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417 results on '"Sowalsky, Adam G."'

1. A deep-learning framework to predict cancer treatment response from histopathology images through imputed transcriptomics

Author

Hoang, Danh-Tai, Dinstag, Gal, Shulman, Eldad D., Hermida, Leandro C., Ben-Zvi, Doreen S., Elis, Efrat, Caley, Katherine, Sammut, Stephen-John, Sinha, Sanju, Sinha, Neelam, Dampier, Christopher H., Stossel, Chani, Patil, Tejas, Rajan, Arun, Lassoued, Wiem, Strauss, Julius, Bailey, Shania, Allen, Clint, Redman, Jason, Beker, Tuvik, Jiang, Peng, Golan, Talia, Wilkinson, Scott, Sowalsky, Adam G., Pine, Sharon R., Caldas, Carlos, Gulley, James L., Aldape, Kenneth, Aharonov, Ranit, Stone, Eric A., and Ruppin, Eytan

Published
2024
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2. Low tristetraprolin expression activates phenotypic plasticity and primes transition to lethal prostate cancer in mice

Author

Morel, Katherine L., German, Beatriz, Hamid, Anis A., Nanda, Jagpreet S., Linder, Simon, Bergman, Andries M., van der Poel, Henk, Hofland, Ingrid, Bekers, Elise M., Trostel, Shana Y., Burkhart, Deborah L., Wilkinson, Scott, Ku, Anson T., Kim, Minhyung, Kim, Jina, Ma, Duanduan, Plummer, Jasmine T., You, Sungyong, Su, Xiaofeng A., Zwart, Wilbert, Sowalsky, Adam G., Sweeney, Christopher J., and Ellis, Leigh

Subjects
Oncology, Experimental, Zinc finger proteins -- Health aspects -- Genetic aspects, Gene expression -- Research, Prostate cancer -- Genetic aspects -- Development and progression, Cancer -- Research, Phenotype -- Research
Abstract

Phenotypic plasticity is a hallmark of cancer and is increasingly realized as a mechanism of resistance to androgen receptor-targeted (AR-targeted) therapy. Now that many prostate cancer (PCa) patients are treated [...]

Published
2025
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3. Pre-operative stereotactic radiosurgery and peri-operative dexamethasone for resectable brain metastases: a two-arm pilot study evaluating clinical outcomes and immunological correlates

Author

Jansen, Caroline S., Pagadala, Meghana S., Cardenas, Maria A., Prabhu, Roshan S., Goyal, Subir, Zhou, Chengjing, Chappa, Prasanthi, Vo, BaoHan T., Ye, Chengyu, Hopkins, Benjamin, Zhong, Jim, Klie, Adam, Daniels, Taylor, Admassu, Maedot, Green, India, Pfister, Neil T., Neill, Stewart G., Switchenko, Jeffrey M., Prokhnevska, Nataliya, Hoang, Kimberly B., Torres, Mylin A., Logan, Suzanna, Olson, Jeffrey J., Nduom, Edjah K., del Balzo, Luke, Patel, Kirtesh, Burri, Stuart H., Asher, Anthony L., Wilkinson, Scott, Lake, Ross, Kesarwala, Aparna H., Higgins, Kristin A., Patel, Pretesh, Dhere, Vishal, Sowalsky, Adam G., Carter, Hannah, Khan, Mohammad K., Kissick, Haydn, and Buchwald, Zachary S.

Published
2024
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4. Increased nuclear factor I-mediated chromatin access drives transition to androgen receptor splice variant dependence in prostate cancer

Author

Poluben, Larysa, Nouri, Mannan, Liang, Jiaqian, Chen, Shaoyong, Varkaris, Andreas, Ersoy-Fazlioglu, Betul, Voznesensky, Olga, Lee, Irene I., Qiu, Xintao, Cato, Laura, Seo, Ji-Heui, Freedman, Matthew L., Sowalsky, Adam G., Lack, Nathan A., Corey, Eva, Nelson, Peter S., Brown, Myles, Long, Henry W., Russo, Joshua W., and Balk, Steven P.

Published
2025
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5. Defining cellular population dynamics at single-cell resolution during prostate cancer progression

Author

Germanos, Alexandre A, Arora, Sonali, Zheng, Ye, Goddard, Erica T, Coleman, Ilsa M, Ku, Anson T, Wilkinson, Scott, Song, Hanbing, Brady, Nicholas J, Amezquita, Robert A, Zager, Michael, Long, Annalysa, Yang, Yu Chi, Bielas, Jason H, Gottardo, Raphael, Rickman, David S, Huang, Franklin W, Ghajar, Cyrus M, Nelson, Peter S, Sowalsky, Adam G, Setty, Manu, and Hsieh, Andrew C

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Immunology, Oncology and Carcinogenesis, Prostate Cancer, Cancer, Genetics, Aging, Urologic Diseases, Aetiology, 2.1 Biological and endogenous factors, Male, Humans, Mice, Animals, Androgens, Prostate, Prostatic Neoplasms, Orchiectomy, Population Dynamics, Receptors, Androgen, Disease Progression, Tumor Microenvironment, prostate cancer, PTEN, Single cell RNAseq, mRNA Translation, epithelial cells, immune microenvironment, Mouse, cancer biology, computational biology, mouse, systems biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Advanced prostate malignancies are a leading cause of cancer-related deaths in men, in large part due to our incomplete understanding of cellular drivers of disease progression. We investigate prostate cancer cell dynamics at single-cell resolution from disease onset to the development of androgen independence in an in vivo murine model. We observe an expansion of a castration-resistant intermediate luminal cell type that correlates with treatment resistance and poor prognosis in human patients. Moreover, transformed epithelial cells and associated fibroblasts create a microenvironment conducive to pro-tumorigenic immune infiltration, which is partially androgen responsive. Androgen-independent prostate cancer leads to significant diversification of intermediate luminal cell populations characterized by a range of androgen signaling activity, which is inversely correlated with proliferation and mRNA translation. Accordingly, distinct epithelial populations are exquisitely sensitive to translation inhibition, which leads to epithelial cell death, loss of pro-tumorigenic signaling, and decreased tumor heterogeneity. Our findings reveal a complex tumor environment largely dominated by castration-resistant luminal cells and immunosuppressive infiltrates.

Published
2022

6. Quantitative and Qualitative Analysis of Blood-based Liquid Biopsies to Inform Clinical Decision-making in Prostate Cancer

Author

Casanova-Salas, Irene, Athie, Alejandro, Boutros, Paul C, Del Re, Marzia, Miyamoto, David T, Pienta, Kenneth J, Posadas, Edwin M, Sowalsky, Adam G, Stenzl, Arnulf, Wyatt, Alexander W, and Mateo, Joaquin

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Precision Medicine, Human Genome, Clinical Research, Prostate Cancer, Urologic Diseases, Genetic Testing, Aging, Cancer, Genetics, Biotechnology, Cancer Genomics, 4.1 Discovery and preclinical testing of markers and technologies, 4.2 Evaluation of markers and technologies, Generic health relevance, Good Health and Well Being, Biomarkers, Tumor, Circulating Tumor DNA, Clinical Decision-Making, Humans, Liquid Biopsy, Male, Neoplastic Cells, Circulating, Prostatic Neoplasms, Prostate cancer, Genomics, Liquid biopsy, Circulating tumor cell, Circulating tumor DNA, Extracellular vesicles, Precision medicine, Urology & Nephrology, Clinical sciences
Abstract

ContextGenomic stratification can impact prostate cancer (PC) care through diagnostic, prognostic, and predictive biomarkers that aid in clinical decision-making. The temporal and spatial genomic heterogeneity of PC together with the challenges of acquiring metastatic tissue biopsies hinder implementation of tissue-based molecular profiling in routine clinical practice. Blood-based liquid biopsies are an attractive, minimally invasive alternative.ObjectiveTo review the clinical value of blood-based liquid biopsy assays in PC and identify potential applications to accelerate the development of precision medicine.Evidence acquisitionA systematic review of PubMed/MEDLINE was performed to identify relevant literature on blood-based circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and extracellular vesicles (EVs) in PC.Evidence synthesisLiquid biopsy has emerged as a practical tool to profile tumor dynamics over time, elucidating features that evolve (genome, epigenome, transcriptome, and proteome) with tumor progression. Liquid biopsy tests encompass analysis of DNA, RNA, and proteins that can be detected in CTCs, ctDNA, or EVs. Blood-based liquid biopsies have demonstrated promise in the context of localized tumors (diagnostic signatures, risk stratification, and disease monitoring) and advanced disease (response/resistance biomarkers and prognostic markers).ConclusionsLiquid biopsies have value as a source of prognostic, predictive, and response biomarkers in PC. Most clinical applications have been developed in the advanced metastatic setting, where CTC and ctDNA yields are significantly higher. However, standardization of assays and analytical/clinical validation is necessary prior to clinical implementation.Patient summaryTraces of tumors can be isolated from blood samples from patients with prostate cancer either as whole cells or as DNA fragments. These traces provide information on tumor features. These minimally invasive tests can guide diagnosis and treatment selection.

Published
2021

7. Association of localized high-risk prostate cancer (PC) and an androgen receptor low subpopulation susceptible to HER2 inhibition.

Author

Sowalsky, Adam G., Wilkinson, Scott C., Ku, Anson T., Lis, Rosina T., King, Isaiah M., Low, Daniel, Trostel, Shana Y., Baj, Anna, Kartal, Sumeyra, Heyward, Kayla, Vo, Baohan Thi, Jansen, Caroline Stewart, Ye, Huihui, Harmon, Stephanie A., Kissick, Haydn T., Pinto, Peter A., Choyke, Peter L., Turkbey, Baris, Dahut, William L., and Karzai, Fatima

Published
2025
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9. Tumor-derived biomarkers predict efficacy of B7H3 antibody-drug conjugate treatment in metastatic prostate cancer models

Author

Agarwal, Supreet, Fang, Lei, McGowen, Kerry, Yin, JuanJuan, Bowman, Joel, Ku, Anson T., Alilin, Aian Neil, Corey, Eva, Roudier, Martine P., True, Lawrence D., Dumpit, Ruth, Coleman, Ilsa, Lee, John K., Nelson, Peter S., Capaldo, Brian J., Mariani, Aida, Hoover, Clare, Senatorov, Ilya S., Beshiri, Michael, Sowalsky, Adam G., Hurt, Elaine M., and Kelly, Kathleen

Subjects
Diagnosis, Care and treatment, Analysis, Health aspects, Prostate cancer -- Diagnosis -- Care and treatment, Antibodies -- Health aspects, Biological markers -- Analysis, Viral antibodies -- Health aspects
Abstract

Introduction Metastatic prostate cancer (mPC) remains a lethal disease accounting for more than 30,000 deaths annually in the United States (1). The use of androgen deprivation therapy (ADT) and androgen [...], Antibody-drug conjugates (ADCs) are a promising targeted cancer therapy; however, patient selection based solely on target antigen expression without consideration for cytotoxic payload vulnerabilities has plateaued clinical benefits. Biomarkers to capture patients who might benefit from specific ADCs have not been systematically determined for any cancer. We present a comprehensive therapeutic and biomarker analysis of a B7H3-ADC with pyrrolobenzodiazepine(PBD) payload in 26 treatment- resistant, metastatic prostate cancer (mPC) models. B7H3 is a tumor-specific surface protein widely expressed in mPC, and PBD is a DNA cross-linking agent. B7H3 expression was necessary but not sufficient for B7H3-PBD-ADC responsiveness. RB1 deficiency and/or replication stress, characteristics of poor prognosis, and conferred sensitivity were associated with complete tumor regression in both neuroendocrine (NEPC) and androgen receptor positive (ARPC) prostate cancer models, even with low B7H3 levels. Non-ARPC models, which are currently lacking efficacious treatment, demonstrated the highest replication stress and were most sensitive to treatment. In RB1 WT ARPC tumors, SLFN11 expression or select DNA repair mutations in SLFN11 nonexpressors governed response. Importantly, WT TP53 predicted nonresponsiveness (7 of 8 models). Overall, biomarker-focused selection of models led to high efficacy of in vivo treatment. These data enable a paradigm shift to biomarker-driven trial designs for maximizing clinical benefit of ADC therapies.

Published
2023
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10. Nascent Prostate Cancer Heterogeneity Drives Evolution and Resistance to Intense Hormonal Therapy

Author

Wilkinson, Scott, Ye, Huihui, Karzai, Fatima, Harmon, Stephanie A., Terrigino, Nicholas T., VanderWeele, David J., Bright, John R., Atway, Rayann, Trostel, Shana Y., Carrabba, Nicole V., Whitlock, Nichelle C., Walker, Stephanie M., Lis, Rosina T., Abdul Sater, Houssein, Capaldo, Brian J., Madan, Ravi A., Gulley, James L., Chun, Guinevere, Merino, Maria J., Pinto, Peter A., Salles, Daniela C., Kaur, Harsimar B., Lotan, Tamara L., Venzon, David J., Choyke, Peter L., Turkbey, Baris, Dahut, William L., and Sowalsky, Adam G.

Published
2021
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12. Stem cell dynamics and cellular heterogeneity across lineage subtypes of castrate resistant prostate cancer

Author

Beshiri, Michael L, primary, Capaldo, Brian J, additional, Lake, Ross, additional, Ku, Anson T, additional, Burner, Danielle, additional, Tice, Caitlin M, additional, Tran, Crystal, additional, Kostas, Julianna, additional, Alilin, Aian Neil, additional, Yin, Juan Juan, additional, Agarwal, Supreet, additional, Morris, Samantha A, additional, Karzai, Fatima H, additional, Lotan, Tamara L, additional, Dahut, William L, additional, Sowalsky, Adam G, additional, and Kelly, Kathleen, additional

Published
2024
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13. EZH2 inhibition activates a dsRNA–STING–interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer

Author

Morel, Katherine L., Sheahan, Anjali V., Burkhart, Deborah L., Baca, Sylvan C., Boufaied, Nadia, Liu, Yin, Qiu, Xintao, Cañadas, Israel, Roehle, Kevin, Heckler, Max, Calagua, Carla, Ye, Huihui, Pantelidou, Constantia, Galbo, Phillip, Panja, Sukanya, Mitrofanova, Antonina, Wilkinson, Scott, Whitlock, Nichelle C., Trostel, Shana Y., Hamid, Anis A., Kibel, Adam S., Barbie, David A., Choudhury, Atish D., Pomerantz, Mark M., Sweeney, Christopher J., Long, Henry W., Einstein, David J., Shapiro, Geoffrey I., Dougan, Stephanie K., Sowalsky, Adam G., He, Housheng Hansen, Freedman, Matthew L., Balk, Steven P., Loda, Massimo, Labbé, David P., Olson, Brian M., and Ellis, Leigh

Published
2021
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15. CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer

Author

Hwang, Justin H., Seo, Ji-Heui, Beshiri, Michael L., Wankowicz, Stephanie, Liu, David, Cheung, Alexander, Li, Ji, Qiu, Xintao, Hong, Andrew L., Botta, Ginevra, Golumb, Lior, Richter, Camden, So, Jonathan, Sandoval, Gabriel J., Giacomelli, Andrew O., Ly, Seav Huong, Han, Celine, Dai, Chao, Pakula, Hubert, Sheahan, Anjali, Piccioni, Federica, Gjoerup, Ole, Loda, Massimo, Sowalsky, Adam G., Ellis, Leigh, Long, Henry, Root, David E., Kelly, Kathleen, Van Allen, Eliezer M., Freedman, Matthew L., Choudhury, Atish D., and Hahn, William C.

Published
2019
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18. Abstract PR005: Tracing the clonal dynamic of metastatic castration-resistant prostate cancer over immunotherapy using circulating tumor DNA

Author

Li, Chennan, primary, Baj, Anna, additional, Seo, Clara C. Y., additional, Terrigino, Nicholas T., additional, Bright, John R., additional, Hennigan, S. Thomas, additional, King, Isaiah M., additional, Wilkinson, Scott, additional, Trostel, Shana Y., additional, Figg, William D., additional, Dahut, William L., additional, Lee, Jung Min, additional, Takeda, David Y., additional, Karzai, Fatima, additional, and Sowalsky, Adam G., additional

Published
2024
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19. FIGURE 4 from FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

Author

Dairo, Oluwademilade, primary, DePaula Oliveira, Lia, primary, Schaffer, Ethan, primary, Vidotto, Thiago, primary, Mendes, Adrianna A., primary, Lu, Jiayun, primary, Huynh, Sophie Vo, primary, Hicks, Jessica, primary, Sowalsky, Adam G., primary, De Marzo, Angelo M., primary, Joshu, Corrine E., primary, Hanratty, Brian, primary, Sfanos, Karen S., primary, Isaacs, William B., primary, Haffner, Michael C., primary, and Lotan, Tamara L., primary

Published
2024
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20. Supplementary Figure S2 from FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

Author

Dairo, Oluwademilade, primary, DePaula Oliveira, Lia, primary, Schaffer, Ethan, primary, Vidotto, Thiago, primary, Mendes, Adrianna A., primary, Lu, Jiayun, primary, Huynh, Sophie Vo, primary, Hicks, Jessica, primary, Sowalsky, Adam G., primary, De Marzo, Angelo M., primary, Joshu, Corrine E., primary, Hanratty, Brian, primary, Sfanos, Karen S., primary, Isaacs, William B., primary, Haffner, Michael C., primary, and Lotan, Tamara L., primary

Published
2024
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21. FIGURE 3 from FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

Author

Dairo, Oluwademilade, primary, DePaula Oliveira, Lia, primary, Schaffer, Ethan, primary, Vidotto, Thiago, primary, Mendes, Adrianna A., primary, Lu, Jiayun, primary, Huynh, Sophie Vo, primary, Hicks, Jessica, primary, Sowalsky, Adam G., primary, De Marzo, Angelo M., primary, Joshu, Corrine E., primary, Hanratty, Brian, primary, Sfanos, Karen S., primary, Isaacs, William B., primary, Haffner, Michael C., primary, and Lotan, Tamara L., primary

Published
2024
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22. Data from FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

Author

Dairo, Oluwademilade, primary, DePaula Oliveira, Lia, primary, Schaffer, Ethan, primary, Vidotto, Thiago, primary, Mendes, Adrianna A., primary, Lu, Jiayun, primary, Huynh, Sophie Vo, primary, Hicks, Jessica, primary, Sowalsky, Adam G., primary, De Marzo, Angelo M., primary, Joshu, Corrine E., primary, Hanratty, Brian, primary, Sfanos, Karen S., primary, Isaacs, William B., primary, Haffner, Michael C., primary, and Lotan, Tamara L., primary

Published
2024
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23. Supplementary Tables S1-S7 from FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

Author

Dairo, Oluwademilade, primary, DePaula Oliveira, Lia, primary, Schaffer, Ethan, primary, Vidotto, Thiago, primary, Mendes, Adrianna A., primary, Lu, Jiayun, primary, Huynh, Sophie Vo, primary, Hicks, Jessica, primary, Sowalsky, Adam G., primary, De Marzo, Angelo M., primary, Joshu, Corrine E., primary, Hanratty, Brian, primary, Sfanos, Karen S., primary, Isaacs, William B., primary, Haffner, Michael C., primary, and Lotan, Tamara L., primary

Published
2024
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24. FIGURE 5 from FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

Author

Dairo, Oluwademilade, primary, DePaula Oliveira, Lia, primary, Schaffer, Ethan, primary, Vidotto, Thiago, primary, Mendes, Adrianna A., primary, Lu, Jiayun, primary, Huynh, Sophie Vo, primary, Hicks, Jessica, primary, Sowalsky, Adam G., primary, De Marzo, Angelo M., primary, Joshu, Corrine E., primary, Hanratty, Brian, primary, Sfanos, Karen S., primary, Isaacs, William B., primary, Haffner, Michael C., primary, and Lotan, Tamara L., primary

Published
2024
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25. FIGURE 6 from FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

Author

Dairo, Oluwademilade, primary, DePaula Oliveira, Lia, primary, Schaffer, Ethan, primary, Vidotto, Thiago, primary, Mendes, Adrianna A., primary, Lu, Jiayun, primary, Huynh, Sophie Vo, primary, Hicks, Jessica, primary, Sowalsky, Adam G., primary, De Marzo, Angelo M., primary, Joshu, Corrine E., primary, Hanratty, Brian, primary, Sfanos, Karen S., primary, Isaacs, William B., primary, Haffner, Michael C., primary, and Lotan, Tamara L., primary

Published
2024
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26. FIGURE 2 from FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

Author

Dairo, Oluwademilade, primary, DePaula Oliveira, Lia, primary, Schaffer, Ethan, primary, Vidotto, Thiago, primary, Mendes, Adrianna A., primary, Lu, Jiayun, primary, Huynh, Sophie Vo, primary, Hicks, Jessica, primary, Sowalsky, Adam G., primary, De Marzo, Angelo M., primary, Joshu, Corrine E., primary, Hanratty, Brian, primary, Sfanos, Karen S., primary, Isaacs, William B., primary, Haffner, Michael C., primary, and Lotan, Tamara L., primary

Published
2024
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27. TABLE 2 from FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

Author

Dairo, Oluwademilade, primary, DePaula Oliveira, Lia, primary, Schaffer, Ethan, primary, Vidotto, Thiago, primary, Mendes, Adrianna A., primary, Lu, Jiayun, primary, Huynh, Sophie Vo, primary, Hicks, Jessica, primary, Sowalsky, Adam G., primary, De Marzo, Angelo M., primary, Joshu, Corrine E., primary, Hanratty, Brian, primary, Sfanos, Karen S., primary, Isaacs, William B., primary, Haffner, Michael C., primary, and Lotan, Tamara L., primary

Published
2024
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28. TABLE 1 from FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

Author

Dairo, Oluwademilade, primary, DePaula Oliveira, Lia, primary, Schaffer, Ethan, primary, Vidotto, Thiago, primary, Mendes, Adrianna A., primary, Lu, Jiayun, primary, Huynh, Sophie Vo, primary, Hicks, Jessica, primary, Sowalsky, Adam G., primary, De Marzo, Angelo M., primary, Joshu, Corrine E., primary, Hanratty, Brian, primary, Sfanos, Karen S., primary, Isaacs, William B., primary, Haffner, Michael C., primary, and Lotan, Tamara L., primary

Published
2024
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29. FIGURE 1 from FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

Author

Dairo, Oluwademilade, primary, DePaula Oliveira, Lia, primary, Schaffer, Ethan, primary, Vidotto, Thiago, primary, Mendes, Adrianna A., primary, Lu, Jiayun, primary, Huynh, Sophie Vo, primary, Hicks, Jessica, primary, Sowalsky, Adam G., primary, De Marzo, Angelo M., primary, Joshu, Corrine E., primary, Hanratty, Brian, primary, Sfanos, Karen S., primary, Isaacs, William B., primary, Haffner, Michael C., primary, and Lotan, Tamara L., primary

Published
2024
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34. An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

Author

Jansen, Caroline S., Prokhnevska, Nataliya, Master, Viraj A., Sanda, Martin G., Carlisle, Jennifer W., Bilen, Mehmet Asim, Cardenas, Maria, Wilkinson, Lake, Ross, Sowalsky, Adam G., Valanparambil, Rajesh M., Hudson, William H., McGuire, Donald, Melnick, Kevin, Khan, Amir I., Kim, Kyu, Chang, Yu Min, Kim, Alice, Filson, Christopher P., Alemozaffar, Mehrdad, Osunkoya, Adeboye O., Mullane, Patrick, Ellis, Carla, Akondy, Rama, Im, Se Jin, Kamphorst, Alice O., Reyes, Adriana, Liu, Yuan, and Kissick, Haydn

Subjects
Physiological aspects, Development and progression, Research, Health aspects, CD8 lymphocytes -- Physiological aspects -- Health aspects, Cell differentiation -- Research, Cancer research, Tumors -- Physiological aspects -- Development and progression, Oncology, Experimental, Cancer -- Research
Abstract

Author(s): Caroline S. Jansen [sup.1] , Nataliya Prokhnevska [sup.1] , Viraj A. Master [sup.1] [sup.2] , Martin G. Sanda [sup.1] [sup.2] , Jennifer W. Carlisle [sup.2] [sup.3] , Mehmet Asim [...], Tumour-infiltrating lymphocytes are associated with a survival benefit in several tumour types and with the response to immunotherapy.sup.1-8. However, the reason some tumours have high CD8 T cell infiltration while others do not remains unclear. Here we investigate the requirements for maintaining a CD8 T cell response against human cancer. We find that CD8 T cells within tumours consist of distinct populations of terminally differentiated and stem-like cells. On proliferation, stem-like CD8 T cells give rise to more terminally differentiated, effector-molecule-expressing daughter cells. For many T cells to infiltrate the tumour, it is critical that this effector differentiation process occur. In addition, we show that these stem-like T cells reside in dense antigen-presenting-cell niches within the tumour, and that tumours that fail to form these structures are not extensively infiltrated by T cells. Patients with progressive disease lack these immune niches, suggesting that niche breakdown may be a key mechanism of immune escape. The authors examine the immune cell infiltrates of human tumours and provide evidence for a population of CD8 T cells with stem-cell characteristics and proliferative capacity that reside in an antigen-presenting niche within tumours.

Published
2019
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35. FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-Genomic Features of Prostate Cancer

Author

Dairo, Oluwademilade O, primary, DePaula Oliveira, Lia, additional, Schaffer, Ethan, additional, Vidotto, Thiago, additional, Mendes, Adrianna A A, additional, Lu, Jiayun, additional, Huynh, Sophie Vo, additional, Hicks, Jessica L., additional, Sowalsky, Adam G., additional, De Marzo, Angelo M, additional, Joshu, Corinne E, additional, Hanratty, Brian, additional, Sfanos, Karen S, additional, Isaacs, William B., additional, Haffner, Michael C., additional, and Lotan, Tamara L, additional

Published
2023
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38. A case report of multiple primary prostate tumors with differential drug sensitivity

Author

Wilkinson, Scott, Harmon, Stephanie A., Terrigino, Nicholas T., Karzai, Fatima, Pinto, Peter A., Madan, Ravi A., VanderWeele, David J., Lake, Ross, Atway, Rayann, Bright, John R., Carrabba, Nicole V., Trostel, Shana Y., Lis, Rosina T., Chun, Guinevere, Gulley, James L., Merino, Maria J., Choyke, Peter L., Ye, Huihui, Dahut, William L., Turkbey, Baris, and Sowalsky, Adam G.

Published
2020
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39. Radiogenomic profiling of prostate tumors prior to external beam radiotherapy converges on a transcriptomic signature of TGF-β activity driving tumor recurrence

Author

Ku, Anson T., primary, Shankavaram, Uma, additional, Trostel, Shana Y., additional, Zhang, Hong, additional, Sater, Houssein A., additional, Harmon, Stephanie A., additional, Carrabba, Nicole V., additional, Liu, Yang, additional, Wood, Bradford J., additional, Pinto, Peter A., additional, Choyke, Peter L., additional, Stoyanova, Radka, additional, Davicioni, Elai, additional, Pollack, Alan, additional, Turkbey, Baris, additional, Sowalsky, Adam G., additional, and Citrin, Deborah E., additional

Published
2023
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40. Data from Modeling Androgen Deprivation Therapy–Induced Prostate Cancer Dormancy and Its Clinical Implications

Author

Dong, Xin, primary, Xue, Hui, primary, Mo, Fan, primary, Lin, Yen-yi, primary, Lin, Dong, primary, Wong, Nelson K.Y., primary, Sun, Yingqiang, primary, Wilkinson, Scott, primary, Ku, Anson T., primary, Hao, Jun, primary, Ci, Xinpei, primary, Wu, Rebecca, primary, Haegert, Anne, primary, Silver, Rebecca, primary, Taplin, Mary-Ellen, primary, Balk, Steven P., primary, Alumkal, Joshi J., primary, Sowalsky, Adam G., primary, Gleave, Martin, primary, Collins, Colin, primary, and Wang, Yuzhuo, primary

Published
2023
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