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6. Autologous bone marrow transplantation for treatment of isolated central nervous system relapse of childhood acute lymphoblastic leukemia

Author

Messina, C, Valsecchi, MG, Aricò, M, Locatelli, F, Rossetti, F, Rondelli, R, Cesaro, S, Uderzo, C, Conter, V, Pession, A, Sotti, G, Loiacono, G, Santoro, N, Miniero, R, Dini, G, Favre, C, Meloni, G, Testi, AM, Werner, B, Silvestri, D, Arrighini, A, Varotto, S, Pillon, M, Basso, G, Lombardi, A, Masera, G, and Zanesco, L

Published
1998
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10. Soft Tissue Sarcomas in Infants Less than 1 Year Old: Experience of the Italian Cooperative Study RMS-791

Author

Carli, M., primary, Grotto, P., additional, Perilongo, G., additional, di Montezemolo, L. Cordero, additional, Cecchetto, G., additional, De Bernardi, B., additional, Deb, G., additional, Di Tullio, M. T., additional, Bagnulo, S., additional, LoCurto, M., additional, Mancini, A., additional, Andrello, L., additional, Sotti, G., additional, and Masarotto, G., additional

Published
1990
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13. Preoperative localization and radioguided parathyroid surgery

Author

Mariani, Giuliano, Mariani, G., Boni, G., Marco Puccini, Pelizzo, Mr, Manca, G., Casara, D., Sotti, G., PAOLA ANNA ERBA, DUCCIO VOLTERRANI, Giuliano, Ae, Mariani, G, Gulec, S, Rubello, D, Boni, G, Puccini, M, Pelizzo, M, Manca, G, Casara, D, Sotti, G, Erba, P, Volterrani, D, and Giuliano, A

Subjects
Parathyroid Glands, Parathyroidectomy, Technetium Tc 99m Sestamibi, Intraoperative Care, Surgery, Computer-Assisted, Hyperparathyroidism, Preoperative Care, Humans, Minimally Invasive Surgical Procedures, Radiopharmaceuticals, Radionuclide Imaging, iperparathyroidism, radioguides surgery, nucléé medicine, PTH
Abstract

Clinical or subclinical hyperparathyroidism is one of the most common endocrine disorders. Excessive secretion of parathyroid hormone is most frequently caused by an adenoma of >or=1 parathyroid gland. Unsuccessful surgery with persistent hyperparathyroidism, due to inadequate preoperative or intraoperative localization, may be observed in about 10% of patients. The conventional surgical approach is bilateral neck exploration, whereas minimally invasive parathyroidectomy (MIP) has been made possible by the introduction of (99m)Tc-sestamibi scintigraphy for preoperative localization of parathyroid adenomas. In MIP, the incision is small, dissection is minimal, postoperative pain is less, and hospital stay is shorter. Localization imaging techniques include ultrasonography, CT, MRI, and scintigraphy. Parathyroid scintigraphy with (99m)Tc-sestamibi is based on longer retention of the tracer in parathyroid than in thyroid tissue. Because of the frequent association of parathyroid adenomas with nodular goiter, the optimal imaging combination is (99m)Tc-sestamibi scintigraphy and ultrasonography. Different protocols are used for (99m)Tc-sestamibi parathyroid scintigraphy, depending on the institutional logistics and experience (classical dual-phase scintigraphy, various subtraction techniques in combination with radioiodine or (99m)Tc-pertechnetate). MIP is greatly aided by intraoperative guidance with a gamma-probe, based on in vivo radioactivity counting after injection of (99m)Tc-sestamibi. Different protocols used for gamma-probe-guided MIP are based on different timing and doses of tracer injected. Gamma-probe-guided MIP is a very attractive surgical approach to treat patients with primary hyperparathyroidism due to a solitary parathyroid adenoma. The procedure is technically easy, safe, with a low morbidity rate, and has better cosmetic results and lower overall cost than conventional bilateral neck exploration. Specific guidelines should be followed when selecting patients for gamma-probe-guided MIP.

Published
2003

18. SALIVARY GLANDS IRRADIATION INHEAD&NECK CARCINOMA ANDOROPHARYNGEAL MYCOSIS. A POSSIBLERELATIONSHIP? ANSWERS FROM MIR(MYCOSIS IN RADIOTHERAPY) STUDY ONPROGNOSTIC FACTORS

Author

Busetto, M., Fusco, V., Pavanato, G., Maggio, F., Corbella, F., Bonetti, B., Orsatti, M., Panizzoni, G., DE RENZIS, Costantino, Montemaggi, P., Cionini, L., Loreggian, L., Lastrucci, L., Castaldo, G., Colombo, S., Mandoliti, G., Berlinghieri, S., Guglielmi, R. B., Sansotta, G., Sciumé, F., Antonello, M., Matteucci, F., Delia, P., Sotti, G., Frata, P., Turcato, G., and Bolzan, M.

Published
2011

21. INFLUENZA DELLA MICOSI OROFARINGEA SULLA TOLLERANZA DEI TESSUTI SANI IN CORSO DI RT PER CANCRO DEL CAPOCOLLO.PRIMI RISULTATI DELLO STUDIO MIR (MICOSI IN RADIOTERAPIA) SUI FATTORI PROGNOSTICI

Author

Busetto, M., Fusco, V., Pavanato, G., Maggio, F., Corbella, F., Bonetti, B., Orsatti, M., Panizzoni, G., DE RENZIS, Costantino, Montemaggi, P., Cionini, L., Loreggian, L., Lastrucci, L., Castaldo, G., Colombo, S., Mandoliti, G., Berlinghieri, S., Guglielmi, R. B., Sansotta, G., Sciumé, F., Antonello, M., Matteucci, F., Delia, P., Sotti, G., Frata, P., Turcato, G., and Bolzan, M.

Published
2010

23. GESTIONE DEL RISCHIO DI MICOSI IN CORSO DI TRATTAMENTI INTEGRATI O RADIOTERAPIA ESCLUSIVA PER CARCINOMI DEL CAPO-COLLO. RISULTATI PRELIMINARI DELLO STUDIO MIR (MICOSI IN RADIOTERAPIA) SUI FATTORI PROGNOSTICI

Author

Busetto, M., Fusco, V., Corbella, F., Pavanato, G., Bonetti, B., Orsatti, M., Panizzoni, G., DE RENZIS, Costantino, Montemaggi, P., Cionini, L., Loreggian, L., Lastrucci, L., Castaldo, G., Colombo, S., Mandoliti, G., Berlinghieri, S., Maggio, F., Guglielmi, R. B., Sansotta, G., Sciumé, F., Antonello, M., Matteucci, F., Delia, P., Sotti, G., Frata, P., Turcato, G., Pizzi, G. B., and Bolzan, M.

Published
2009

24. Risk management of mycosis during integrated or exclusive radiotherapy for head and neck cancer. Preliminary results of MIR (Mycosis In Radiotherapy) study on prognostic factors

Author

Busetto, M, Fusco, V, Corbella, F, Pavanato, G, Bonetti, B, Orsatti, M, Panizzoni, G, DE RENZIS, C, Montemaggi, P, Cionici, L, Loreggian, L, Lastrucci, L, Castaldo, G, Colombo, S, Mandoliti, G, Berlinghieri, S, Maggio, F, Guglielmi, Rb, Sansotta, G, Sciume', F, Antonello, M, Matteucci, F, Delia, P, Sotti, G, Frata, Paolo, Turcato, G, Pizzi, Gb, and Bolzan, M.

Published
2009

25. Autologous bone marrow transplantation for treatment of isolated central nervous system relapse of childhood acute lymphoblastic leukemia. AIEOP/FONOP-TMO group. Associzione Italiana Emato-Oncologia Pediatrica

Author

Messina, C, Aricò, M, Locatelli, F, Rossetti, F, Rondelli, R, Cesaro, S, Uderzo, C, Conter, V, Pession, A, Sotti, G, Loiacono, G, Santoro, N, Miniero, R, Dini, G, Favre, C, Meloni, G, Testi, AM, Werner, B, Silvestri, D, Arrighini, A, Varotto, S, Pillon, M, Basso, G, Zanesco, L., VALSECCHI, MARIA GRAZIA, Messina, C, Valsecchi, M, Aricò, M, Locatelli, F, Rossetti, F, Rondelli, R, Cesaro, S, Uderzo, C, Conter, V, Pession, A, Sotti, G, Loiacono, G, Santoro, N, Miniero, R, Dini, G, Favre, C, Meloni, G, Testi, A, Werner, B, Silvestri, D, Arrighini, A, Varotto, S, Pillon, M, Basso, G, and Zanesco, L

Subjects
Male, Antineoplastic Combined Chemotherapy Protocol, Adolescent, Infant, Newborn, Infant, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Transplantation, Autologous, Disease-Free Survival, Transplantation, Autologou, childhood lymphoblastic leukemia, meningeal relapse, autologous marrow transplantation, Recurrence, Child, Preschool, Antineoplastic Combined Chemotherapy Protocols, Meningeal Neoplasms, Humans, Female, Meningeal Neoplasm, Child, Human, Bone Marrow Transplantation
Abstract

The purpose of this study was to assess the role of ABMT in children with ALL who are in 2nd CR after an early isolated CNS relapse. All children experiencing an isolated CNS relapse at 10 AIEOP centers (Associazione Italiana Emato-Oncologia Pediatrica) from 1986 to 1992 were eligible for this study. The series included 69 patients who relapsed within 3 years from diagnosis: 19 underwent ABMT, nine patients underwent ALLO-BMT from an HLA-identical sibling, and 41 received conventional chemotherapy (CHEMO). Statistical analysis was performed using a Cox's regression model, adjusting for the waiting time before transplantation and prognostic factors. The 5 years DFS was 56.3% (s.e. 12.3) for patients in the ABMT group. This compared favorably with the poor result (12.6% (s.e. 5.9)) seen in the CHEMO group. The risk of failures was reduced by one-third in the ABMT group as compared to the CHEMO group in the multivariate analysis (P < 0.01). In the ALLO group four out of nine patients were in CCR 4-5 years post-transplant. This study suggests that ABMT may also represent a valuable therapeutic choice for patients lacking a matched familiar donor in 2nd CR after an early isolated CNS relapse.

Published
1998

28. La palliazione in radioterapia oncologica

Author

Aglietta, M, Anselmo, P, AUSILI-CEFARO, G, Basagni, Ml, Brandes, Aa, Buffoli, A, Cellini, N, Chirico, L, Conforti, F, Corvo', R, Costantini, S, Donato, V, Ferrara, T, Franceschi, E, Fiusco, V, Gabriele, P, Garibaldi, E, Gava, A, Genovesi, D, Ippolito, E, Lazzari, G, Livi, L, Luca', F, Lupattelli, M, Magnani, K, Malinverni, G, Mandoliti, G, Manzo, R, Marangolo, M, Mattiucci, Gc, Maranzano, E, Marmiroli, L, Mazzarotto, R, Monaco, A, Muto, P, Paiar, F, Paoletti, L, Pergolizzi, S, Rossi, R, Sacco, S, Scopa, A, Signor, A, Signor, M, Silvano, G, Soffietti, R, Sotti, G, Toniolo, E, Trevisan, E, Trippa, F, Turriziani, A, Vagge, S, Valentini, V, Vianello, F, and Zorat, Pl

Published
2007

31. Acute and late morbidity after limited resection and focal radiation therapy in criniopharyngiomas

Author

Scarzello, G., Buzzaccarini, Ms, GIORGIO PERILONGO, Viscardi, E., Faggin, R., Carollo, C., Calderone, M., Franchi, A., and Sotti, G.

Subjects
Craniopharyngioma, Treatment Outcome, Radiotherapy, Humans, CHILDREN, TUMORS, Pituitary Neoplasms, Child, Combined Modality Therapy, Neurosurgical Procedures
Abstract

Aggressive surgery of craniopharyngioma can cause severe, life-long hypothalamic and pituitary dysfunctions and possibly further impair visual function; conventional radiation therapy (RT) can affect intellectual functioning and cause secondary tumours. Because of the severe morbidity associated with aggressive surgery, many authors nowadays recommend a less radical approach followed by RT. This combined approach allows achieving 70-83% 10-year local control rates which are comparable to that achieved with aggressive surgery. The main morbidity of this conservative combined approach is represented by pituitary dysfunction secondary to RT, however, sparing severe hypothalamic disturbances. The interval between treatment and onset of the disorder is much longer than in the case of aggressive surgery and this can have a beneficial impact on quality of life, especially in children. This alternative therapeutic approach has become more appealing now that modern RT techniques allow safer delivery of the RT, particularly in childhood.

Published
2006

37. ABMT for early isolated extramedullary relapse of childhood ALL

Author

Rossetti F, Messina C, Miniero R, Busca A, Sotti G, Simone Cesaro, Zanesco L, Colleselli P, and Scotti G [corrected to Sotti G

Subjects
Male, Adolescent, Bone Marrow Purging, Cytarabine, Infant, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Combined Modality Therapy, Transplantation, Autologous, Recurrence, Child, Preschool, Humans, Female, Child, Whole-Body Irradiation, Bone Marrow Transplantation
Abstract

From July 1987 to July 1991, 12 children underwent AMBT following high-dose cytarabine (HD Ara-C) plus 14.4 Gy hyperfractionated total body irradiation (hyfr-TBI) for early isolated extramedullary relapse of ALL, while in first BM remission. No patient received intrathecal prophylaxis following AMBT. One patient died on day +5 due to sepsis and three patients, two of them transplanted in second and third CNS relapse, respectively, died from BM relapse occurring 1.5, 4 and 5 months after AMBT. Eight of the 12 survive disease-free with a median follow-up of 24 months (range 14-62 months). The toxicity of HD Ara-C plus hyfr-TBI was acceptable and well controlled with supportive therapy. These results suggest that ABMT following HD Ara-C plus hyfr-TBI may eradicate leukemia from extramedullary sites of ALL relapse.

Published
1993

41. PHOTODYNAMIC THERAPY IN EARLY OESOPHAGEAL CANCER AND LONG TERM SURVIVAL

Author

Corti, L., Boso, C., Cardin, F., Norberto, Lorenzo, Battaglia, G., and Sotti, G.

Subjects
esophagectomy, esophageal cancer, esophagectomy, neoadjuvant therapy, elderly patients, morbidity, mortality, survival, morbidity, esophageal cancer, neoadjuvant therapy, elderly patients, mortality, survival
Published
2002

42. Advances in the INFN-Legnaro BNCT project for skin melanoma

Author

Agosteo, S., Casoli, L., Cesari, V., Colautti, P., Colonna, N., Conte, V., Curzio, G., DE NARDO, Laura, Derrico, F., Don, G., Fabris, C., Fortuna, G., Gambarini, G., Geronazzo, M., Giuntini, F., Jori, G., Lollo, M., Roncucci, G., Sotti, G., Tecchio, L., Tinti, R., and Tornielli, Giorgio

Subjects
Skin melanoma, BNCT
Published
2001

47. HASH(0x5563c55eec20)

Author

Nachtnebel, A., Sotti, G., Vitale, A., Perrini, MR., Nachtnebel, A., Sotti, G., Vitale, A., and Perrini, MR.

Abstract

HASH(0x5563c5436060), HASH(0x5563c55843b0)

Published
2011

48. Clinical approach in patients with metastatic differentiated thyroid carcinoma and negative 131I whole body scintigraphy: importance of 99mTc MIBI scan combined with high resolution neck ultrasonography

Author

Casara, D, Rubello, D, Saladini, G, Mazzarotto, R, Sotti, G, Tomasella, G, and Pelizzo, MARIA ROSA

Subjects
Adult, Aged, 80 and over, Male, Technetium Tc 99m Sestamibi, Lung Neoplasms, Bone Neoplasms, Middle Aged, Magnetic Resonance Imaging, Sensitivity and Specificity, Iodine Radioisotopes, Lymphatic Metastasis, Humans, Female, Thyroid Neoplasms, Radiopharmaceuticals, Radionuclide Imaging, Tomography, X-Ray Computed, Neck, Aged, Ultrasonography
Abstract

The aim of this study was to define the clinical impact of MIBI scan combined with neck ultrasonography on the detection of metastates in differentiated thyroid carcinoma (DTC) patients with elevated serum Tg levels but negative 131I scan (non-functioning DTC).Eighty-two patients with non-functioning DTC, 19 patients with 131I-positive metastases (functioning DTC), and 24 DTC patients who were disease free after therapy (no cancer patients) were enrolled. 131I scan was performed after administration of low diagnostic and high therapeutic tracer doses. Early and delayed images were obtained after MIBI injection. Neck-chest CT scan and/or MRI were also performed in patients with non-functioning DTC.In the group of non-functioning DTC patients, metastatic foci were detected in 71/82 cases: in the cervical lymph nodes in 51 cases (sensitivity 94.1% with MIBI, 90.2% with US, 35.3% with CT/MRI), mediastinal lymph nodes in 31 cases (sensitivity 100% with MIBI, 58% with CT/MRI), lungs in 8 cases (sensitivity 100% with both MIBI and CT/MRI), and bone in 2 cases (sensitivity 50% with MIBI, 100% with MDP bone scan). Among the 19 patients with functioning DTC a close relationship between MIBI and 131I findings was observed. As regards the 24 tumor-free patients, MIBI was correctly negative in all cases, while US visualized enlarged cervical lymph nodes that were suspected to be neoplastic but proved to be inflammatory lesions at cytology in three patients.On the basis of these data, MIBI scan combined with neck US could be proposed as a first-line diagnostic imaging modality in the follow-up of DTC patients with elevated serum Tg levels and negative 131I scan.

Published
1999

50. Autologous bone marrow transplantation for childhood acute lymphoblastic leukaemia in Italy. AIEOP/FONOP-TMO Group. Italian Association of Paediatric Haemato-Oncology

Author

Messina, C., Cesaro, S., Rondelli, R., Rossetti, F., Locatelli, F., Pession, A., Miniero, R., Dini, G., Uderzo, C., Dallorso, S., Meloni, Giovanna, Vignetti, Marco, Andolina, M., Porta, F., Amici, A., Favre, C., Basso, G., Sotti, G., Varotto, S., Destro, R., Gazzola, M. V., Pillon, M., Petris, M. G., Rabusin, M., and Scarzello, G.

Published
1998

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