comparative effects of glucagon-like peptide-1 receptors agonists, 4-dipeptidyl peptidase inhibitors, and metformin on metabolic syndrome

2. Polyphenol intake and cardiovascular risk in the PREDIMED-Plus trial. A comparison of different risk equations

3. Ingesta de polifenoles y riesgo cardiovascular en el ensayo PREDIMED-Plus. Una comparación de diferentes ecuaciones de riesgo

4. Pro-vegetarian food patterns and cardiometabolic risk in the PREDIMED-Plus study: a cross-sectional baseline analysis

5. Association between ankle-brachial index and cognitive function in participants in the PREDIMED-Plus study: cross-sectional assessment

6. Asociación entre índice tobillo-brazo y rendimiento cognitivo en participantes del estudio PREDIMED-Plus: estudio transversal

7. Desired weight loss and its association with health, health behaviors and perceptions in an adult population with weight excess: One-year follow-up

8. Dietary diversity and depression: cross-sectional and longitudinal analyses in Spanish adult population with metabolic syndrome. Findings from PREDIMED-Plus trial

9. Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk

10. Pro‑vegetarian food patterns and cardiometabolic risk in the PREDIMED‑Plus study: a cross‑sectional baseline analysis

11. Pro‑vegetarian food patterns and cardiometabolic risk in the PREDIMED‑Plus study: a cross‑sectional baseline analysis

12. Association between the Prime Diet Quality Score and depressive symptoms in a Mediterranean population with metabolic syndrome. Cross-sectional and 2-year follow-up assessment from PREDIMED-PLUS study

13. Pro-vegetarian food patterns and cardiometabolic risk in the PREDIMED-Plus study: a cross-sectional baseline analysis

14. Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial

15. The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

16. Leisure-Time Physical Activity, Sedentary Behaviour and Diet Quality are Associated with Metabolic Syndrome Severity: The PREDIMED-Plus Study

17. Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study

18. The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

19. Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study

20. The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

21. The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

22. The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

23. Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study

24. Total and Subtypes of Dietary Fat Intake and Its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk

25. The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

26. Impact of mediterranean diet promotion on environmental sustainability: a longitudinal analysis

27. Dietary diversity and depression: cross-sectional and longitudinal analyses in Spanish adult population with metabolic syndrome. Findings from PREDIMED-Plus trial.

28. Association between the Prime Diet Quality Score and depressive symptoms in a Mediterranean population with metabolic syndrome. Cross-sectional and 2-year follow-up assessment from PREDIMED-PLUS study.

29. Desired weight loss and its association with health, health behaviors and perceptions in an adult population with weight excess: One-year follow-up.

30. Effect of changes in adherence to Mediterranean diet on nutrient density after 1-year of follow-up: results from the PREDIMED-Plus Study.

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