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23 results on '"Spada Alessandro"'

1. Differential diagnosis: retroperitoneal fibrosis and oncological diseases

Author

Sica Antonello, Casale Beniamino, Spada Alessandro, Teresa Di Dato Maria, Sagnelli Caterina, Calogero Armando, Buonavolontà Pietro, Salzano Anna, Martinelli Erika, Saracco Elisabetta, Troiani Teresa, Anna Dodaro Concetta, Tammaro Dario, Luisa De Rimini Maria, Ciardiello Fortunato, and Papa Alfonso

Subjects
retroperitoneal fibrosis, oncological disease, lymphomas, Medicine
Abstract

Retroperitoneal fibrosis is a connective disease of the auto-inflammatory/auto-immune type of the retroperitoneum with unknown etiology and pathological mechanism. The manifestations of the pathology can be local or systemic. Amongst the local symptoms, the dull and constant pain in the hips, back or abdomen is the most frequent.

Published
2019
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2. Cancer- and non-cancer related chronic pain: from the physiopathological basics to management

Author

Sica Antonello, Casale Beniamino, Dato Maria Teresa Di, Calogero Armando, Spada Alessandro, Sagnelli Caterina, Santagata Mario, Buonavolontà Pietro, Fiorelli Alfonso, Salzano Anna, Dodaro Concetta Anna, Martinelli Erika, Saracco Elisabetta, Troiani Teresa, Tammaro Dario, Ciardiello Fortunato, and Papa Alfonso

Subjects
pain, chronic pain, non-cancer pain, cancer pain, intrathecal therapy, chronic pain therapy, Medicine
Abstract

The prevalence of chronic pain is between 33% to 64% and is due to cancer pain, but it has also been observed in non-cancer patients. Chronic pain is associated with lower quality of life and higher psychological distress and depressive/anxiety disorders in patients without a history of disorder.

Published
2019
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3. Locomotion and Telepresence in Virtual and Real Worlds

Author

Spada, Alessandro, Cognetti, Marco, De Luca, Alessandro, Siciliano, Bruno, Series Editor, Khatib, Oussama, Series Editor, Antonelli, Gianluca, Advisory Editor, Fox, Dieter, Advisory Editor, Harada, Kensuke, Advisory Editor, Hsieh, M. Ani, Advisory Editor, Kröger, Torsten, Advisory Editor, Kulic, Dana, Advisory Editor, Park, Jaeheung, Advisory Editor, Ficuciello, Fanny, editor, Ruggiero, Fabio, editor, and Finzi, Alberto, editor

Published
2019
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5. Elbasvir/Grazoprevir combination therapy in a B-NHL patient with HCV genotype 1 infection

Author

Sica, Antonello, Spada, Alessandro, Sagnelli, Caterina, Verolino, Pasquale, Mazzocca, Annalisa, Sagnelli, Evangelista, Colella, Giuseppe, Guastafierro, Salvatore, Marrone, Aldo, Sica, Antonello, Spada, Alessandro, Sagnelli, Caterina, Verolino, Pasquale, Mazzocca, Annalisa, Sagnelli, Evangelista, Colella, Giuseppe, Guastafierro, Salvatore, and Marrone, Aldo

Subjects
Antiviral Agent, Genotype, Sustained Virologic Response, Lymphoma, Non-Hodgkin, Imidazoles, Hepatitis C, Chronic, Middle Aged, Antiviral Agents, hemic and lymphatic diseases, Humans, Female, Benzofuran, Imidazole, Human, Benzofurans
Abstract

Patients with indolent non-Hodgkin lymphomas (NHL) may often be followed up only with observation, reserving chemotherapy in case of spread. Patients with chronic HCV infection and B cell NHL frequently undergo regression of lymphoproliferative disease once HCV infection is eradicated by treatment. Interferon (IFN)-based therapy has been the treatment of choice for years, remaining unclear whether it is effective in B cell NHL directly or through HCV eradication, since IFN is effective in both HCV infection and B cell NHL. IFN therapy for HCV infection became obsolete with the advent of the well tolerated direct-acting antiviral agents (DAAs), whose excellent efficacy in treating patients with chronic HCV infection and B cell NHL has been recently highlighted. We treated a 53-year-old woman with chronic HCV infection and marginal zone lymphoma (MZL) with elbasvir plus grazoprevir in 2018, with complete remission and persisting excellent results: sustained virological response 24 weeks after treatment (SVR24). The exclusive role of HCV eradication in B cell NHL regression is also underlined.

Published
2021

6. Post-heart transplantation lymphoproliferative diseases (PTLDs) and the diagnostic role of [18f] FDG-PET/CT

Author

SICA, Antonello, primary, DE RIMINI, Maria L., additional, SAGNELLI, Caterina, additional, CASALE, Beniamino, additional, SPADA, Alessandro, additional, REGINELLI, Alfonso, additional, AMARELLI, Cristiano, additional, MAIELLO, Ciro, additional, BELFIORE, Maria P., additional, CRETA, Massimiliano, additional, CICCOZZI, Massimo, additional, SAGNELLI, Evangelista, additional, TROIANI, Teresa, additional, and CAPPABIANCA, Salvatore, additional

Published
2021
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7. Unusual oxidative bond-forming reactions upon 1,4-dihydropyridines: manganese(III)-promoted, single- and double-malonate additions

Author

Lavilla, Rodolfo, Spada, Alessandro, Carranco, Ines, and Bosch, Joan

Subjects
Chemical reactions -- Analysis, Natural products -- Research, Chemical bonds -- Influence, Oxidizing agents -- Research, Biological sciences, Chemistry
Abstract

Research examines the oxidation of N-alkyl-1,4-dihydropyridines mediating a triple action mode for the manganese(III) oxidant that selectively interacts with a malonate forming the radical, which upon beta-addition leads to dihydropyridine.

Published
2001

8. Post-Transplant Lymphoproliferative Diseases in an Elderly Population Who Underwent Cardiac Transplantation: Role of Physical Activity Rehabilitation Program

Author

Sica, Antonello, primary, Sagnelli, Caterina, additional, Fasano, Morena, additional, Spada, Alessandro, additional, Munier, Giacomo, additional, Famiglietti, Vincenzo, additional, Dodaro, Concetta Anna, additional, Calogero, Armando, additional, Ciccozzi, Massimo, additional, Sagnelli, Evangelista, additional, Amarelli, Cristiano, additional, Maiello, Ciro, additional, and Casale, Beniamino, additional

Published
2019
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9. Post-Operative Chronic Pain Control in Mediastinal Lymphomas in An Elderly Population: the Role of Physical Activity

Author

Sica, Antonello, primary, Casale, Beniamino, additional, Sagnelli, Caterina, additional, Calogero, Armando, additional, Di Dato, Maria Teresa, additional, Spada, Alessandro, additional, Rispoli, Marco, additional, Santagata, Mario, additional, Buonavolontà, Pietro, additional, Fiorelli, Alfonso, additional, Tammaro, Vincenzo, additional, Ciccozzi, Massimo, additional, Salzano, Anna, additional, Sagnelli, Evangelista, additional, Saracco, Elisabetta, additional, Tammaro, Dario, additional, and Papa, Alfonso, additional

Published
2019
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10. Post-Transplant Lymphoproliferative Diseases in the Elderly after Cardiac Transplantation: The Diagnostic Role of [18f] FDG-PET With Co-Registered CT and the Effect of Sports Activity Rehabilitation Program

Author

Sica, Antonello, primary, de Rimini, Maria Luisa, additional, Casale, Beniamino, additional, Sagnelli, Caterina, additional, Spada, Alessandro, additional, Reginelli, Alfonso, additional, Calogero, Armando, additional, Amarelli, Cristiano, additional, Maiello, Ciro, additional, Sagnelli, Evangelista, additional, Belfiore, Maria Paola, additional, and Cappabianca, Salvatore, additional

Published
2019
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11. Differential diagnosis: retroperitoneal fibrosis and oncological diseases.

Author

Sica, Antonello, Casale, Beniamino, Spada, Alessandro, Teresa Di Dato, Maria, Sagnelli, Caterina, Calogero, Armando, Buonavolontà, Pietro, Salzano, Anna, Martinelli, Erika, Saracco, Elisabetta, Troiani, Teresa, Anna Dodaro, Concetta, Tammaro, Dario, Luisa De Rimini, Maria, Ciardiello, Fortunato, and Papa, Alfonso

Subjects
DIFFERENTIAL diagnosis, RETROPERITONEAL fibrosis, OVARIAN cancer, DISEASES, ETIOLOGY of diseases, RETROPERITONEUM
Abstract

Retroperitoneal fibrosis is a connective disease of the auto-inflammatory/auto-immune type of the retroperitoneum with unknown etiology and pathological mechanism. The manifestations of the pathology can be local or systemic. Amongst the local symptoms, the dull and constant pain in the hips, back or abdomen is the most frequent. We report here a case of a 47-year-old woman, whose pathogenic mechanism could be related to an "IgG4-related disease" disorder as suggested by an increased serum level of this subclass of IgG and the positive immunohistochemistry. The diagnosis is not easy, because this pathology generates masses; adenomegalies with retro peritoneal development, that makes it similar to lymphomas or metastases from ovarian tumors. [ABSTRACT FROM AUTHOR]

Published
2020
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12. Synthesis and evaluation of diverse analogs of amygdalin as potential peptidomimetics of peptide T

Author

Araya, Eyleen, Rodriguez, Alex, Rubio, Jaime, Spada, Alessandro, Joglar Tamargo, Jesús, Llebaria, Amadeu, Lagunas, Carmen, Fernández, Andrés G., Spisani, Susanna, Pérez, Juan J., Araya, Eyleen, Rodriguez, Alex, Rubio, Jaime, Spada, Alessandro, Joglar Tamargo, Jesús, Llebaria, Amadeu, Lagunas, Carmen, Fernández, Andrés G., Spisani, Susanna, and Pérez, Juan J.

Abstract

Peptide T (ASTTTNYT) is a promising molecule to prevent the neuropsychometric symptoms of patients suffering AIDS and for the treatment of psoriasis. In order to fully prove its therapeutic benefits, efforts were put forward to design peptidomimetics of the peptide. In this direction, in a recent computational study the natural product amygdalin was identified as a prospective peptidomimetic of the peptide and later proved to exhibit a similar chemotactic profile to the peptide. However, the cyanide moiety of amygdalin provides to the molecule a toxic profile. The present study reports the synthesis of a set of amygdalin analogs lacking the cyanide group with improved chemotactic profiles.

Published
2005

15. Productive trapping of NAD-type radicals. Non-biomimetic reduction of pyridinium saltsElectronic supplementary information (ESI) available: experimental procedure and characterization data. See: http://www.rsc.org/suppdata/cc/b2/b201813f/

Author

Lavilla, Rodolfo, primary, Bernabeu, M. Carmen, additional, Brillas, Enric, additional, Carranco, Inés, additional, Díaz, José Luis, additional, Llorente, Nereida, additional, Rayo, Marta, additional, and Spada, Alessandro, additional

Published
2002
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21. Cancer- and Non-cancer Related Chronic Pain: From the Physiopathological Basics to Management

Author

Alessandro Spada, Elisabetta Saracco, Teresa Troiani, Mario Santagata, Maria Teresa Di Dato, Anna Maria Salzano, Fortunato Ciardiello, Antonello Sica, Dario Tammaro, Caterina Sagnelli, Pietro Buonavolontà, Armando Calogero, Erika Martinelli, Concetta Anna Dodaro, Alfonso Fiorelli, Beniamino Casale, Alfonso Papa, Sica, Antonello, Casale, Beniamino, Dato, Maria Teresa Di, Calogero, Armando, Spada, Alessandro, Sagnelli, Caterina, Santagata, Mario, Buonavolontà, Pietro, Fiorelli, Alfonso, Salzano, Anna, Dodaro, Concetta Anna, Martinelli, Erika, Saracco, Elisabetta, Troiani, Teresa, Tammaro, Dario, Ciardiello, Fortunato, Papa, Alfonso, Sica, A., Casale, B., Dato, M. T. D., Calogero, A., Spada, A., Sagnelli, C., Santagata, M., Buonavolonta, P., Fiorelli, A., Salzano, A., Dodaro, C. A., Martinelli, E., Saracco, E., Troiani, T., Tammaro, D. F., Ciardiello, F., and Papa, A.

Subjects
medicine.medical_specialty, Dose, Intrathecal therapy, Pain, Chronic pain, 03 medical and health sciences, 0302 clinical medicine, Refractory, Quality of life, Internal medicine, chronic pain therapy, Medicine, Intrathecal pump, 030212 general & internal medicine, Cancer pain, business.industry, Cancer, General Medicine, medicine.disease, Anxiety, medicine.symptom, business, 030217 neurology & neurosurgery, Research Article, Non-cancer pain
Abstract

The prevalence of chronic pain is between 33% to 64% and is due to cancer pain, but it has also been observed in non-cancer patients. Chronic pain is associated with lower quality of life and higher psychological distress and depressive/anxiety disorders in patients without a history of disorder. In this study we evaluated in clinical practice the effectiveness of the intrathecal pump in 140 patients who underwent pain therapy at our Center. These patients were consecutively enrolled from January 2010 to July 2018. Follow-up was carried out over these eight years regarding the infusion modalities. Pain relief was obtained in 71 (50,7%) patients out of the 140 that experienced satisfactory pain control globally. Intrathecal therapy is one of the best options for chronic severe refractory pain. The greatest advantage of this therapy is due to the possibility of treating the pain with minimal dosages of the drug, avoiding the appearance of troublesome side effects.

Published
2019

22. Post-heart transplantation lymphoproliferative diseases (PTLDs) and the diagnostic role of [18f] FDG-PET/CT

Author

Salvatore Cappabianca, Evangelista Sagnelli, Caterina Sagnelli, Antonello Sica, Alessandro Spada, Cristiano Amarelli, Maria Luisa De Rimini, Massimiliano Creta, Massimo Ciccozzi, Ciro Maiello, Teresa Troiani, Maria Paola Belfiore, Beniamino Casale, Alfonso Reginelli, Sica, Antonello, De Rimini, Maria Luisa, Sagnelli, Caterina, Casale, Beniamino, Spada, Alessandro, Reginelli, Alfonso, Amarelli, Cristiano, Maiello, Ciro, Belfiore, Maria Paola, Creta, Massimiliano, Ciccozzi, Massimo, Sagnelli, Evangelista, Troiani, Teresa, Cappabianca, Salvatore, and Massimiliano, Creta

Subjects
Adult, Male, medicine.medical_specialty, Urinary system, medicine.medical_treatment, Malignancy, 03 medical and health sciences, Immunocompromised Host, 0302 clinical medicine, Postoperative Complications, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Thyroid cancer, Aged, Heart transplantation, Hyperplasia, medicine.diagnostic_test, business.industry, Incidence (epidemiology), Lymphoma, Non-Hodgkin, Cancer, General Medicine, Middle Aged, medicine.disease, Hodgkin Disease, Lymphoproliferative Disorders, Positron emission tomography, 030220 oncology & carcinogenesis, Heart Transplantation, 030211 gastroenterology & hepatology, Female, Radiology, Sarcoma, Radiopharmaceuticals, business
Abstract

Introduction The incidence of cancer is higher in transplant patients than in the normal population, mostly due to the assumption of immunosuppressants able to reduce the possibility of rejection. In addition, immunocompromised patients have a greater susceptibility to EBV, HPV and HIV, infectious agents that by themselves may favor the onset of malignancies. Post-Transplant Lymphoproliferative Diseases (PLDs) are among the most frequent neoplasms in transplant patients which like other aggressive neoplasms may be identified by the [18f] fluoro-D-deoxyglucose positron emission tomography/computed tomography (FDG- PET/CT). Methods We evaluated the clinical use of FDG-PET/CT in detecting PTLDs and other neoplasms performed at the lowest clinical or laboratory suspicion of malignancy in 127 consecutive subjects who underwent heart transplantation. Results A SUV ≥ 4 more confirmed the suspect of malignancy and induced us to further investigations. Of the 127 transplant subjects who underwent FDG-PET/CT, 64 showed a SUV value ≥ 4. Of these 64, 8 had PTLDs, 49 other neoplasms (urinary tract tumors, thyroid cancer, HPV cancer related, Kaposi' sarcoma and EBV related head and neck neoplasms) and 7 patients chronic non-neoplastic inflammatory diseases. Conclusions In the present study, FDG-PET/CT examination was of great use for an early identification and for an early treatment of PTLDs and other neoplasms.

Published
2020

23. Children and coronavirus: The necessary search for a balance between the alleged risks and documented collateral damage [Bambini e coronavirus: La doverosa ricerca di un equilibrio tra i presunti rischi e i documentati danni collaterali]

Author

Giorgio Tamburlini, Federico Marchetti, Enrico Bertino, Giovanna Bestetti, Giacomo Biasucci, Andrea Biondi, Maurizio Bonati, Antonella Brunelli, Giovanni Corsello, Susanna Esposito, Franca Fagioli, Daniele Farina, Luigi Gagliardi, Michele Gangemi, Luigi Greco, Marcello Lanari, Marzia Lazzerini, Giuseppe Maggiore, Stefano Martelossi, Ugo Ramenghi, Antonio Piga, Angelo Selicorni, Marco Spada, Alessandro Ventura, Stefano Vicari, Giuseppe Zampino, Federica Zanetto, Tamburlini, G, Marchetti, F, Bertino, E, Bestetti, G, Biasucci, G, Biondi, A, Bonati, M, Brunelli, A, Corsello, G, Esposito, S, Fagioli, F, Farina, D, Gagliardi, L, Gangemi, M, Greco, L, Lanari, M, Lazzerini, M, Maggiore, G, Martelossi, S, Ramenghi, U, Piga, A, Selicorni, A, Spada, M, Ventura, A, Vicari, S, Zampino, G, Zanetto, F, and Giorgio Tamburlini, Federico Marchetti, Enrico Bertino, Giovanna Bestetti, Giacomo Biasucci, Andrea Biondi, Maurizio Bonati, Antonella Brunelli, Giovanni Corsello, Susanna Esposito, Franca Fagioli, Daniele Farina, Luigi Gagliardi, Michele Gangemi, Luigi Greco, Marcello Lanari, Marzia Lazzerini, Giuseppe Maggiore, Stefano Martelossi, Ugo Ramenghi, Antonio Piga, Angelo Selicorni, Marco Spada, Alessandro Ventura, Stefano Vicari, Giuseppe Zampino, Federica Zanetto

Subjects
N/A, coronavirus, Children
Abstract

N/A

Published
2020

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