Search

Your search keyword '"Spaan, Mandy"' showing total 34 results
Start Over Author "Spaan, Mandy"
34 results on '"Spaan, Mandy"'

1. Overweight or obesity in children born after assisted reproductive technologies in Denmark: A population-based cohort study.

Author

Laugesen, Kristina, Veres, Katalin, Hernandez-Diaz, Sonia, Chiu, Yu-Han, Oberg, Anna, Hsu, John, Rinaudo, Paolo, Spaan, Mandy, van Leeuwen, Flora, and Sørensen, Henrik

Subjects
Pregnancy, Female, Child, Male, Humans, Child, Preschool, Cohort Studies, Pediatric Obesity, Overweight, Semen, Reproductive Techniques, Assisted, Infertility, Denmark
Abstract

BACKGROUND: The association between assisted reproductive technologies (ARTs) and the body mass index (BMI) of children remains controversial. Confounding by morbidity and other factors associated with parental infertility may have biased studies comparing children born after ART with children born after no treatment. We investigated the associations between different fertility treatments and BMI in children at age 5 to 8 years, adjusting for and stratifying by causes of parental infertility. METHODS AND FINDINGS: This Danish cohort study included 327,301 children born between 2007 and 2012 (51% males, median age at follow-up 7 years). Of these, 13,675 were born after ART, 7,728 were born after ovulation induction with or without intrauterine insemination [OI/IUI], and 305,898 were born after no fertility treatments. Using the International Obesity Task Force (IOTF) standards, we defined overweight (BMI ≥ IOTF-25) and obesity (BMI ≥ IOTF-30). We compared children born after ART versus OI/IUI; intracytoplasmic sperm injection (ICSI) versus conventional in vitro fertilization (IVF); and frozen-thawed versus fresh embryo transfer and estimated crude and adjusted prevalences of children with overweight or obesity at age 5 to 8 years, prevalence odds ratios (PORs), and differences in mean BMI z-scores. Adjustment was performed using stabilized inverse probability of treatment weights, including parity, year of conception, parental causes of infertility, age, educational level, comorbidities, maternal country of origin, BMI, and smoking as covariates. The crude prevalence of obesity was 1.9% in children born after ART, 2.0% in those born after OI/IUI, and 2.7% in those born after no fertility treatment. After adjustment, children born after ART and OI/IUI had the same prevalence of being overweight (11%; POR 1.00, 95% confidence interval [CI] 0.91 to 1.11; p = 0.95) or obese (1.9%; POR 1.01, 95% CI 0.79 to 1.29; p = 0.94). Comparison of ICSI with conventional IVF yielded similar pattern (POR 0.95, 95% CI 0.83 to 1.07; p = 0.39 for overweight and POR 1.16, 95% CI 0.84 to 1.61; p = 0.36 for obesity). Obesity was more prevalent after frozen-thawed (2.7%) than fresh embryo transfer (1.8%) (POR 1.54, 95% CI 1.09 to 2.17; p = 0.01). The associations between fertility treatments and BMI were only modestly different in subgroups defined by the cause of infertility. Study limitations include potential residual confounding, restriction to live births, and lack of detailed technical information about the IVF procedures. CONCLUSIONS: We found no association with BMI at age 5 to 8 years when comparing ART versus OI/IUI or when comparing ICSI versus conventional IVF. However, use of frozen-thawed embryo transfer was associated with a 1.5-fold increased risk of obesity compared to fresh embryo transfer. Despite an elevated relative risk, the absolute risk difference was low.

Published
2023

3. The mediating role of health behaviors in the association between depression, anxiety and cancer incidence: an individual participant data meta-analysis

Author

Pan, Kuan-Yu, primary, van Tuijl, Lonneke, additional, Basten, Maartje, additional, Rijnhart, Judith J. M., additional, de Graeff, Alexander, additional, Dekker, Joost, additional, Geerlings, Mirjam I., additional, Hoogendoorn, Adriaan, additional, Ranchor, Adelita V., additional, Vermeulen, Roel, additional, Portengen, Lützen, additional, Voogd, Adri C., additional, Abell, Jessica, additional, Awadalla, Philip, additional, Beekman, Aartjan T. F., additional, Bjerkeset, Ottar, additional, Boyd, Andy, additional, Cui, Yunsong, additional, Frank, Philipp, additional, Galenkamp, Henrike, additional, Garssen, Bert, additional, Hellingman, Sean, additional, Hollander, Monika, additional, Huisman, Martijn, additional, Huss, Anke, additional, Keats, Melanie R., additional, Kok, Almar A. L., additional, Krokstad, Steinar, additional, van Leeuwen, Flora E., additional, Luik, Annemarie I., additional, Noisel, Nolwenn, additional, Payette, Yves, additional, Penninx, Brenda W. J. H., additional, Picavet, Susan, additional, Rissanen, Ina, additional, Roest, Annelieke M., additional, Rosmalen, Judith G. M., additional, Ruiter, Rikje, additional, Schoevers, Robert A., additional, Soave, David, additional, Spaan, Mandy, additional, Steptoe, Andrew, additional, Stronks, Karien, additional, Sund, Erik R., additional, Sweeney, Ellen, additional, Teyhan, Alison, additional, Twait, Emma L., additional, van der Willik, Kimberly D., additional, and Lamers, Femke, additional

Published
2024
Full Text
View/download PDF

4. Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta-analysis

Author

Basten, Maartje, Pan, Kuan-Yu, van Tuijl, Lonneke A, de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W, Lamers, Femke, Ranchor, Adelita V, Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Geerlings, Mirjam I, Basten, Maartje, Pan, Kuan-Yu, van Tuijl, Lonneke A, de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W, Lamers, Femke, Ranchor, Adelita V, Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, and Geerlings, Mirjam I

Abstract

Depression, anxiety and other psychosocial factors are hypothesized to be involved in cancer development. We examined whether psychosocial factors interact with or modify the effects of health behaviors, such as smoking and alcohol use, in relation to cancer incidence. Two-stage individual participant data meta-analyses were performed based on 22 cohorts of the PSYchosocial factors and CAncer (PSY-CA) study. We examined nine psychosocial factors (depression diagnosis, depression symptoms, anxiety diagnosis, anxiety symptoms, perceived social support, loss events, general distress, neuroticism, relationship status), seven health behaviors/behavior-related factors (smoking, alcohol use, physical activity, body mass index, sedentary behavior, sleep quality, sleep duration) and seven cancer outcomes (overall cancer, smoking-related, alcohol-related, breast, lung, prostate, colorectal). Effects of the psychosocial factor, health behavior and their product term on cancer incidence were estimated using Cox regression. We pooled cohort-specific estimates using multivariate random-effects meta-analyses. Additive and multiplicative interaction/effect modification was examined. This study involved 437,827 participants, 36,961 incident cancer diagnoses, and 4,749,481 person years of follow-up. Out of 744 combinations of psychosocial factors, health behaviors, and cancer outcomes, we found no evidence of interaction. Effect modification was found for some combinations, but there were no clear patterns for any particular factors or outcomes involved. In this first large study to systematically examine potential interaction and effect modification, we found no evidence for psychosocial factors to interact with or modify health behaviors in relation to cancer incidence. The behavioral risk profile for cancer incidence is similar in people with and without psychosocial stress.

Published
2024

5. Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta-analysis

Author

Cardiovasculaire Epidemiologie, MS Medische Oncologie, Planetary Health & Exposoom, Cancer, Circulatory Health, Cardiovasculaire Epi Team 7a, Cardiometabolic Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, HAG Zorg, Cardiovasculaire Epi Team 5, Brain, Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., Geerlings, Mirjam I., Cardiovasculaire Epidemiologie, MS Medische Oncologie, Planetary Health & Exposoom, Cancer, Circulatory Health, Cardiovasculaire Epi Team 7a, Cardiometabolic Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, HAG Zorg, Cardiovasculaire Epi Team 5, Brain, Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., and Geerlings, Mirjam I.

Published
2024

6. Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta-analysis

Author

Leerstoel Boelen, Trauma and Grief, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Basten, Maartje, Pan, Kuan-Yu, van Tuijl, Lonneke A, de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W, Lamers, Femke, Ranchor, Adelita V, Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Geerlings, Mirjam I, Leerstoel Boelen, Trauma and Grief, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Basten, Maartje, Pan, Kuan-Yu, van Tuijl, Lonneke A, de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W, Lamers, Femke, Ranchor, Adelita V, Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, and Geerlings, Mirjam I

Published
2024

7. Psychosocial factors, health behaviors and risk of cancer incidence:Testing interaction and effect modification in an individual participant data meta-analysis

Author

Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., Geerlings, Mirjam I., Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., and Geerlings, Mirjam I.

Abstract

Depression, anxiety and other psychosocial factors are hypothesized to be involved in cancer development. We examined whether psychosocial factors interact with or modify the effects of health behaviors, such as smoking and alcohol use, in relation to cancer incidence. Two-stage individual participant data meta-analyses were performed based on 22 cohorts of the PSYchosocial factors and CAncer (PSY-CA) study. We examined nine psychosocial factors (depression diagnosis, depression symptoms, anxiety diagnosis, anxiety symptoms, perceived social support, loss events, general distress, neuroticism, relationship status), seven health behaviors/behavior-related factors (smoking, alcohol use, physical activity, body mass index, sedentary behavior, sleep quality, sleep duration) and seven cancer outcomes (overall cancer, smoking-related, alcohol-related, breast, lung, prostate, colorectal). Effects of the psychosocial factor, health behavior and their product term on cancer incidence were estimated using Cox regression. We pooled cohort-specific estimates using multivariate random-effects meta-analyses. Additive and multiplicative interaction/effect modification was examined. This study involved 437,827 participants, 36,961 incident cancer diagnoses, and 4,749,481 person years of follow-up. Out of 744 combinations of psychosocial factors, health behaviors, and cancer outcomes, we found no evidence of interaction. Effect modification was found for some combinations, but there were no clear patterns for any particular factors or outcomes involved. In this first large study to systematically examine potential interaction and effect modification, we found no evidence for psychosocial factors to interact with or modify health behaviors in relation to cancer incidence. The behavioral risk profile for cancer incidence is similar in people with and without psychosocial stress.

Published
2024

8. Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta‐analysis

Author

Basten, Maartje, primary, Pan, Kuan‐Yu, additional, van Tuijl, Lonneke A., additional, de Graeff, Alexander, additional, Dekker, Joost, additional, Hoogendoorn, Adriaan W., additional, Lamers, Femke, additional, Ranchor, Adelita V., additional, Vermeulen, Roel, additional, Portengen, Lützen, additional, Voogd, Adri C., additional, Abell, Jessica, additional, Awadalla, Philip, additional, Beekman, Aartjan T. F., additional, Bjerkeset, Ottar, additional, Boyd, Andy, additional, Cui, Yunsong, additional, Frank, Philipp, additional, Galenkamp, Henrike, additional, Garssen, Bert, additional, Hellingman, Sean, additional, Huisman, Martijn, additional, Huss, Anke, additional, Keats, Melanie R., additional, Kok, Almar A. L., additional, Krokstad, Steinar, additional, van Leeuwen, Flora E., additional, Luik, Annemarie I., additional, Noisel, Nolwenn, additional, Payette, Yves, additional, Penninx, Brenda W. J. H., additional, Rissanen, Ina, additional, Roest, Annelieke M., additional, Rosmalen, Judith G. M., additional, Ruiter, Rikje, additional, Schoevers, Robert A., additional, Soave, David, additional, Spaan, Mandy, additional, Steptoe, Andrew, additional, Stronks, Karien, additional, Sund, Erik R., additional, Sweeney, Ellen, additional, Twait, Emma L., additional, Teyhan, Alison, additional, Verschuren, W. M. Monique, additional, van der Willik, Kimberly D., additional, and Geerlings, Mirjam I., additional

Published
2024
Full Text
View/download PDF

9. Depression, anxiety, and the risk of cancer: An individual participant data meta‐analysis

Author

van Tuijl, Lonneke A., primary, Basten, Maartje, additional, Pan, Kuan‐Yu, additional, Vermeulen, Roel, additional, Portengen, Lützen, additional, de Graeff, Alexander, additional, Dekker, Joost, additional, Geerlings, Mirjam I., additional, Hoogendoorn, Adriaan, additional, Lamers, Femke, additional, Voogd, Adri C., additional, Abell, Jessica, additional, Awadalla, Philip, additional, Beekman, Aartjan T. F., additional, Bjerkeset, Ottar, additional, Boyd, Andy, additional, Cui, Yunsong, additional, Frank, Philipp, additional, Galenkamp, Henrike, additional, Garssen, Bert, additional, Hellingman, Sean, additional, Huisman, Martijn, additional, Huss, Anke, additional, de Jong, Trynke R., additional, Keats, Melanie R., additional, Kok, Almar A. L., additional, Krokstad, Steinar, additional, van Leeuwen, Flora E., additional, Luik, Annemarie I., additional, Noisel, Nolwenn, additional, Onland‐Moret, N. Charlotte, additional, Payette, Yves, additional, Penninx, Brenda W. J. H., additional, Rissanen, Ina, additional, Roest, Annelieke M., additional, Ruiter, Rikje, additional, Schoevers, Robert A., additional, Soave, David, additional, Spaan, Mandy, additional, Steptoe, Andrew, additional, Stronks, Karien, additional, Sund, Erik R., additional, Sweeney, Ellen, additional, Twait, Emma L., additional, Teyhan, Alison, additional, Verschuren, W. M. Monique, additional, van der Willik, Kimberly D., additional, Rosmalen, Judith G. M., additional, and Ranchor, Adelita V., additional

Published
2023
Full Text
View/download PDF

10. Depression, anxiety, and the risk of cancer: An individual participant data meta-analysis

Author

van Tuijl, Lonneke A, Basten, Maartje, Pan, Kuan-Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Rosmalen, Judith G M, Ranchor, Adelita V, van Tuijl, Lonneke A, Basten, Maartje, Pan, Kuan-Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Rosmalen, Judith G M, and Ranchor, Adelita V

Abstract

BACKGROUND: Depression and anxiety have long been hypothesized to be related to an increased cancer risk. Despite the great amount of research that has been conducted, findings are inconclusive. To provide a stronger basis for addressing the associations between depression, anxiety, and the incidence of various cancer types (overall, breast, lung, prostate, colorectal, alcohol-related, and smoking-related cancers), individual participant data (IPD) meta-analyses were performed within the Psychosocial Factors and Cancer Incidence (PSY-CA) consortium.METHODS: The PSY-CA consortium includes data from 18 cohorts with measures of depression or anxiety (up to N = 319,613; cancer incidences, 25,803; person-years of follow-up, 3,254,714). Both symptoms and a diagnosis of depression and anxiety were examined as predictors of future cancer risk. Two-stage IPD meta-analyses were run, first by using Cox regression models in each cohort (stage 1), and then by aggregating the results in random-effects meta-analyses (stage 2).RESULTS: No associations were found between depression or anxiety and overall, breast, prostate, colorectal, and alcohol-related cancers. Depression and anxiety (symptoms and diagnoses) were associated with the incidence of lung cancer and smoking-related cancers (hazard ratios [HRs], 1.06-1.60). However, these associations were substantially attenuated when additionally adjusting for known risk factors including smoking, alcohol use, and body mass index (HRs, 1.04-1.23).CONCLUSIONS: Depression and anxiety are not related to increased risk for most cancer outcomes, except for lung and smoking-related cancers. This study shows that key covariates are likely to explain the relationship between depression, anxiety, and lung and smoking-related cancers. PREREGISTRATION NUMBER: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=157677.

Published
2023

11. Cancer risk in children, adolescents, and young adults conceived by ART in 1983-2011

Author

Spaan, Mandy, Pontesilli, Martina, Van Den Belt-Dusebout, Alexandra W., Burger, Curt W., Van Den Heuvel-Eibrink, Marry M., Ravelli, Anita C.J., Goddijn, Mariëtte, Lambalk, Cornelis B., Roseboom, Tessa J., Van Leeuwen, Flora E., Spaan, Mandy, Pontesilli, Martina, Van Den Belt-Dusebout, Alexandra W., Burger, Curt W., Van Den Heuvel-Eibrink, Marry M., Ravelli, Anita C.J., Goddijn, Mariëtte, Lambalk, Cornelis B., Roseboom, Tessa J., and Van Leeuwen, Flora E.

Abstract

STUDY QUESTION: Do children, adolescents, and young adults born after ART, including IVF, ICSI and frozen-thawed embryo transfer (FET), have an increased risk of cancer compared with children born to subfertile couples not conceived by ART and children from the general population? SUMMARY ANSWER: After a median follow-up of 18 years, the overall cancer risk was not increased in children conceived by ART, but a slight risk increase was observed in children conceived after ICSI. WHAT IS KNOWN ALREADY: There is growing evidence that ART procedures could perturb epigenetic processes during the pre-implantation period and influence long-term health. Recent studies showed (non-)significantly increased cancer risks after ICSI and FET, but not after IVF. STUDY DESIGN, SIZE, DURATION: A nationwide historical cohort study with prospective follow-up was carried out, including all live-born offspring from women treated with ART between 1983 and 2011 and subfertile women not treated with ART in one of the 13 Dutch IVF clinics and two fertility centers. PARTICIPANTS/MATERIALS, SETTING, METHODS: Children were identified through the mothers' records in the Personal Records Database. Information on the conception method of each child was collected through the mother's medical record. In total, the cohort comprises 89 249 live-born children of subfertile couples, of whom 51 417 were conceived using ART and 37 832 were not (i.e. conceived naturally, through ovulation induction, or after IUI). Cancer incidence was ascertained through linkage with the Netherlands Cancer Registry for the period 1989-2019. Cancer risk in children conceived using ART was compared with risk in children born to subfertile couples but not conceived by ART (hazard ratio (HR)) and children from the general population (standardized incidence ratios (SIRs)). MAIN RESULTS AND THE ROLE OF CHANCE:

Published
2023

12. Depression, anxiety, and the risk of cancer:An individual participant data meta-analysis

Author

van Tuijl, Lonneke A., Basten, Maartje, Pan, Kuan Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I., Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R., Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., Rosmalen, Judith G.M., Ranchor, Adelita V., van Tuijl, Lonneke A., Basten, Maartje, Pan, Kuan Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I., Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R., Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., Rosmalen, Judith G.M., and Ranchor, Adelita V.

Abstract

Background: Depression and anxiety have long been hypothesized to be related to an increased cancer risk. Despite the great amount of research that has been conducted, findings are inconclusive. To provide a stronger basis for addressing the associations between depression, anxiety, and the incidence of various cancer types (overall, breast, lung, prostate, colorectal, alcohol-related, and smoking-related cancers), individual participant data (IPD) meta-analyses were performed within the Psychosocial Factors and Cancer Incidence (PSY-CA) consortium. Methods: The PSY-CA consortium includes data from 18 cohorts with measures of depression or anxiety (up to N = 319,613; cancer incidences, 25,803; person-years of follow-up, 3,254,714). Both symptoms and a diagnosis of depression and anxiety were examined as predictors of future cancer risk. Two-stage IPD meta-analyses were run, first by using Cox regression models in each cohort (stage 1), and then by aggregating the results in random-effects meta-analyses (stage 2). Results: No associations were found between depression or anxiety and overall, breast, prostate, colorectal, and alcohol-related cancers. Depression and anxiety (symptoms and diagnoses) were associated with the incidence of lung cancer and smoking-related cancers (hazard ratios [HRs], 1.06–1.60). However, these associations were substantially attenuated when additionally adjusting for known risk factors including smoking, alcohol use, and body mass index (HRs, 1.04–1.23). Conclusions: Depression and anxiety are not related to increased risk for most cancer outcomes, except for lung and smoking-related cancers. This study shows that key covariates are likely to explain the relationship between depression, anxiety, and lung and smoking-related cancers. Preregistration number: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=157677.

Published
2023

13. Depression, anxiety, and the risk of cancer: An individual participant data meta-analysis

Author

Trauma and Grief, Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, van Tuijl, Lonneke A, Basten, Maartje, Pan, Kuan-Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Rosmalen, Judith G M, Ranchor, Adelita V, Trauma and Grief, Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, van Tuijl, Lonneke A, Basten, Maartje, Pan, Kuan-Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Rosmalen, Judith G M, and Ranchor, Adelita V

Published
2023

14. Cancer risk in children, adolescents, and young adults conceived by ART in 1983-2011

Author

Speerpunt, Zorg en O&O, Cancer, Child Health, Spaan, Mandy, Pontesilli, Martina, Van Den Belt-Dusebout, Alexandra W., Burger, Curt W., Van Den Heuvel-Eibrink, Marry M., Ravelli, Anita C.J., Goddijn, Mariëtte, Lambalk, Cornelis B., Roseboom, Tessa J., Van Leeuwen, Flora E., Speerpunt, Zorg en O&O, Cancer, Child Health, Spaan, Mandy, Pontesilli, Martina, Van Den Belt-Dusebout, Alexandra W., Burger, Curt W., Van Den Heuvel-Eibrink, Marry M., Ravelli, Anita C.J., Goddijn, Mariëtte, Lambalk, Cornelis B., Roseboom, Tessa J., and Van Leeuwen, Flora E.

Published
2023

15. Depression, anxiety, and the risk of cancer: An individual participant data meta-analysis

Author

Cardiovasculaire Epidemiologie, MS Medische Oncologie, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Brain, Cardiovasculaire Epi Team 3, Cardiovasculaire Epi Team 7a, Cardiometabolic Health, van Tuijl, Lonneke A, Basten, Maartje, Pan, Kuan-Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma, Teyhan, Alison, Verschuren, MW, van der Willik, Kimberly D, Rosmalen, Judith G M, Ranchor, Adelita V, Cardiovasculaire Epidemiologie, MS Medische Oncologie, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Brain, Cardiovasculaire Epi Team 3, Cardiovasculaire Epi Team 7a, Cardiometabolic Health, van Tuijl, Lonneke A, Basten, Maartje, Pan, Kuan-Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma, Teyhan, Alison, Verschuren, MW, van der Willik, Kimberly D, Rosmalen, Judith G M, and Ranchor, Adelita V

Published
2023

17. Risk of ovarian cancer in women who give birth after assisted reproductive technology (ART)—a registry-based Nordic cohort study with follow-up from first pregnancy

Author

Sandvei, Marie Søfteland, primary, Pinborg, Anja, additional, Gissler, Mika, additional, Bergh, Christina, additional, Romundstad, Liv Bente, additional, van Leeuwen, Flora E., additional, Spaan, Mandy, additional, Tiitinen, Aila, additional, Wennerholm, Ulla-Britt, additional, Henningsen, Anna-Karina, additional, and Opdahl, Signe, additional

Published
2022
Full Text
View/download PDF

18. Psychosocial factors and cancer incidence (PSY‐CA): Protocol for individual participant data meta‐analyses

Author

Tuijl, Lonneke A., primary, Voogd, Adri C., additional, Graeff, Alexander, additional, Hoogendoorn, Adriaan W., additional, Ranchor, Adelita V., additional, Pan, Kuan‐Yu, additional, Basten, Maartje, additional, Lamers, Femke, additional, Geerlings, Mirjam I., additional, Abell, Jessica G., additional, Awadalla, Philip, additional, Bakker, Marije F., additional, Beekman, Aartjan T. F., additional, Bjerkeset, Ottar, additional, Boyd, Andy, additional, Cui, Yunsong, additional, Galenkamp, Henrike, additional, Garssen, Bert, additional, Hellingman, Sean, additional, Huisman, Martijn, additional, Huss, Anke, additional, Keats, Melanie R., additional, Kok, Almar A. L., additional, Luik, Annemarie I., additional, Noisel, Nolwenn, additional, Onland‐Moret, N. Charlotte, additional, Payette, Yves, additional, Penninx, Brenda W. J. H., additional, Portengen, Lützen, additional, Rissanen, Ina, additional, Roest, Annelieke M., additional, Rosmalen, Judith G. M., additional, Ruiter, Rikje, additional, Schoevers, Robert A., additional, Soave, David M., additional, Spaan, Mandy, additional, Steptoe, Andrew, additional, Stronks, Karien, additional, Sund, Erik R., additional, Sweeney, Ellen, additional, Teyhan, Alison, additional, Vaartjes, Ilonca, additional, Willik, Kimberly D., additional, Leeuwen, Flora E., additional, Petersen, Rutger, additional, Verschuren, W. M. Monique, additional, Visseren, Frank, additional, Vermeulen, Roel, additional, and Dekker, Joost, additional

Published
2021
Full Text
View/download PDF

19. Long-Term Risk of Ovarian Cancer and Borderline Tumors After Assisted Reproductive Technology

Author

Spaan, Mandy, primary, van den Belt-Dusebout, Alexandra W., additional, Lambalk, Cornelis B., additional, van Boven, Hester H., additional, Schats, Roel, additional, Kortman, Marian, additional, Broekmans, Frank J. M., additional, Laven, Joop S. E., additional, van Santbrink, Evert J. P., additional, Braat, Didi D. M., additional, van der Westerlaken, Lucette A. J., additional, Cohlen, Ben J., additional, Cantineau, Astrid E. P., additional, Smeenk, Jesper M. J., additional, van Rumste, Minouche M., additional, Goddijn, Mariëtte, additional, van Golde, Ron J. T., additional, Meeuwissen, Paul A. M., additional, Hamilton, Carl J. C. M., additional, Ouwens, Gabriële M., additional, Gerritsma, Miranda A., additional, Schaapveld, Michael, additional, Burger, Curt W., additional, and van Leeuwen, Flora E., additional

Published
2021
Full Text
View/download PDF

20. Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Author

van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Abstract

OBJECTIVES: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer.METHODS: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2).CONCLUSION: PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.

Published
2021

21. Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Author

Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Trauma and Grief, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Trauma and Grief, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Published
2021

22. Psychosocial factors and cancer incidence (PSY-CA):Protocol for individual participant data meta-analyses

Author

van Tuijl, Lonneke A., Voogd, Adri C., de Graeff, Alexander, Hoogendoorn, Adriaan W., Ranchor, Adelita V., Pan, Kuan Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I., Abell, Jessica G., Awadalla, Philip, Bakker, Marije F., Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David M., Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D., van Leeuwen, Flora E., van Petersen, Rutger, Verschuren, W. M.Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, van Tuijl, Lonneke A., Voogd, Adri C., de Graeff, Alexander, Hoogendoorn, Adriaan W., Ranchor, Adelita V., Pan, Kuan Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I., Abell, Jessica G., Awadalla, Philip, Bakker, Marije F., Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David M., Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D., van Leeuwen, Flora E., van Petersen, Rutger, Verschuren, W. M.Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Abstract

Objectives: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer. Methods: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2). Conclusion: PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.

Published
2021

23. Long-Term Risk of Ovarian Cancer and Borderline Tumors After Assisted Reproductive Technology

Author

Pathologie Algemene Pat.zorg, MS VPG/Gynaecologie, Child Health, Spaan, Mandy, van den Belt-Dusebout, Alexandra W., Lambalk, Cornelis B., van Boven, Hester H., Schats, Roel, Kortman, Marian, Broekmans, Frank J.M., Laven, Joop S.E., van Santbrink, Evert J.P., Braat, Didi D.M., van der Westerlaken, Lucette A.J., Cohlen, Ben J., Cantineau, Astrid E.P., Smeenk, Jesper M.J., van Rumste, Minouche M., Goddijn, Mariëtte, van Golde, Ron J.T., Meeuwissen, Paul A.M., Hamilton, Carl J.C.M., Ouwens, Gabriële M., Gerritsma, Miranda A., Schaapveld, Michael, Burger, Curt W., van Leeuwen, Flora E., Pathologie Algemene Pat.zorg, MS VPG/Gynaecologie, Child Health, Spaan, Mandy, van den Belt-Dusebout, Alexandra W., Lambalk, Cornelis B., van Boven, Hester H., Schats, Roel, Kortman, Marian, Broekmans, Frank J.M., Laven, Joop S.E., van Santbrink, Evert J.P., Braat, Didi D.M., van der Westerlaken, Lucette A.J., Cohlen, Ben J., Cantineau, Astrid E.P., Smeenk, Jesper M.J., van Rumste, Minouche M., Goddijn, Mariëtte, van Golde, Ron J.T., Meeuwissen, Paul A.M., Hamilton, Carl J.C.M., Ouwens, Gabriële M., Gerritsma, Miranda A., Schaapveld, Michael, Burger, Curt W., and van Leeuwen, Flora E.

Published
2021

24. Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Author

MS Medische Oncologie, Cancer, Cardiovasculaire Epi Team 7a, Brain, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Cardiovasculaire Epi Team 3, Cardiovasculaire Epi Team 5, Public Health Practice, Interne Geneeskunde Vasculaire, AIOS Psychiatrie, van Tuijl, Lonneke A., Voogd, Adri C., de Graeff, Alexander, Hoogendoorn, Adriaan W., Ranchor, Adelita V., Pan, Kuan Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I., Abell, Jessica G., Awadalla, Philip, Bakker, Marije F., Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David M., Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D., van Leeuwen, Flora E., van Petersen, Rutger, Verschuren, W. M.Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, MS Medische Oncologie, Cancer, Cardiovasculaire Epi Team 7a, Brain, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Cardiovasculaire Epi Team 3, Cardiovasculaire Epi Team 5, Public Health Practice, Interne Geneeskunde Vasculaire, AIOS Psychiatrie, van Tuijl, Lonneke A., Voogd, Adri C., de Graeff, Alexander, Hoogendoorn, Adriaan W., Ranchor, Adelita V., Pan, Kuan Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I., Abell, Jessica G., Awadalla, Philip, Bakker, Marije F., Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David M., Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D., van Leeuwen, Flora E., van Petersen, Rutger, Verschuren, W. M.Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Published
2021

26. Long-Term Risk of Ovarian Cancer and Borderline Tumors After Assisted Reproductive Technology

Author

Spaan, Mandy, primary, van den Belt-Dusebout, Alexandra W, additional, Lambalk, Cornelis B, additional, van Boven, Hester H, additional, Schats, Roel, additional, Kortman, Marian, additional, Broekmans, Frank J M, additional, Laven, Joop S E, additional, van Santbrink, Evert J P, additional, Braat, Didi D M, additional, van der Westerlaken, Lucette A J, additional, Cohlen, Ben J, additional, Cantineau, Astrid E P, additional, Smeenk, Jesper M J, additional, van Rumste, Minouche M, additional, Goddijn, Mariëtte, additional, van Golde, Ron J T, additional, Meeuwissen, Paul A M, additional, Hamilton, Carl J C M, additional, Ouwens, Gabriële M, additional, Gerritsma, Miranda A, additional, Schaapveld, Michael, additional, Burger, Curt W, additional, and van Leeuwen, Flora E, additional

Published
2020
Full Text
View/download PDF

27. Long-Term Risk of Ovarian Cancer and Borderline Tumors After Assisted Reproductive Technology.

Author

Spaan, Mandy, Belt-Dusebout, Alexandra W van den, Lambalk, Cornelis B, Boven, Hester H van, Schats, Roel, Kortman, Marian, Broekmans, Frank J M, Laven, Joop S E, Santbrink, Evert J P van, Braat, Didi D M, Westerlaken, Lucette A J van der, Cohlen, Ben J, Cantineau, Astrid E P, Smeenk, Jesper M J, Rumste, Minouche M van, Goddijn, Mariëtte, Golde, Ron J T van, Meeuwissen, Paul A M, Hamilton, Carl J C M, and Ouwens, Gabriële M

Subjects
*DISEASE risk factors, *OVARIAN cancer, *REPRODUCTIVE technology, *OVARIAN tumors, *INDUCED ovulation, *TUMORS, *RESEARCH, *RESEARCH methodology, *EVALUATION research, *COMPARATIVE studies, *HUMAN reproductive technology, *LONGITUDINAL method
Abstract

Background: Long-term effects of assisted reproductive technology (ART) on ovarian tumor risk are unknown.Methods: This nationwide cohort study comprises 30 625 women who received ovarian stimulation for ART in 1983-2000 and 9988 subfertile women not treated with ART. Incident invasive and borderline ovarian tumors were ascertained through linkage with the Netherlands Cancer Registry and the Dutch Pathology Registry until July 2018. Ovarian tumor risk in ART-treated women was compared with risks in the general population and the subfertile non-ART group. Statistical tests were 2-sided.Results: After a median follow-up of 24 years, 158 invasive and 100 borderline ovarian tumors were observed. Ovarian cancer risk in the ART group was increased compared with the general population (standardized incidence ratio [SIR] = 1.43, 95% confidence interval [CI] = 1.18 to 1.71) but not when compared with the non-ART group (age- and parity-adjusted hazard ratio [HR] = 1.02, 95% CI = 0.70 to 1.50). Risk decreased with higher parity and with a larger number of successful ART cycles (resulting in childbirth, Ptrend = .001) but was not associated with the number of unsuccessful ART cycles. Borderline ovarian tumor risk was increased in ART-treated women compared with the general population (SIR = 2.20, 95% CI = 1.66 to 2.86) and with non-ART women (HR = 1.84, 95% CI = 1.08 to 3.14). Risk did not increase with more ART cycles or longer follow-up time.Conclusions: Increased ovarian cancer risk in ART-treated women compared with the general population is likely explained by nulliparity rather than ART treatment. The increased risk of borderline ovarian tumors after ART must be interpreted with caution because no dose-response relationship was observed. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

28. Ovarian Stimulation for In Vitro Fertilization and Long-term Risk of Breast Cancer EDITORIAL COMMENT

Author

van den Belt-Dusebout, Alexandra W., Spaan, Mandy, Lambalk, Cornelis B., Kortman, Marian, Laven, Joop S. E., van Santbrink, Evert J. P., van der Westerlaken, Lucette A. J., Cohlen, Ben J., Braat, Didi D. M., Smeenk, Jesper M. J., Land, Jolande A., Goddijn, Mariette, van Golde, Ron J. T., van Rumste, Minouche M., Schats, Roel, Jozwiak, Katarzyna, Hauptmann, Michael, Rookus, Matti A., Burger, Curt W., van Leeuwen, Flora E., Medical oncology, Obstetrics and gynaecology, Epidemiology and Data Science, EMGO - Quality of care, Obstetrics & Gynecology, Amsterdam Reproduction & Development (AR&D), Center for Reproductive Medicine, and Reproductive Origins of Adult Health and Disease (ROAHD)

Subjects
SDG 3 - Good Health and Well-being, hormones, hormone substitutes, and hormone antagonists, reproductive and urinary physiology, female genital diseases and pregnancy complications
Abstract

Previous studies have shown that both exogenous and endogenous estrogens and progestogens increase the risk of breast cancer. it has been suggested that in vitro fertilization (IVF) procedures may increase breast cancer risk. This risk could be could be due to a temporary decrease in estradiol and progesterone levels (during down-regulation of the natural cycle), as well as strongly elevated levels (during stimulation phase). Results of previous studies investigating breast cancer risk after IVF treatment were inconclusive because of limited follow-up. Recent studies have reported no increased risk of this cancer after IVT at a mean follow-up of 8 and 16 years. This historical cohort (OMEGA) study quantified long-term risk of breast cancer after ovarian stimulation for IVF. The aim of the study was to compare the long-term risk of breast cancer among a nationwide cohort of women receiving ovarian stimulation for IVF with that of women receiving other fertility treatments and those in the general population. The study was conducted in 12 IVF clinics in the Netherlands. The cohort was composed of 19,158 women who started IVF treatment between 1983 and 1995 (IVF group) and 5950 women who started other fertility treatments between 1980 and 1995 (non-IVF group) Data were obtained from all 12 IVF clinics. There was complete follow-up through December 2013 for 96% of the cohort. At end of follow-up, the median age was 53.8 years in the IVF group and 55.3 years in the non-IVF group. Information on ovarian stimulation for IVF, other fertility treatments, and potential confounders was obtained from medical records and mailed questionnaires. First invasive and in situ breast cancer incidence among women who underwent fertility treatments was obtained through linkage with the Netherlands Cancer Registry (1989-2013). Risk of breast cancer in the IVF group was compared with risk in the non-IVF group (hazard ratios [HRs]) and the general population (standardized incidence ratios [SIRs]). In the total cohort, the mean age at baseline was 32.8 years, and the mean number of IVF cycles was 3.6. After a median follow-up of 21.1 years, 839 of the cohort had invasive breast cancer, and 109 had in situ breast cancer. Compared with the general population, breast cancer risks were not increased either in the IVF group (SIR, 1.01; 95% confidence interval [CI], 0.93-1.09) or the non-IVF group (SIR, 1.00; 95% CI, 0.88-1.15). At the age of 55 years, cumulative incidence rates of breast cancer were 3.0% in the IVF group and 2.9% in the non-IVF group (P = 0.85). With longer time since treatment (>= 20 years), the SIR did not increase in the IVF group (SIR, 0.92; 95% CI, 0.73-1.15) or in the non-IVF group (SIR, 1.03; 95% CI, 0.82-1.29). Women with 7 or more IVF cycles had a significantly decreased risk of breast cancer than did women who were treated with 1 to 2 IVF cycles; the HR was 0.55, with a 95% CI of 0.39 to 0.77. The risk was also significantly lower (HR, 0.77; 95% CI, 0.61-0.96) after poor response to the first IVF cycle (= 4 collected oocytes). These data show that IVT treatment did not increase the risk of breast cancer in a cohort of women undergoing fertility treatment in the Netherlands between 1980 and 1995 when compared with women who received non-IVF treatment or those in the general population after a median follow-up of 21 years. These findings are consistent with those from recent reviews showing no significant increase in long-term risk of breast cancer among IVF-treated women.

Published
2016
Full Text
View/download PDF

29. Editorial comment: Ovarian Stimulation for In Vitro Fertilization and Long-term Risk of Breast Cancer (JAMA 2016;316:300–312)

Author

van den Belt-Dusebout, Alexandra W., Spaan, Mandy, Lambalk, Cornelis B., Kortman, Marian, Laven, Joop S. E., van Santbrink, Evert J. P., van der Westerlaken, Lucette A. J., Cohlen, Ben J., Braat, Didi D. M., Smeenk, Jesper M. J., Land, Jolande A., Goddijn, Mariette, van Golde, Ron J. T., van Rumste, Minouche M., Schats, Roel, Jozwiak, Katarzyna, Hauptmann, Michael, Rookus, Matti A., Burger, Curt W., van Leeuwen, Flora E., Obstetrie & Gynaecologie, RS: GROW - R4 - Reproductive and Perinatal Medicine, and MUMC+: MA Medische Staf Obstetrie Gynaecologie (9)

Abstract

Previous studies have shown that both exogenous and endogenous estrogens and progestogens increase the risk of breast cancer. it has been suggested that in vitro fertilization (IVF) procedures may increase breast cancer risk. This risk could be could be due to a temporary decrease in estradiol and progesterone levels (during down-regulation of the natural cycle), as well as strongly elevated levels (during stimulation phase). Results of previous studies investigating breast cancer risk after IVF treatment were inconclusive because of limited follow-up. Recent studies have reported no increased risk of this cancer after IVT at a mean follow-up of 8 and 16 years. This historical cohort (OMEGA) study quantified long-term risk of breast cancer after ovarian stimulation for IVF. The aim of the study was to compare the long-term risk of breast cancer among a nationwide cohort of women receiving ovarian stimulation for IVF with that of women receiving other fertility treatments and those in the general population. The study was conducted in 12 IVF clinics in the Netherlands. The cohort was composed of 19,158 women who started IVF treatment between 1983 and 1995 (IVF group) and 5950 women who started other fertility treatments between 1980 and 1995 (non-IVF group) Data were obtained from all 12 IVF clinics. There was complete follow-up through December 2013 for 96% of the cohort. At end of follow-up, the median age was 53.8 years in the IVF group and 55.3 years in the non-IVF group. Information on ovarian stimulation for IVF, other fertility treatments, and potential confounders was obtained from medical records and mailed questionnaires. First invasive and in situ breast cancer incidence among women who underwent fertility treatments was obtained through linkage with the Netherlands Cancer Registry (1989-2013). Risk of breast cancer in the IVF group was compared with risk in the non-IVF group (hazard ratios [HRs]) and the general population (standardized incidence ratios [SIRs]). In the total cohort, the mean age at baseline was 32.8 years, and the mean number of IVF cycles was 3.6. After a median follow-up of 21.1 years, 839 of the cohort had invasive breast cancer, and 109 had in situ breast cancer. Compared with the general population, breast cancer risks were not increased either in the IVF group (SIR, 1.01; 95% confidence interval [CI], 0.93-1.09) or the non-IVF group (SIR, 1.00; 95% CI, 0.88-1.15). At the age of 55 years, cumulative incidence rates of breast cancer were 3.0% in the IVF group and 2.9% in the non-IVF group (P = 0.85). With longer time since treatment (>= 20 years), the SIR did not increase in the IVF group (SIR, 0.92; 95% CI, 0.73-1.15) or in the non-IVF group (SIR, 1.03; 95% CI, 0.82-1.29). Women with 7 or more IVF cycles had a significantly decreased risk of breast cancer than did women who were treated with 1 to 2 IVF cycles; the HR was 0.55, with a 95% CI of 0.39 to 0.77. The risk was also significantly lower (HR, 0.77; 95% CI, 0.61-0.96) after poor response to the first IVF cycle (= 4 collected oocytes). These data show that IVT treatment did not increase the risk of breast cancer in a cohort of women undergoing fertility treatment in the Netherlands between 1980 and 1995 when compared with women who received non-IVF treatment or those in the general population after a median follow-up of 21 years. These findings are consistent with those from recent reviews showing no significant increase in long-term risk of breast cancer among IVF-treated women.

Published
2016

30. Risk of cancer in children and young adults conceived by assisted reproductive technology.

Author

Spaan, Mandy, Belt-Dusebout, Alexandra W van den, Heuvel-Eibrink, Marry M van den, Hauptmann, Michael, Lambalk, Cornelis B, Burger, Curt W, Leeuwen, Flora E van, van den Belt-Dusebout, Alexandra W, van den Heuvel-Eibrink, Marry M, van Leeuwen, Flora E, and OMEGA-steering group

Subjects
*CHILDHOOD cancer, *YOUNG adults, *REPRODUCTIVE technology, *FERTILITY drugs, *CHILDREN, *CANCER risk factors
Abstract

Study Question: Do children conceived by ART have an increased risk of cancer?Summary Answer: Overall, ART-conceived children do not appear to have an increased risk of cancer.What Is Known Already: Despite the increasing use of ART, i.e. IVF or ICSI worldwide, information about possible long-term health risks for children conceived by these techniques is scarce.Study Design, Size, Duration: A nationwide historical cohort study with prospective follow-up (median 21 years), including all live-born offspring from women treated with subfertility treatments between 1980 and 2001.Participants/materials, Setting, Methods: All offspring of a nationwide cohort of subfertile women (OMEGA study) treated in one of the 12 Dutch IVF clinics or two fertility clinics. Of 47 690 live-born children, 24 269 were ART-conceived, 13 761 naturally conceived and 9660 were conceived naturally or through fertility drugs, but not by ART. Information on the conception method of each child and potential confounders were collected through the mothers' questionnaires and medical records. Cancer incidence was ascertained through linkage with The Netherlands Cancer Registry from 1 January 1989 until 1 November 2016. Cancer risk in ART-conceived children was compared with risks in naturally conceived children from subfertile women (hazard ratios [HRs]) and with the general population (standardized incidence ratios [SIRs]).Main Results and the Role Of Chance: The median follow-up was 21 years (interquartile range (IQR): 17-25) and was shorter in ART-conceived children (20 years, IQR: 17-23) compared with naturally conceived children (24 years, IQR: 20-30). In total, 231 cancers were observed. Overall cancer risk was not increased in ART-conceived children, neither compared with naturally conceived children from subfertile women (HR: 1.00, 95% CI 0.72-1.38) nor compared with the general population (SIR = 1.11, 95% CI: 0.90-1.36). From 18 years of age onwards, the HR of cancer in ART-conceived versus naturally conceived individuals was 1.25 (95% CI: 0.73-2.13). Slightly but non-significantly increased risks were observed in children conceived by ICSI or cryopreservation (HR = 1.52, 95% CI: 0.81-2.85; 1.80, 95% CI: 0.65-4.95, respectively). Risks of lymphoblastic leukemia (HR = 2.44, 95% CI: 0.81-7.37) and melanoma (HR = 1.86, 95% CI: 0.66-5.27) were non-significantly increased for ART-conceived compared with naturally conceived children.Limitations, Reasons For Caution: Despite the large size and long follow-up of the cohort, the number of cancers was rather small for subgroup analyses as cancer in children and young adults is rare.Wider Implications Of the Findings: Overall, ART-conceived children do not appear to have an increased cancer risk after a median follow-up of 21 years. This large study provides important results, enabling physicians to better inform couples considering ART about the long-term safety of ART for their children. However, larger studies with prolonged follow-up are needed to investigate cancer risk in adults and in children conceived by ICSI and/or from cryopreserved embryos.Study Funding/competing Interest(s): This work was supported by The Dutch Cancer Society (NKI 2006-3631) which funded the OMEGA-women's cohort and Children Cancer Free (KIKA;147) which funded the OMEGA-offspring cohort. We declare no competing interests. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

31. Ovarian Stimulation for In Vitro Fertilization and Long-term Risk of Breast Cancer

Author

van den Belt-Dusebout, Alexandra W., primary, Spaan, Mandy, additional, Lambalk, Cornelis B., additional, Kortman, Marian, additional, Laven, Joop S. E., additional, van Santbrink, Evert J. P., additional, van der Westerlaken, Lucette A. J., additional, Cohlen, Ben J., additional, Braat, Didi D. M., additional, Smeenk, Jesper M. J., additional, Land, Jolande A., additional, Goddijn, Mariëtte, additional, van Golde, Ron J. T., additional, van Rumste, Minouche M., additional, Schats, Roel, additional, Józwiak, Katarzyna, additional, Hauptmann, Michael, additional, Rookus, Matti A., additional, Burger, Curt W., additional, and van Leeuwen, Flora E., additional

Published
2016
Full Text
View/download PDF

32. [Childhood cancer after fertility treatments?]

Author

Spaan M, Lambalk CBN, and van Leeuwen FE

Subjects
Child, Humans, Pregnancy, Female, Embryo Transfer, Parturition, Neoplasms epidemiology, Neoplasms etiology, Neoplasms therapy
Abstract

Since the introduction of Assisted Reproductive Technology (ART) in 1978, more than 10 million ART-conceived children have been born. Each phase of the ART procedure is substantially different from natural conception and these processes occur in the same timeframe as epigenetic programming. It seems plausible that ART could influence early stages of embryogenesis and thereby permanently influence the development and health of these individuals. Several epidemiological studies investigated the risk of childhood cancer after ART. Overall, results appear reassuring and do not indicate an increased risk. However, for subgroups, including children born after frozen-thawed embryo transfer(FET) there might be a modestly increased risk. There are some biological explanations for an increased risk of cancer after FET. However, as results are based on a small number of cancer cases, results must be replicated in other large cohort studies before translation into clinical practice.

Published
2023

33. Cancer risk in children, adolescents, and young adults conceived by ART in 1983-2011.

Author

Spaan M, Pontesilli M, van den Belt-Dusebout AW, Burger CW, van den Heuvel-Eibrink MM, Ravelli ACJ, Goddijn M, Lambalk CB, Roseboom TJ, and van Leeuwen FE

Abstract

Study Question: Do children, adolescents, and young adults born after ART, including IVF, ICSI and frozen-thawed embryo transfer (FET), have an increased risk of cancer compared with children born to subfertile couples not conceived by ART and children from the general population?, Summary Answer: After a median follow-up of 18 years, the overall cancer risk was not increased in children conceived by ART, but a slight risk increase was observed in children conceived after ICSI., What Is Known Already: There is growing evidence that ART procedures could perturb epigenetic processes during the pre-implantation period and influence long-term health. Recent studies showed (non-)significantly increased cancer risks after ICSI and FET, but not after IVF., Study Design Size Duration: A nationwide historical cohort study with prospective follow-up was carried out, including all live-born offspring from women treated with ART between 1983 and 2011 and subfertile women not treated with ART in one of the 13 Dutch IVF clinics and two fertility centers., Participants/materials Setting Methods: Children were identified through the mothers' records in the Personal Records Database. Information on the conception method of each child was collected through the mother's medical record. In total, the cohort comprises 89 249 live-born children of subfertile couples, of whom 51 417 were conceived using ART and 37 832 were not (i.e. conceived naturally, through ovulation induction, or after IUI). Cancer incidence was ascertained through linkage with the Netherlands Cancer Registry for the period 1989-2019. Cancer risk in children conceived using ART was compared with risk in children born to subfertile couples but not conceived by ART (hazard ratio (HR)) and children from the general population (standardized incidence ratios (SIRs))., Main Results and the Role of Chance: In total, 358 cancers were observed after a median follow-up of 18 years. Overall cancer risk was not increased in children conceived using ART, when compared with the general population (SIR = 0.96, 95% CI = 0.81-1.12) or with children from subfertile couples not conceived by ART (HR = 1.06, 95% CI = 0.84-1.33). Compared with children from subfertile couples not conceived by ART, the use of IVF or FET was not associated with increased cancer risk, but ICSI was associated with a slight risk increase (HR = 1.58, 95% CI = 1.08-2.31). Risk of cancer after ART did not increase at older ages (≥18 years, HR = 1.26, 95% CI = 0.88-1.81) compared to cancer risk in children not conceived by ART., Limitations Reasons for Caution: The observed increased risk among children conceived using ICSI must be interpreted with caution owing to the small number of cases., Wider Implications of the Findings: After a median follow-up of 18 years, children conceived using ART do not have an increased overall cancer risk. Many large studies with prolonged follow-up are needed to investigate cancer risk in (young) adults conceived by different types of ART. In addition, international pooling of studies is recommended to provide sufficient power to study risk of specific cancer sites after ART., Study Funding/competing Interests: This work was supported by The Dutch Cancer Society (NKI 2006-3631) that funded the OMEGA-women's cohort, Children Cancer Free (KIKA; 147) that funded the OMEGA-I-II offspring cohort. The OMEGA-III offspring cohort was supported by a Postdoc Stipend of Amsterdam Reproduction & Development, and the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health under Award Number R01HD088393. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors declare no competing interests., Trial Registration Number: N/A., Competing Interests: The authors declare no competing interests., (© The Author(s) 2023. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.)

Published
2023
Full Text
View/download PDF

34. Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses.

Author

van Tuijl LA, Voogd AC, de Graeff A, Hoogendoorn AW, Ranchor AV, Pan KY, Basten M, Lamers F, Geerlings MI, Abell JG, Awadalla P, Bakker MF, Beekman ATF, Bjerkeset O, Boyd A, Cui Y, Galenkamp H, Garssen B, Hellingman S, Huisman M, Huss A, Keats MR, Kok AAL, Luik AI, Noisel N, Onland-Moret NC, Payette Y, Penninx BWJH, Portengen L, Rissanen I, Roest AM, Rosmalen JGM, Ruiter R, Schoevers RA, Soave DM, Spaan M, Steptoe A, Stronks K, Sund ER, Sweeney E, Teyhan A, Vaartjes I, van der Willik KD, van Leeuwen FE, van Petersen R, Verschuren WMM, Visseren F, Vermeulen R, and Dekker J

Subjects
Anxiety, Cohort Studies, Humans, Incidence, Male, Meta-Analysis as Topic, Social Support, Neoplasms epidemiology
Abstract

Objectives: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer., Methods: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2)., Conclusion: PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses., (© 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC.)

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results