19 results on '"Soukara S"'
Search Results
2. Traditional foods: Why and how to sustain them
- Author
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Trichopoulou, A., Vasilopoulou, E., Georga, K., Soukara, S., and Dilis, V.
- Published
- 2006
- Full Text
- View/download PDF
3. Socioeconomic position and the risk of gastric and oesophageal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
- Author
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Nagel, G. Linseisen, J. Boshuizen, H.C. Pera, G. Del Giudice, G. Westert, G.P. Bueno-de-Mesquita, H.B. Allen, N.E. Key, T.J. Numans, M.E. PeetersP.H.M., Petra H.M. Sieri, S. Siman, H. Berglund, G. Hallmans, G. Stenling, R. Martinez, C. Arriola, L. Barricarte, A. Chirlaque, M.D. Quiros, J.R. Vineis, P. Masala, G. Palli, D. Panico, S. Tumino, R. Bingham, S. Boeing, H. Bergmann, M.M. Overvad, K. Boutron-Ruault, M.-C. Clavel-Chapelon, F. Olsen, A. Tjonneland, A. Trichopoulou, A. Bamia, C. Soukara, S. Sabourin, J.-C. Carneiro, F. Slimani, N. Jenab, M. Norat, T. Riboli, E. González, C.A.
- Abstract
Objectives: To evaluate the association of socioeconomic position with adenocarcinoma of the oesophagus and stomach. Methods: The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort comprises about 520 000 participants mostly aged 35-70 years. Information on diet and lifestyle was collected at recruitment. After an average follow-up of 6.5 years, 268 cases with adenocarcinoma of the stomach and 56 of the oesophagus were confirmed. We examined the effect of socioeconomic position on cancer risk by means of educational data and a computed Relative Index of Inequality (RII). In a nested case-control study, adjustment for Helicobacter pylori (H. pylori) infection was performed. Results: Higher education was significantly associated with a reduced risk of gastric cancer [vs lowest level of education, hazard ratio (HR): 0.64, 95% Confidence intervals (CI): 0.43-0.98]. This effect was more pronounced for cancer of the cardia (HR: 0.42, 95% CI: 0.20-0.89) as compared to non-cardia gastric cancer (HR: 0.66, 95% CI: 0.36-1.22). Additionally, the inverse association of educational level and gastric cancer was stronger for cases with intestinal (extreme categories, HR: 0.13, 95% CI: 0.04-0.44) rather than diffuse histological subtype (extreme categories, HR: 0.71 95% CI: 0.37-1.40). In the nested case-control study, inverse but statistically non-significant associations were found after additional adjustment for H. pylori infection [highest vs lowest level of education: Odds ratio (OR) 0.53, 95% CI: 0.24-1.18]. Educational level was non-significantly, inversely associated with carcinoma of the oesophagus. Conclusion: A higher socioeconomic position was associated with a reduced risk of gastric adenocarcinoma, which was strongest for cardia cancer or intestinal histological subtype, suggesting different risk profiles according to educational level. These effects appear to be explained only partially by established risk factors. © The Author 2007; all rights reserved.
- Published
- 2007
4. Traditional foods: a science and society perspective
- Author
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Trichopoulou, A. Soukara, S. Vasilopoulou, E.
- Subjects
digestive, oral, and skin physiology - Abstract
Traditional foods reflect cultural inheritance and have left their imprints on contemporary dietary patterns. They are key elements for the dietary patterns in different countries and consequently are important to accurately estimate population dietary intakes. However, this information is missing from most current national food composition databases. EuroFIR aims to enrich national food composition tables that lack nutrient data on traditional foods and to provide data on selected bioactive components. In this context, a common definition of traditional foods has been agreed upon for the classification of traditional foods in European food composition tables. A list of traditional foods, for which analytical nutritional and bioactive data will be provided, has been developed. © 2007 Elsevier Ltd. All rights reserved.
- Published
- 2007
5. Traditional foods: Why and how to sustain them
- Author
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Trichopoulou, A. Vasilopoulou, E. Georga, K. Soukara, S. Dilis, V.
- Abstract
The longevity associated with the Mediterranean Diet could be partly attributed to Mediterranean traditional foods, which this diet incorporates. A weekly menu, representative of the Greek traditional diet, was found compatible with the nutritional recommendations of the European Commission and with a high flavonoid content. The analysis of several traditional Greek foods indicated that they may contribute to the apparent health benefits of the Greek version of the Mediterranean diet. The methodology for the study of traditional foods in Greece is currently being expanded to 12 European countries in the 'EuroFIR' project. One of the aims is to define the term 'traditional' ensuring the classification and exclusive registration of traditional foods. © 2006 Elsevier Ltd. All rights reserved.
- Published
- 2006
6. Detecting deceit via analyses of verbal and nonverbal behaviour in children and adults
- Author
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Aldert Vrij, Lucy Akehurst, Soukara, S., and Ray Bull
- Subjects
Psychology - Abstract
This experiment examined children's and undergraduates' verbal and nonverbal deceptive behavior, and the extent to which their truths and lies could be correctly classified by paying attention to these responses. A total of 196 participants (aged 5-6, 10-11, 14-15, and undergraduates) participated in an erasing the blackboard event, and told the truth or lied about the event afterwards. Nonverbal and verbal responses were coded, the latter with Criteria-Based Content Analysis and Reality Monitoring. Although children and undergraduates demonstrated different behaviors (for example, the children obtained lower CBCA scores and made more movements), actual cues to deceit were remarkably similar across different age groups (for example, both 5-6-year-olds and undergraduates obtained lower CBCA scores and made fewer movements while lying). A combination of verbal and nonverbal lie detection methods resulted in more correct classifications of liars and truth tellers than the verbal and nonverbal lie detection methods individually, with the combined method obtaining hit rates as high as 88%
- Published
- 2004
7. Ethanol intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).
- Author
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Rohrmann, S., Linseisen, J., Boshuizen, H.C., Whittaker, J., Agudo, A., Vineis, P., Boffetta, P., Jensen, M.K., Olsen, A., Overvad, K., Tjonneland, A., Boutron-Ruault, M.C., Clavel-Chapelon, F., Bergmann, M.M., Boeing, H., Allen, N., Key, T.J., Bingham, S., Khaw, K.T., Kyriazi, G., Soukara, S., Trichopoulou, A., Panico, S., Palli, D., Sieri, S., Tumino, R., Peeters, P.H., Bueno-De-Mesquita, H.B., Buchner, F.L., Gram, I.T., Lund, E., Ardanaz, E., Chirlaque, M.D., Dorronsoro, M., Perez, M.J., Quiros, J.R., Berglund, G., Janzon, L., Rasmuson, T., Weinehall, L., Ferrari, P., Jenab, M., Norat, T., Riboli, E., Rohrmann, S., Linseisen, J., Boshuizen, H.C., Whittaker, J., Agudo, A., Vineis, P., Boffetta, P., Jensen, M.K., Olsen, A., Overvad, K., Tjonneland, A., Boutron-Ruault, M.C., Clavel-Chapelon, F., Bergmann, M.M., Boeing, H., Allen, N., Key, T.J., Bingham, S., Khaw, K.T., Kyriazi, G., Soukara, S., Trichopoulou, A., Panico, S., Palli, D., Sieri, S., Tumino, R., Peeters, P.H., Bueno-De-Mesquita, H.B., Buchner, F.L., Gram, I.T., Lund, E., Ardanaz, E., Chirlaque, M.D., Dorronsoro, M., Perez, M.J., Quiros, J.R., Berglund, G., Janzon, L., Rasmuson, T., Weinehall, L., Ferrari, P., Jenab, M., Norat, T., and Riboli, E.
- Abstract
Contains fulltext : 49956.pdf (publisher's version ) (Closed access), Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake (887 cases) with lung cancer. Information on baseline and past alcohol consumption, lifetime tobacco smoking, diet, and the anthropometric characteristics of 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. Overall, neither ethanol intake at recruitment nor mean lifelong ethanol intake was significantly associated with lung cancer. However, moderate intake (5-14.9 g/day) at recruitment (hazard ratio (HR) = 0.76, 95% confidence interval (CI): 0.63, 0.90) and moderate mean lifelong intake (HR = 0.80, 95% CI: 0.66, 0.97) were associated with a lower lung cancer risk in comparison with low consumption (0.1-4.9 g/day). Compared with low intake, a high (> or =60 g/day) mean lifelong ethanol intake tended to be related to a higher risk of lung cancer (HR = 1.29, 95% CI: 0.93, 1.74), but high intake at recruitment was not. Although there was no overall association between ethanol intake and risk of lung cancer, the authors cannot rule out a lower risk for moderate consumption and a possibly increased risk for high lifelong consumption.
- Published
- 2006
8. What really happens in police interviews of suspects? Tactics and confessions
- Author
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Soukara, S., primary, Bull, R., additional, Vrij, A., additional, Turner, M., additional, and Cherryman, J., additional
- Published
- 2009
- Full Text
- View/download PDF
9. Traditional foods: a science and society perspective
- Author
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TRICHOPOULOU, A, primary, SOUKARA, S, additional, and VASILOPOULOU, E, additional
- Published
- 2007
- Full Text
- View/download PDF
10. Socioeconomic position and the risk of gastric and oesophageal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
- Author
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Nagel, G., primary, Linseisen, J., additional, Boshuizen, H. C, additional, Pera, G., additional, Del Giudice, G., additional, Westert, G. P, additional, Bueno-de-Mesquita, H B., additional, Allen, N. E, additional, Key, T. J, additional, Numans, M. E, additional, Peeters, P. H., additional, Sieri, S., additional, Siman, H., additional, Berglund, G., additional, Hallmans, G., additional, Stenling, R., additional, Martinez, C., additional, Arriola, L., additional, Barricarte, A., additional, Chirlaque, M D., additional, Quiros, J. R, additional, Vineis, P., additional, Masala, G., additional, Palli, D., additional, Panico, S., additional, Tumino, R., additional, Bingham, S., additional, Boeing, H., additional, Bergmann, M. M, additional, Overvad, K., additional, Boutron-Ruault, M.-C., additional, Clavel-Chapelon, F., additional, Olsen, A., additional, Tjonneland, A., additional, Trichopoulou, A., additional, Bamia, C., additional, Soukara, S., additional, Sabourin, J.-C., additional, Carneiro, F., additional, Slimani, N., additional, Jenab, M., additional, Norat, T., additional, Riboli, E., additional, and Gonzalez, C. A, additional
- Published
- 2007
- Full Text
- View/download PDF
11. Ethanol Intake and Risk of Lung Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
- Author
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Rohrmann, S., primary, Linseisen, J., additional, Boshuizen, H. C., additional, Whittaker, J., additional, Agudo, A., additional, Vineis, P., additional, Boffetta, P., additional, Jensen, M. K., additional, Olsen, A., additional, Overvad, K., additional, Tjonneland, A., additional, Boutron-Ruault, M.-C., additional, Clavel-Chapelon, F., additional, Bergmann, M. M., additional, Boeing, H., additional, Allen, N., additional, Key, T., additional, Bingham, S., additional, Khaw, K.-T., additional, Kyriazi, G., additional, Soukara, S., additional, Trichopoulou, A., additional, Panico, S., additional, Palli, D., additional, Sieri, S., additional, Tumino, R., additional, Peeters, P. H. M., additional, Bueno-de-Mesquita, H. B., additional, Buchner, F. L., additional, Gram, I. T., additional, Lund, E., additional, Ardanaz, E., additional, Chirlaque, M.-D., additional, Dorronsoro, M., additional, Perez, M.-J. S., additional, Quiros, J. R., additional, Berglund, G., additional, Janzon, L., additional, Rasmuson, T., additional, Weinehall, L., additional, Ferrari, P., additional, Jenab, M., additional, Norat, T., additional, and Riboli, E., additional
- Published
- 2006
- Full Text
- View/download PDF
12. Elementary Processes in Peptides: Electron Mobility and Dissociation in Peptide Cations in the Gas Phase
- Author
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Weinkauf, R., primary, Schanen, P., additional, Yang, D., additional, Soukara, S., additional, and Schlag, E. W., additional
- Published
- 1995
- Full Text
- View/download PDF
13. Methylated Analogues of Methyl (R)-4-(3,4-Dichlorophenylacetyl)- 3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate (GR-89,696) as Highly Potent κ-Receptor Agonists: Stereoselective Synthesis, Opioid-Receptor Affinity, Receptor Selectivity, and Functional Studies
- Author
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Soukara, S., Maier, C. A., Predoiu, U., Ehret, A., Jackisch, R., and Wunsch, B.
- Abstract
Analogues of the κ-receptor agonist methyl (R)-4-(3,4-dichlorophenylacetyl)-3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate (GR-89,696,
6 ) bearing an additional methyl substituent in the side chain are synthesized and evaluated for their κ-receptor affinity and selectivity. A key step in the synthesis is the stereoselective reductive amination of the ketones9 ,18 , and19 with pyrrolidine and NaBH3 CN, which succeeds only in the presence of the Lewis acid Ti(OiPr)4 . Whereas the BOC-substituted ketone9 affords the unlike and like diastereomers of10 in a ratio of 70:30, the diastereoselectivity during the reductive amination of the butyl and phenyl substituted ketones18 and19 is enhanced to 85:15 (butyl derivative) and >95:<5 (phenyl derivative) in favor of the unlike diastereomers. In receptor binding studies using the radioligand [3H]U-69,593 the (S,S)-configured methyl carbamate (S,S)-14 reveals the highest κ-receptor affinity (Ki = 0.31 nM) within this series, even exceeding the lead κ-agonist6 (GR-89,696). A slightly reduced κ-receptor affinity is observed with the propionamide (S,S)-13 (Ki = 0.67 nM). The κ-receptor affinity of piperazines with acyl or alkoxycarbonyl residues at both nitrogen atoms (11 ,13 ,14 ) decreases in the order (S,S) > (R,R) > (S,R) > (R,S). The methyl carbamate (S,S)-14 discloses a unique activity profile also binding at μ-receptors in the subnanomolar range (Ki = 0.36 nM). In a functional assay, i.e., by measuring acetylcholine release in rabbit hippocampus slices, the agonistic effects of the methyl carbamate (S,S)-14 and the propionamide (S,S)-13 are demonstrated. Only weak κ- and μ-receptor affinities are found with the butyl- and phenyl-substituted piperazines22 and23 . However, considerable σ1 -receptor affinity is determined for the enantiomeric, unlike-configured butyl derivatives (R,S)-22 and (S,R)-22 with Ki -values of 40.2 nM and 81.0 nM, respectively.- Published
- 2001
14. Synthesis and stereoselective kappa-receptor binding of methylated analogues of GR-89.696
- Author
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Rohr, C., Soukara, S., and Wunsch, B.
- Published
- 2001
- Full Text
- View/download PDF
15. Ethanol intake and the risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
- Author
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Rohrmann, S., Linseisen, J., Hc, Boshuizen, Whittaker, J., Agudo, A., Vineis, P., Boffetta, P., Mk, Jensen, Anja Viendahl Olsen, Kim Overvad, Anne Tjønneland, M-C, Boutron-Ruault, Clavel-Chapelon, F., Mm, Bergmann, Boeing, H., Allen, N., Key, T., Bingham, S., K-T, Khaw, Kyriazi, G., Soukara, S., Trichopoulou, A., Panico, S., Palli, D., Sieri, S., Tumino, R., Phm, Peeters, Hb, Bueno-De-Mesquita, Fl, Büchner, It, Gram, Lund, E., Arnanaz, E., M-D, Chirlaque, Dorronsoro, M., Pèrez, M-J S., Jr, Quirós, Berglund, G., Janzon, L., Rasmuson, T., Weinehall, L., Ferrari, P., Jenab, M., Norat, T., and Riboli, E.
16. Ethanol Intake and Risk of Lung Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
- Author
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Pietro Ferrari, Paolo Vineis, John C. Whittaker, Anne Tjønneland, Rosario Tumino, Torgny Rasmuson, Frederike L. Büchner, Hendriek C. Boshuizen, Timothy J. Key, María Dolores Chirlaque, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Domenico Palli, Salvatore Panico, Manuela M. Bergmann, Eva Ardanaz, Majken K. Jensen, H. Bas Bueno-de-Mesquita, Jakob Linseisen, Inger T. Gram, Sabine Rohrmann, Göran Berglund, Petra H.M. Peeters, Elio Riboli, Eiliv Lund, Teresa Norat, Kim Overvad, Stavroula Soukara, María José Sánchez Pérez, Sabina Sieri, Lars Weinehall, Anja Olsen, Antonio Agudo, Naomi E. Allen, Mazda Jenab, Georgia Kyriazi, Sheila Bingham, Antonia Trichopoulou, Lars Janzon, José Ramón Quirós, Paolo Boffetta, Miren Dorronsoro, Kay-Tee Khaw, Heiner Boeing, Rohrmann, S, Linseisen, J, Boshuizen, Hc, Whittaker, J, Agudo, A, Vineis, P, Boffetta, P, Jensen, Mk, Olsen, A, Overvad, K, Tjonneland, A, BOUTRON RUAULT, Mc, CLAVEL CHAPELON, F, Bergmann, Mm, Boeing, H, Allen, N, Key, T, Bingham, S, Khaw, Kt, Kyriazi, G, Soukara, S, Trichopoulou, A, Panico, Salvatore, Palli, D, Sieri, S, Tumino, R, Peeters, Ph, BUENO DE MESQUITA, Hb, Buchner, Fl, Gram, It, Lund, E, Ardanaz, E, Chirlaque, Md, Dorronsoro, M, Perez, Mj, Quiros, Jr, Berglund, G, Janzon, L, Rasmuson, T, Weinehall, L, Ferrari, P, Jenab, M, Norat, T, Riboli, E., Rohrmann, S., Linseisen, J., Boshuizen, H.C., Whittaker, J., Agudo, A., Vineis, P., Boffetta, P., Jensen, M.K., Olsen, A., Overvad, K., Tjønneland, A., Boutron-Ruault, M.-C., Clavel-Chapelon, F., Bergmann, M.M., Boeing, H., Allen, N., Key, T., Bingham, S., Khaw, K.-T., Kyriazi, G., Soukara, S., Trichopoulou, A., Panico, S., Palli, D., Sieri, S., Tumino, R., Peeters, P.H.M., Bueno-De-Mesquita, H.B., Büchner, F.L., Gram, I.T., Lund, E., Ardanaz, E., Chirlaque, M.-D., Dorronsoro, M., Pérez, M.-J.S., Quirós, J.R., Berglund, G., Janzon, L., Rasmuson, T., Weinehall, L., Ferrari, P., Jenab, M., and Norat, T.
- Subjects
Adult ,Male ,medicine.medical_specialty ,Epidemiology ,lung neoplasms ,Lower risk ,Risk Assessment ,cohort studies ,Risk Factors ,Interventional oncology [UMCN 1.5] ,Surveys and Questionnaires ,Internal medicine ,Determinants in Health and Disease [EBP 1] ,Humans ,Medicine ,Prospective Studies ,ddc:610 ,Risk factor ,Lung cancer ,alcohol drinking ,ethanol ,Proportional Hazards Models ,Ethanol intake and risk of lung cancer ,business.industry ,Incidence ,Hazard ratio ,Middle Aged ,Anthropometry ,medicine.disease ,Confidence interval ,European Prospective Investigation into Cancer and Nutrition ,Surgery ,Europe ,Female ,business ,Follow-Up Studies ,Cohort study - Abstract
Contains fulltext : 49956.pdf (Publisher’s version ) (Closed access) Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake (887 cases) with lung cancer. Information on baseline and past alcohol consumption, lifetime tobacco smoking, diet, and the anthropometric characteristics of 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. Overall, neither ethanol intake at recruitment nor mean lifelong ethanol intake was significantly associated with lung cancer. However, moderate intake (5-14.9 g/day) at recruitment (hazard ratio (HR) = 0.76, 95% confidence interval (CI): 0.63, 0.90) and moderate mean lifelong intake (HR = 0.80, 95% CI: 0.66, 0.97) were associated with a lower lung cancer risk in comparison with low consumption (0.1-4.9 g/day). Compared with low intake, a high (> or =60 g/day) mean lifelong ethanol intake tended to be related to a higher risk of lung cancer (HR = 1.29, 95% CI: 0.93, 1.74), but high intake at recruitment was not. Although there was no overall association between ethanol intake and risk of lung cancer, the authors cannot rule out a lower risk for moderate consumption and a possibly increased risk for high lifelong consumption.
- Published
- 2006
17. Socioeconomic position and the risk of gastric and oesophageal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
- Author
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Gabriele Nagel, Fátima Carneiro, Giuseppe Del Giudice, Sabina Sieri, Paolo Vineis, M. Dolores Chirlaque, José Ramón Quirós, Roger Stenling, Anne Tjønneland, Françoise Clavel-Chapelon, Larraitz Arriola, Göran Hallmans, Aurelio Barricarte, Carmen Martinez, Mazda Jenab, Gert P. Westert, Carlos A. González, Heiner Boeing, Naomi E. Allen, Petra H.M. Peeters, Timothy J. Key, Elio Riboli, Stavroula Soukara, Jean-Christoph Sabourin, H. Bas Bueno-de-Mesquita, Sheila Bingham, Kim Overvad, Rosario Tumino, Antonia Trichopoulou, Domenico Palli, Teresa Norat, Marie-Christine Boutron-Ruault, Göran Berglund, Anja Olsen, Guillem Pera, Henrik Simán, Salvatore Panico, Nadia Slimani, Giovanna Masala, Christina Bamia, Mattijs E. Numans, Hendriek C. Boshuizen, Manuela M. Bergmann, Jakob Linseisen, Nagel, G, Linseisen, J, Boshuizen, Hc, Pera, G, DEL GIUDICE, G, Westert, Gp, BUENO DE MESQUITA, Hb, Allen, Ne, Key, Tj, Numans, Me, Peeters, Ph, Sieri, S, Siman, H, Berglund, G, Hallmans, G, Stenling, R, Martinez, C, Arriola, L, Barricarte, A, Chirlaque, Md, Quiros, Jr, Vineis, P, Masala, G, Palli, D, Panico, Salvatore, Tumino, R, Bingham, S, Boeing, H, Bergmann, Mm, Overvad, K, BOUTRON RUAULT, Mc, CLAVEL CHAPELON, F, Olsen, A, Tjonneland, A, Trichopoulou, A, Bamia, C, Soukara, S, Sabourin, Jc, Carneiro, F, Slimani, N, Jenab, M, Norat, T, Riboli, E, and Gonzalez, Ca
- Subjects
Adult ,Male ,medicine.medical_specialty ,Esophageal Neoplasms ,Epidemiology ,Adenocarcinoma ,Gastroenterology ,Age Distribution ,Risk Factors ,Stomach Neoplasms ,Internal medicine ,mental disorders ,Intestinal Neoplasms ,medicine ,Humans ,Prospective Studies ,ddc:610 ,Risk factor ,Sex Distribution ,Prospective cohort study ,Stomach cancer ,Life Style ,Aged ,Gastrointestinal Neoplasms ,biology ,business.industry ,Incidence ,Cancer ,Cardia ,General Medicine ,Helicobacter pylori ,Esophageal cancer ,Middle Aged ,biology.organism_classification ,medicine.disease ,European Prospective Investigation into Cancer and Nutrition ,Diet ,Europe ,Socioeconomic Factors ,Case-Control Studies ,Educational Status ,Female ,business - Abstract
OBJECTIVES: To evaluate the association of socioeconomic position with adenocarcinoma of the oesophagus and stomach. METHODS: The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort comprises about 520 000 participants mostly aged 35-70 years. Information on diet and lifestyle was collected at recruitment. After an average follow-up of 6.5 years, 268 cases with adenocarcinoma of the stomach and 56 of the oesophagus were confirmed. We examined the effect of socioeconomic position on cancer risk by means of educational data and a computed Relative Index of Inequality (RII). In a nested case-control study, adjustment for Helicobacter pylori (H. pylori) infection was performed. RESULTS: Higher education was significantly associated with a reduced risk of gastric cancer [vs lowest level of education, hazard ratio (HR): 0.64, 95% Confidence intervals (CI): 0.43-0.98]. This effect was more pronounced for cancer of the cardia (HR: 0.42, 95% CI: 0.20-0.89) as compared to non-cardia gastric cancer (HR: 0.66, 95% CI: 0.36-1.22). Additionally, the inverse association of educational level and gastric cancer was stronger for cases with intestinal (extreme categories, HR: 0.13, 95% CI: 0.04-0.44) rather than diffuse histological subtype (extreme categories, HR: 0.71 95% CI: 0.37-1.40). In the nested case-control study, inverse but statistically non-significant associations were found after additional adjustment for H. pylori infection [highest vs lowest level of education: Odds ratio (OR) 0.53, 95% CI: 0.24-1.18]. Educational level was non-significantly, inversely associated with carcinoma of the oesophagus. CONCLUSION: A higher socioeconomic position was associated with a reduced risk of gastric adenocarcinoma, which was strongest for cardia cancer or intestinal histological subtype, suggesting different risk profiles according to educational level. These effects appear to be explained only partially by established risk factors.
- Published
- 2007
18. Will the truth come out? the effect of deception, age, status, coaching, and social skills on CBCA scores.
- Author
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Vrij A, Akehurst L, Soukara S, and Bull R
- Subjects
- Adolescent, Adult, Analysis of Variance, Child, Child, Preschool, Female, Humans, Male, Observer Variation, Reproducibility of Results, United Kingdom, Lie Detection, Psychological Tests
- Abstract
The impact of Veracity, Age, Status (witness or suspect), Coaching (informed or uninformed regarding CBCA), and Social Skills (social anxiety, social adroitness, and self-monitoring) on Criteria-Based Content Analysis scores was examined. Participants (aged 5-6, 10-11, 14-15, and undergraduates) participated in a "rubbing the blackboard" event. In a subsequent interview they told the truth or lied about the event. They were accused of having rubbed the blackboard themselves (suspect condition) or were thought to have witnessed the event (witness condition), and were or were not taught some CBCA criteria prior to the interview. CBCA scores discriminated between liars and truth tellers in children, adults, witnesses, and suspects. However, truth tellers obtained higher CBCA scores than liars only when the liars were uninformed about CBCA. CBCA scores were correlated with social skills. It is argued that thesefindings should caution those who believe that the validity of CBCA has been conclusively demonstrated.
- Published
- 2002
- Full Text
- View/download PDF
19. Methylated analogues of methyl (R)-4-(3,4-dichlorophenylacetyl)- 3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate (GR-89,696) as highly potent kappa-receptor agonists: stereoselective synthesis, opioid-receptor affinity, receptor selectivity, and functional studies.
- Author
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Soukara S, Maier CA, Predoiu U, Ehret A, Jackisch R, and Wünsch B
- Subjects
- 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer chemistry, Acetylcholine metabolism, Animals, Binding Sites, Brain metabolism, Electric Stimulation, Guinea Pigs, Hippocampus metabolism, In Vitro Techniques, Piperazines chemistry, Piperazines metabolism, Piperazines pharmacology, Pyrrolidines chemistry, Pyrrolidines metabolism, Pyrrolidines pharmacology, Rabbits, Radioligand Assay, Receptors, N-Methyl-D-Aspartate metabolism, Receptors, Opioid, delta metabolism, Receptors, Opioid, kappa metabolism, Receptors, Opioid, mu metabolism, Stereoisomerism, Structure-Activity Relationship, Piperazines chemical synthesis, Pyrrolidines chemical synthesis, Receptors, Opioid, kappa agonists
- Abstract
Analogues of the kappa-receptor agonist methyl (R)-4-(3,4-dichlorophenylacetyl)-3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate (GR-89,696, 6) bearing an additional methyl substituent in the side chain are synthesized and evaluated for their kappa-receptor affinity and selectivity. A key step in the synthesis is the stereoselective reductive amination of the ketones 9, 18, and 19 with pyrrolidine and NaBH(3)CN, which succeeds only in the presence of the Lewis acid Ti(OiPr)(4). Whereas the BOC-substituted ketone 9 affords the unlike and like diastereomers of 10 in a ratio of 70:30, the diastereoselectivity during the reductive amination of the butyl and phenyl substituted ketones 18 and 19 is enhanced to 85:15 (butyl derivative) and >95:<5 (phenyl derivative) in favor of the unlike diastereomers. In receptor binding studies using the radioligand [(3)H]U-69,593 the (S,S)-configured methyl carbamate (S,S)-14 reveals the highest kappa-receptor affinity (K(i) = 0.31 nM) within this series, even exceeding the lead kappa-agonist 6 (GR-89,696). A slightly reduced kappa-receptor affinity is observed with the propionamide (S,S)-13 (K(i) = 0.67 nM). The kappa-receptor affinity of piperazines with acyl or alkoxycarbonyl residues at both nitrogen atoms (11, 13, 14) decreases in the order (S,S) > (R,R) > (S,R) > (R,S). The methyl carbamate (S,S)-14 discloses a unique activity profile also binding at mu-receptors in the subnanomolar range (K(i) = 0.36 nM). In a functional assay, i.e., by measuring acetylcholine release in rabbit hippocampus slices, the agonistic effects of the methyl carbamate (S,S)-14 and the propionamide (S,S)-13 are demonstrated. Only weak kappa- and mu-receptor affinities are found with the butyl- and phenyl-substituted piperazines 22 and 23. However, considerable sigma(1)-receptor affinity is determined for the enantiomeric, unlike-configured butyl derivatives (R,S)-22 and (S,R)-22 with K(i)-values of 40.2 nM and 81.0 nM, respectively.
- Published
- 2001
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