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174 results on '"Soto Parra, Hector"'

2. Standardized and simplified reporting of next-generation sequencing results in advanced non-small-cell lung cancer: Practical indications from an Italian multidisciplinary group

Author

Malapelle, Umberto, Donne, Alessandro Delle, Pagni, Fabio, Fraggetta, Filippo, Rocco, Elena Guerini, Pasello, Giulia, Perrone, Giuseppe, Pepe, Francesco, Vatrano, Simona, Pignata, Sandro, Pinto, Carmine, Pruneri, Giancarlo, Russo, Antonio, Soto Parra, Hector J., Vallone, Stefania, Marchetti, Antonio, Troncone, Giancarlo, and Novello, Silvia

Published
2024
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3. Real-world experience of abiraterone acetate plus prednisone in chemotherapy-naive patients with metastatic castration-resistant prostate cancer: long-term results of the prospective ABItude study

Author

Procopio, Giuseppe, Chiuri, Vincenzo, Mantini, Giovanna, Roberto Bordonaro, Roberto Maisano., Cinieri, Saverio, Rossetti, Sabrina, De Placido, Sabino, Airoldi, Mario, Galli, Luca, Gasparro, Donatello, Ludovico, Giuseppe Mario, Guglielmini, Pamela Francesca, Santini, Daniele, Naglieri, Emanuele, Fagnani, Daniele, Aglietta, Massimo, Livi, Lorenzo, Schips, Luigi, Passalacqua, Rodolfo, Fiore, Michele, D'Angelillo, Rolando Maria, Ceresoli, Giovanni Luca, Magrini, Stefano, Rondonotti, David, Mirone, Vincenzo, Ferriero, Maria Consiglia, Sciarra, Alessandro, Acquati, Mirko, Boccardo, Francesco, Scagliotti, Giorgio Vittorio, Mencoboni, Manlio, De Giorgi, Ugo, Micheletti, Gennaro, Lanzetta, Gaetano, Sartori, Donata, Carlini, Paolo, Soto Parra, Hector Josè, Battaglia, Michele, Uricchio, Francesco, Bernardo, Antonio, De Lisa, Antonello, Carrieri, Giuseppe, Ardizzoia, Antonio, Aieta, Michele, Pisconti, Salvatore, Marchetti, Paolo, Paiar, Fabiola, Procopio, G., Chiuri, V.E., Giordano, M., Alitto, A.R., Maisano, R., Bordonaro, R., Cinieri, S., Rossetti, S., De Placido, S., Airoldi, M., Galli, L., Gasparro, D., Ludovico, G.M., Guglielmini, P.F., Carella, C., Nova, P., Aglietta, M., Schips, L., Beccaglia, P., Sciarra, A., Livi, L., and Santini, D.

Published
2022
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4. Gemcitabine with or without ramucirumab as second-line treatment for malignant pleural mesothelioma (RAMES): a randomised, double-blind, placebo-controlled, phase 2 trial

Author

Pinto, Carmine, Zucali, Paolo Andrea, Pagano, Maria, Grosso, Federica, Pasello, Giulia, Garassino, Marina Chiara, Tiseo, Marcello, Soto Parra, Hector, Grossi, Francesco, Cappuzzo, Federico, de Marinis, Filippo, Pedrazzoli, Paolo, Bonomi, Maria, Gianoncelli, Letizia, Perrino, Matteo, Santoro, Armando, Zanelli, Francesca, Bonelli, Candida, Maconi, Antonio, Frega, Stefano, Gervasi, Erika, Boni, Luca, and Ceresoli, Giovanni Luca

Published
2021
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5. The prognostic value of the previous nephrectomy in pretreated metastatic renal cell carcinoma receiving immunotherapy: a sub-analysis of the Meet-URO 15 study

Author

Rebuzzi, Sara Elena, Signori, Alessio, Banna, Giuseppe Luigi, Gandini, Annalice, Fornarini, Giuseppe, Damassi, Alessandra, Maruzzo, Marco, De Giorgi, Ugo, Basso, Umberto, Chiellino, Silvia, Galli, Luca, Zucali, Paolo Andrea, Fantinel, Emanuela, Naglieri, Emanuele, Procopio, Giuseppe, Milella, Michele, Boccardo, Francesco, Fratino, Lucia, Pipitone, Stefania, Ricotta, Riccardo, Panni, Stefano, Mollica, Veronica, Sorarù, Mariella, Santoni, Matteo, Cortellini, Alessio, Prati, Veronica, Soto Parra, Hector Josè, Santini, Daniele, Atzori, Francesco, Di Napoli, Marilena, Caffo, Orazio, Messina, Marco, Morelli, Franco, Prati, Giuseppe, Nolè, Franco, Vignani, Francesca, Cavo, Alessia, Roviello, Giandomenico, Rescigno, Pasquale, and Buti, Sebastiano

Published
2022
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6. Virtual Multidisciplinary Tumor Boards: A Narrative Review Focused on Lung Cancer

Author

Gebbia, Vittorio, Guarini, Aurelia, Piazza, Dario, Bertani, Alessandro, Spada, Massimiliano, Verderame, Francesco, Sergi, Concetta, Potenza, Enrico, Fazio, Ivan, Blasi, Livio, La Sala, Alba, Mortillaro, Gianluca, Roz, Elena, Marchese, Roberto, Chiarenza, Maurizio, Soto-Parra, Hector, Valerio, Maria Rosaria, Agneta, Giuseppe, Amato, Carmela, Lipari, Helga, Baldari, Sergio, Ferraù, Francesco, Di Grazia, Alfio, Mancuso, Gianfranco, Rizzo, Sergio, and Firenze, Alberto

Published
2021
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7. A Randomized, Placebo-Controlled Trial of Pembrolizumab Plus Chemotherapy in Patients With Metastatic Squamous NSCLC: Protocol-Specified Final Analysis of KEYNOTE-407

Author

Paz-Ares, Luis, Vicente, David, Tafreshi, Ali, Robinson, Andrew, Soto Parra, Hector, Mazières, Julien, Hermes, Barbara, Cicin, Irfan, Medgyasszay, Balazs, Rodríguez-Cid, Jerónimo, Okamoto, Isamu, Lee, SungSook, Ramlau, Rodryg, Vladimirov, Vladimir, Cheng, Ying, Deng, Xuan, Zhang, Ying, Bas, Tuba, Piperdi, Bilal, and Halmos, Balazs

Published
2020
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8. Standardized and simplified reporting of next-generation sequencing results in advanced non-small-cell lung cancer: practical indications from an Italian multidisciplinary group

Author

Malapelle, U, Donne, A, Pagni, F, Fraggetta, F, Rocco, E, Pasello, G, Perrone, G, Pepe, F, Vatrano, S, Pignata, S, Pinto, C, Pruneri, G, Russo, A, Soto Parra, H, Vallone, S, Marchetti, A, Troncone, G, Novello, S, Malapelle, Umberto, Donne, Alessandro Delle, Pagni, Fabio, Fraggetta, Filippo, Rocco, Elena Guerini, Pasello, Giulia, Perrone, Giuseppe, Pepe, Francesco, Vatrano, Simona, Pignata, Sandro, Pinto, Carmine, Pruneri, Giancarlo, Russo, Antonio, Soto Parra, Hector J, Vallone, Stefania, Marchetti, Antonio, Troncone, Giancarlo, Novello, Silvia, Malapelle, U, Donne, A, Pagni, F, Fraggetta, F, Rocco, E, Pasello, G, Perrone, G, Pepe, F, Vatrano, S, Pignata, S, Pinto, C, Pruneri, G, Russo, A, Soto Parra, H, Vallone, S, Marchetti, A, Troncone, G, Novello, S, Malapelle, Umberto, Donne, Alessandro Delle, Pagni, Fabio, Fraggetta, Filippo, Rocco, Elena Guerini, Pasello, Giulia, Perrone, Giuseppe, Pepe, Francesco, Vatrano, Simona, Pignata, Sandro, Pinto, Carmine, Pruneri, Giancarlo, Russo, Antonio, Soto Parra, Hector J, Vallone, Stefania, Marchetti, Antonio, Troncone, Giancarlo, and Novello, Silvia

Abstract

Molecular biomarker testing is increasingly becoming standard of care for advanced non-small cell lung cancer (NSCLC). Tissue and liquid biopsy-based next-generation sequencing (NGS) is now highly recommended and has become an integral part of the routine management of advanced NSCLC patients. This highly sensitive approach can simultaneously and efficiently detect multiple biomarkers even in scant samples. However full optimization of NGS in clinical practice requires accurate reporting and interpretation of NGS findings. Indeed, as the number of NSCLC biomarkers continues to grow, clinical reporting of NGS data is becoming increasingly complex. In this scenario, achieving standardization, simplification, and improved readability of NGS reports is key to ensuring timely and appropriate treatment decisions. In an effort to address the complexity and lengthy reporting of NGS mutation results, an Italian group of 14 healthcare professionals involved in NSCLC management convened in 2023 to address the content, structure, and ease-of-use of NGS reporting practices and proposed a standard report template for clinical use This article presents the key discussion points addressed by the Italian working group and describes the essential elements of the report template.

Published
2024

9. Real-life results from the overall population and key subgroups within the Italian cohort of nivolumab expanded access program in non-squamous non–small cell lung cancer

Author

Grossi, Francesco, Genova, Carlo, Crinò, Lucio, Delmonte, Angelo, Turci, Daniele, Signorelli, Diego, Passaro, Antonio, Soto Parra, Hector, Catino, Annamaria, Landi, Lorenza, Gelsomino, Francesco, Tiseo, Marcello, Puppo, Gianfranco, Roila, Fausto, Ricciardi, Serena, Tonini, Giuseppe, Cognetti, Francesco, Toschi, Luca, Tassinari, Davide, Scoppola, Alessandro, Giannarelli, Diana, and Cortesi, Enrico

Published
2019
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10. Tissue- and liquid-biopsy based NGS profiling in advanced non-small-cell lung cancer in a real-world setting: the IMMINENT study.

Author

Sposito, Marco, Belluomini, Lorenzo, Nocini, Riccardo, Insolda, Jessica, Mariangela Scaglione, Ilaria, Menis, Jessica, Simbolo, Michele, Lugini, Antonio, Buzzacchino, Federica, Verderame, Francesco, Spinnato, Francesca, Aprile, Giuseppe, Calvetti, Lorenzo, Occhipinti, Mario, Marinelli, Daniele, Veccia, Antonello, Lombardo, Fiorella, Soto Parra, Hector José, Ferraù, Francesco, and Savastano, Clementina

Subjects
NON-small-cell lung carcinoma, NUCLEOTIDE sequencing
Abstract

Introduction: To date, for all non-small cell lung cancer (NSCLC) cases, it is recommended to test for driver alterations to identify actionable therapeutic targets. In this light, comprehensive genomic profiling (CGP) with next generation sequencing (NGS) has progressively gained increasing importance in clinical practice. Here, with the aim of assessing the distribution and the real-world frequency of gene alterations and their correlation with patient characteristics, we present the outcomes obtained using FoundationOne (F1CDx) and FoundationLiquid CDx (F1L/F1LCDx) NGS-based profiling in a nationwide initiative for advanced NSCLC patients. Methods: F1CDx (324 genes) was used for tissue samples, and F1L (70 genes) or F1LCDx (324 genes) for liquid biopsy, aiming to explore the real-world occurrence of molecular alterations in aNSCLC and their relationship with patients' characteristics. Results: Overall, 232 advanced NSCLC patients from 11 Institutions were gathered [median age 63 years; never/former or current smokers 29.3/65.9%; adenocarcinoma/squamous 79.3/12.5%; F1CDx/F1L+F1LCDx 59.5/40.5%]. Alterations were found in 170 different genes. Median number of mutated genes per sample was 4 (IQR 3--6) and 2 (IQR 1-3) in the F1CDx and F1L/F1LCDx cohorts, respectively. TP53 (58%), KRAS (22%), CDKN2A/B (19%), and STK11 (17%) alterations were the most frequently detected. Actionability rates (tier I and II) were comparable: 36.2% F1CDx vs. 34% ctDNA NGS assays (29.5% and 40.9% F1L and F1LCDx, respectively). Alterations in KEAP1 were significantly associated with STK11 and KRAS, so as TP53 with RB1. Median tumor mutational burden was 6 (IQR 3-10) and was significantly higher in smokers. Median OS from metastatic diagnosis was 23 months (IQR 18.5-19.5) and significantly lower in patients harboring ≥3 gene mutations. Conditional three-year survival probabilities increased over time for patients profiled at initial diagnosis and exceeded those of individuals tested later in their clinical history after 12 months. Conclusion: This study confirms that NGS-based molecular profiling of aNSCLC on tissue or blood samples offers valuable predictive and prognostic insights. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Italian Nivolumab Expanded Access Program in Nonsquamous Non–Small Cell Lung Cancer Patients: Results in Never-Smokers and EGFR-Mutant Patients

Author

Garassino, Marina Chiara, Gelibter, Alain Jonathan, Grossi, Francesco, Chiari, Rita, Soto Parra, Hector, Cascinu, Stefano, Cognetti, Francesco, Turci, Daniele, Blasi, Livio, Bengala, Carmelo, Mini, Enrico, Baldini, Editta, Quadrini, Silvia, Ceresoli, Giovanni Luca, Antonelli, Paola, Vasile, Enrico, Pinto, Carmine, Fasola, Gianpiero, Galetta, Domenico, Macerelli, Marianna, Giannarelli, Diana, Lo Russo, Giuseppe, and de Marinis, Filippo

Published
2018
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12. Durvalumab as third-line or later treatment for advanced non-small-cell lung cancer (ATLANTIC): an open-label, single-arm, phase 2 study

Author

Paz-Ares Rodriguez, Luis, Novello, Silvia, Hiret, Sandrine, Schmid, Peter, Laack, Eckart, Califano, Raffaele, Maemondo, Makoto, Kim, Sang-We, Chaft, Jamie, Vicente Baz, David, Berghmans, Thierry, Kim, Dong-Wan, Surmont, Veerle, Reck, Martin, Han, Ji-Youn, Holgado Martin, Esther, Belda Iniesta, Cristobal, Oe, Yuichiro, Chella, Antonio, Chopra, Akhil, Robinet, Gilles, Soto Parra, Hector, Thomas, Michael, Cheema, Parneet, Katakami, Nobuyuki, Su, Wu-Chou, Kim, Young-Chul, Wolf, Juergen, Lee, Jong-Seok, Saka, Hideo, Milella, Michele, Ramos Garcia, Inmaculada, Sibille, Anne, Yokoi, Takashi, Kang, Eun Joo, Atagi, Shinji, Spaeth-Schwalbe, Ernst, Nishio, Makoto, Imamura, Fumio, Gabrail, Nashat, Veillon, Remi, Derijcke, Sofie, Maeda, Tadashi, Zylla, Dylan, Kubiak, Kendra, Santoro, Armando, Uy, Ma. Noemi, Lucien Geater, Sarayut, Italiano, Antoine, Kowalski, Dariusz, Barlesi, Fabrice, Chen, Yuh-Min, Spigel, David, Chewaskulyong, Busyamas, Garcia Gomez, Ramon, Alvarez Alvarez, Rosa, Yang, Chih-Hsin, Hsia, Te-Chun, Denis, Fabrice, Sakai, Hiroshi, Vincent, Mark, Goto, Koichi, Bosch-Barrera, Joaquim, Weiss, Glen, Canon, Jean-Luc, Scholz, Christian, Aglietta, Massimo, Kemmotsu, Hirotsugu, Azuma, Koichi, Bradbury, Penelope, Feld, Ronald, Chachoua, Abraham, Jassem, Jacek, Juergens, Rosalyn, Palmero Sanchez, Ramon, Malcolm, Albert, Vrindavanam, Nandagopal, Kubota, Kaoru, Waller, Cornelius, Waterhouse, David, Coudert, Bruno, Mark, Zsuzsanna, Satouchi, Miyako, Chang, Gee-Chen, Herzmann, Christian, Chaudhry, Arvind, Giridharan, Selvaraj, Hesketh, Paul, Ikeda, Norihiko, Boccia, Ralph, Iannotti, Nichola, Haigentz, Missak, Reynolds, John, Querol, John, Nakagawa, Kazuhiko, Sugawara, Shunichi, Tan, Eng Huat, Hirashima, Tomonori, Gettinger, Scott, Kato, Terufumi, Takeda, Koji, Juan Vidal, Oscar, Mohn-Staudner, Andrea, Panwalkar, Amit, Daniel, Davey, Kobayashi, Kunihiko, Ladrera, Guia Elena Imelda, Schulte, Clemens, Sebastian, Martin, Cernovska, Marketa, Coupkova, Helena, Havel, Libor, Pauk, Norbert, Singh, Joginder, Murakami, Shuji, Csoszi, Tibor, Losonczy, Gyorgy, Price, Allan, Anderson, Ian, Iqbal, Mussawar, Torri, Vamsee, Juhasz, Erzsebet, Khanani, Saleem, Koubkova, Leona, Levy, Benjamin, Page, Ray, Bocskei, Csaba, Crinò, Lucio, Einspahr, David, Hagenstad, Christopher, Juat, Necy, Overton, Lindsay, Garrison, Mitchell, Szalai, Zsuzsanna, Garassino, Marina Chiara, Cho, Byoung-Chul, Kim, Joo-Hang, Mazières, Julien, Vansteenkiste, Johan, Lena, Hervé, Corral Jaime, Jesus, Gray, Jhanelle E, Powderly, John, Chouaid, Christos, Bidoli, Paolo, Wheatley-Price, Paul, Park, Keunchil, Soo, Ross A, Huang, Yifan, Wadsworth, Catherine, Dennis, Phillip A, and Rizvi, Naiyer A

Published
2018
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13. Malignant Pleural Mesothelioma: Staging and Radiological Response Criteria in Patients Treated with Immune Checkpoint Inhibitors

Author

Martella, Serafina, primary, Aiello, Marco Maria, additional, Bertaglia, Valentina, additional, Cau, Riccardo, additional, Denaro, Nerina, additional, Cadoni, Andrea, additional, Novello, Silvia, additional, Scartozzi, Mario, additional, Novello, Giuseppe, additional, Soto Parra, Hector Josè, additional, Saba, Luca, additional, Solinas, Cinzia, additional, and Porcu, Michele, additional

Published
2023
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14. Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Harvey, Vernon, Tomek, Rudolf, Robert, Nicholas J., Gore, Ira, Jr., Smith, John W., II, Masuda, Norikazu, Di Sean Kendall, S., Harker, William Graydon, Petrakova, Katarina, Guerrero Zotano, Angel, Simon, Amparo Ruiz, Konstantinovic, Zora Neskovic, Iannotti, Nicholas O., Tassone, Pierfrancesco, Rodriguez, Gladys I., Jáñez Martinez, Noelia, Crespo Massieu, Carmen, Smickoska, Snezana, Somali, Isil, Yilmaz, Ugur, Alonso, Mirta Garcia, Rosales, Adolfo Murias, Cold, Soeren, Knoop, Ann Soegaard, Patt, Debra, Hellerstedt, Beth A., Morales Murillo, Serafin, Mayer, Ingrid A., Means-Powell, Julie Ann, Hui, Rina, Senecal, Francis M., De Boer, Richard Hendry, Shen, Zhenzhou, Luczak, Adam Andrzej, Chui, Joanna W.Y., Tsang, Janice Wing-hang, Lang, Istvan, Rai, Yoshiaki, Hozumi, Yasuo, Ten Tije, Albert J., Bhandari, Manish, Osborne, Cynthia R.C., Ohtani, Shoichiro, Higaki, Kenji, Watanabe, Kenichi, Taguchi, Kazunori, Takahashi, Masato, Filipovic, Sladjana, Hansen, Vincent L., Rao, Vijayarama Phooshkooru, Gupta, Manish, Petrov, Petar, Coudert, Bruno, Vojnovic, Zeljko, Polya, Zsofia, Miyaki, Toshiko, Yamamoto, Naohito, Brincat, Stephen, Lesniewski-Kmak, Krzysztof, Chmielowska, Ewa, Birhiray, Ruemu E., Citron, Marc L., Papish, Steven William, Berry, William R., Langkjer, Sven Tyge, Garcia Sáenz, José Angel, Arance, Ana Maria, Efrat, Noa, Sarosiek, Tomasz, Grzeda, Lukasz, Manalo, Yvonne, Smith, Julie C., Vaziri, Irfan, Healey, Tabitha, Rahim, Yasmin, Luk, Cynthia, Dingle, Brian, Franco, Sandra, Sorensen, Peter Grundtvig, Anand, Anjana, Khan, Sarah, Fountzilas, George, Aogi, Kenjiro, Shimizu, Satoru, Mikulova, Milada, Spanik, Stanislav, Somer, Robert A., Flynn, Patrick J., Coward, Jermaine, Mainwaring, Paul, Jerusalem, Guy, Segura-Ojezzar, Carine, Levy, Christelle, Delozier, Thierry, Khayat, David, Coleman, Robert E., Rolles, Martin J., Maisano, Robert, Nardi, Mario, Ito, Yoshinori, Yumuk, Perran Fulden, Basaran, Gul, Serdar Turhal, Nazim, Wilkinson, Mary J., Green, Nathan B., Sidrys, Algis P., Hallmeyer, Sigrun, Testori, Douglas J., Sridhar, Srikala, Chang, Jose, Sun, Qiang, Jara-Sanchez, Carlos, Rubio, Xabier, Garrido, Maria Lomas, De La Haba Rodriguez, Juan Rafael, Perello Martorell, Antonia, Avelia Mestre, Antoni, Rifa Ferrer, Julio, del Barco Berron, Sonia, Nagy, Zsuzsanna, Tanaka, Maki, Im, Young-Hyuck, Carroll, Robert R., Dickerson, Laura C., Mace, Joseph R., Rivera, Ragene, Klein, Leonard M., Ruxer, Robert, Wilks, Sharon T., Kotasek, Dusan, Popov, Vasil, Taskova, Violina, Marinova-Venkova, Violetka, Timcheva, Constanta, Desbiens, Christine, Ayoub, Jean-Pierre, Grenier, Debjani, Marschner, Norbert, Tesch, Hans, Lueck, Hans-Joachim, Janssen, Jan, Schwaner, Ingo, Wahlstrom, Stine, Brix, Eva Harder, Vallentin, Susanne, Kristensen, Dan, Andreeva, Anna, Glavicic, Vesna, Calvo Plaza, Isabel, Anton Torres, Antonio, Veyret, Corinne, Bergerat, Jean-Pierre, Bourbouloux, Emmanuelle, Ella, Wendy Ann, Algurafi, Hafiz, Robinson, Anne, Kim, Seung Jin, Taguchi, Tetsuya, Juozaityte, Elona, Madretsma, Stanley, Radema, Sandra, Czerniawska-Meier, Malgorzata, Rogowski, Wojciech, Wagnerova, Maria, Richards, Donald A., Tan-Chiu, Elizabeth, Vasileios, Asskikis, Henderson, Charles Arthur, Holden, Viran Roger, Wang, Xiaojia, Tong, Zhongsheng, Yang, Junlan, Gonzalez, Manuel Enrique, Rezai, Mahdi, Hackmann, John, de Dueñas, Eduardo Martinez, de las Heras, Begoña Bermejo, Dourthe, Louis Marie, Chocteau-Bouju, Dorothee, Bougnoux, Philippe, Kakolyris, Stylianos, Kalofonos, Haralabos, Pectasidis, Dimitrios, Ng, Ting Ying, Pajkos, Gabor, Somogyine, Eva Ezer, Tonini, Giuseppe, Giuffrida, Dario, Takao, Shintaro, Ishitobi, Makoto, Inaji, Hideo, Tokuda, Yutaka, Wozniak, Katarzyna, Lungulescu, Dan, Lu, Yen-Shen, Chang, King-Jen, Hill, Julian, Croot, Christopher Charles, Dekker, Albert, Belman, Neil D., Conde, Miguel, Michaelson, Richard A., Kemmer, Kathleen, Chui, Stephen, Luoh, Shiuh-Wen, Nahum, Kenneth, Greenspan, Andrew R., Nichols, Joni C., Encarnacion, Carlos A., Niederman, Thomas M.J., Lee, Theresa, Alexander, Roland, Gordon, Robert, Tomova, Antoanet, Rauch, Daniel, Popescu, Razvan Andrei, Rojas, Gustavo Adolfo, Vanasek, Jaroslav, Neunhoeffer, Tanja, Barinoff, Jana, Graffunder, Gerd, Wolfgang, Abenhardt, Bojko, Peter, Heinrich, Bernhard, von der Assen, Albert, Antonovic, Bogovic Jurij, Adrian, Lene, Ramos Vazquez, Manuel, Gonzalez Santiago, Santiago, Dieras, Veronique, Bishop, Jill Mercia, Perren, Timothy John, Varthalitis, Ioannis, Mavroudis, Dimitris, Georgoulias, Vassilis, Chow, Louis W.C., Yau, Chung Cheung Thomas, Liang, Raymond Hin-Suen, Pikó, Béla, Wéber, Agnes, Kaufman, Bella, Drumea, Karen, Nuzzo, Francesco, De Matteis, Andrea, Carteni, Giacomo, Tokunaga, Eriko, Ishida, Mayumi, Ohno, Shinji, Sato, Nobuaki, Kuroi, Katsumasa, Nishimura, Reiki, Watanabe, Junichiro, Choi, Yoon Ji, Park, Kyong Hwa, Wojtukiewicz, Marek, Jassem, Jacek, Loman, Niklas, Askoy, Sercan, Altundag, Mustafa Kadri, Saip, Pinar, Ali, Muhammad Amjad, Wade, James Lloyd, III, Chien, Amy Jo, Brandt, Debra, Novik, Yelena, Jani, Chirag, Rice, Robert L., Gaffar, Yousuf A. R, Keaton, Mark R., Bajaj, Rajesh, Kimmick, Gretchen, Campbell, David, Turnquest, Theodore, Lucas, Sideras, Dube, Pierre, Xu, Binghe, Schilling, Joerg, Apel, Klaus, Vestlev, Peter Michael, Jensen, Brita Bjerregaard, Haahr, Vera, Lescure, Alvaro Rodriguez, Grana Suarez, Begona, Saura Manich, Cristina, Jacquin, Jean-Philippe, Samreen, Ahmed, Boiangiu, Ion, Dank, Magdolna, Falci, Cristina, Jirillo, Antonio, Cinieri, Saverio, Ueno, Takayuki, Sato, Fumiaki, Yamashiro, Hiroyasu, Sugie, Tomoharu, Lee, Keun Seok, Ro, Jung Sil, Park, In Hae, Bustam, Anita Zarina, Suszko-Kazarnowicz, Malgorzata, Piktel, Artur, Krzemieniecki, Krzysztof, Iorga, Polizenia Georgeta, Yap, Yoon Sim, Kakalejcik, Marian, Sevinc, Alper, Ozguroglu, Mustafa, Chen, Shin-Cheh, Greenberg, Richard H., Eisemann, Allan Daniel, Droder, Robert, Abbasi, M. Rashid, Vaysburd, Marina, Caldera, Humberto Jose, Haley, Barbara Bacsik, Robin, Erwin, Inhorn, Roger C., Hufnagel, David, Kenyon, Peter D., Spremulli, Ellen, Silverman, Paula, Jain, Sharad, Weigand, Robert, Mebis, Jeroen, Koynova, Tatyana, Lesperance, Bernard, Prausova, Jana, Kohne, Claus-Henning, Schneeweiss, Andreas, Jackisch, Christian, Fuxius, Stefan, Cubedo Cervera, Ricardo, Urruticoechea Ribate, Ander, Pernas Simon, Sonia, Valero Gallego, Jose, Arcusa Lanza, Angels, del Pilar Alvarez, Maria, Florian Gerico, Jesus, Cany, Laurent, Stebbing, Justin, Labudovic, Dejan, Gugic, Damir, Vrbanec, Damir, Roila, Fausto, Barni, Sandro, Bidoli, Paolo, Mukai, Hirofumi, Bermudez, Vanessa, Eniu, Alexandru, Mirtsching, Barry C., Ibrahim, Emad, Trey, Joan, Hergenroeder, Paul Francis, Mahmood, Aftab, Gonzalez, Anneliese, Kaplan, Edward H., Ban, Stacy, Patel, Dhimant, Clowney, Billy, Hoelzer, Karen, Schwartz, Garry H., Salkeni, Mohamed, Abraham, Jame, Narula, Sunil, Jabboury, Khaled, Mocharnuk, Robert Scott, McDonough, Richard H., Sikes, David H., Kawanchi, Ronald H., Schlabach, Larry, McCachren, Samuel Spence, Jr., Cosgriff, Thomas M., Dreisbach, Luke, DeMichele, Angela, Pawl, Lawrence, Lucas, Jennifer, Shinn, Lowell C., Alkhouri, Nabiel, Monga, Manish, Lindquist, Deborah L., Anderson, Thomas C., Khurshid, Humera, Witherby, Sabrina, Erickson, Nicholette, Traynor, Ann, Bose, Ron, Pluard, Timothy J., Jones, Michael C., Prakash, Sucharu, Volterra, Fabio, Capo, Gerardo, Flaherty, Lawrence E., Gartner, Elaina, Baidas, Said, Okazaki, Ian, Nguyen, Bichlien, Rakowski, Thomas, Oliff, Ira, Leach, Joseph W., Anderson, Daniel, Kubiak, Kendra, Tsai, Michaela, Vroman, Philippe, Deleu, Ines, Lybaert, Willem, Borms, Marleen, Couture, Felix, Wilson, Jonathan J., Hunt, Gordon, Holland, David R., Mingrone, Walter, Wang, Shusen, Liu, Donggeng, Jiang, Zefei, Benesova, Vera, Smakal, Martin, Garnolova, Petra, Vesper, Anne-Sophie, Neumann, Monika, Janni, Wolfgang, Liedtke, Cornelia, Fischer, Dorothea, Grischke, Eva-Maria, Seeger, Dietmar, Moebus, Volker, Prechtl, Anita, Carlos Camara Toral, Juan, Sanchez Munoz, Alfonso, Gonzalez Jimenez, Sonia, Cassinello Espinosa, Javier, Cirauqui, Beatriz, Margeli Vila, Mireia, Batista Lopez, Norberto, Chacon Lopez-Muniz, Jose Ignacio, de la Cruz Mora, Miguel Angel, Mailliez, Audrey, Vanlemmens, Laurence, Pouessel, Damien, Espie, Marc, Conibear, John, Roylance, Rebecca, Harnett, Adrian, Geffen, David, Ruggeri, Enzo Maria, Gamucci, Teresa, Van Groeningen, Cees J., Banas, Renata, Alkis, Necati, Hou, Ming-Feng, Krie, Amy K., Vrindavanam, Nandagopal S., Howard, Orion M., Citrin, Dennis, Morginstin, Mark S., Desai, Ajit, Sanchez, Ines J., Nixon, David Allen, Jr., Beatty, Patrick G., Edmiston, Kathryn, McLaughlin, Marilyn, Eneman, Jonathan D., Lynch, Cynthia A., O'Brien, Edward, Call, Justin A., Lanier, Keith S., Conlin, Alison, Brooks, Donald J., McIntyre, Kristi, Saltzman, Marc A., Castine, Michael J., III, Ortega, Gregory L., Choi, Young M., Reynolds, Craig H., Brescia, Frankie Ann, Kramer, Rita, Kohn, Aimee D., Micha, John P., Rhee, Jessica M., Shah, Satish, Riseberg, David A., Patterson, William Kevin, Salmon, Jean-Paul, Andre, Chantal, Bols, Alain, D'hondt, Randal, Luce, Sylvie, Nouwynck, Claire, Pelgrims, Gino, Richard, Vincent, Verschuere, Johan, Geldhof, Kurt, Caspar, Clemens, Luo, Rongcheng, Bednarik, Otakar, Schwedler, Kathrin, Schmidt, Marcus, Neumeister, Romy, Bischoff, Joachim, Rack, Brigitte, Repp, Roland, Fries, Stefan, Adrion, Ralf, Schulz, Volker, Klare, Peter, Danei, Mahmoud, Ossenbuhl, Dirk, Kusche, Jakob Manfred, Griesinger, Frank, Baena Canada, Jose Manuel, Martinez del Prado, Purificacion, Machover, David, Mayeur, Didier, Trufflandier, Nathalie, Delecroix, Valerie, Mousseau, Mireille, Mouret-Reynier, Marie-Ange, Nabholtz, Jean-Marc, Chetiyawardana, Anula D., Papandreou, Christos, Hornyak, Lajos, Faluhelyi, Zsolt, Simo, Erzsebet, Di Palma, Mario, Cognetti, Francesco, Gorzegno, Gabriella, Dogliotti, Luigi, Gridelli, Cesare, Falcone, Alfredo, Soto Parra, Hector, Buscarino, Calogero, Im, Seock-Ah, Sanchez Llamas, Benito, Dercksen, Wouter, Erdkamp, Franciscus, Ruit, Jan B., Braun, Hans, Portielje, Joanneke E.A., Ciltas, Aydin, Buyukberber, Suleyman, Benekli, Mustafa, Zahalsky, Andrew J., Jaslow, Rebecca, Thomas, Gary W., Maini, Archana, Wiznitzer, Israel, Khojasteh, Ali, Francisco Gonzalez, Manuel, Kong, Lynn R., Padmanabhan, Aruna, Conkright, William A., Swain, Sandra M., Faig, Douglas E., Jain, Kirti, Yanagihara, Ronald H., Ottaviano, Yvonne, Delmas, Andrew, Steele, Heather A., Rainey, Gordon K., Harris, Penelope J., Burris, Jason K., Rupard, Erik J., Tan, Esther, Whitworth, Pat W., Bova, Abby R., Anderson, Ian C., Shirinian, Mihran, Tin-u, Caesar, O'Rourke, Timothy J., Roberts, Michael S., Francisco, Michael, Pierson, A. Scott, Byeff, Peter D., Kovach, Peter A., Caton, John R., Jr., Rarick, Mark Urban, Schimidt, William G., Jr., Stopeck, Alison T., Swart, Rachel, Carrillo Flores, Maria Regina, Alemany, Carlos A., Lozada, Brennely, Weinstein, Paul L., Wang, Wei, Porubcin, Michael, Ellison, David M., Geils, George F., Rivera, Edgardo, Charif, Mahmoud, Martin, Miguel, Holmes, Frankie A, Ejlertsen, Bent, Delaloge, Suzette, Moy, Beverly, Iwata, Hiroji, von Minckwitz, Gunter, Chia, Stephen K L, Mansi, Janine, Barrios, Carlos H, Gnant, Michael, Tomašević, Zorica, Denduluri, Neelima, Šeparović, Robert, Gokmen, Erhan, Bashford, Anna, Ruiz Borrego, Manuel, Kim, Sung-Bae, Jakobsen, Erik Hugger, Ciceniene, Audrone, Inoue, Kenichi, Overkamp, Friedrich, Heijns, Joan B, Armstrong, Anne C, Link, John S, Joy, Anil Abraham, Bryce, Richard, Wong, Alvin, Moran, Susan, Yao, Bin, Xu, Feng, Auerbach, Alan, Buyse, Marc, and Chan, Arlene

Published
2017
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15. Bone metastases and immunotherapy in patients with advanced non-small-cell lung cancer

Author

Landi, Lorenza, D’Incà, Federica, Gelibter, Alain, Chiari, Rita, Grossi, Francesco, Delmonte, Angelo, Passaro, Antonio, Signorelli, Diego, Gelsomino, Francesco, Galetta, Domenico, Giannarelli, Diana, Soto Parra, Hector, Minuti, Gabriele, Tiseo, Marcello, Migliorino, Maria Rita, Cognetti, Francesco, Toschi, Luca, Bidoli, Paolo, Piantedosi, Francovito, Calabro’, Luana, and Cappuzzo, Federico

Published
2019
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16. Validation of the AJCC prognostic stage for HER2-positive breast cancer in the ShortHER trial

Author

Dieci, Maria Vittoria, Bisagni, Giancarlo, Brandes, Alba A., Frassoldati, Antonio, Cavanna, Luigi, Giotta, Francesco, Aieta, Michele, Gebbia, Vittorio, Musolino, Antonino, Garrone, Ornella, Donadio, Michela, Rimanti, Anita, Beano, Alessandra, Zamagni, Claudio, Soto Parra, Hector, Piacentini, Federico, Danese, Saverio, Ferro, Antonella, Cagossi, Katia, Sarti, Samanta, Gambaro, Anna Rita, Romito, Sante, Bazan, Viviana, Amaducci, Laura, Moretti, Gabriella, Foschini, Maria Pia, Balduzzi, Sara, Vicini, Roberto, D’Amico, Roberto, Griguolo, Gaia, Guarneri, Valentina, and Conte, Pier Franco

Published
2019
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18. The prognostic value of baseline and early variations of peripheral blood inflammatory ratios and their cellular components in patients with metastatic renal cell carcinoma treated with nivolumab: The Δ-Meet-URO analysis

Author

Rebuzzi, Sara Elena, primary, Signori, Alessio, additional, Stellato, Marco, additional, Santini, Daniele, additional, Maruzzo, Marco, additional, De Giorgi, Ugo, additional, Pedrazzoli, Paolo, additional, Galli, Luca, additional, Zucali, Paolo Andrea, additional, Fantinel, Emanuela, additional, Carella, Claudia, additional, Procopio, Giuseppe, additional, Milella, Michele, additional, Boccardo, Francesco, additional, Fratino, Lucia, additional, Sabbatini, Roberto, additional, Ricotta, Riccardo, additional, Panni, Stefano, additional, Massari, Francesco, additional, Sorarù, Mariella, additional, Santoni, Matteo, additional, Cortellini, Alessio, additional, Prati, Veronica, additional, Soto Parra, Hector Josè, additional, Atzori, Francesco, additional, Di Napoli, Marilena, additional, Caffo, Orazio, additional, Messina, Marco, additional, Morelli, Franco, additional, Prati, Giuseppe, additional, Nolè, Franco, additional, Vignani, Francesca, additional, Cavo, Alessia, additional, Roviello, Giandomenico, additional, Llaja Obispo, Miguel Angel, additional, Porta, Camillo, additional, Buti, Sebastiano, additional, Fornarini, Giuseppe, additional, and Banna, Giuseppe Luigi, additional

Published
2022
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19. Efficacy and Safety of Autologous Dendritic Cell-Based Immunotherapy, Docetaxel, and Prednisone vs Placebo in Patients With Metastatic Castration-Resistant Prostate Cancer The VIABLE Phase 3 Randomized Clinical Trial

Author

Vogelzang, Nicholas J, Beer, Tomasz M, Gerritsen, Winald, Oudard, Stéphane, Wiechno, Pawel, Kukielka-Budny, Bozena, Samal, Vladimir, Hajek, Jaroslav, Feyerabend, Susan, Khoo, Vincent, Stenzl, Arnulf, Csöszi, Tibor, Filipovic, Zoran, Goncalves, Frederico, Prokhorov, Alexander, Cheung, Eric, Hussain, Arif, Sousa, Nuno, Bahl, Amit, Hussain, Syed, Fricke, Harald, Kadlecova, Pavla, Scheiner, Tomas, Korolkiewicz, Roman P, Bartunkova, Jirina, Spisek, Radek, and Soto Parra, Hector

Subjects
Male, Cancer Research, Prostatic Neoplasms, Dendritic Cells, Docetaxel, Cancer Vaccines, Prostatic Neoplasms, Castration-Resistant, All institutes and research themes of the Radboud University Medical Center, Oncology, Double-Blind Method, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Antineoplastic Combined Chemotherapy Protocols, Prednisone, Humans, Female, Immunotherapy, Aged, Original Investigation
Abstract

IMPORTANCE: DCVAC/PCa is an active cellular immunotherapy designed to initiate an immune response against prostate cancer. OBJECTIVE: To evaluate the efficacy and safety of DCVAC/PCa plus chemotherapy followed by DCVAC/PCa maintenance treatment in patients with metastatic castration-resistant prostate cancer (mCRPC). DESIGN, SETTING, AND PARTICIPANTS: The VIABLE double-blind, parallel-group, placebo-controlled, phase 3 randomized clinical trial enrolled patients with mCRPC among 177 hospital clinics in the US and Europe between June 2014 and November 2017. Data analyses were performed from December 2019 to July 2020. INTERVENTIONS: Eligible patients were randomized (2:1) to receive DCVAC/PCa (add-on and maintenance) or placebo, both in combination with chemotherapy (docetaxel plus prednisone). The stratification was applied according to geographical region (US or non-US), prior therapy (abiraterone, enzalutamide, or neither), and Eastern Cooperative Oncology Group performance status (0-1 or 2). DCVAC/PCa or placebo was administered subcutaneously every 3 to 4 weeks (up to 15 doses). MAIN OUTCOMES AND MEASURES: The primary outcome was overall survival (OS), defined as the time from randomization until death due to any cause, in all randomized patients. Survival was compared using 2-sided log-rank test stratified by geographical region, prior therapy with abiraterone and/or enzalutamide, and Eastern Cooperative Oncology Group performance status. RESULTS: A total of 1182 men with mCRPC (median [range] age, 68 [46-89] years) were randomized to receive DCVAC/PCa (n = 787) or placebo (n = 395). Of these, 610 (81.8%) started DCVAC/PCa, and 376 (98.4%) started placebo. There was no difference in OS between the DCVAC/PCa and placebo groups in all randomized patients (median OS, 23.9 months [95% CI, 21.6-25.3] vs 24.3 months [95% CI, 22.6-26.0]; hazard ratio, 1.04; 95% CI, 0.90-1.21; P = .60). No differences in the secondary efficacy end points (radiological progression-free survival, time to prostate-specific antigen progression, or skeletal-related events) were observed. Treatment-emergent adverse events related to DCVAC/PCa or placebo occurred in 69 of 749 (9.2%) and 48 of 379 (12.7%) patients, respectively. The most common treatment-emergent adverse events (DCVAC/PCa [n = 749] vs placebo [n = 379]) were fatigue (271 [36.2%] vs 152 [40.1%]), alopecia (222 [29.6%] vs 130 [34.3%]), and diarrhea (206 [27.5%] vs 117 [30.9%]). CONCLUSIONS AND RELEVANCE: In this phase 3 randomized clinical trial, DCVAC/PCa combined with docetaxel plus prednisone and continued as maintenance treatment did not extend OS in patients with mCRPC and was well tolerated. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02111577

Published
2022

21. Mechanistic Translation of Melanoma Genetic Landscape in Enriched Pathways and Oncogenic Protein-Protein Interactions

Author

MASSIMINO, MICHELE, primary, STELLA, STEFANIA, additional, MICALE, GIOVANNI, additional, MOTTA, LUCIA, additional, PAVONE, GIULIANA, additional, BROGGI, GIUSEPPE, additional, PIOMBINO, ELIANA, additional, MAGRO, GAETANO, additional, SOTO PARRA, HECTOR JOSE, additional, MANZELLA, LIVIA, additional, and VIGNERI, PAOLO, additional

Published
2022
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22. Predictive and prognostic value of early response assessment using 18FDG-PET in advanced non-small cell lung cancer patients treated with erlotinib

Author

Tiseo, Marcello, Ippolito, Massimo, Scarlattei, Maura, Spadaro, Pietro, Cosentino, Sebastiano, Latteri, Fiorenza, Ruffini, Livia, Bartolotti, Marco, Bortesi, Beatrice, Fumarola, Claudia, Caffarra, Cristina, Cavazzoni, Andrea, Alfieri, Roberta R., Petronini, Pier Giorgio, Bordonaro, Roberto, Bruzzi, Paolo, Ardizzoni, Andrea, and Soto Parra, Hector J.

Published
2014
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24. Phase II, noncomparative, open label, multicenter, study of osimertinib, in patients with locally advanced or metastatic EGFR mutated, T790M undetectable or unknown non-small cell lung cancer (Stage IIIB-IV) after no immediate prior EGFR TKI (OSIRIS study).

Author

Soto Parra, Hector J., primary, Noto, Laura, additional, Verderame, Francesco, additional, Galetta, Domenico, additional, Barbieri, Vito, additional, Ferrau, Francesco, additional, Migliorino, Maria Rita, additional, Catino, Annamaria, additional, Aiello, Marco M., additional, Capelletto, Enrica, additional, Ricciardi, Serena, additional, Spinnato, Francesca, additional, Tassone, Pierfrancesco, additional, Morelli, Anna Maria, additional, Latteri, Fiorenza, additional, Gozzo, Lucia, additional, Valerio, Oriana, additional, Avola, Rossana, additional, and Novello, Silvia, additional

Published
2021
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25. The Impact of the SARS-CoV-2 Outbreak on the Psychological Flexibility and Behaviour of Cancelling Medical Appointments of Italian Patients with Pre-Existing Medical Condition: The “ImpACT-COVID-19 for Patients” Multi-Centre Observational Study

Author

Deledda, Giuseppe, primary, Riccardi, Niccolò, additional, Gori, Stefania, additional, Poli, Sara, additional, Giansante, Matteo, additional, Geccherle, Eleonora, additional, Mazzi, Cristina, additional, Silva, Ronaldo, additional, Desantis, Nicoletta, additional, Giovannetti, Ambra Mara, additional, Solari, Alessandra, additional, Confalonieri, Paolo, additional, Grazzi, Licia, additional, Sarcletti, Elena, additional, Biffa, Gabriella, additional, Biagio, Antonio Di, additional, Sestito, Carlo, additional, Keim, Roland, additional, Gangi Hermis, Alida M. R. Di, additional, Mazzoldi, Mariantonietta, additional, Failo, Alessandro, additional, Scaglione, Anna, additional, Faldetta, Naida, additional, Dorangricchia, Patrizia, additional, Moschetto, Maria, additional, Soto Parra, Hector Josè, additional, Faietti, Jennifer, additional, Profio, Anna Di, additional, Rusconi, Stefano, additional, Giacomelli, Andrea, additional, Marchioretto, Fabio, additional, Alongi, Filippo, additional, Marchetta, Antonio, additional, Molon, Giulio, additional, Bisoffi, Zeno, additional, and Angheben, Andrea, additional

Published
2021
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26. Inflammatory indices and clinical factors in metastatic renal cell carcinoma patients treated with nivolumab: the development of a novel prognostic score (Meet-URO 15 study)

Author

Rebuzzi, Sara Elena, primary, Signori, Alessio, additional, Banna, Giuseppe Luigi, additional, Maruzzo, Marco, additional, De Giorgi, Ugo, additional, Pedrazzoli, Paolo, additional, Sbrana, Andrea, additional, Zucali, Paolo Andrea, additional, Masini, Cristina, additional, Naglieri, Emanuele, additional, Procopio, Giuseppe, additional, Merler, Sara, additional, Tomasello, Laura, additional, Fratino, Lucia, additional, Baldessari, Cinzia, additional, Ricotta, Riccardo, additional, Panni, Stefano, additional, Mollica, Veronica, additional, Sorarù, Mariella, additional, Santoni, Matteo, additional, Cortellini, Alessio, additional, Prati, Veronica, additional, Soto Parra, Hector Josè, additional, Stellato, Marco, additional, Atzori, Francesco, additional, Pignata, Sandro, additional, Messina, Carlo, additional, Messina, Marco, additional, Morelli, Franco, additional, Prati, Giuseppe, additional, Nolè, Franco, additional, Vignani, Francesca, additional, Cavo, Alessia, additional, Roviello, Giandomenico, additional, Pierantoni, Francesco, additional, Casadei, Chiara, additional, Bersanelli, Melissa, additional, Chiellino, Silvia, additional, Paolieri, Federico, additional, Perrino, Matteo, additional, Brunelli, Matteo, additional, Iacovelli, Roberto, additional, Porta, Camillo, additional, Buti, Sebastiano, additional, and Fornarini, Giuseppe, additional

Published
2021
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27. High Prevalence and Early Occurrence of Skeletal Complications in EGFR Mutated NSCLC Patients With Bone Metastases

Author

Laganà, Marta, primary, Gurizzan, Cristina, additional, Roca, Elisa, additional, Cortinovis, Diego, additional, Signorelli, Diego, additional, Pagani, Filippo, additional, Bettini, Anna, additional, Bonomi, Lucia, additional, Rinaldi, Silvia, additional, Berardi, Rossana, additional, Filetti, Marco, additional, Giusti, Raffaele, additional, Pilotto, Sara, additional, Milella, Michele, additional, Intagliata, Salvatore, additional, Baggi, Alice, additional, Cortellini, Alessio, additional, Soto Parra, Hector, additional, Brighenti, Matteo, additional, Petrelli, Fausto, additional, Bennati, Chiara, additional, Bidoli, Paolo, additional, Garassino, Marina Chiara, additional, and Berruti, Alfredo, additional

Published
2020
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28. Mutational Profile of Malignant Pleural Mesothelioma (MPM) in the Phase II RAMES Study

Author

Pagano, Maria, primary, Ceresoli, Luca Giovanni, additional, Zucali, Paolo Andrea, additional, Pasello, Giulia, additional, Garassino, Marina, additional, Grosso, Federica, additional, Tiseo, Marcello, additional, Soto Parra, Hector, additional, Zanelli, Francesca, additional, Cappuzzo, Federico, additional, Grossi, Francesco, additional, De Marinis, Filippo, additional, Pedrazzoli, Paolo, additional, Gnoni, Roberta, additional, Bonelli, Candida, additional, Torricelli, Federica, additional, Ciarrocchi, Alessia, additional, Normanno, Nicola, additional, and Pinto, Carmine, additional

Published
2020
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29. Metronomic oral vinorelbine in patients with advanced non-small cell lung cancer progressing after nivolumab immunotherapy: a retrospective analysis

Author

Gebbia, Vittorio, primary, Aiello, Marco Maria, additional, Banna, Giuseppe, additional, Blanco, Giusi, additional, Blasi, Livio, additional, Borsellino, Nicolò, additional, Giuffrida, Dariio, additional, Lo Mauro, Mario, additional, Mancuso, Gianfranco, additional, Piazza, Dario, additional, Savio, Giuseppina, additional, Soto Parra, Hector, additional, Valerio, Maria Rosaria, additional, Verderame, Francesco, additional, and Vigneri, Paolo, additional

Published
2020
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30. ROC Analysis Identifies Baseline and Dynamic NLR and dNLR Cut-Offs to Predict ICI Outcome in 402 Advanced NSCLC Patients

Author

Carnio, Simona, primary, Mariniello, Annapaola, additional, Pizzutilo, Pamela, additional, Numico, Gianmauro, additional, Borra, Gloria, additional, Lunghi, Alice, additional, Soto Parra, Hector, additional, Buosi, Roberta, additional, Vavalà, Tiziana, additional, Stura, Ilaria, additional, Genestroni, Silvia, additional, Alemanni, Alessandra, additional, Arizio, Francesca, additional, Catino, Annamaria, additional, Montrone, Michele, additional, Tabbò, Fabrizio, additional, Galetta, Domenico, additional, Migliaretti, Giuseppe, additional, and Novello, Silvia, additional

Published
2020
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31. Late Breaking Abstract - Comparison of VATS debulking surgery and HITHOC vs VATS talc pleurodesis alone in malignant pleural mesothelioma: a pilot study

Author

Migliore, Marcello, primary, Nardini, Marco, additional, Meli, Alfreda, additional, Spatola, Corrado, additional, Monte, Ines, additional, Nicolosi, Tommaso, additional, Scuderi, Mariacristina, additional, Soto Parra, Hector, additional, Aiello, Marco, additional, Vigneri, Paolo, additional, and Fantaci, Giovanna, additional

Published
2020
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32. Excision Repair Cross Complementation Group 1 Single Nucleotide Polymorphisms and Nivolumab in Advanced Non-Small Cell Lung Cancer

Author

Aiello, Marco Maria, primary, Solinas, Cinzia, additional, Santoni, Matteo, additional, Battelli, Nicola, additional, Restuccia, Nunzio, additional, Latteri, Fiorenza, additional, Paratore, Sabrina, additional, Verderame, Francesco, additional, Albanese, Giuseppina Valeria, additional, Bruzzi, Paolo, additional, and Soto Parra, Hector Josè, additional

Published
2020
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33. Association of high TUBB3 with resistance to adjuvant docetaxel-based chemotherapy in gastric cancer: translational study of ITACA-S

Author

Di Bartolomeo, Maria, primary, Raimondi, Alessandra, additional, Cecchi, Fabiola, additional, Catenacci, Daniel V.T., additional, Schwartz, Sarit, additional, Sellappan, Shankar, additional, Tian, Yuan, additional, Miceli, Rosalba, additional, Pellegrinelli, Alessandro, additional, Giommoni, Elisa, additional, Aitini, Enrico, additional, Spada, Francesca, additional, Rosati, Gerardo, additional, Marchet, Alberto, additional, Pucci, Francesca, additional, Zaniboni, Alberto, additional, Tamberi, Stefano, additional, Pressiani, Tiziana, additional, Sanna, Gianni, additional, Cantore, Maurizio, additional, Mosconi, Stefania, additional, Bolzoni, Paola, additional, Pinto, Carmine, additional, Landi, Lorenza, additional, Soto Parra, Hector Josè, additional, Cavanna, Luigi, additional, Corallo, Salvatore, additional, Martinetti, Antonia, additional, Hembrough, Todd A., additional, and Pietrantonio, Filippo, additional

Published
2020
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34. Baseline and early change of systemic inflammation index (bSII and ΔSII) as prognostic factors in metastatic renal cell carcinoma (mRCC) patients treated with Nivolumab: Final results of the Meet-URO 15 (I-BIO-REC) study.

Author

Rebuzzi, Sara Elena, primary, Atzori, Francesco, additional, Di Napoli, Marilena, additional, Stellato, Marco, additional, Messina, Marco, additional, Chiellino, Silvia, additional, Vignani, Francesca, additional, Cavo, Alessia, additional, Soto Parra, Hector J., additional, Roviello, Giandomenico, additional, Prati, Veronica, additional, Bimbatti, Davide, additional, De Giorgi, Ugo, additional, Bersanelli, Melissa, additional, Paolieri, Federico, additional, Zucali, Paolo Andrea, additional, Fantinel, Emanuela, additional, Procopio, Giuseppe, additional, Signori, Alessio, additional, and Fornarini, Giuseppe, additional

Published
2020
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35. Randomized phase II study on gemcitabine with or without ramucirumab as second-line treatment for advanced malignant pleural mesothelioma (MPM): Results of Italian Rames Study.

Author

Pagano, Maria, primary, Ceresoli, Giovanni Luca, additional, Zucali, Paolo Andrea, additional, Pasello, Giulia, additional, Garassino, Marina Chiara, additional, Grosso, Federica, additional, Tiseo, Marcello, additional, Soto Parra, Hector J., additional, Zanelli, Francesca, additional, Cappuzzo, Federico, additional, Grossi, Francesco, additional, de Marinis, Filippo, additional, Pedrazzoli, Paolo, additional, Gnoni, Roberta, additional, Bonelli, Candida, additional, Berselli, Annalisa, additional, Boni, Luca, additional, Normanno, Nicola, additional, and Pinto, Carmine, additional

Published
2020
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36. Reactions and countermeasures of medical oncologists towards the incoming COVID-19 pandemic: a WhatsApp messenger-based report from the Italian College of Chief Medical Oncologists

Author

Blasi, Livio, primary, Bordonaro, Roberto, additional, Borsellino, Nicolò, additional, Butera, Alfredo, additional, Caruso, Michele, additional, Cordio, Stefano, additional, Liborio, Di Cristina, additional, Ferraù, Francesco, additional, Giuffrida, Dario, additional, Soto Parra, Hector, additional, Spada, Massimiliano, additional, Tralongo, Paolo, additional, Valenza, Roberto, additional, Verderame, Francesco, additional, Vitello, Stefano, additional, Zerilli, Filippo, additional, Piazza, Dario, additional, Firenze, Alberto, additional, and Gebbia, Vittorio, additional

Published
2020
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38. Excision Repair Cross Complementation Group 1 Single Nucleotide Polymorphisms and Nivolumab in Advanced Non-Small Cell Lung Cancer

Author

Aiello, Marco Maria M., Solinas, Cinzia, Santoni, Matteo, Battelli, Nicola, Restuccia, Nunzio, Latteri, Fiorenza, Paratore, Sabrina, Verderame, Francesco, Albanese, Giuseppina Valeria, Bruzzi, Paolo, Soto Parra, Hector Josè, Aiello, Marco Maria M., Solinas, Cinzia, Santoni, Matteo, Battelli, Nicola, Restuccia, Nunzio, Latteri, Fiorenza, Paratore, Sabrina, Verderame, Francesco, Albanese, Giuseppina Valeria, Bruzzi, Paolo, and Soto Parra, Hector Josè

Abstract

Background: We hypothesized that non-small cell lung cancer (NSCLC) patients with a tumor positive for single nucleotide polymorphisms (SNPs) of the Excision Repair Cross Complementation Group 1 (ERCC-1) gene could be more genetically instable and consequently more responsive to a programmed cell death-1 (PD-1) blockade. Methods: We evaluated the T19007C and C8092A ERCC-1 SNPs by pyrosequencing assay, on tumor specimens from two independent cohorts of patients who relapsed after one or more prior systemic treatments for advanced NSCLC and who received nivolumab (3 mg/kg intravenously every 2 weeks) as part of the Italian Expanded Access Program. We aimed to assess the outcome of enrolled subjects according to the ERCC-1 SNPs status, to evaluate the role of these polymorphisms as putative biomarkers associated with a response/clinical benefit to anti-PD-1 therapies. Results: Of the 45 patients included in the final analysis, 21 (47%) and 16 (36%) were positive for the T19007C and C8092A polymorphic genotype (PG), respectively. In univariate analyses, overall survival (OS) and progression free survival (PFS) were shorter in patients with the T19007C PG, but neither difference achieved statistical significance (P = 0.131 and P = 0.717, respectively). The presence of the C8092A PG was associated with a longer OS and PFS, although statistical significance was only reached for PFS (P = 0.112 and P = 0.025, respectively). These results were confirmed by multivariate analyses. The response rate was only significantly higher in patients with the C8092A PG vs. wild type ERCC-1 (62 vs. 7%, P < 0.001). Conclusions: Results from this hypothesis generating pilot study, provided suggestive evidence that a subgroup of NSCLC patients could benefit differently from nivolumab according to the C8092A ERCC-1 SNP status. However, these data warrant further investigation., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2020

41. Malignant pleural mesothelioma (MPM) genomic profile in the randomized phase II RAMES Study.

Author

Pagano, Maria, primary, Gnoni, Roberta, additional, Bonelli, Candida, additional, Zanelli, Francesca, additional, Garassino, Marina Chiara, additional, Ceresoli, Giovanni Luca, additional, Pasello, Giulia, additional, Tiseo, Marcello, additional, Soto Parra, Hector J., additional, Grosso, Federica, additional, Zucali, Paolo Andrea, additional, Torricelli, Federica, additional, and Pinto, Carmine, additional

Published
2019
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42. Eribulin mesylate use as third-line therapy in patients with metastatic breast cancer (VESPRY): a prospective, multicentre, observational study

Author

Adamo, Vincenzo, primary, Ricciardi, Giuseppina Rosaria Rita, additional, Giuffrida, Dario, additional, Scandurra, Giuseppa, additional, Russo, Antonio, additional, Blasi, Livio, additional, Spadaro, Pietro, additional, Iacono, Carmelo, additional, Soto Parra, Hector J., additional, Savarino, Antonino, additional, Ferraú, Francesco, additional, Zerilli, Filippo, additional, Verderame, Francesco, additional, Butera, Alfredo, additional, Santangelo, Carlo, additional, Franchina, Veronica, additional, and Caruso, Michele, additional

Published
2019
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43. Monitoring blood biomarkers to predict nivolumab effectiveness in NSCLC patients

Author

Passiglia, Francesco, primary, Galvano, Antonio, additional, Castiglia, Marta, additional, Incorvaia, Lorena, additional, Calò, Valentina, additional, Listì, Angela, additional, Mazzarisi, Salvatore, additional, Perez, Alessandro, additional, Gallina, Giuseppe, additional, Rizzo, Sergio, additional, Soto Parra, Hector, additional, Bazan, Viviana, additional, and Russo, Antonio, additional

Published
2019
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44. Durvalumab as third-line or later treatment for advanced non-small-cell lung cancer (ATLANTIC): an open-label, single-arm, phase 2 study

Author

Garassino, Marina Chiara, primary, Cho, Byoung-Chul, additional, Kim, Joo-Hang, additional, Mazières, Julien, additional, Vansteenkiste, Johan, additional, Lena, Hervé, additional, Corral Jaime, Jesus, additional, Gray, Jhanelle E, additional, Powderly, John, additional, Chouaid, Christos, additional, Bidoli, Paolo, additional, Wheatley-Price, Paul, additional, Park, Keunchil, additional, Soo, Ross A, additional, Huang, Yifan, additional, Wadsworth, Catherine, additional, Dennis, Phillip A, additional, Rizvi, Naiyer A, additional, Paz-Ares Rodriguez, Luis, additional, Novello, Silvia, additional, Hiret, Sandrine, additional, Schmid, Peter, additional, Laack, Eckart, additional, Califano, Raffaele, additional, Maemondo, Makoto, additional, Kim, Sang-We, additional, Chaft, Jamie, additional, Vicente Baz, David, additional, Berghmans, Thierry, additional, Kim, Dong-Wan, additional, Surmont, Veerle, additional, Reck, Martin, additional, Han, Ji-Youn, additional, Holgado Martin, Esther, additional, Belda Iniesta, Cristobal, additional, Oe, Yuichiro, additional, Chella, Antonio, additional, Chopra, Akhil, additional, Robinet, Gilles, additional, Soto Parra, Hector, additional, Thomas, Michael, additional, Cheema, Parneet, additional, Katakami, Nobuyuki, additional, Su, Wu-Chou, additional, Kim, Young-Chul, additional, Wolf, Juergen, additional, Lee, Jong-Seok, additional, Saka, Hideo, additional, Milella, Michele, additional, Ramos Garcia, Inmaculada, additional, Sibille, Anne, additional, Yokoi, Takashi, additional, Kang, Eun Joo, additional, Atagi, Shinji, additional, Spaeth-Schwalbe, Ernst, additional, Nishio, Makoto, additional, Imamura, Fumio, additional, Gabrail, Nashat, additional, Veillon, Remi, additional, Derijcke, Sofie, additional, Maeda, Tadashi, additional, Zylla, Dylan, additional, Kubiak, Kendra, additional, Santoro, Armando, additional, Uy, Ma. Noemi, additional, Lucien Geater, Sarayut, additional, Italiano, Antoine, additional, Kowalski, Dariusz, additional, Barlesi, Fabrice, additional, Chen, Yuh-Min, additional, Spigel, David, additional, Chewaskulyong, Busyamas, additional, Garcia Gomez, Ramon, additional, Alvarez Alvarez, Rosa, additional, Yang, Chih-Hsin, additional, Hsia, Te-Chun, additional, Denis, Fabrice, additional, Sakai, Hiroshi, additional, Vincent, Mark, additional, Goto, Koichi, additional, Bosch-Barrera, Joaquim, additional, Weiss, Glen, additional, Canon, Jean-Luc, additional, Scholz, Christian, additional, Aglietta, Massimo, additional, Kemmotsu, Hirotsugu, additional, Azuma, Koichi, additional, Bradbury, Penelope, additional, Feld, Ronald, additional, Chachoua, Abraham, additional, Jassem, Jacek, additional, Juergens, Rosalyn, additional, Palmero Sanchez, Ramon, additional, Malcolm, Albert, additional, Vrindavanam, Nandagopal, additional, Kubota, Kaoru, additional, Waller, Cornelius, additional, Waterhouse, David, additional, Coudert, Bruno, additional, Mark, Zsuzsanna, additional, Satouchi, Miyako, additional, Chang, Gee-Chen, additional, Herzmann, Christian, additional, Chaudhry, Arvind, additional, Giridharan, Selvaraj, additional, Hesketh, Paul, additional, Ikeda, Norihiko, additional, Boccia, Ralph, additional, Iannotti, Nichola, additional, Haigentz, Missak, additional, Reynolds, John, additional, Querol, John, additional, Nakagawa, Kazuhiko, additional, Sugawara, Shunichi, additional, Tan, Eng Huat, additional, Hirashima, Tomonori, additional, Gettinger, Scott, additional, Kato, Terufumi, additional, Takeda, Koji, additional, Juan Vidal, Oscar, additional, Mohn-Staudner, Andrea, additional, Panwalkar, Amit, additional, Daniel, Davey, additional, Kobayashi, Kunihiko, additional, Ladrera, Guia Elena Imelda, additional, Schulte, Clemens, additional, Sebastian, Martin, additional, Cernovska, Marketa, additional, Coupkova, Helena, additional, Havel, Libor, additional, Pauk, Norbert, additional, Singh, Joginder, additional, Murakami, Shuji, additional, Csoszi, Tibor, additional, Losonczy, Gyorgy, additional, Price, Allan, additional, Anderson, Ian, additional, Iqbal, Mussawar, additional, Torri, Vamsee, additional, Juhasz, Erzsebet, additional, Khanani, Saleem, additional, Koubkova, Leona, additional, Levy, Benjamin, additional, Page, Ray, additional, Bocskei, Csaba, additional, Crinò, Lucio, additional, Einspahr, David, additional, Hagenstad, Christopher, additional, Juat, Necy, additional, Overton, Lindsay, additional, Garrison, Mitchell, additional, and Szalai, Zsuzsanna, additional

Published
2018
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45. Association of high TUBB3 with resistance to adjuvant docetaxel-based chemotherapy in gastric cancer: translational study of ITACA-S

Author

Di Bartolomeo, Maria, Raimondi, Alessandra, Cecchi, Fabiola, Catenacci, Daniel V.T., Schwartz, Sarit, Sellappan, Shankar, Tian, Yuan, Miceli, Rosalba, Pellegrinelli, Alessandro, Giommoni, Elisa, Aitini, Enrico, Spada, Francesca, Rosati, Gerardo, Marchet, Alberto, Pucci, Francesca, Zaniboni, Alberto, Tamberi, Stefano, Pressiani, Tiziana, Sanna, Gianni, Cantore, Maurizio, Mosconi, Stefania, Bolzoni, Paola, Pinto, Carmine, Landi, Lorenza, Soto Parra, Hector Josè, Cavanna, Luigi, Corallo, Salvatore, Martinetti, Antonia, Hembrough, Todd A., and Pietrantonio, Filippo

Abstract

Background: No predictive markers for chemotherapy activity have been validated in gastric cancer (GC). The potential value of class III β-tubulin (TUBB3) as biomarker for prognosis and resistance to taxane-based therapy was reported.Methods: We analyzed GC samples of patients enrolled in the Intergroup Trial of Adjuvant Chemotherapy in Adenocarcinoma of the Stomach (ITACA-S), a randomized adjuvant study comparing 5-fluorouracil/leucovorin (5-FU/LV) and docetaxel-based sequential chemotherapy. TUBB3 was quantitated by selected reaction monitoring mass spectrometry and patients were stratified using a threshold of 750 attomoles per microgram (amol/µg). Cox proportional modeling and Kaplan-Meier survival analysis were used to assess the impact of TUBB3 expression on overall survival (OS) and disease-free survival.Results: Patients with TUBB3 protein levels >750 and <750 amol/µg were 21.9% and 78.1%, respectively, and were well-balanced between treatment arms. TUBB3 protein levels were not prognostic. Whereas no survival differences according to the 2 arms were observed in the subgroup with low TUBB3 expression (5-year OS 47% vs 40%; p= 0.44), patients with high TUBB3 had a clinically meaningful poorer OS when receiving docetaxel-based versus 5-FU/LV chemotherapy (5-year OS 31% vs 54%; p= 0.09), with a statistically significant interaction between TUBB3 and treatment (p= 0.049).Conclusions: The quantification of TUBB3 might be considered as a negative predictive biomarker of benefit from taxane-based therapy in GC. Studies are needed to evaluate its role in the neoadjuvant setting.

Published
2021
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46. Ceritinib compassionate use for patients with crizotinib-refractory, anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer

Author

Metro, Giulio, primary, Passaro, Antonio, additional, Lo Russo, Giuseppe, additional, Bonanno, Laura, additional, Giusti, Raffaele, additional, Gregorc, Vanesa, additional, Capelletto, Enrica, additional, Martelli, Olga, additional, Cecere, Fabiana L, additional, Giannarelli, Diana, additional, Luciani, Andrea, additional, Bearz, Alessandra, additional, Tuzi, Alessandro, additional, Scotti, Vieri, additional, Tonini, Giuseppe, additional, Galetta, Domenico, additional, Carta, Annamaria, additional, Soto Parra, Hector, additional, Rebonato, Alberto, additional, Morabito, Alessandro, additional, and Chiari, Rita, additional

Published
2018
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47. Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Martin, Miguel, primary, Holmes, Frankie A, additional, Ejlertsen, Bent, additional, Delaloge, Suzette, additional, Moy, Beverly, additional, Iwata, Hiroji, additional, von Minckwitz, Gunter, additional, Chia, Stephen K L, additional, Mansi, Janine, additional, Barrios, Carlos H, additional, Gnant, Michael, additional, Tomašević, Zorica, additional, Denduluri, Neelima, additional, Šeparović, Robert, additional, Gokmen, Erhan, additional, Bashford, Anna, additional, Ruiz Borrego, Manuel, additional, Kim, Sung-Bae, additional, Jakobsen, Erik Hugger, additional, Ciceniene, Audrone, additional, Inoue, Kenichi, additional, Overkamp, Friedrich, additional, Heijns, Joan B, additional, Armstrong, Anne C, additional, Link, John S, additional, Joy, Anil Abraham, additional, Bryce, Richard, additional, Wong, Alvin, additional, Moran, Susan, additional, Yao, Bin, additional, Xu, Feng, additional, Auerbach, Alan, additional, Buyse, Marc, additional, Chan, Arlene, additional, Harvey, Vernon, additional, Tomek, Rudolf, additional, Robert, Nicholas J., additional, Gore, Ira, additional, Smith, John W., additional, Masuda, Norikazu, additional, Di Sean Kendall, S., additional, Harker, William Graydon, additional, Petrakova, Katarina, additional, Guerrero Zotano, Angel, additional, Simon, Amparo Ruiz, additional, Konstantinovic, Zora Neskovic, additional, Iannotti, Nicholas O., additional, Tassone, Pierfrancesco, additional, Rodriguez, Gladys I., additional, Jáñez Martinez, Noelia, additional, Crespo Massieu, Carmen, additional, Smickoska, Snezana, additional, Somali, Isil, additional, Yilmaz, Ugur, additional, Alonso, Mirta Garcia, additional, Rosales, Adolfo Murias, additional, Cold, Soeren, additional, Knoop, Ann Soegaard, additional, Patt, Debra, additional, Hellerstedt, Beth A., additional, Morales Murillo, Serafin, additional, Mayer, Ingrid A., additional, Means-Powell, Julie Ann, additional, Hui, Rina, additional, Senecal, Francis M., additional, De Boer, Richard Hendry, additional, Shen, Zhenzhou, additional, Luczak, Adam Andrzej, additional, Chui, Joanna W.Y., additional, Tsang, Janice Wing-hang, additional, Lang, Istvan, additional, Rai, Yoshiaki, additional, Hozumi, Yasuo, additional, Ten Tije, Albert J., additional, Bhandari, Manish, additional, Osborne, Cynthia R.C., additional, Ohtani, Shoichiro, additional, Higaki, Kenji, additional, Watanabe, Kenichi, additional, Taguchi, Kazunori, additional, Takahashi, Masato, additional, Filipovic, Sladjana, additional, Hansen, Vincent L., additional, Rao, Vijayarama Phooshkooru, additional, Gupta, Manish, additional, Petrov, Petar, additional, Coudert, Bruno, additional, Vojnovic, Zeljko, additional, Polya, Zsofia, additional, Miyaki, Toshiko, additional, Yamamoto, Naohito, additional, Brincat, Stephen, additional, Lesniewski-Kmak, Krzysztof, additional, Chmielowska, Ewa, additional, Birhiray, Ruemu E., additional, Citron, Marc L., additional, Papish, Steven William, additional, Berry, William R., additional, Langkjer, Sven Tyge, additional, Garcia Sáenz, José Angel, additional, Arance, Ana Maria, additional, Efrat, Noa, additional, Sarosiek, Tomasz, additional, Grzeda, Lukasz, additional, Manalo, Yvonne, additional, Smith, Julie C., additional, Vaziri, Irfan, additional, Healey, Tabitha, additional, Rahim, Yasmin, additional, Luk, Cynthia, additional, Dingle, Brian, additional, Franco, Sandra, additional, Sorensen, Peter Grundtvig, additional, Anand, Anjana, additional, Khan, Sarah, additional, Fountzilas, George, additional, Aogi, Kenjiro, additional, Shimizu, Satoru, additional, Mikulova, Milada, additional, Spanik, Stanislav, additional, Somer, Robert A., additional, Flynn, Patrick J., additional, Coward, Jermaine, additional, Mainwaring, Paul, additional, Jerusalem, Guy, additional, Segura-Ojezzar, Carine, additional, Levy, Christelle, additional, Delozier, Thierry, additional, Khayat, David, additional, Coleman, Robert E., additional, Rolles, Martin J., additional, Maisano, Robert, additional, Nardi, Mario, additional, Ito, Yoshinori, additional, Yumuk, Perran Fulden, additional, Basaran, Gul, additional, Serdar Turhal, Nazim, additional, Wilkinson, Mary J., additional, Green, Nathan B., additional, Sidrys, Algis P., additional, Hallmeyer, Sigrun, additional, Testori, Douglas J., additional, Sridhar, Srikala, additional, Chang, Jose, additional, Sun, Qiang, additional, Jara-Sanchez, Carlos, additional, Rubio, Xabier, additional, Garrido, Maria Lomas, additional, De La Haba Rodriguez, Juan Rafael, additional, Perello Martorell, Antonia, additional, Avelia Mestre, Antoni, additional, Rifa Ferrer, Julio, additional, del Barco Berron, Sonia, additional, Nagy, Zsuzsanna, additional, Tanaka, Maki, additional, Im, Young-Hyuck, additional, Carroll, Robert R., additional, Dickerson, Laura C., additional, Mace, Joseph R., additional, Rivera, Ragene, additional, Klein, Leonard M., additional, Ruxer, Robert, additional, Wilks, Sharon T., additional, Kotasek, Dusan, additional, Popov, Vasil, additional, Taskova, Violina, additional, Marinova-Venkova, Violetka, additional, Timcheva, Constanta, additional, Desbiens, Christine, additional, Ayoub, Jean-Pierre, additional, Grenier, Debjani, additional, Marschner, Norbert, additional, Tesch, Hans, additional, Lueck, Hans-Joachim, additional, Janssen, Jan, additional, Schwaner, Ingo, additional, Wahlstrom, Stine, additional, Brix, Eva Harder, additional, Vallentin, Susanne, additional, Kristensen, Dan, additional, Andreeva, Anna, additional, Glavicic, Vesna, additional, Calvo Plaza, Isabel, additional, Anton Torres, Antonio, additional, Veyret, Corinne, additional, Bergerat, Jean-Pierre, additional, Bourbouloux, Emmanuelle, additional, Ella, Wendy Ann, additional, Algurafi, Hafiz, additional, Robinson, Anne, additional, Kim, Seung Jin, additional, Taguchi, Tetsuya, additional, Juozaityte, Elona, additional, Madretsma, Stanley, additional, Radema, Sandra, additional, Czerniawska-Meier, Malgorzata, additional, Rogowski, Wojciech, additional, Wagnerova, Maria, additional, Richards, Donald A., additional, Tan-Chiu, Elizabeth, additional, Vasileios, Asskikis, additional, Henderson, Charles Arthur, additional, Holden, Viran Roger, additional, Wang, Xiaojia, additional, Tong, Zhongsheng, additional, Yang, Junlan, additional, Gonzalez, Manuel Enrique, additional, Rezai, Mahdi, additional, Hackmann, John, additional, de Dueñas, Eduardo Martinez, additional, de las Heras, Begoña Bermejo, additional, Dourthe, Louis Marie, additional, Chocteau-Bouju, Dorothee, additional, Bougnoux, Philippe, additional, Kakolyris, Stylianos, additional, Kalofonos, Haralabos, additional, Pectasidis, Dimitrios, additional, Ng, Ting Ying, additional, Pajkos, Gabor, additional, Somogyine, Eva Ezer, additional, Tonini, Giuseppe, additional, Giuffrida, Dario, additional, Takao, Shintaro, additional, Ishitobi, Makoto, additional, Inaji, Hideo, additional, Tokuda, Yutaka, additional, Wozniak, Katarzyna, additional, Lungulescu, Dan, additional, Lu, Yen-Shen, additional, Chang, King-Jen, additional, Hill, Julian, additional, Croot, Christopher Charles, additional, Dekker, Albert, additional, Belman, Neil D., additional, Conde, Miguel, additional, Michaelson, Richard A., additional, Kemmer, Kathleen, additional, Chui, Stephen, additional, Luoh, Shiuh-Wen, additional, Nahum, Kenneth, additional, Greenspan, Andrew R., additional, Nichols, Joni C., additional, Encarnacion, Carlos A., additional, Niederman, Thomas M.J., additional, Lee, Theresa, additional, Alexander, Roland, additional, Gordon, Robert, additional, Tomova, Antoanet, additional, Rauch, Daniel, additional, Popescu, Razvan Andrei, additional, Rojas, Gustavo Adolfo, additional, Vanasek, Jaroslav, additional, Neunhoeffer, Tanja, additional, Barinoff, Jana, additional, Graffunder, Gerd, additional, Wolfgang, Abenhardt, additional, Bojko, Peter, additional, Heinrich, Bernhard, additional, von der Assen, Albert, additional, Antonovic, Bogovic Jurij, additional, Adrian, Lene, additional, Ramos Vazquez, Manuel, additional, Gonzalez Santiago, Santiago, additional, Dieras, Veronique, additional, Bishop, Jill Mercia, additional, Perren, Timothy John, additional, Varthalitis, Ioannis, additional, Mavroudis, Dimitris, additional, Georgoulias, Vassilis, additional, Chow, Louis W.C., additional, Yau, Chung Cheung Thomas, additional, Liang, Raymond Hin-Suen, additional, Pikó, Béla, additional, Wéber, Agnes, additional, Kaufman, Bella, additional, Drumea, Karen, additional, Nuzzo, Francesco, additional, De Matteis, Andrea, additional, Carteni, Giacomo, additional, Tokunaga, Eriko, additional, Ishida, Mayumi, additional, Ohno, Shinji, additional, Sato, Nobuaki, additional, Kuroi, Katsumasa, additional, Nishimura, Reiki, additional, Watanabe, Junichiro, additional, Choi, Yoon Ji, additional, Park, Kyong Hwa, additional, Wojtukiewicz, Marek, additional, Jassem, Jacek, additional, Loman, Niklas, additional, Askoy, Sercan, additional, Altundag, Mustafa Kadri, additional, Saip, Pinar, additional, Ali, Muhammad Amjad, additional, Wade, James Lloyd, additional, Chien, Amy Jo, additional, Brandt, Debra, additional, Novik, Yelena, additional, Jani, Chirag, additional, Rice, Robert L., additional, Gaffar, Yousuf A. R, additional, Keaton, Mark R., additional, Bajaj, Rajesh, additional, Kimmick, Gretchen, additional, Campbell, David, additional, Turnquest, Theodore, additional, Lucas, Sideras, additional, Dube, Pierre, additional, Xu, Binghe, additional, Schilling, Joerg, additional, Apel, Klaus, additional, Vestlev, Peter Michael, additional, Jensen, Brita Bjerregaard, additional, Haahr, Vera, additional, Lescure, Alvaro Rodriguez, additional, Grana Suarez, Begona, additional, Saura Manich, Cristina, additional, Jacquin, Jean-Philippe, additional, Samreen, Ahmed, additional, Boiangiu, Ion, additional, Dank, Magdolna, additional, Falci, Cristina, additional, Jirillo, Antonio, additional, Cinieri, Saverio, additional, Ueno, Takayuki, additional, Sato, Fumiaki, additional, Yamashiro, Hiroyasu, additional, Sugie, Tomoharu, additional, Lee, Keun Seok, additional, Ro, Jung Sil, additional, Park, In Hae, additional, Bustam, Anita Zarina, additional, Suszko-Kazarnowicz, Malgorzata, additional, Piktel, Artur, additional, Krzemieniecki, Krzysztof, additional, Iorga, Polizenia Georgeta, additional, Yap, Yoon Sim, additional, Kakalejcik, Marian, additional, Sevinc, Alper, additional, Ozguroglu, Mustafa, additional, Chen, Shin-Cheh, additional, Greenberg, Richard H., additional, Eisemann, Allan Daniel, additional, Droder, Robert, additional, Abbasi, M. Rashid, additional, Vaysburd, Marina, additional, Caldera, Humberto Jose, additional, Haley, Barbara Bacsik, additional, Robin, Erwin, additional, Inhorn, Roger C., additional, Hufnagel, David, additional, Kenyon, Peter D., additional, Spremulli, Ellen, additional, Silverman, Paula, additional, Jain, Sharad, additional, Weigand, Robert, additional, Mebis, Jeroen, additional, Koynova, Tatyana, additional, Lesperance, Bernard, additional, Prausova, Jana, additional, Kohne, Claus-Henning, additional, Schneeweiss, Andreas, additional, Jackisch, Christian, additional, Fuxius, Stefan, additional, Cubedo Cervera, Ricardo, additional, Urruticoechea Ribate, Ander, additional, Pernas Simon, Sonia, additional, Valero Gallego, Jose, additional, Arcusa Lanza, Angels, additional, del Pilar Alvarez, Maria, additional, Florian Gerico, Jesus, additional, Cany, Laurent, additional, Stebbing, Justin, additional, Labudovic, Dejan, additional, Gugic, Damir, additional, Vrbanec, Damir, additional, Roila, Fausto, additional, Barni, Sandro, additional, Bidoli, Paolo, additional, Mukai, Hirofumi, additional, Bermudez, Vanessa, additional, Eniu, Alexandru, additional, Mirtsching, Barry C., additional, Ibrahim, Emad, additional, Trey, Joan, additional, Hergenroeder, Paul Francis, additional, Mahmood, Aftab, additional, Gonzalez, Anneliese, additional, Kaplan, Edward H., additional, Ban, Stacy, additional, Patel, Dhimant, additional, Clowney, Billy, additional, Hoelzer, Karen, additional, Schwartz, Garry H., additional, Salkeni, Mohamed, additional, Abraham, Jame, additional, Narula, Sunil, additional, Jabboury, Khaled, additional, Mocharnuk, Robert Scott, additional, McDonough, Richard H., additional, Sikes, David H., additional, Kawanchi, Ronald H., additional, Schlabach, Larry, additional, McCachren, Samuel Spence, additional, Cosgriff, Thomas M., additional, Dreisbach, Luke, additional, DeMichele, Angela, additional, Pawl, Lawrence, additional, Lucas, Jennifer, additional, Shinn, Lowell C., additional, Alkhouri, Nabiel, additional, Monga, Manish, additional, Lindquist, Deborah L., additional, Anderson, Thomas C., additional, Khurshid, Humera, additional, Witherby, Sabrina, additional, Erickson, Nicholette, additional, Traynor, Ann, additional, Bose, Ron, additional, Pluard, Timothy J., additional, Jones, Michael C., additional, Prakash, Sucharu, additional, Volterra, Fabio, additional, Capo, Gerardo, additional, Flaherty, Lawrence E., additional, Gartner, Elaina, additional, Baidas, Said, additional, Okazaki, Ian, additional, Nguyen, Bichlien, additional, Rakowski, Thomas, additional, Oliff, Ira, additional, Leach, Joseph W., additional, Anderson, Daniel, additional, Kubiak, Kendra, additional, Tsai, Michaela, additional, Vroman, Philippe, additional, Deleu, Ines, additional, Lybaert, Willem, additional, Borms, Marleen, additional, Couture, Felix, additional, Wilson, Jonathan J., additional, Hunt, Gordon, additional, Holland, David R., additional, Mingrone, Walter, additional, Wang, Shusen, additional, Liu, Donggeng, additional, Jiang, Zefei, additional, Benesova, Vera, additional, Smakal, Martin, additional, Garnolova, Petra, additional, Vesper, Anne-Sophie, additional, Neumann, Monika, additional, Janni, Wolfgang, additional, Liedtke, Cornelia, additional, Fischer, Dorothea, additional, Grischke, Eva-Maria, additional, Seeger, Dietmar, additional, Moebus, Volker, additional, Prechtl, Anita, additional, Carlos Camara Toral, Juan, additional, Sanchez Munoz, Alfonso, additional, Gonzalez Jimenez, Sonia, additional, Cassinello Espinosa, Javier, additional, Cirauqui, Beatriz, additional, Margeli Vila, Mireia, additional, Batista Lopez, Norberto, additional, Chacon Lopez-Muniz, Jose Ignacio, additional, de la Cruz Mora, Miguel Angel, additional, Mailliez, Audrey, additional, Vanlemmens, Laurence, additional, Pouessel, Damien, additional, Espie, Marc, additional, Conibear, John, additional, Roylance, Rebecca, additional, Harnett, Adrian, additional, Geffen, David, additional, Ruggeri, Enzo Maria, additional, Gamucci, Teresa, additional, Van Groeningen, Cees J., additional, Banas, Renata, additional, Alkis, Necati, additional, Hou, Ming-Feng, additional, Krie, Amy K., additional, Vrindavanam, Nandagopal S., additional, Howard, Orion M., additional, Citrin, Dennis, additional, Morginstin, Mark S., additional, Desai, Ajit, additional, Sanchez, Ines J., additional, Nixon, David Allen, additional, Beatty, Patrick G., additional, Edmiston, Kathryn, additional, McLaughlin, Marilyn, additional, Eneman, Jonathan D., additional, Lynch, Cynthia A., additional, O'Brien, Edward, additional, Call, Justin A., additional, Lanier, Keith S., additional, Conlin, Alison, additional, Brooks, Donald J., additional, McIntyre, Kristi, additional, Saltzman, Marc A., additional, Castine, Michael J., additional, Ortega, Gregory L., additional, Choi, Young M., additional, Reynolds, Craig H., additional, Brescia, Frankie Ann, additional, Kramer, Rita, additional, Kohn, Aimee D., additional, Micha, John P., additional, Rhee, Jessica M., additional, Shah, Satish, additional, Riseberg, David A., additional, Patterson, William Kevin, additional, Salmon, Jean-Paul, additional, Andre, Chantal, additional, Bols, Alain, additional, D'hondt, Randal, additional, Luce, Sylvie, additional, Nouwynck, Claire, additional, Pelgrims, Gino, additional, Richard, Vincent, additional, Verschuere, Johan, additional, Geldhof, Kurt, additional, Caspar, Clemens, additional, Luo, Rongcheng, additional, Bednarik, Otakar, additional, Schwedler, Kathrin, additional, Schmidt, Marcus, additional, Neumeister, Romy, additional, Bischoff, Joachim, additional, Rack, Brigitte, additional, Repp, Roland, additional, Fries, Stefan, additional, Adrion, Ralf, additional, Schulz, Volker, additional, Klare, Peter, additional, Danei, Mahmoud, additional, Ossenbuhl, Dirk, additional, Kusche, Jakob Manfred, additional, Griesinger, Frank, additional, Baena Canada, Jose Manuel, additional, Martinez del Prado, Purificacion, additional, Machover, David, additional, Mayeur, Didier, additional, Trufflandier, Nathalie, additional, Delecroix, Valerie, additional, Mousseau, Mireille, additional, Mouret-Reynier, Marie-Ange, additional, Nabholtz, Jean-Marc, additional, Chetiyawardana, Anula D., additional, Papandreou, Christos, additional, Hornyak, Lajos, additional, Faluhelyi, Zsolt, additional, Simo, Erzsebet, additional, Di Palma, Mario, additional, Cognetti, Francesco, additional, Gorzegno, Gabriella, additional, Dogliotti, Luigi, additional, Gridelli, Cesare, additional, Falcone, Alfredo, additional, Soto Parra, Hector, additional, Buscarino, Calogero, additional, Im, Seock-Ah, additional, Sanchez Llamas, Benito, additional, Dercksen, Wouter, additional, Erdkamp, Franciscus, additional, Ruit, Jan B., additional, Braun, Hans, additional, Portielje, Joanneke E.A., additional, Ciltas, Aydin, additional, Buyukberber, Suleyman, additional, Benekli, Mustafa, additional, Zahalsky, Andrew J., additional, Jaslow, Rebecca, additional, Thomas, Gary W., additional, Maini, Archana, additional, Wiznitzer, Israel, additional, Khojasteh, Ali, additional, Francisco Gonzalez, Manuel, additional, Kong, Lynn R., additional, Padmanabhan, Aruna, additional, Conkright, William A., additional, Swain, Sandra M., additional, Faig, Douglas E., additional, Jain, Kirti, additional, Yanagihara, Ronald H., additional, Ottaviano, Yvonne, additional, Delmas, Andrew, additional, Steele, Heather A., additional, Rainey, Gordon K., additional, Harris, Penelope J., additional, Burris, Jason K., additional, Rupard, Erik J., additional, Tan, Esther, additional, Whitworth, Pat W., additional, Bova, Abby R., additional, Anderson, Ian C., additional, Shirinian, Mihran, additional, Tin-u, Caesar, additional, O'Rourke, Timothy J., additional, Roberts, Michael S., additional, Francisco, Michael, additional, Pierson, A. Scott, additional, Byeff, Peter D., additional, Kovach, Peter A., additional, Caton, John R., additional, Rarick, Mark Urban, additional, Schimidt, William G., additional, Stopeck, Alison T., additional, Swart, Rachel, additional, Carrillo Flores, Maria Regina, additional, Alemany, Carlos A., additional, Lozada, Brennely, additional, Weinstein, Paul L., additional, Wang, Wei, additional, Porubcin, Michael, additional, Ellison, David M., additional, Geils, George F., additional, Rivera, Edgardo, additional, and Charif, Mahmoud, additional

Published
2017
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48. Multicenter study of the evaluation of eribulin (E) use in Sicily in metastatic breast cancer (MBC): A prospective registry (VESPRY trial).

Author

Adamo, Vincenzo, primary, Ricciardi, Giuseppina, additional, Giuffrida, Dario, additional, Scandurra, Giuseppa, additional, Russo, Antonio, additional, Blasi, Livio, additional, Spadaro, Pietro, additional, Lucenti, Antonio, additional, Soto Parra, Hector J., additional, Savarino, Antonino, additional, Ferraú, Francesco, additional, Zerilli, Filippo, additional, Verderame, Francesco, additional, Butera, Alfredo, additional, Franchina, Veronica, additional, Cottini, Lorenzo, additional, Fedele, Guido, additional, and Caruso, Michele, additional

Published
2017
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50. A phase II, noncomparative, open label, multicentre, study of AZD9291 in patients with locally advanced or metastatic EGFR mutated “T790M undetectable or unknown” non-small cell lung cancer (stage IIIB-IV) after no immediate prior EGFR TKI (OSIRIS study).

Author

Soto Parra, Hector J., primary, Noto, Laura, additional, Galetta, Domenico, additional, Ferraú, Francesco, additional, Gebbia, Vittorio, additional, Tassone, Pierfrancesco, additional, Verderame, Francesco, additional, Aiello, Marco M., additional, Latteri, Fiorenza, additional, and Novello, Silvia, additional

Published
2017
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