Lago, Josilene Nascimento do, Costa, Cosmo de Sousa, Moraes, Larissa Emily de Carvalho, Silva, Raissa Ribeiro da, Gonçalves, Gleiciane Moraes, Oliveira, Thainar Stefanie Barbosa de, Castro, Tatiane Roseli Alves, Souza, Thalles Ricardo Melo de, Almeida, Christian Pacheco de, Ferreira, Lorena Victória de Souza, Silva, Alex Jean Ferreira da, Matos, Widson Davi Vaz de, Granato, Renan Rocha, Júnior, Ademir Ferreira da Silva, Lago, Josilene Nascimento do, Costa, Cosmo de Sousa, Moraes, Larissa Emily de Carvalho, Silva, Raissa Ribeiro da, Gonçalves, Gleiciane Moraes, Oliveira, Thainar Stefanie Barbosa de, Castro, Tatiane Roseli Alves, Souza, Thalles Ricardo Melo de, Almeida, Christian Pacheco de, Ferreira, Lorena Victória de Souza, Silva, Alex Jean Ferreira da, Matos, Widson Davi Vaz de, Granato, Renan Rocha, and Júnior, Ademir Ferreira da Silva
Objective: identify and analyse the evidences about the use of hydroxychloroquine with or without azithromycin in covid-19. Methods: This is a systematic review with meta-analysis using posted articles in December 2019 until May 2020. The research was formulated by a question structured using PICO strategy, in these data bases: BVS, PUBMED, MEDLINE, LILACS, BDENF e SCIELO. Results and discussion: Resulted in 9 articles founded by the PRISMA, approaching 4182 patients. PICO strategy selected and analysed 5 articles projected in Forest plots. Resulting in tree clinical trials (RR: 1.15; IC95%, 0.76 a 1.73), which did not found big differences in the outcome in the groups of patients who used HCQ with or without AZT, comparing with the control group. Two studies analysed the number of deaths/intubations in comparative group, experimental group and control (RR:1.86; IC: 95%, 1.54 a 2.26) resulting in more chance of death /intubation in patients who used HCQ. Conclusion: It was found that is not possible to prove the efficacy of these drugs, due to the limited number of randomized and controlled clinical trials. Therefore, the encourage of scientific production about the HCQ and AZT against Covid-19 is more than necessary.