1. Hepatitis A virus sequence detected in clotting factor concentrates associated with disease transmission.
- Author
-
Robertson BH, Alter MJ, Bell BP, Evatt B, McCaustland KA, Shapiro CN, Sinha SD, and Souci JM
- Subjects
- Detergents, Disease Outbreaks, Factor IX adverse effects, Factor IX isolation & purification, Genotype, Germany epidemiology, Hemophilia A therapy, Hepatitis A epidemiology, Hepatovirus classification, Hepatovirus genetics, Humans, Ireland epidemiology, Male, RNA, Viral genetics, Solvents, United States epidemiology, Factor VIII adverse effects, Factor VIII isolation & purification, Hepatitis A blood, Hepatitis A transmission, Hepatovirus isolation & purification, RNA, Viral blood
- Abstract
Since the early 1990s hepatitis A virus (HAV) infections among recipients of solvent-detergent treated factor VIII concentrates have occurred in Europe, South Africa and the United States. A review of the epidemiological and laboratory-based investigations of the outbreaks in Germany and Ireland were consistent with transmission by factor concentrates but limited information about transmission based upon nucleic acid sequences was obtained, and no clear chain of transmission could be established. Within the United States, hepatitis A infections associated with solvent detergent concentrate occurred in a single patient in 1993, and a cluster of cases in 1995. Although the 1993 factor concentrate was positive for virus, samples from the patient were not available. The virus present in the cluster of 1995 factor VIII patients, the factor concentrate they received, and the original plasma pool was identical, while the virus identified in the factor IX patient differed by a single base., (Copyright 1998 The International Association of Biological Standardization)
- Published
- 1998
- Full Text
- View/download PDF