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3. Prognostic Value of "Basal-like" Morphology, Tumor-Infiltrating Lymphocytes and Multi-MAGE-A Expression in Triple-Negative Breast Cancer.

Author

Čeprnja, Toni, Tomić, Snježana, Perić Balja, Melita, Marušić, Zlatko, Blažićević, Valerija, Spagnoli, Giulio Cesare, Juretić, Antonio, Čapkun, Vesna, Vuger, Ana Tečić, Pogorelić, Zenon, and Mrklić, Ivana

Subjects
TRIPLE-negative breast cancer, TUMOR-infiltrating immune cells, PROGNOSIS, PROGRAMMED death-ligand 1, TESTICULAR cancer, BREAST
Abstract

"Basal-like" (BL) morphology and the expression of cancer testis antigens (CTA) in breast cancer still have unclear prognostic significance. The aim of our research was to explore correlations of the morphological characteristics and tumor microenvironment in triple-negative breast carcinomas (TNBCs) with multi-MAGE-A CTA expression and to determine their prognostic significance. Clinical records of breast cancer patients who underwent surgery between January 2017 and December 2018 in four major Croatian clinical centers were analyzed. A total of 97 non-metastatic TNBCs with available tissue samples and treatment information were identified. Cancer tissue sections were additionally stained with programmed death-ligand 1 (PD-L1) Ventana (SP142) and multi-MAGE-A (mAb 57B). BL morphology was detected in 47 (49%) TNBCs and was associated with a higher Ki-67 proliferation index and histologic grade. Expression of multi-MAGE-A was observed in 77 (79%) TNBCs and was significantly associated with BL morphology. Lymphocyte-predominant breast cancer (LPBC) status was detected in 11 cases (11.3%) and significantly correlated with the Ki-67 proliferation index, increased number of intratumoral lymphocytes (itTIL), and PD-L1 expression. No impact of BL morphology, multi-MAGE-A expression, histologic type, or LPBC status on disease-free survival was observed. Our data suggest that tumor morphology could help identify patients with potential benefits from CTA-targeting immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Data from Infiltration by IL22-Producing T Cells Promotes Neutrophil Recruitment and Predicts Favorable Clinical Outcome in Human Colorectal Cancer

Author

Tosti, Nadia, primary, Cremonesi, Eleonora, primary, Governa, Valeria, primary, Basso, Camilla, primary, Kancherla, Venkatesh, primary, Coto-Llerena, Mairene, primary, Amicarella, Francesca, primary, Weixler, Benjamin, primary, Däster, Silvio, primary, Sconocchia, Giuseppe, primary, Majno, Pietro Edoardo, primary, Christoforidis, Dimitri, primary, Tornillo, Luigi, primary, Terracciano, Luigi, primary, Ng, Charlotte K.Y., primary, Piscuoglio, Salvatore, primary, von Flüe, Markus, primary, Spagnoli, Giulio, primary, Eppenberger-Castori, Serenella, primary, Iezzi, Giandomenica, primary, and Droeser, Raoul Andre, primary

Published
2023
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8. Supplementary Tables from Infiltration by IL22-Producing T Cells Promotes Neutrophil Recruitment and Predicts Favorable Clinical Outcome in Human Colorectal Cancer

Author

Tosti, Nadia, primary, Cremonesi, Eleonora, primary, Governa, Valeria, primary, Basso, Camilla, primary, Kancherla, Venkatesh, primary, Coto-Llerena, Mairene, primary, Amicarella, Francesca, primary, Weixler, Benjamin, primary, Däster, Silvio, primary, Sconocchia, Giuseppe, primary, Majno, Pietro Edoardo, primary, Christoforidis, Dimitri, primary, Tornillo, Luigi, primary, Terracciano, Luigi, primary, Ng, Charlotte K.Y., primary, Piscuoglio, Salvatore, primary, von Flüe, Markus, primary, Spagnoli, Giulio, primary, Eppenberger-Castori, Serenella, primary, Iezzi, Giandomenica, primary, and Droeser, Raoul Andre, primary

Published
2023
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9. Supplementary Figure Legends from Infiltration by IL22-Producing T Cells Promotes Neutrophil Recruitment and Predicts Favorable Clinical Outcome in Human Colorectal Cancer

Author

Tosti, Nadia, primary, Cremonesi, Eleonora, primary, Governa, Valeria, primary, Basso, Camilla, primary, Kancherla, Venkatesh, primary, Coto-Llerena, Mairene, primary, Amicarella, Francesca, primary, Weixler, Benjamin, primary, Däster, Silvio, primary, Sconocchia, Giuseppe, primary, Majno, Pietro Edoardo, primary, Christoforidis, Dimitri, primary, Tornillo, Luigi, primary, Terracciano, Luigi, primary, Ng, Charlotte K.Y., primary, Piscuoglio, Salvatore, primary, von Flüe, Markus, primary, Spagnoli, Giulio, primary, Eppenberger-Castori, Serenella, primary, Iezzi, Giandomenica, primary, and Droeser, Raoul Andre, primary

Published
2023
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10. Supplementary Figures from Infiltration by IL22-Producing T Cells Promotes Neutrophil Recruitment and Predicts Favorable Clinical Outcome in Human Colorectal Cancer

Author

Tosti, Nadia, primary, Cremonesi, Eleonora, primary, Governa, Valeria, primary, Basso, Camilla, primary, Kancherla, Venkatesh, primary, Coto-Llerena, Mairene, primary, Amicarella, Francesca, primary, Weixler, Benjamin, primary, Däster, Silvio, primary, Sconocchia, Giuseppe, primary, Majno, Pietro Edoardo, primary, Christoforidis, Dimitri, primary, Tornillo, Luigi, primary, Terracciano, Luigi, primary, Ng, Charlotte K.Y., primary, Piscuoglio, Salvatore, primary, von Flüe, Markus, primary, Spagnoli, Giulio, primary, Eppenberger-Castori, Serenella, primary, Iezzi, Giandomenica, primary, and Droeser, Raoul Andre, primary

Published
2023
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11. Data from Microtubule-Depolymerizing Agents Used in Antibody–Drug Conjugates Induce Antitumor Immunity by Stimulation of Dendritic Cells

Author

Müller, Philipp, primary, Martin, Kea, primary, Theurich, Sebastian, primary, Schreiner, Jens, primary, Savic, Spasenija, primary, Terszowski, Grzegorz, primary, Lardinois, Didier, primary, Heinzelmann-Schwarz, Viola A., primary, Schlaak, Max, primary, Kvasnicka, Hans-Michael, primary, Spagnoli, Giulio, primary, Dirnhofer, Stephan, primary, Speiser, Daniel E., primary, von Bergwelt-Baildon, Michael, primary, and Zippelius, Alfred, primary

Published
2023
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12. Supplementary Methods from Microtubule-Depolymerizing Agents Used in Antibody–Drug Conjugates Induce Antitumor Immunity by Stimulation of Dendritic Cells

Author

Müller, Philipp, primary, Martin, Kea, primary, Theurich, Sebastian, primary, Schreiner, Jens, primary, Savic, Spasenija, primary, Terszowski, Grzegorz, primary, Lardinois, Didier, primary, Heinzelmann-Schwarz, Viola A., primary, Schlaak, Max, primary, Kvasnicka, Hans-Michael, primary, Spagnoli, Giulio, primary, Dirnhofer, Stephan, primary, Speiser, Daniel E., primary, von Bergwelt-Baildon, Michael, primary, and Zippelius, Alfred, primary

Published
2023
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13. Supplementary Figures 1 - 9, Table 1 from Microtubule-Depolymerizing Agents Used in Antibody–Drug Conjugates Induce Antitumor Immunity by Stimulation of Dendritic Cells

Author

Müller, Philipp, primary, Martin, Kea, primary, Theurich, Sebastian, primary, Schreiner, Jens, primary, Savic, Spasenija, primary, Terszowski, Grzegorz, primary, Lardinois, Didier, primary, Heinzelmann-Schwarz, Viola A., primary, Schlaak, Max, primary, Kvasnicka, Hans-Michael, primary, Spagnoli, Giulio, primary, Dirnhofer, Stephan, primary, Speiser, Daniel E., primary, von Bergwelt-Baildon, Michael, primary, and Zippelius, Alfred, primary

Published
2023
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14. Supplementary Materials and Methods from Characterization and Clinical Relevance of ALDHbright Populations in Prostate Cancer

Author

Le Magnen, Clémentine, primary, Bubendorf, Lukas, primary, Rentsch, Cyrill A., primary, Mengus, Chantal, primary, Gsponer, Joel, primary, Zellweger, Tobias, primary, Rieken, Malte, primary, Thalmann, George N., primary, Cecchini, Marco G., primary, Germann, Markus, primary, Bachmann, Alexander, primary, Wyler, Stephen, primary, Heberer, Michael, primary, and Spagnoli, Giulio C., primary

Published
2023
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15. Supplementary Table 2 from The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer

Author

Governa, Valeria, primary, Trella, Emanuele, primary, Mele, Valentina, primary, Tornillo, Luigi, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Muraro, Manuele Giuseppe, primary, Xu, Hui, primary, Droeser, Raoul, primary, Däster, Silvio R., primary, Bolli, Martin, primary, Rosso, Raffaele, primary, Oertli, Daniel, primary, Eppenberger-Castori, Serenella, primary, Terracciano, Luigi M., primary, Iezzi, Giandomenica, primary, and Spagnoli, Giulio C., primary

Published
2023
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16. Supplementary Figure 2 from Characterization and Clinical Relevance of ALDHbright Populations in Prostate Cancer

Author

Le Magnen, Clémentine, primary, Bubendorf, Lukas, primary, Rentsch, Cyrill A., primary, Mengus, Chantal, primary, Gsponer, Joel, primary, Zellweger, Tobias, primary, Rieken, Malte, primary, Thalmann, George N., primary, Cecchini, Marco G., primary, Germann, Markus, primary, Bachmann, Alexander, primary, Wyler, Stephen, primary, Heberer, Michael, primary, and Spagnoli, Giulio C., primary

Published
2023
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17. Supplementary Figure 3 from The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer

Author

Governa, Valeria, primary, Trella, Emanuele, primary, Mele, Valentina, primary, Tornillo, Luigi, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Muraro, Manuele Giuseppe, primary, Xu, Hui, primary, Droeser, Raoul, primary, Däster, Silvio R., primary, Bolli, Martin, primary, Rosso, Raffaele, primary, Oertli, Daniel, primary, Eppenberger-Castori, Serenella, primary, Terracciano, Luigi M., primary, Iezzi, Giandomenica, primary, and Spagnoli, Giulio C., primary

Published
2023
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18. Supplementary Figure 2 from GM-CSF Production by Tumor Cells Is Associated with Improved Survival in Colorectal Cancer

Author

Nebiker, Christian A., primary, Han, Junyi, primary, Eppenberger-Castori, Serenella, primary, Iezzi, Giandomenica, primary, Hirt, Christian, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Huber, Xaver, primary, Padovan, Elisabetta, primary, Angrisani, Basilio, primary, Droeser, Raoul A., primary, Rosso, Raffaele, primary, Bolli, Martin, primary, Oertli, Daniel, primary, von Holzen, Urs, primary, Adamina, Michel, primary, Muraro, Manuele G., primary, Mengus, Chantal, primary, Zajac, Paul, primary, Sconocchia, Giuseppe, primary, Zuber, Markus, primary, Tornillo, Luigi, primary, Terracciano, Luigi, primary, and Spagnoli, Giulio C., primary

Published
2023
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19. Supplementary Figure 2 from The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer

Author

Governa, Valeria, primary, Trella, Emanuele, primary, Mele, Valentina, primary, Tornillo, Luigi, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Muraro, Manuele Giuseppe, primary, Xu, Hui, primary, Droeser, Raoul, primary, Däster, Silvio R., primary, Bolli, Martin, primary, Rosso, Raffaele, primary, Oertli, Daniel, primary, Eppenberger-Castori, Serenella, primary, Terracciano, Luigi M., primary, Iezzi, Giandomenica, primary, and Spagnoli, Giulio C., primary

Published
2023
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20. Supplementary Table 1 from Characterization and Clinical Relevance of ALDHbright Populations in Prostate Cancer

Author

Le Magnen, Clémentine, primary, Bubendorf, Lukas, primary, Rentsch, Cyrill A., primary, Mengus, Chantal, primary, Gsponer, Joel, primary, Zellweger, Tobias, primary, Rieken, Malte, primary, Thalmann, George N., primary, Cecchini, Marco G., primary, Germann, Markus, primary, Bachmann, Alexander, primary, Wyler, Stephen, primary, Heberer, Michael, primary, and Spagnoli, Giulio C., primary

Published
2023
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21. Supplementary Figure 1 from The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer

Author

Governa, Valeria, primary, Trella, Emanuele, primary, Mele, Valentina, primary, Tornillo, Luigi, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Muraro, Manuele Giuseppe, primary, Xu, Hui, primary, Droeser, Raoul, primary, Däster, Silvio R., primary, Bolli, Martin, primary, Rosso, Raffaele, primary, Oertli, Daniel, primary, Eppenberger-Castori, Serenella, primary, Terracciano, Luigi M., primary, Iezzi, Giandomenica, primary, and Spagnoli, Giulio C., primary

Published
2023
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22. Supplementary Table 2 from Characterization and Clinical Relevance of ALDHbright Populations in Prostate Cancer

Author

Le Magnen, Clémentine, primary, Bubendorf, Lukas, primary, Rentsch, Cyrill A., primary, Mengus, Chantal, primary, Gsponer, Joel, primary, Zellweger, Tobias, primary, Rieken, Malte, primary, Thalmann, George N., primary, Cecchini, Marco G., primary, Germann, Markus, primary, Bachmann, Alexander, primary, Wyler, Stephen, primary, Heberer, Michael, primary, and Spagnoli, Giulio C., primary

Published
2023
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23. Legend from The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer

Author

Governa, Valeria, primary, Trella, Emanuele, primary, Mele, Valentina, primary, Tornillo, Luigi, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Muraro, Manuele Giuseppe, primary, Xu, Hui, primary, Droeser, Raoul, primary, Däster, Silvio R., primary, Bolli, Martin, primary, Rosso, Raffaele, primary, Oertli, Daniel, primary, Eppenberger-Castori, Serenella, primary, Terracciano, Luigi M., primary, Iezzi, Giandomenica, primary, and Spagnoli, Giulio C., primary

Published
2023
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24. Supplementary Table 1 from The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer

Author

Governa, Valeria, primary, Trella, Emanuele, primary, Mele, Valentina, primary, Tornillo, Luigi, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Muraro, Manuele Giuseppe, primary, Xu, Hui, primary, Droeser, Raoul, primary, Däster, Silvio R., primary, Bolli, Martin, primary, Rosso, Raffaele, primary, Oertli, Daniel, primary, Eppenberger-Castori, Serenella, primary, Terracciano, Luigi M., primary, Iezzi, Giandomenica, primary, and Spagnoli, Giulio C., primary

Published
2023
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25. Supplementary Figure 1 from Characterization and Clinical Relevance of ALDHbright Populations in Prostate Cancer

Author

Le Magnen, Clémentine, primary, Bubendorf, Lukas, primary, Rentsch, Cyrill A., primary, Mengus, Chantal, primary, Gsponer, Joel, primary, Zellweger, Tobias, primary, Rieken, Malte, primary, Thalmann, George N., primary, Cecchini, Marco G., primary, Germann, Markus, primary, Bachmann, Alexander, primary, Wyler, Stephen, primary, Heberer, Michael, primary, and Spagnoli, Giulio C., primary

Published
2023
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26. Supplementary Figure 1 from GM-CSF Production by Tumor Cells Is Associated with Improved Survival in Colorectal Cancer

Author

Nebiker, Christian A., primary, Han, Junyi, primary, Eppenberger-Castori, Serenella, primary, Iezzi, Giandomenica, primary, Hirt, Christian, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Huber, Xaver, primary, Padovan, Elisabetta, primary, Angrisani, Basilio, primary, Droeser, Raoul A., primary, Rosso, Raffaele, primary, Bolli, Martin, primary, Oertli, Daniel, primary, von Holzen, Urs, primary, Adamina, Michel, primary, Muraro, Manuele G., primary, Mengus, Chantal, primary, Zajac, Paul, primary, Sconocchia, Giuseppe, primary, Zuber, Markus, primary, Tornillo, Luigi, primary, Terracciano, Luigi, primary, and Spagnoli, Giulio C., primary

Published
2023
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35. Direct CD32 T-cell cytotoxicity: implications for breast cancer prognosis and treatment

Author

Sconocchia, Giuseppe, primary, Lanzilli, Giulia, additional, Cesarini, Valeriana, additional, Silvestris, Domenico A, additional, Rezvani, Katayoun, additional, Arriga, Roberto, additional, Caratelli, Sara, additional, Chen, Ken, additional, Dou, Jinzhuang, additional, Cenciarelli, Carlo, additional, Toietta, Gabriele, additional, Baldari, Silvia, additional, Sconocchia, Tommaso, additional, De Paolis, Francesca, additional, Aureli, Anna, additional, Iezzi, Giandomenica, additional, Irno Consalvo, Maria, additional, Buccisano, Francesco, additional, del Principe, Maria I, additional, Maurillo, Luca, additional, Venditti, Adriano, additional, Ottaviani, Alessio, additional, and Spagnoli, Giulio C, additional

Published
2022
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38. HLA Class II Antigen Expression in Colorectal Carcinoma Tumors as a Favorable Prognostic Marker

Author

Sconocchia, Giuseppe, Eppenberger-Castori, Serenella, Zlobec, Inti, Karamitopoulou, Eva, Arriga, Roberto, Coppola, Andrea, Caratelli, Sara, Cesare Spagnoli, Giulio, Lauro, Davide, Lugli, Alessandro, Han#, Junyi, Iezzi, Giandomenica, Ferrone, Cristina, Ferlosio, Amedeo, Tornillo, Luigi, Droeser, Raoul, Rossi, Piero, Attanasio, Antonio, Ferrone, Soldano, and Terracciano, Luigi

Published
2014
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40. Identification of TPM2 and CNN1 as Novel Prognostic Markers in Functionally Characterized Human Colon Cancer-Associated Stromal Cells

Author

Mele, Valentina, primary, Basso, Camilla, additional, Governa, Valeria, additional, Glaus Garzon, Jesus F., additional, Muraro, Manuele G., additional, Däster, Silvio, additional, Nebiker, Christian A., additional, Mechera, Robert, additional, Bolli, Martin, additional, Schmidt, Alexander, additional, Geiger, Roger, additional, Spagnoli, Giulio C., additional, Christoforidis, Dimitri, additional, Majno, Pietro E., additional, Borsig, Lubor, additional, and Iezzi, Giandomenica, additional

Published
2022
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41. Cytotoxic T-cell Induction in Metastatic Melanoma Patients Undergoing Recombinant Vaccinia Virus-based Immuno-gene Therapy

Author

Spagnoli, Giulio C., Zajac, Paul, Marti, Walter R., Oertli, Daniel, Padovan, Elisabetta, Noppen, Christoph, Kocher, Thomas, Adamina, Michel, Heberer, Michael, Schlag, P. M., editor, Senn, H.-J., editor, Kleihues, P., editor, Stiefel, F., editor, Groner, B., editor, Wallgren, A., editor, Dummer, Reinhard, editor, Nestle, Frank O., editor, and Burg, Günter, editor

Published
2002
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44. Antibody-Independent Antitumor Effects of Cd32A-Chimeric Receptor T Cells: Implications for Breast Cancer Prognosis and Treatment

Author

Sconocchia, Giuseppe, primary, Lanzilli, Giulia, additional, Cesarini, Valeriana, additional, Silvestris, Domenico Alessandro, additional, Arriga, Roberto, additional, Rezvani, Katayoun, additional, Caratelli, Sara, additional, Chen, Ken, additional, Dou, Jinzhuang, additional, Cenciarelli, Carlo, additional, Toietta, Gabriele, additional, Baldari, Silvia, additional, Sconocchia, Tommaso, additional, Paolis, Francesca De, additional, Aureli, Anna, additional, Iezzi, Giandomenica, additional, del Principe, Maria Ilaria, additional, Venditti, Adriano, additional, Ottaviani, Alessio, additional, and Spagnoli, Giulio Cesare, additional

Published
2021
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45. High Density of CD16+ Tumor-Infiltrating Immune Cells in Recurrent Ovarian Cancer Is Associated with Enhanced Responsiveness to Chemotherapy and Prolonged Overall Survival

Author

Lalos, Alexandros, primary, Neri, Ornella, additional, Ercan, Caner, additional, Wilhelm, Alexander, additional, Staubli, Sebastian, additional, Posabella, Alberto, additional, Weixler, Benjamin, additional, Terracciano, Luigi, additional, Piscuoglio, Salvatore, additional, Stadlmann, Sylvia, additional, Spagnoli, Giulio C., additional, Droeser, Raoul A., additional, and Singer, Gad, additional

Published
2021
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48. Nestin and CD34 expression in colorectal cancer predicts improved overall survival

Author

Tampakis, Athanasios Weixler, Benjamin Rast, Silvan Tampaki, Ekaterini-Christina Cremonesi, Eleonora Kancherla, Venkatesh and Tosti, Nadia Kettelhack, Christoph Ng, Charlotte K. Y. and Delko, Tarik Soysal, Savas D. von Holzen, Urs Felekouras, Evangelos Nikiteas, Nikolaos Bolli, Martin Tornillo, Luigi and Terracciano, Luigi Eppenberger-Castori, Serenella Spagnoli, Giulio C. Piscuoglio, Salvatore von Flue, Markus Daster, Silvio Droeser, Raoul A.

Abstract

Background Nestin, a class VI intermediate filament protein of the cytoskeleton, and CD34, a transmembrane phosphoglycoprotein, are markers of progenitor cells. This study aimed to evaluate their expression and clinical significance in colorectal cancer. Methods A clinically annotated tissue microarray, including 599 patients with colorectal cancer, was analyzed by immunohistochemistry. Furthermore, nestin and CD34 correlations with HIF-1a and a panel of cytokines and chemokines were assessed using quantitative reverse transcription PCR and The Cancer Genome Atlas dataset. Results Expression of nestin and CD34 was observed only in the tumor stroma. Patients displaying high expression of nestin and CD34 demonstrated higher rates of T1 and T2 tumors (p = .020), lower vascular invasion (p < .001) and improved 5-year overall survival (65%; 95% CI = 55-73 vs 45%; 95% CI = 37-53) after adjusting for clinicopathological characteristics (HR: 0.67; 95% CI = 0.46-0.96). A moderate to strong correlation (r = 0.37-0.78, p < .03) of nestin and CD34 was demonstrated for the following markers; HIF-1 alpha, CD4, CD8, FOXP3, IRF1, GATA3, CCL2, CCL3, CXCL12 and CCL21. Conclusions Combined expression of nestin and CD34 expression is associated with better overall survival possibly by modulating a favorable immune response.

Published
2021

49. Fibrosis and cancer: shared features and mechanisms suggest common targeted therapeutic approaches.

Author

Landolt, Lea, Spagnoli, Giulio C, Hertig, Alexandre, Brocheriou, Isabelle, and Marti, Hans-Peter

Subjects
*THERAPEUTICS, *FIBROSIS, *TRANSFORMING growth factors, *HIPPO signaling pathway, *KIDNEY diseases, *EPITHELIAL-mesenchymal transition, *CHRONIC kidney failure
Abstract

Epidemiological studies support a strong link between organ fibrosis and epithelial cancers. Moreover, clinical and experimental investigations consistently indicate that these diseases intertwine and share strikingly overlapping features. As a deregulated response to injury occurring in all body tissues, fibrosis is characterized by activation of fibroblasts and immune cells, contributing to progressive deposition of extracellular matrix (ECM) and inflammation. Cancers are driven by genetic alterations resulting in dysregulated cell survival, proliferation and dissemination. However, non-cancerous components of tumour tissues including fibroblasts, inflammatory cells and ECM play key roles in oncogenesis and cancer progression by providing a pro-mutagenic environment where cancer cells can develop, favouring their survival, expansion and invasiveness. Additional commonalities of fibrosis and cancer are also represented by overproduction of growth factors, like transforming growth factor β, epithelial-to-mesenchymal transition, high oxidative stress, Hippo pathway dysfunctions and enhanced cellular senescence. Here, we review advances in the analysis of cellular and molecular mechanisms involved in the pathogenesis of both organ fibrosis and cancer, with particular reference to chronic kidney diseases and renal cell cancers. Most importantly, improved understanding of common features is contributing to the development of innovative treatment strategies targeting shared mechanisms. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Simultaneous cytoplasmic and nuclear protein expression of melanoma antigen-A family and NY-ESO-1 cancer-testis antigens represents an independent marker for poor survival in head and neck cancer

Author

Laban, Simon, Atanackovic, Djordje, Luetkens, Tim, Knecht, Rainald, Busch, Chia-Jung, Freytag, Marcus, Spagnoli, Giulio, Ritter, Gerd, Hoffmann, Thomas K., Knuth, Alexander, Sauter, Guido, Wilczak, Waldemar, Blessmann, Marco, Borgmann, Kerstin, Muenscher, Adrian, and Clauditz, Till S.

Published
2014
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