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Thispaper presents a mathematical programming model for the optimalsynthesis and retrofitting of water networks based on the propertiesof the streams that impact the processing in the plant and the environment.One important feature of the proposed approach is that it accountsfor changes in the operation through a time horizon with growing demands.The optimization formulation considers changes in the demands andaccounts for time-based variations in the flow rates required forthe process sinks and constraints for properties in the process sinksand in the environment. Furthermore, the proposed model allows theinstallation of different units and the retrofitting of the waternetwork over the considered time horizon. The objective function minimizesthe total cost associated with the entire life of the project whileaccounting for the time value of money and the specific demands forthe process and the environment that change through the life of theproject. Two case studies are solved to show the applicability ofthe proposed approach. [ABSTRACT FROM AUTHOR]