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484 results on '"Spagnuolo, Vincenzo"'

1. Heavily treatment-experienced persons living with HIV currently in care in Italy: characteristics, risk factors, and therapeutic options—the ICONA Foundation cohort study

Author

Lo Caputo, Sergio, Poliseno, Mariacristina, Tavelli, Alessandro, Gagliardini, Roberta, Rusconi, Stefano, Lapadula, Giuseppe, Antinori, Andrea, Francisci, Daniela, Sarmati, Loredana, Gori, Andrea, Spagnuolo, Vincenzo, Ceccherini-Silberstein, Francesca, d'Arminio Monforte, Antonella, and Cozzi-Lepri, Alessandro

Published
2024
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2. Heavy antiretroviral exposure and exhausted/limited antiretroviral options: predictors and clinical outcomes

Author

Mocroft, Amanda, Pelchen-Matthews, Annegret, Hoy, Jennifer, Llibre, Josep M., Neesgaard, Bastian, Jaschinski, Nadine, Domingo, Pere, Rasmussen, Line Dahlerup, Günthard, Huldrych F., Surial, Bernard, Öllinger, Angela, Knappik, Michael, de Wit, Stephane, Wit, Ferdinand, Mussini, Cristina, Vehreschild, Joerg, Monforte, Antonella D’Arminio, Sonnerborg, Anders, Castagna, Antonella, Anne, Alain Volny, Vannappagari, Vani, Cohen, Cal, Greaves, Wayne, Wasmuth, Jan C., Spagnuolo, Vincenzo, and Ryom, Lene

Published
2024
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3. Characterization and outcomes of difficult-to-treat patients starting modern first-line ART regimens: Data from the ICONA cohort

Author

Gagliardini, Roberta, Tavelli, Alessandro, Rusconi, Stefano, Lo Caputo, Sergio, Spagnuolo, Vincenzo, Santoro, Maria Mercedes, Costantini, Andrea, Vergori, Alessandra, Maggiolo, Franco, Giacomelli, Andrea, Burastero, Giulia, Madeddu, Giordano, Quiros Roldan, Eugenia, d'Arminio Monforte, Antonella, Antinori, Andrea, and Cozzi-Lepri, Alessandro

Published
2024
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4. THU-402 Higher cardiovascular burden in people living with HIV (PLWH) with metabolic syndrome and history of HCV infection

Author

Siribelli, Alessia, primary, Bellomo, Michele, additional, Muccini, Camilla, additional, Lolatto, Riccardo, additional, Morsica, Giulia, additional, Diotallevi, Sara, additional, Gianotti, Nicola, additional, Bossolasco, Simona, additional, Bertoni, Costanza, additional, Spagnuolo, Vincenzo, additional, Castagna, Antonella, additional, and Hasson, Hamid, additional

Published
2024
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8. Cancer in people with multidrug-resistant HIV.

Author

Clemente, Tommaso, Pontillo, Domenico, Malagnino, Vincenzo, Calza, Leonardo, Di Biagio, Antonio, Cenderello, Giovanni, Lolatto, Riccardo, Manzillo, Elio, Moioli, Maria Cristina, De Socio, Giuseppe Vittorio, Castagna, Antonella, and Spagnuolo, Vincenzo

Published
2024
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9. Use of next-generation sequencing on HIV-1 DNA to assess archived resistance in highly treatment-experienced people with multidrug-resistant HIV under virological control: data from the PRESTIGIO Registry.

Author

Armenia, Daniele, Spagnuolo, Vincenzo, Bellocchi, Maria C, Galli, Laura, Duca, Leonardo, Marchegiani, Greta, Clemente, Tommaso, Carioti, Luca, Lolatto, Riccardo, Calza, Leonardo, Celesia, Benedetto M, Cascio, Antonio, Francisci, Daniela, Saracino, Annalisa, Torti, Carlo, Zazzi, Maurizio, Castagna, Antonella, Santoro, Maria M, and Group, PRESTIGIO Study

Subjects
*NUCLEOTIDE sequencing, *DNA sequencing, *DRUG resistance, *GENOTYPES, *GENETIC mutation
Abstract

Background To clarify whether next-generation sequencing (NGS) can be useful for resistance assessment in virologically suppressed highly treatment-experienced (HTE) individuals with MDR HIV. Methods Ninety-one participants from the PRESTIGIO Registry were included. NGS was performed on HIV-DNA at 1%, 5% and 20% cut-offs; major drug resistance mutations (DRMs) were evaluated and compared with those detected in historical plasma genotypic resistance testing (h-GRT). APOBEC editing was also characterized. Results Participants had a complex and long treatment history [median 23 (IQR 21–25) years of ART exposure) and had been virologically suppressed since a median of 3 (IQR 2–5) years. Among all major DRMs detected by HIV-DNA NGS and/or h-GRT, 30% were exclusively found through NGS. The highest detection rate of historical major DRMs was reached with NGS set at 1%, but unusual substitutions and extensive APOBEC hypermutations suggest technical issues and poor clinical relevance in the 1%–5% interval. At NGS set at 5%, 67.2% of historical major DRMs were detected. The number of major DRMs detected exclusively by DNA-NGS as minority variants (frequency 5%–20%) was significantly higher in individuals who later experienced virological rebound compared with those who maintained virological control [median 2 (IQR 1–3) versus 1 (0–2), P  = 0.030] and positively correlated with viraemia levels at rebound (rho = 0.474, P  = 0.030). Conclusions In non-viraemic people with an MDR virus, HIV-1 DNA NGS set at 5% is an acceptable technical cut-off that might help to reveal mutations with a potential clinical relevance. Moreover, the number of minority resistance mutations additionally detected by NGS might be associated with loss of virological control. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Secondary infections in patients hospitalized with COVID-19: incidence and predictive factors

Author

Andolina, Andrea, Redaelli, Martina Baiardo, Bigai, Giorgia, Bigoloni, Alba, Borio, Giorgia, Bossolasco, Simona, Bruzzesi, Elena, Calabrò, Maria Grazia, Calvisi, Stefania, Campochiaro, Corrado, Canetti, Diana, Canti, Valentina, Castellani, Jacopo, Castiglioni, Barbara, Cavalli, Giulio, Cavallo, Ludovica, Cernuschi, Massimo, Chiurlo, Matteo, Cilla, Marta, Cinel, Elena, Cinque, Paola, Conte, Caterina, Da Prat, Valentina, Danise, Anna, De Lorenzo, Rebecca, Dell’Acqua, Antonio, Dell’Acqua, Raffaele, Della Torre, Emanuel, Della Torre, Liviana, Di Terlizzi, Gaetano, Dumea, Iulia, Farolfi, Federica, Ferrante, Marica, Frangi, Claudia, Fumagalli, Luca, Gallina, Gabriele, Germinario, Bruno, Gianotti, Nicola, Guffanti, Monica, Hasson, Hamid, Lalla, Francesca, Lanzillotta, Marco, Li Voti, Raffaele, Messina, Emanuela, Molinari, Chiara, Moizo, Elena, Montagna, Marco, Morsica, Giulia, Nozza, Silvia, Pascali, Maria, Patrizi, Alessandro, Pieri, Marina, Poloniato, Antonella, Prestifilippo, Dario, Ramirez, Giuseppe, Ranzenigo, Martina, Sapienza, Jacopo, Seghi, Federico, Tambussi, Giuseppe, Tassan Din, Chiara, Turi, Stefano, Uberti-Foppa, Caterina, Vinci, Concetta, Ripa, Marco, Galli, Laura, Poli, Andrea, Oltolini, Chiara, Spagnuolo, Vincenzo, Mastrangelo, Andrea, Muccini, Camilla, Monti, Giacomo, De Luca, Giacomo, Landoni, Giovanni, Dagna, Lorenzo, Clementi, Massimo, Rovere Querini, Patrizia, Ciceri, Fabio, Tresoldi, Moreno, Lazzarin, Adriano, Zangrillo, Alberto, Scarpellini, Paolo, and Castagna, Antonella

Published
2021
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11. Cardiometabolic complications in children and adolescents with HIV on antiretroviral therapy

Author

Muccini, Camilla, Bottanelli, Martina, Castagna, Antonella, and Spagnuolo, Vincenzo

Abstract

ABSTRACTIntroductionThe course of HIV infection has changed radically with the introduction of antiretroviral therapy (ART), which has significantly reduced mortality and improved quality of life. However, antiretroviral drugs can cause adverse effects, including cardiometabolic complications and diseases, which are among the most common. Compared to the adult population, there are fewer studies in the pediatric population on treatment-related complications. The purpose of this review is to provide an update on the literature regarding cardiometabolic complications and diseases in children and adolescents with HIV.Areas coveredA comprehensive literature review was conducted using PubMed and related bibliographies to provide an overview of the current knowledge of metabolic complications (dyslipidemia, insulin resistance, lipodystrophy, weight gain and liver complications) and diseases (prediabetes/diabetes and cardiovascular diseases) associated with ART in children and adolescents with HIV.Expert opinionMetabolic complications are conditions that need to be closely monitored in children and adolescents with HIV, as they increase the risk of early development of non-communicable diseases, such as cardiovascular disease. Key areas for improvement include ensuring access to treatment, reducing side effects and improving diagnostic capabilities. Overcoming existing challenges will require collaborative efforts across disciplines, advances in technology, and targeted interventions to address socioeconomic disparities.

Published
2024
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12. Regaining virological suppression in a woman living with a six-class resistant HIV by combining injectable antiretroviral drugs guided by genotypic and phenotypic tests

Author

Monti, B, Soria, A, Saladini, F, Lapadula, G, Squillace, N, Giammarino, F, Paletti, C, Bartolini, N, Spagnuolo, V, Castagna, A, Zazzi, M, Bonfanti, P, Monti, Bianca, Soria, Alessandro, Saladini, Francesco, Lapadula, Giuseppe, Squillace, Nicola, Giammarino, Federica, Paletti, Chiara, Bartolini, Niccolò, Spagnuolo, Vincenzo, Castagna, Antonella, Zazzi, Maurizio, Bonfanti, Paolo, Monti, B, Soria, A, Saladini, F, Lapadula, G, Squillace, N, Giammarino, F, Paletti, C, Bartolini, N, Spagnuolo, V, Castagna, A, Zazzi, M, Bonfanti, P, Monti, Bianca, Soria, Alessandro, Saladini, Francesco, Lapadula, Giuseppe, Squillace, Nicola, Giammarino, Federica, Paletti, Chiara, Bartolini, Niccolò, Spagnuolo, Vincenzo, Castagna, Antonella, Zazzi, Maurizio, and Bonfanti, Paolo

Published
2024

13. Trends in mortality in people with HIV from 1999 to 2020: a multi-cohort collaboration

Author

Tusch, E, Ryom, L, Pelchen-Matthews, A, Mocroft, A, Elbirt, D, Oprea, C, Günthard, H, Staehelin, C, Zangerle, R, Suarez, I, Vehreschild, J, Wit, F, Menozzi, M, d'Arminio Monforte, A, Spagnuolo, V, Pradier, C, Carlander, C, Suanzes, P, Wasmuth, J, Carr, A, Petoumenos, K, Borgans, F, Bonnet, F, De Wit, S, El-Sadr, W, Neesgaard, B, Jaschinski, N, Greenberg, L, Hosein, S, Gallant, J, Vannappagari, V, Young, L, Sabin, C, Lundgren, J, Peters, L, Reekie, J, Calvo, G, Dabis, F, Kirk, O, Law, M, Monforte, A, Morfeldt, L, Reiss, P, Weber, R, Lind-Thomsen, A, Brandt, R, Hillebreght, M, Zaheri, S, Scherrer, A, Schöni-Affolter, F, Rickenbach, M, Tavelli, A, Fanti, I, Leleux, O, Mourali, J, Marec, F, Boerg, E, Thulin, E, Sundström, A, Bartsch, G, Thompsen, G, Necsoi, C, Delforge, M, Fontas, E, Caissotti, C, Dollet, K, Mateu, S, Torres, F, Blance, A, Huang, R, Puhr, R, Laut, K, Kristensen, D, Phillips, A, Kamara, D, Smith, C, Hatleberg, C, Raben, D, Matthews, C, Bojesen, A, Grevsen, A, Powderly, B, Shortman, N, Moecklinghoff, C, Reilly, G, Franquet, X, Smit, C, Ross, M, Fux, C, Morlat, P, Friis-Møller, N, Kowalska, J, Bohlius, J, Bower, M, Fätkenheuer, G, Grulich, A, Sjøl, A, Meidahl, P, Iversen, J, Reiss, C, Hillebregt, M, Prins, J, Kuijpers, T, Scherpbier, H, van der Meer, J, Godfried, M, van der Poll, T, Nellen, F, Geerlings, S, van Vugt, M, Pajkrt, D, Bos, J, Wiersinga, W, van der Valk, M, Goorhuis, A, Hovius, J, van Eden, J, Henderiks, A, van Hes, A, Mutschelknauss, M, Nobel, H, Pijnappel, F, Jurriaans, S, Back, N, Zaaijer, H, Berkhout, B, Cornelissen, M, Schinkel, C, Thomas, X, Ziekenhuis, A, van den Berge, M, Stegeman, A, Baas, S, de Looff, L, Versteeg, D, Ziekenhuis, C, Pronk, M, Ammerlaan, H, De Munnik, E, Jansz, A, Tjhie, J, Wegdam, M, Deiman, B, Scharnhorst, V, van der Plas, A, Weijsenfeld, A, van der Ende, M, De Vries-Sluijs, T, van Gorp, E, Schurink, C, Nouwen, J, Verbon, A, Rijnders, B, Bax, H, van der Feltz, M, Bassant, N, van Beek, J, Vriesde, M, van Zonneveld, L, de Oude-Lubbers, A, van den Berg-Cameron, H, Bruinsma-Broekman, F, de Groot, J, de Man, M, Boucher, C, Koopmans, M, van Kampen, J, Pas, S, Mc–sophia, E, Driessen, G, van Rossum, A, van der Knaap, L, Visser, E, Branger, J, Rijkeboer-Mes, A, de Ven, C, Ziekenhuis, H, Schippers, E, van Nieuwkoop, C, van IJperen, J, Geilings, J, van der Hut, G, Franck, P, van Eeden, A, Brokking, W, Groot, M, Elsenburg, L, Damen, M, Kwa, I, Groeneveld, P, Bouwhuis, J, van den Berg, J, van Hulzen, A, van der Bliek, G, Bor, P, Bloembergen, P, Wolfhagen, M, Ruijs, G, Kroon, F, de Boer, M, Bauer, M, Jolink, H, Vollaard, A, Dorama, W, van Holten, N, Claas, E, Wessels, E, den Hollander, J, Pogany, K, Roukens, A, Kastelijns, M, Smit, J, Smit, E, Struik-Kalkman, D, Tearno, C, Bezemer, M, van Niekerk, T, Pontesilli, O, Lowe, S, Lashof, A, Posthouwer, D, Ackens, R, Schippers, J, Vergoossen, R, Weijenberg-Maes, B, van Loo, I, Havenith, T, Leyten, E, Gelinck, L, van Hartingsveld, A, Meerkerk, C, Wildenbeest, G, Mutsaers, J, Jansen, C, Mulder, J, Vrouenraets, S, Lauw, F, van Broekhuizen, M, Paap, H, Vlasblom, D, Smits, P, Zuiderzee, M, Weijer, S, El Moussaoui, R, Bosma, A, van Vonderen, M, van Houte, D, Kampschreur, L, Dijkstra, K, Faber, S, Weel, J, Kootstra, G, Delsing, C, van der Burg-van de Plas, M, Heins, H, Lucas, E, Kortmann, W, van Twillert, G, Stuart, J, Diederen, B, Pronk, D, van Truijen-Oud, F, van der Reijden, W, Jansen, R, Brinkman, K, van den Berk, G, Blok, W, Frissen, P, Lettinga, K, Schouten, W, Veenstra, J, Brouwer, C, Geerders, G, Hoeksema, K, Kleene, M, van der Meché, I, Spelbrink, M, Sulman, H, Toonen, A, Wijnands, S, Kwa, D, Witte, E, Koopmans, P, Keuter, M, van der Ven, A, ter Hofstede, H, Dofferhoff, A, van Crevel, R, Albers, M, Bosch, M, Grintjes-Huisman, K, Zomer, B, Stelma, F, Rahamat-Langendoen, J, Burger, D, Richter, C, Gisolf, E, Hassing, R, ter Beest, G, van Bentum, P, Langebeek, N, Tiemessen, R, Swanink, C, van Lelyveld, S, Soetekouw, R, Hulshoff, N, van der Prijt, L, van der Swaluw, J, Bermon, N, Herpers, B, Veenendaal, D, Verhagen, D, van Wijk, M, Ziekenhuis, S, van Kasteren, M, Brouwer, A, de Wiel, B, Kuipers, M, Santegoets, R, van der Ven, B, Marcelis, J, Buiting, A, Kabel, P, Bierman, W, Scholvinck, H, Wilting, K, Stienstra, Y, Jonge, H, van der Meulen, P, de Weerd, D, Ludwig-Roukema, J, Niesters, H, Riezebos-Brilman, A, van Leer-Buter, C, Knoester, M, Hoepelman, A, Mudrikova, T, Ellerbroek, P, Oosterheert, J, Arends, J, Barth, R, Wassenberg, M, Schadd, E, van Elst-Laurijssen, D, van Oers-Hazelzet, E, Vervoort, S, van Berkel, M, Schuurman, R, Verduyn-Lunel, F, Wensing, A, Peters, E, van Agtmael, M, Bomers, M, de Vocht, J, Heitmuller, M, Laan, L, Pettersson, A, Vandenbroucke-Grauls, C, Ang, C, Kinderziekenhuis, W, Geelen, S, Wolfs, T, Bont, L, Nauta, N, Bezemer, D, van Sighem, A, Boender, T, de Jong, A, Bergsma, D, Hoekstra, P, de Lang, A, Grivell, S, Jansen, A, Rademaker, M, Raethke, M, Meijering, R, Schnörr, S, de Groot, L, van den Akker, M, Bakker, Y, Claessen, E, El Berkaoui, A, Koops, J, Kruijne, E, Lodewijk, C, Munjishvili, L, Peeck, B, Ree, C, Regtop, R, Ruijs, Y, Rutkens, T, van de Sande, L, Schoorl, M, Timmerman, A, Tuijn, E, Veenenberg, L, van der Vliet, S, Wisse, A, Woudstra, T, Tuk, B, Dupon, M, Gaborieau, V, Lacoste, D, Malvy, D, Mercié, P, Neau, D, Pellegrin, J, Tchamgoué, S, Lazaro, E, Cazanave, C, Vandenhende, M, Vareil, M, Gérard, Y, Blanco, P, Bouchet, S, Breilh, D, Fleury, H, Pellegrin, I, Chêne, G, Thiébaut, R, Wittkop, L, Lawson-Ayayi, S, Gimbert, A, Desjardin, S, Lacaze-Buzy, L, Petrov-Sanchez, V, André, K, Bernard, N, Caubet, O, Caunegre, L, Chossat, I, Courtault, C, Dauchy, F, De Witte, S, Dondia, D, Duffau, P, Dutronc, H, Farbos, S, Faure, I, Ferrand, H, Gerard, Y, Greib, C, Hessamfar, M, Imbert, Y, Lataste, P, Marie, J, Mechain, M, Monlun, E, Ochoa, A, Pistone, T, Raymond, I, Receveur, M, Rispal, P, Sorin, L, Valette, C, Viallard, J, Wille, H, Wirth, G, Lafon, M, Trimoulet, P, Bellecave, P, Tumiotto, C, Haramburu, F, Miremeont-Salamé, G, Blaizeau, M, Decoin, M, Hannapier, C, Lenaud, E, Pougetoux, A, Delveaux, S, D’Ivernois, C, Diarra, F, Uwamaliya-Nziyumvira, B, Palmer, G, Conte, V, Sapparrart, V, Law, C, Moore, R, Edwards, S, Hoy, J, Watson, K, Roth, N, Lau, H, Bloch, M, Baker, D, Cooper, D, O’Sullivan, M, Nolan, D, Guelfi, G, Calvo, C, Domingo, P, Sambeat, M, Gatell, J, Del Cacho, E, Cadafalch, J, Fuster, M, Codina, C, Sirera, G, Vaqué, A, Clumeck, N, Gennotte, A, Gerard, M, Kabeya, K, Konopnicki, D, Libois, A, Martin, C, Payen, M, Semaille, P, Van Laethem, Y, Neaton, C, Krum, E, Thompson, G, Wentworth, D, Luskin-Hawk, R, Telzak, E, Abrams, D, Cohn, D, Markowitz, N, Arduino, R, Mushatt, D, Friedland, G, Perez, G, Tedaldi, E, Fisher, E, Gordin, F, Crane, L, Sampson, J, Baxter, J, Gazzard, B, Horban, A, Karpov, I, Losso, M, Pedersen, C, Ristola, M, Rockstroh, J, Fischer, A, Larsen, J, Podlekareva, D, Cozzi-Lepri, A, Shepherd, L, Schultze, A, Amele, S, Kundro, M, Schmied, B, Wien, P, Vassilenko, A, Mitsura, V, Paduto, D, Florence, E, Vandekerckhove, L, Hadziosmanovic, V, Begovac, J, Machala, L, Jilich, D, Sedlacek, D, Kronborg, G, Benfield, T, Gerstoft, J, Katzenstein, T, Møller, N, Ostergaard, L, Wiese, L, Nielsen, L, Zilmer, K, Smidt, J, Siseklinik, N, Aho, I, Viard, J, Duvivier, C, Schmidt, R, Degen, O, Stellbrink, H, Stefan, C, Goethe, J, Bogner, J, Chkhartishvili, N, Gargalianos, P, Xylomenos, G, Armenis, K, Sambatakou, H, Szlávik, J, Gottfredsson, M, Mulcahy, F, Yust, I, Turner, D, Burke, M, Shahar, E, Hassoun, G, Elinav, H, Haouzi, M, Sthoeger, Z, Esposito, R, Mazeu, I, Mussini, C, Mazzotta, F, Gabbuti, A, Annunziata, O, Vullo, V, Lichtner, M, Zaccarelli, M, Antinori, A, Acinapura, R, Plazzi, M, Lazzarin, A, Castagna, A, Gianotti, N, Galli, M, Ridolfo, A, Rozentale, B, Uzdaviniene, V, Matulionyte, R, Staub, T, Hemmer, R, Ormaasen, V, Maeland, A, Bruun, J, Knysz, B, Gasiorowski, J, Inglot, M, Bakowska, E, Flisiak, R, Grzeszczuk, A, Parczewski, M, Maciejewska, K, Aksak-Was, B, Beniowski, M, Mularska, E, Smiatacz, T, Gensing, M, Jablonowska, E, Malolepsza, E, Wojcik, K, Mozer-Lisewska, I, Caldeira, L, Mansinho, K, Maltez, F, Radoi, R, Panteleev, A, Panteleev, O, Yakovlev, A, Trofimora, T, Khromova, I, Kuzovatova, E, Blokhina, I, Novogrod, N, Borodulina, E, Vdoushkina, E, Jevtovic, D, Tomazic, J, Miró, J, Moreno, S, Rodriguez, J, Clotet, B, Jou, A, Paredes, R, Tural, C, Puig, J, Bravo, I, Gutierrez, M, Mateo, G, Laporte, J, Sonnerborg, A, Brännström, I, Flamholc, L, Cavassini, M, Calmy, A, Furrer, H, Battegay, M, Schmid, P, Kuznetsova, A, Kyselyova, G, Sluzhynska, M, Johnson, A, Simons, E, Johnson, M, Orkin, C, Weber, J, Scullard, G, Clarke, A, Leen, C, Morfeldt, C, Thulin, G, Åkerlund, B, Koppel, K, Karlsson, A, Håkangård, C, Castelli, F, Cauda, R, Perri, G, Iardino, R, Ippolito, G, Marchetti, G, Perno, C, von Schloesser, F, Viale, P, Ceccherini-Silberstein, F, Girardi, E, Caputo, S, Puoti, M, Andreoni, M, Ammassari, A, Balotta, C, Bandera, A, Bonfanti, P, Bonora, S, Borderi, M, Calcagno, A, Calza, L, Capobianchi, M, Cingolani, A, Cinque, P, De Luca, A, Biagio, A, Gori, A, Guaraldi, G, Lapadula, G, Madeddu, G, Maggiolo, F, Marcotullio, S, Monno, L, Nozza, S, Roldan, E, Rossotti, R, Rusconi, S, Santoro, M, Saracino, A, Galli, L, Lorenzini, P, Rodano, A, Shanyinde, M, Carletti, F, Carrara, S, Caro, A, Graziano, S, Petrone, F, Prota, G, Quartu, S, Truffa, S, Giacometti, A, Costantini, A, Barocci, V, Angarano, G, Santoro, C, Suardi, C, Donati, V, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Cacopardo, B, Celesia, B, Vecchiet, J, Falasca, K, Pan, A, Lorenzotti, S, Sighinolfi, L, Segala, D, Vichi, F, Cassola, G, Viscoli, C, Alessandrini, A, Bobbio, N, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Chiodera, A, Milini, P, Rizzardini, G, Moioli, M, Piolini, R, Salpietro, S, Tincati, C, Puzzolante, C, Abrescia, N, Chirianni, A, Borgia, G, Orlando, R, Bonadies, G, Martino, F, Gentile, I, Maddaloni, L, Cattelan, A, Marinello, S, Cascio, A, Colomba, C, Baldelli, F, Schiaroli, E, Parruti, G, Sozio, F, Magnani, G, Ursitti, M, Cristaudo, A, Baldin, G, Capozzi, M, Cicalini, S, Sulekova, L, Iaiani, G, Latini, A, Mastrorosa, I, Savinelli, S, Vergori, A, Cecchetto, M, Viviani, F, Bagella, P, Rossetti, B, Franco, A, Del Vecchio, R, Francisci, D, Giuli, C, Caramello, P, Orofino, G, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V, Starnini, G, Ialungo, A, Central, C, Dellamonica, P, Bernard, E, Courjon, J, Cua, E, De Salvador-Guillouet, F, Durant, J, Etienne, C, Ferrando, S, Mondain-Miton, V, Naqvi, A, Perbost, I, Pillet, S, Prouvost-Keller, B, Pugliese, P, Rio, V, Risso, K, Roger, P, Aubert, V, Bernasconi, E, Böni, J, Braun, D, Bucher, H, Ciuffi, A, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Haerry, D, Hasse, B, Hirsch, H, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R, Kovari, H, Ledergerber, B, 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Capobianchi, M, Cingolani, A, Cinque, P, De Luca, A, Biagio, A, Gori, A, Guaraldi, G, Lapadula, G, Madeddu, G, Maggiolo, F, Marcotullio, S, Monno, L, Nozza, S, Roldan, E, Rossotti, R, Rusconi, S, Santoro, M, Saracino, A, Galli, L, Lorenzini, P, Rodano, A, Shanyinde, M, Carletti, F, Carrara, S, Caro, A, Graziano, S, Petrone, F, Prota, G, Quartu, S, Truffa, S, Giacometti, A, Costantini, A, Barocci, V, Angarano, G, Santoro, C, Suardi, C, Donati, V, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Cacopardo, B, Celesia, B, Vecchiet, J, Falasca, K, Pan, A, Lorenzotti, S, Sighinolfi, L, Segala, D, Vichi, F, Cassola, G, Viscoli, C, Alessandrini, A, Bobbio, N, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Chiodera, A, Milini, P, Rizzardini, G, Moioli, M, Piolini, R, Salpietro, S, Tincati, C, Puzzolante, C, Abrescia, N, Chirianni, A, Borgia, G, Orlando, R, Bonadies, G, Martino, F, Gentile, I, Maddaloni, L, Cattelan, A, Marinello, S, Cascio, A, Colomba, C, Baldelli, F, Schiaroli, E, Parruti, G, Sozio, F, Magnani, G, Ursitti, M, Cristaudo, A, Baldin, G, Capozzi, M, Cicalini, S, Sulekova, L, Iaiani, G, Latini, A, Mastrorosa, I, Savinelli, S, Vergori, A, Cecchetto, M, Viviani, F, Bagella, P, Rossetti, B, Franco, A, Del Vecchio, R, Francisci, D, Giuli, C, Caramello, P, Orofino, G, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V, Starnini, G, Ialungo, A, Central, C, Dellamonica, P, Bernard, E, Courjon, J, Cua, E, De Salvador-Guillouet, F, Durant, J, Etienne, C, Ferrando, S, Mondain-Miton, V, Naqvi, A, Perbost, I, Pillet, S, Prouvost-Keller, B, Pugliese, P, Rio, V, Risso, K, Roger, P, Aubert, V, Bernasconi, E, Böni, J, Braun, D, Bucher, H, Ciuffi, A, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Haerry, D, Hasse, B, Hirsch, H, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R, Kovari, H, Ledergerber, B, Martinetti, G, de Tejada, B, Marzolini, C, Metzner, K, Müller, N, Nicca, D, Pantaleo, G, Paioni, P, Rauch, A, Rudin, C, Speck, R, Stöckle, M, Tarr, P, Trkola, A, Vernazza, P, Wandeler, G, Yerly, S, Valk, M, Hutchinson, J, Rupasinghe, D, Han, W, Appoyer, H, Vera, J, Broster, B, Barbour, L, Carney, D, Greenland, L, Coughlan, R, Saint-Pierre, C, Stephan, C, Bucht, M, Chokoshvili, O, Borghi, V, Casabona, J, Miro, J, Lampe, F, Burns, F, Chaloner, C, Muccini, C, Lolatto, R, Sönnerborg, A, Nowak, P, Vesterbacka, J, Mattsson, L, Carrick, D, Stigsäter, K, Kusejko, K, Schulze, N, Franke, B, Rooney, J, Mcnicholl, I, Garges, H, Campo, R, Volny-Anne, A, Dedes, N, Williams, E, Bruguera, A, Volny-Anne, R, Mendão, L, Timiryasova, A, Fursa, O, Jakobsen, M, Kraef, C, Gardizi, M, Andersen, K, Kumar, L, Elsing, T, Shahi, S, Valdenmaiier, O, Bansi-Matharu, L, Byonanebye, D, Bannister, W, Roen, A, Null, N, Tusch, Erich, Ryom, Lene, Pelchen-Matthews, Annegret, Mocroft, Amanda, Elbirt, Daniel, Oprea, Cristiana, Günthard, Huldrych F, Staehelin, Cornelia, Zangerle, Robert, Suarez, Isabelle, Vehreschild, Jörg Janne, Wit, Ferdinand, Menozzi, Marianna, d'Arminio Monforte, Antonella, Spagnuolo, Vincenzo, Pradier, Christian, Carlander, Christina, Suanzes, Paula, Wasmuth, Jan-Christian, Carr, Andrew, Petoumenos, Kathy, Borgans, Frauke, Bonnet, Fabrice, De Wit, Stephane, El-Sadr, Wafaa, Neesgaard, Bastian, Jaschinski, Nadine, Greenberg, Lauren, Hosein, Sean R, Gallant, Joel, Vannappagari, Vani, Young, Lital, Sabin, Caroline, Lundgren, Jens, Peters, Lars, Reekie, Joanne, Monforte, A d’Arminio, Brandt, R Salbøl, Wit, F W N M, Marec, F Le, Laut, K Grønborg, Sabin, C A, Phillips, A N, Kamara, D A, Smith, C J, Hatleberg, C I, Brandt, R S, Grevsen, A L, Lundgren, J D, Fux, C A, Monforte, A d'Arminio, Iversen, J S, Reiss, Central P, Prins, J M, Kuijpers, T W, Scherpbier, H J, van der Meer, J T M, Godfried, M H, Nellen, F J B, Geerlings, S E, Bos, J C, Wiersinga, W J, Hovius, J W, van Hes, A M H, Nobel, H E, Pijnappel, F J J, Back, N K T, Zaaijer, H L, Cornelissen, M T E, Schinkel, C J, Thomas, X V, Ziekenhuis, Admiraal De Ruyter, de Looff, L Hage, Ziekenhuis, Catharina, Pronk, M J H, Ammerlaan, H S M, De Munnik, E S, Jansz, A R, Wegdam, M C A, Weijsenfeld, A M, van der Ende, M E, De Vries-Sluijs, T E M S, van Gorp, E C M, Schurink, C A M, Nouwen, J L, Rijnders, B J A, Bax, H I, van Beek, J E A, van Zonneveld, L M, van den Berg-Cameron, H J, Bruinsma-Broekman, F B, de Man, M de Zeeuw, Boucher, C A B, Koopmans, M P G, van Kampen, J J A, Pas, S D, MC–Sophia, Erasmus, Driessen, G J A, van Rossum, A M C, van der Knaap, L C, de Ven, C J H M Duijf-van, Ziekenhuis, Haga, Schippers, E F, van IJperen, J M, Franck, P F H, Elsenburg, L J M, Kwa, I S, Groeneveld, P H P, Bouwhuis, J W, van den Berg, J F, van Hulzen, A G W, van der Bliek, G L, Bor, P C J, Wolfhagen, M J H M, Ruijs, G J H M, Kroon, F P, de Boer, M G J, Bauer, M P, Vollaard, A M, Claas, E C J, den Hollander, J G, Smit, J V, Lowe, S H, Lashof, A M L Oude, Ackens, R P, van Loo, I H M, Havenith, T R A, Leyten, E M S, Gelinck, L B S, Wildenbeest, G S, Mutsaers, J A E M, Jansen, C L, Mulder, J W, Vrouenraets, S M E, Lauw, F N, van Broekhuizen, M C, Vlasblom, D J, Smits, P H M, Zuiderzee, M C, Bosma, A S, van Vonderen, M G A, van Houte, D P F, Kampschreur, L M, Kootstra, G J, Delsing, C E, Stuart, J W T Cohen, Diederen, B M W, van Truijen-Oud, F A, van der Reijden, W A, van den Berk, G E L, Blok, W L, Frissen, P H J, Lettinga, K D, Schouten, W E M, Brouwer, C J, Geerders, G F, Kleene, M J, van der Meché, I B, Toonen, A J M, Koopmans, P P, van der Ven, A J A M, ter Hofstede, H J M, Dofferhoff, A S M, Bosch, M E W, Grintjes-Huisman, K J T, Zomer, B J, Stelma, F F, Gisolf, E H, Hassing, R J, van Bentum, P H M, Swanink, C M A, van Lelyveld, S F L, van der Prijt, L M M, Herpers, B L, Verhagen, D W M, Ziekenhuis, St Elisabeth, van Kasteren, M E E, Brouwer, A E, de Wiel, B A F M de Kruijf-van, Santegoets, R M W J, Marcelis, J H, Buiting, A G M, Kabel, P J, Bierman, W F W, Wilting, K R, Jonge, H de Groot-de, van der Meulen, P A, de Weerd, D A, Niesters, H G M, van Leer-Buter, C C, Hoepelman, A I M, Ellerbroek, P M, Oosterheert, J J, Arends, J E, Barth, R E, Wassenberg, M W M, Schadd, E M, van Elst-Laurijssen, D H M, van Oers-Hazelzet, E E B, Wensing, A M J, Peters, E J G, van Agtmael, M A, Laan, L M, Pettersson, A M, Vandenbroucke-Grauls, C M J E, Ang, C W, Kinderziekenhuis, Wilhelmina, Geelen, S P M, Wolfs, T F W, Bont, L J, Bezemer, D O, van Sighem, A I, Boender, T S, Rademaker, M J, Pellegrin, J L, Vareil, M O, Dauchy, F A, Receveur, M C, Vandenhende, M A, Viallard, J F, Lafon, Me, Blaizeau, M J, Boerg, Eloïse, Law, Central M, Calvo, Central G, Sambeat, M A, Gennotte, A F, Payen, M C, Neaton, Central J, El-Sadr, W M, Abrams, D I, Crane, L R, Fischer, A H, Larsen, J F, Wien, Pulmologisches Zentrum der Stadt, Mitsura, V M, Møller, N F, Nielsen, L N, Smidt, Jelena, Siseklinik, Nakkusosakond, Viard, J-P, Stellbrink, H J, Goethe, J W, Sthoeger, Z M, Monforte, A D’Arminio, Annunziata, Ospedale S Maria, Blokhina, I N, Novogrod, Nizhny, Gatell, J M, Miró, J M, Rodriguez, J M, Laporte, J M, Johnson, A M, Johnson, M A, Morfeldt, Central L, Perri, G Di, Marchetti, G C, Perno, C F, Caputo, S Lo, Capobianchi, M R, Biagio, A Di, Roldan, E Quiros, Santoro, M M, Caro, A Di, Manconi, P E, Moioli, M C, Ridolfo, A L, Martino, F Di, Cattelan, A M, Ursitti, M A, Sulekova, L Fontanelli, Plazzi, M M, Del Vecchio, R Fontana, Giuli, C Di, Orofino, G C, Roger, P M, Braun, D L, Bucher, H C, Günthard, H F, Hirsch, H H, Kouyos, R D, de Tejada, B Martinez, Metzner, K J, Scherrer, A U, Valk, Marc vd, Han, W Min, Saint-Pierre, C H U, Miro, J M, Wasmuth, J C, Vehreschild, J J, McNicholl, I, Williams, E D, Volny-Anne, R Campo Alain, Dedes, Nikos, Mendão, Luis, Jakobsen, M L, Kumar, L Ramesh, Elsing, T W, and null, null

Abstract

Background: Mortality among people with HIV declined with the introduction of combination antiretroviral therapy. We investigated trends over time in all-cause and cause-specific mortality in people with HIV from 1999-2020. Methods: Data were collected from the D:A:D cohort from 1999 through January 2015 and RESPOND from October 2017 through 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV (CoDe), were calculated. Poisson regression models were used to assess mortality trends over time. Results: Among 55716 participants followed for a median of 6 years (IQR 3-11), 5263 participants died (crude mortality rate [MR] 13.7/1000 PYFU; 95%CI 13.4-14.1). Changing patterns of mortality were observed with AIDS as the most common cause of death between 1999- 2009 (n = 952, MR 4.2/1000 PYFU; 95%CI 4.0-4.5) and non-AIDS defining malignancy (NADM) from 2010 -2020 (n = 444, MR 2.8/1000 PYFU; 95%CI 2.5-3.1). In multivariable analysis, all-cause mortality declined over time (adjusted mortality rate ratio [aMRR] 0.97 per year; 95%CI 0.96, 0.98), mostly from 1999 through 2010 (aMRR 0.96 per year; 95%CI 0.95-0.97), and with no decline shown from 2011 through 2020 (aMRR 1·00 per year; 95%CI 0·96-1·05). Mortality due all known causes except NADM also declined over the entire follow-up period. Conclusion: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts decreased between 1999 and 2009 and was stable over the period from 2010 through 2020. The decline in mortality rates was not fully explained by improvements in immunologic-virologic status or other risk factors.

Published
2024

14. One Year of Long-Acting Cabotegravir and Rilpivirine in People With Human Immunodeficiency Virus and Long Exposure to Antiretroviral Therapy: Data From the SCohoLART Study.

Author

Muccini, Camilla, Gianotti, Nicola, Diotallevi, Sara, Lolatto, Riccardo, Spagnuolo, Vincenzo, Canetti, Diana, Bagaglio, Sabrina, Perez, Victoria Gordo, Clemente, Tommaso, Bottanelli, Martina, Candela, Caterina, Nozza, Silvia, and Castagna, Antonella

Subjects
HIV, EXPOSURE therapy, TERMINATION of treatment, ANTIRETROVIRAL agents, CONFIDENCE intervals
Abstract

Background The aim of the study was to evaluate the 12-month cumulative probability of treatment discontinuation (TD) in people with human immunodeficiency virus (HIV; PWH) and a long exposure to antiretroviral therapy (ART) switching to long-acting cabotegravir and rilpivirine (CAB/RPV). Methods SCohoLART is a single-center, prospective, cohort study designed to collect both samples and clinical data from PWH with virological suppression who switched to bimonthly long-acting CAB/RPV. TD occurred at switch to another regimen for any reason including virological failure (VF); VF was defined as HIV RNA levels ≥50 copies/mL at 2 consecutive measurements or a single HIV RNA level ≥1000 copies/mL. Results were reported as median (interquartile range [IQR]) or frequency (percentage). Cumulative probabilities of TD were estimated using Kaplan-Meier curves. Results We evaluated 514 participants; 467 (90.9%) were male, and their median age (IQR) was 49 (40–56) years. At the time of switching, the median time from HIV diagnosis and the median duration of ART were 14.0 (IQR, 8.8–20.5) and 11.4 (7.9–17.4) years, respectively; before starting CAB/RPV, the median number of antiretroviral regimens was 3 (2–4). During a median study follow-up (IQR) of 13.1 (9.1–15.5) months, 52 PWH (10.1%) experienced TD, including 4 (0.8%) for VF. The 12-month cumulative probability of TD was 11% (95% confidence interval, 8%–14%). The main cause of TD was injection site reaction (15 participants [28.8%]). Conclusions The 1-year cumulative probability of TD with long-acting CAB/RPV was quite low in this cohort of people with a median exposure to ART of 10 years, in whom injection site reaction was the leading cause of TD. VFs were rare during study follow-up. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Cohort profile: PRESTIGIO, an Italian prospective registry-based cohort of people with HIV-1 resistant to reverse transcriptase, protease and integrase inhibitors

Author

Clemente, Tommaso, primary, Galli, Laura, additional, Lolatto, Riccardo, additional, Gagliardini, Roberta, additional, Lagi, Filippo, additional, Ferrara, Micol, additional, Cattelan, Anna Maria, additional, Focà, Emanuele, additional, Di Biagio, Antonio, additional, Cervo, Adriana, additional, Calza, Leonardo, additional, Maggiolo, Franco, additional, Marchetti, Giulia, additional, Cenderello, Giovanni, additional, Rusconi, Stefano, additional, Zazzi, Maurizio, additional, Santoro, Maria Mercedes, additional, Spagnuolo, Vincenzo, additional, and Castagna, Antonella, additional

Published
2024
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16. Heavy arv exposure and exhausted/limited arv options: predictors and clinical outcomes

Author

Mocroft, Amanda, primary, Pelchen-Matthews, Annegret, additional, Hoy, Jennifer, additional, Llibre, Josep M., additional, Neesgaard, Bastian, additional, Jaschinski, Nadine, additional, Domingo, Pere, additional, Rasmussen, Line Dahlerup, additional, Günthard, Huldrych F., additional, Surial, Bernard, additional, Öllinger, Angela, additional, Knappik, Michael, additional, De Wit, Stephan, additional, Wit, Ferdinand, additional, Mussini, Cristina, additional, Vehreschild, Joerg, additional, Monforte, Antonella D’Arminio, additional, Sonnerborg, Anders, additional, Castagna, Antonella, additional, Anne, Alain Volny, additional, Vannappagari, Vani, additional, Cohen, Cal, additional, Greaves, Wayne, additional, Wasmuth, Jan C., additional, Spagnuolo, Vincenzo, additional, and Ryom, Lene, additional

Published
2023
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17. Bictegravir/Emtricitabine/Tenofovir Alafenamide Treatment: Efficacy and Tolerability in Clinical Practice

Author

Canetti, Diana, primary, Galli, Laura, additional, Lolatto, Riccardo, additional, Nozza, Silvia, additional, Spagnuolo, Vincenzo, additional, Muccini, Camilla, additional, Trentacapilli, Benedetta, additional, Bruzzesi, Elena, additional, Ranzenigo, Martina, additional, Chiurlo, Matteo, additional, Castagna, Antonella, additional, and Gianotti, Nicola, additional

Published
2023
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20. Correspondence.

Author

Borjesson, Rebecka Papaioannu, Galli, Laura, Lolatto, Riccardo, Menzaghi, Barbara, Feasi, Marcello, Gulminetti, Roberto, Fornabaio, Chiara, Cattelan, Anna Maria, Bonora, Stefano, Lagi, Filippo, Zazzi, Maurizio, Castagna, Antonella, and Spagnuolo, Vincenzo

Published
2024
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21. 2408. Is Shorter Antibiotic Treatment Feasible in Patients with Cardiac Implantable Electronic Devices (CIED) Infections? Impact of Treatment Duration on 6-Month Recurrence and Mortality

Author

Ponta, Giacomo, primary, Ranzenigo, Martina, additional, Marzi, Alessandra, additional, Oltolini, Chiara, additional, Din, Chiara Tassan, additional, Uberti-Foppa, Caterina, additional, Spagnuolo, Vincenzo, additional, Mazzone, Patrizio, additional, Della Bella, Paolo, additional, Scarpellini, Paolo, additional, Castagna, Antonella, additional, and Ripa, Marco, additional

Published
2023
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22. Sexually transmitted infections in people with multidrug-resistant HIV

Author

Clemente, Tommaso, primary, Lolatto, Riccardo, additional, Papaioannu Borjesson, Rebecka, additional, Fabbiani, Massimiliano, additional, Manzillo, Elio, additional, Fronti, Elisa, additional, Di Giambenedetto, Simona, additional, Gagliardini, Roberta, additional, Rusconi, Stefano, additional, Santoro, Maria M., additional, Castagna, Antonella, additional, and Spagnuolo, Vincenzo, additional

Published
2023
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23. Characterization and outcomes of difficult-to-treat patients starting modern first-line ART regimens: data from the ICONA cohort

Author

Gagliardini, Roberta, primary, Tavelli, Alessandro, additional, Rusconi, Stefano, additional, Lo Caputo, Sergio, additional, Spagnuolo, Vincenzo, additional, Santoro, Maria Mercedes, additional, Costantini, Andrea, additional, Vergori, Alessandra, additional, Maggiolo, Franco, additional, Giacomelli, Andrea, additional, Burastero, Giulia, additional, Madeddu, Giordano, additional, Quiros Roldan, Eugenia, additional, d'Arminio Monforte, Antonella, additional, Antinori, Andrea, additional, and Cozzi-Lepri, Alessandro, additional

Published
2023
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26. Risk of virological failure after drug burden reduction in people with 4-class drug-resistant HIV on virological suppression: A retrospective cohort analysis of data from the PRESTIGIO Registry

Author

Clemente, Tommaso, Diotallevi, Sara, Lolatto, Riccardo, Gagliardini, Roberta, Giacomelli, Andrea, Fiscon, Marta, Ferrara, Micol, Cervo, Adriana, Calza, Leonardo, Maggiolo, Franco, Rusconi, Stefano, Santoro, Maria Mercedes, Castagna, Antonella, and Spagnuolo, Vincenzo

Published
2024
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28. Regaining virological suppression in a woman living with a six‐class resistant HIV by combining injectable antiretroviral drugs guided by genotypic and phenotypic tests.

Author

Monti, Bianca, Soria, Alessandro, Saladini, Francesco, Lapadula, Giuseppe, Squillace, Nicola, Giammarino, Federica, Paletti, Chiara, Bartolini, Niccolò, Spagnuolo, Vincenzo, Castagna, Antonella, Zazzi, Maurizio, and Bonfanti, Paolo

Subjects
NUCLEOSIDE reverse transcriptase inhibitors, DRUG monitoring, SUBCUTANEOUS injections, HIV, PATIENT compliance
Abstract

This article discusses a case study of a 60-year-old woman living with HIV who had developed resistance to multiple classes of antiretroviral drugs. Despite various treatment adjustments, sustained virologic suppression remained elusive due to poor adherence and the accumulation of resistance mutations. The patient's viral sequence showed extensive resistance to multiple classes of drugs. However, through a combination of antivirals the patient was naïve to and the recycling of partially active drugs, virological control was regained. The article emphasizes the importance of a personalized therapy that meets the patient's desired quality of life and highlights the need for patient engagement and adherence for treatment efficacy. [Extracted from the article]

Published
2024
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30. Treatment success of rescue regimens after dual therapy failure in people living with HIV in a real-life setting

Author

Clemente, Tommaso, primary, Galli, Laura, additional, Poli, Andrea, additional, Papaioannu Borjesson, Rebecka, additional, Bresciani, Livia, additional, Muccini, Camilla, additional, Canetti, Diana, additional, Candela, Caterina, additional, Bossolasco, Simona, additional, Hasson, Hamid, additional, Castagna, Antonella, additional, and Spagnuolo, Vincenzo, additional

Published
2023
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31. Real-life use of high-dose anakinra in patients with COVID-19 treated with remdesivir.

Author

Monardo, Roberta, Mastrangelo, Andrea, Galli, Laura, Tomelleri, Alessandro, Spagnuolo, Vincenzo, Oltolini, Chiara, Ponta, Giacomo, Campochiaro, Corrado, Cavalli, Giulio, Dagna, Lorenzo, Ciceri, Fabio, Cinque, Paola, Scarpellini, Paolo, Castagna, Antonella, and Ripa, Marco

Abstract

Aim: Aim of this study was to evaluate the effect of anakinra (ANK) addition to remdesivir (RDV) on all-cause 28-day mortality in patients hospitalized with COVID-19. Patients & methods: ANK was administered intravenously at a dose of 5 mg/kg every 12 h in patients with severe respiratory failure and pronounced inflammatory status. 58 patients were treated with RDV + ANK, 219 patients with RDV. Results: The estimate of mortality at 28 days was 17.2% in the RDV + ANK group and 21.4% in the RDV group. Median time to death was 14 days in the RDV + ANK group and 19 in the RDV group. Conclusion: Despite severe respiratory failure and pronounced inflammatory status, patients who received RDV + ANK had similar mortality compared with patients who received RDV. In this study, we looked at hospitalized patients with COVID-19 pneumonia who were given different treatments. These included a combination therapy, an antiviral medication only or an antiviral and anti-inflammatory. Almost all patients received treatment with corticosteroids, another common anti-inflammatory medication that is currently part of standard COVID-19 treatment. Patients treated with the antiviral and anti-inflammatory showed more severe pneumonia compared with patients who received just the antiviral, probably reflecting the physicians' choice to give an anti-inflammatory to patients with a more serious clinical condition. Nevertheless, the mortality rate was similar in the two groups. The combination therapy of the antiviral and anti-inflammatory might improve mortality in COVID-19 patients with severe pneumonia to be comparable to mortality in patients with less severe clinical presentations. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Uptake and Discontinuation of Integrase Inhibitors (INSTIs) in a Large Cohort Setting

Author

Greenberg, Lauren, Ryom, Lene, Wandeler, Gilles, Grabmeier-Pfistershammer, Katharina, Öllinger, Angela, Neesgaard, Bastian, Stephan, Christoph, Calmy, Alexandra, Rauch, Andri, Castagna, Antonella, Spagnuolo, Vincenzo, Johnson, Margaret, Stingone, Christof, Mussini, Cristina, De Wit, Stéphane, Necsoi, Coca, Campins, Antoni A., Pradier, Christian, Stecher, Melanie, Wasmuth, Jan-Christian, Monforte, Antonella dʼArminio, Law, Matthew, Puhr, Rainer, Chkhartishvilli, Nikoloz, Tsertsvadze, Tengiz, Garges, Harmony, Thorpe, David, Lundgren, Jens D., Peters, Lars, Bansi-Matharu, Loveleen, and Mocroft, Amanda

Published
2020
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36. Inflammation burden score in multidrug-resistant HIV-1 infection

Author

Clemente, Tommaso, primary, Caccia, Roberta, additional, Galli, Laura, additional, Galli, Andrea, additional, Poli, Andrea, additional, Marchetti, Giulia Carla, additional, Bandera, Alessandra, additional, Zazzi, Maurizio, additional, Santoro, Maria Mercedes, additional, Cinque, Paola, additional, Castagna, Antonella, additional, and Spagnuolo, Vincenzo, additional

Published
2023
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37. Bictegravir/Emtricitabine/Tenofovir Alafenamide Treatment: Efficacy and Tolerability in Clinical Practice

Author

Canetti,Diana, Galli,Laura, Lolatto,Riccardo, Nozza,Silvia, Spagnuolo,Vincenzo, Muccini,Camilla, Trentacapilli,Benedetta, Bruzzesi,Elena, Ranzenigo,Martina, Chiurlo,Matteo, Castagna,Antonella, Gianotti,Nicola, Canetti,Diana, Galli,Laura, Lolatto,Riccardo, Nozza,Silvia, Spagnuolo,Vincenzo, Muccini,Camilla, Trentacapilli,Benedetta, Bruzzesi,Elena, Ranzenigo,Martina, Chiurlo,Matteo, Castagna,Antonella, and Gianotti,Nicola

Abstract

Diana Canetti,1 Laura Galli,1 Riccardo Lolatto,1 Silvia Nozza,2 Vincenzo Spagnuolo,1 Camilla Muccini,1 Benedetta Trentacapilli,2 Elena Bruzzesi,2 Martina Ranzenigo,2 Matteo Chiurlo,2 Antonella Castagna,1,2 Nicola Gianotti1 1Infectious Diseases Unit, San Raffaele Scientific Institute, Milan, Italy; 2Infectious Diseases Unit, Vita Salute San Raffaele University, Milan, ItalyCorrespondence: Diana Canetti, Infectious Diseases Unit San Raffaele Scientific Institute, Via Stamira D’Ancona 20, Milano, 20127, Italy, Tel +390226432461, Fax +390226437943, Email canetti.diana@hsr.itObjective: Analysis of bictegravir/emtricitabine/tenofovir alafenamide (BFTAF) efficacy and safety in virologically suppressed people living with HIV (PLWH) in clinical practice.Patients and methods: The retrospective cohort study, which included adult treatment-experienced and virologically suppressed PLWH, switched to BFTAF from June 2019 to June 2021. Efficacy and safety were evaluated as virological failure (VF=2 consecutive HIV-RNA> 50 copies/mL or a single HIV-RNA> 400 copies/mL) and treatment failure (TF=VF or discontinuation for any reason) until data freezing (August 2022).Results: Of the 1040 PLWH included, 67.8% switched from elvitegravir/cobicistat/FTAF. VF occurred in 4.2% (n=44), with incidence rate of 1.63 per 1000 person-months of follow-up (PMFU) and probability at 24– 30 months of 3.8%– 4.0%, respectively. Out of the 44 VF, in 75% virological re-suppression was achieved while maintaining BFTAF. Discontinuation occurred in 15% after a median time of 13.5 months of follow-up, with an incidence rate of 5.67 per 1000 PMFU, and a probability at 24– 30 months of 11.9%– 15.3%, respectively. Main discontinuation reasons were simplification (51.3%) and toxicity (21.8%, involving CNS in half of cases). TF occurred in 18.6% with an incidence rate of 7.01 per 1000 PMFU after a median time of 13.6 observation months; probability at 24– 30 months was 14.8%– 18.4%, respectively

Published
2023

38. High Risk of Secondary Infections Following Thrombotic Complications in Patients With COVID-19

Author

Ripa, Marco, Galli, Laura, D’Angelo, Armando, Apruzzi, Luca, Palumbo, Diego, Campochiaro, Corrado, Tassan Din, Chiara, Danise, Anna, Da Prat, Valentina, Vitali, Giordano, Brugliera, Luigia, Poli, Andrea, Monardo, Roberta, Monti, Giacomo, Baccellieri, Domenico, De Cobelli, Francesco, Clementi, Massimo, Iannaccone, Sandro, Dagna, Lorenzo, Rovere-Querini, Patrizia, Ciceri, Fabio, Tresoldi, Moreno, Zangrillo, Alberto, Scarpellini, Paolo, Castagna, Antonella, Andolina, Andrea, Bigoloni, Alba, Bossolasco, Simona, Bruzzesi, Elena, Canetti, Diana, Castiglioni, Barbara, Cernuschi, Massimo, Chiurlo, Matteo, Cinque, Paola, Dell’Acqua, Raffaele, Della Torre, Liviana, Gianotti, Nicola, Guffanti, Monica, Hasson, Hamid, Messina, Emanuela, Morsica, Giulia, Nozza, Silvia, Ranzenigo, Martina, Uberti-Foppa, Caterina, Vinci, Concetta, Badalucco Ciotta, Flavia, Bottanelli, Martina, Clemente, Tommaso, Mainardi, Ilaria, Mori, Giovanni, Papaioannu Borjesson, Rebecka, Ponta, Giacomo, Muccini, Camilla, Mastrangelo, Andrea, Oltolini, Chiara, Spagnuolo, Vincenzo, Benassi, Luca, Bigai, Giorgia, Bozzolo, Enrica, Borio, Giorgia, Bussolari, Cecilia, Calvisi, Stefania, Canti, Valentina, Castellani, Jacopo, Cavallo, Ludovica, Cilla, Marta, Cinel, Elena, Compagnone, Nicola, D’Aliberti, Teresa, Damanti, Sarah, De Lorenzo, Rebecca, Di Lucca, Giuseppe, Di Terlizzi, Gaetano, Dumea, Iulia, Farolfi, Federica, Ferrante, Marica, Frangi, Claudia, Gallina, Gabriele, Germinario Bruno, Nicolò, Lanzillotta, Marco, Li Voti, Raffaele, Marinosci, Alessandro, Martinenghi, Sabina, Memoli, Massimo, Montagna, Marco, Pascali, Maria, Patrizi, Alessandro, Pomaranzi, Chiara, Scotti, Raffaella, Strada, Silvia, Boffini, Nicola, Cavalli, Giulio, Della Torre, Emanuel, De Luca, Giacomo, Farina, Nicola, Moroni, Luca, Ramirez Giuseppe, Alvise, Tomelleri, Alessandro, Azzolini Maria, Luisa, Baiardo Redaelli, Martina, Calabrò Maria, Grazia, Casiraghi Giuseppina, Maria, Dell’Acqua, Antonio, Fresilli, Stefano, Guzzo, Francesca, Landoni, Giovanni, Lombardi, Gaetano, Maimeri, Nicolò, Moizo, Elena, Nisi Francesco, Giuseppe, Oriani, Alessandro, Ortalda, Alessandro, Pasculli, Nicola, Pieri, Marina, Turi, Stefano, Bertoglio, Luca, Bilman, Victor, Carletti, Silvia, Gona, Floriana, Mancini, Nicasio, Della Valle, Patrizia, Molinari, Chiara, Poloniato, Antonella, Lalla, Francesca, Prestifilippo, Dario, Sapienza, Jacopo, Seghi, Federico, Ripa, Marco, Galli, Laura, D’Angelo, Armando, Apruzzi, Luca, Palumbo, Diego, Campochiaro, Corrado, Tassan Din, Chiara, Danise, Anna, Da Prat, Valentina, Vitali, Giordano, Brugliera, Luigia, Poli, Andrea, Monardo, Roberta, Monti, Giacomo, Baccellieri, Domenico, De Cobelli, Francesco, Clementi, Massimo, Iannaccone, Sandro, Dagna, Lorenzo, Rovere-Querini, Patrizia, Ciceri, Fabio, Tresoldi, Moreno, Zangrillo, Alberto, Scarpellini, Paolo, Castagna, Antonella, Andolina, Andrea, Bigoloni, Alba, Bossolasco, Simona, Bruzzesi, Elena, Canetti, Diana, Castiglioni, Barbara, Cernuschi, Massimo, Chiurlo, Matteo, Cinque, Paola, Dell’Acqua, Raffaele, Della Torre, Liviana, Gianotti, Nicola, Guffanti, Monica, Hasson, Hamid, Messina, Emanuela, Morsica, Giulia, Nozza, Silvia, Ranzenigo, Martina, Uberti-Foppa, Caterina, Vinci, Concetta, Badalucco Ciotta, Flavia, Bottanelli, Martina, Clemente, Tommaso, Mainardi, Ilaria, Mori, Giovanni, Papaioannu Borjesson, Rebecka, Ponta, Giacomo, Muccini, Camilla, Mastrangelo, Andrea, Oltolini, Chiara, Spagnuolo, Vincenzo, Benassi, Luca, Bigai, Giorgia, Bozzolo, Enrica, Borio, Giorgia, Bussolari, Cecilia, Calvisi, Stefania, Canti, Valentina, Castellani, Jacopo, Cavallo, Ludovica, Cilla, Marta, Cinel, Elena, Compagnone, Nicola, D’Aliberti, Teresa, Damanti, Sarah, De Lorenzo, Rebecca, Di Lucca, Giuseppe, Di Terlizzi, Gaetano, Dumea, Iulia, Farolfi, Federica, Ferrante, Marica, Frangi, Claudia, Gallina, Gabriele, Germinario Bruno, Nicolò, Lanzillotta, Marco, Li Voti, Raffaele, Marinosci, Alessandro, Martinenghi, Sabina, Memoli, Massimo, Montagna, Marco, Pascali, Maria, Patrizi, Alessandro, Pomaranzi, Chiara, Scotti, Raffaella, Strada, Silvia, Boffini, Nicola, Cavalli, Giulio, Della Torre, Emanuel, De Luca, Giacomo, Farina, Nicola, Moroni, Luca, Ramirez Giuseppe, Alvise, Tomelleri, Alessandro, Azzolini Maria, Luisa, Baiardo Redaelli, Martina, Calabrò Maria, Grazia, Casiraghi Giuseppina, Maria, Dell’Acqua, Antonio, Fresilli, Stefano, Guzzo, Francesca, Landoni, Giovanni, Lombardi, Gaetano, Maimeri, Nicolò, Moizo, Elena, Nisi Francesco, Giuseppe, Oriani, Alessandro, Ortalda, Alessandro, Pasculli, Nicola, Pieri, Marina, Turi, Stefano, Bertoglio, Luca, Bilman, Victor, Carletti, Silvia, Gona, Floriana, Mancini, Nicasio, Della Valle, Patrizia, Molinari, Chiara, Poloniato, Antonella, Lalla, Francesca, Prestifilippo, Dario, Sapienza, Jacopo, and Seghi, Federico

Subjects
pulmonary embolism, Infectious Diseases, Oncology, bacteria, coronavirus, infections, thrombosis
Abstract

BackgroundThis study’s primary aim was to evaluate the impact of thrombotic complications on the development of secondary infections. The secondary aim was to compare the etiology of secondary infections in patients with and without thrombotic complications.MethodsThis was a cohort study (NCT04318366) of coronavirus disease 2019 (COVID-19) patients hospitalized at IRCCS San Raffaele Hospital between February 25 and June 30, 2020. Incidence rates (IRs) were calculated by univariable Poisson regression as the number of cases per 1000 person-days of follow-up (PDFU) with 95% confidence intervals. The cumulative incidence functions of secondary infections according to thrombotic complications were compared with Gray's method accounting for competing risk of death. A multivariable Fine-Gray model was applied to assess factors associated with risk of secondary infections.ResultsOverall, 109/904 patients had 176 secondary infections (IR, 10.0; 95% CI, 8.8–11.5; per 1000-PDFU). The IRs of secondary infections among patients with or without thrombotic complications were 15.0 (95% CI, 10.7–21.0) and 9.3 (95% CI, 7.9–11.0) per 1000-PDFU, respectively (P = .017). At multivariable analysis, thrombotic complications were associated with the development of secondary infections (subdistribution hazard ratio, 1.788; 95% CI, 1.018–3.140; P = .043). The etiology of secondary infections was similar in patients with and without thrombotic complications.ConclusionsIn patients with COVID-19, thrombotic complications were associated with a high risk of secondary infections.

Published
2022

39. Cardiac implantable electronic device infections: impact of initiation of antimicrobial treatment before or after device removal on microbiological yield

Author

Ponta, Giacomo, primary, Ranzenigo, Martina, additional, Marzi, Alessandra, additional, Oltolini, Chiara, additional, Tassan Din, Chiara, additional, Spagnuolo, Vincenzo, additional, Mazzone, Patrizio, additional, Carletti, Silvia, additional, Mancini, Nicasio, additional, Uberti-Foppa, Caterina, additional, Della Bella, Paolo, additional, Scarpellini, Paolo, additional, Castagna, Antonella, additional, and Ripa, Marco, additional

Published
2023
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40. Residual phenotypic susceptibility to doravirine in multidrug resistant HIV-1 from subjects enrolled in the PRESTIGIO Registry

Author

SALADINI, Francesco, primary, Giammarino, Federica, additional, Maggiolo, Franco, additional, Ferrara, Micol, additional, Cenderello, Giovanni, additional, Celesia, Benedetto M., additional, Martellotta, Ferdinando, additional, Spagnuolo, Vincenzo, additional, Corbelli, Giulio M., additional, Gianotti, Nicola, additional, Santoro, Maria M., additional, Rusconi, Stefano, additional, Zazzi, Maurizio, additional, and Castagna, Antonella, additional

Published
2023
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43. The propensity for long‐acting cabotegravir and rilpivirine every 2 months among HIV‐infected people eligible for treatment

Author

Alberton, Francesca, primary, Nozza, Silvia, additional, Raccagni, Angelo Roberto, additional, Galli, Laura, additional, Spagnuolo, Vincenzo, additional, Bossolasco, Simona, additional, Cernuschi, Massimo, additional, Canetti, Diana, additional, Hasson, Hamid, additional, Castagna, Antonella, additional, and Gianotti, Nicola, additional

Published
2022
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44. Prevalence and Risk Factors of Anal HPV Infection in MSM Living With HIV: Identifying the Target Groups to Prioritize for Immunization

Author

Bruzzesi, Elena, primary, Galli, Laura, additional, Poli, Andrea, additional, Bossolasco, Simona, additional, Cernuschi, Massimo, additional, Spagnuolo, Vincenzo, additional, Tamburini, Andrea Marco, additional, Canetti, Diana, additional, Messina, Emanuela, additional, Gianotti, Nicola, additional, Raccagni, Angelo Roberto, additional, Castagna, Antonella, additional, and Nozza, Silvia, additional

Published
2022
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45. Impact of Remdesivir on SARS-CoV-2 Clearance in a Real-Life Setting: A Matched-Cohort Study

Author

Spagnuolo, Vincenzo, primary, Voarino, Marta, additional, Tonelli, Marco, additional, Galli, Laura, additional, Poli, Andrea, additional, Bruzzesi, Elena, additional, Racca, Sara, additional, Clementi, Nicola, additional, Oltolini, Chiara, additional, Tresoldi, Moreno, additional, Rovere Querini, Patrizia, additional, Dagna, Lorenzo, additional, Zangrillo, Alberto, additional, Ciceri, Fabio, additional, Clementi, Massimo, additional, and Castagna, Antonella, additional

Published
2022
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46. Switching from a Non-Protease Inhibitor-Based Regimen to the Fixed Dose Combination of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide in Clinical Practice [Corrigendum]

Author

Ranzenigo, Martina, primary, Gianotti, Nicola, additional, Galli, Laura, additional, Poli, Andrea, additional, Mastrangelo, Andrea, additional, Bruzzesi, Elena, additional, Chiurlo, Matteo, additional, Nozza, Silvia, additional, Bossolasco, Simona, additional, Spagnuolo, Vincenzo, additional, Mancusi, Daniela, additional, Termini, Roberta, additional, Carini, Elisabetta, additional, Lazzarin, Adriano, additional, and Castagna, Antonella, additional

Published
2022
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48. Incidence of hypertension in people with HIV who are treated with integrase inhibitors versus other antiretroviral regimens in the RESPOND cohort consortium

Author

Byonanebye, Dathan M., Polizzotto, Mark N., Neesgaard, Bastian, Sarcletti, Mario, Matulionyte, Raimonda, Braun, Dominique L., Castagna, Antonella, de Wit, Stephane, Wit, Ferdinand, Fontas, Eric, Vehreschild, Joerg Janne, Vesterbacka, Jan, Greenberg, Lauren, Hatleberg, Camilla, Garges, Harmony, Gallant, Joel, Anne, Alain Volny, Oellinger, Angela, Mozer-Lisewska, Iwona, Surial, Bernard, Spagnuolo, Vincenzo, Necsoi, Coca, van der Valk, Marc, Mocroft, Amanda, Law, Matthew, Ryom, Lene, Petoumenos, Kathy, Byonanebye, Dathan M., Polizzotto, Mark N., Neesgaard, Bastian, Sarcletti, Mario, Matulionyte, Raimonda, Braun, Dominique L., Castagna, Antonella, de Wit, Stephane, Wit, Ferdinand, Fontas, Eric, Vehreschild, Joerg Janne, Vesterbacka, Jan, Greenberg, Lauren, Hatleberg, Camilla, Garges, Harmony, Gallant, Joel, Anne, Alain Volny, Oellinger, Angela, Mozer-Lisewska, Iwona, Surial, Bernard, Spagnuolo, Vincenzo, Necsoi, Coca, van der Valk, Marc, Mocroft, Amanda, Law, Matthew, Ryom, Lene, and Petoumenos, Kathy

Abstract

Objective To compare the incidence of hypertension in people living with HIV receiving integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) versus non-nucleoside reverse transcriptase inhibitors (NNRTIs) or boosted protease inhibitors (PIs) in the RESPOND consortium of HIV cohorts. Methods Eligible people with HIV were aged >= 18 years who initiated a new three-drug ART regimen for the first time (baseline), did not have hypertension, and had at least two follow-up blood pressure (BP) measurements. Hypertension was defined as two consecutive systolic BP measurements >= 140 mmHg and/or diastolic BP >= 90 mmHg or initiation of antihypertensives. Multivariable Poisson regression was used to determine adjusted incidence rate ratios (aIRRs) of hypertension, overall and in those who were ART naive or experienced at baseline. Results Overall, 4606 people living with HIV were eligible (INSTIs 3164, NNRTIs 807, PIs 635). The median baseline systolic BP, diastolic BP, and age were 120 (interquartile range [IQR] 113-130) mmHg, 78 (70-82) mmHg, and 43 (34-50) years, respectively. Over 8380.4 person-years (median follow-up 1.5 [IQR 1.0-2.7] years), 1058 (23.0%) participants developed hypertension (incidence rate 126.2/1000 person-years, 95% confidence interval [CI] 118.9-134.1). Participants receiving INSTIs had a higher incidence of hypertension than those receiving NNRTIs (aIRR 1.76; 95% CI 1.47-2.11), whereas the incidence was no different in those receiving PIs (aIRR 1.07; 95% CI 0.89-1.29). The results were similar when the analysis was stratified by ART status at baseline. Conclusion Although unmeasured confounding and channelling bias cannot be excluded, INSTIs were associated with a higher incidence of hypertension than were NNRTIs, but rates were similar to those of PIs overall, in ART-naive and ART-experienced participants within RESPOND.

Published
2022

49. Switching from a Non-Protease inhibitor-Based Regimen To the Fixed Dose Combination of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide in Clinical Practice

Author

Ranzenigo,Martina, Gianotti,Nicola, Galli,Laura, Poli,Andrea, Mastrangelo,Andrea, Bruzzesi,Elena, Chiurlo,Matteo, Nozza,Silvia, Bossolasco,Simona, Spagnuolo,Vincenzo, Mancusi,Daniela, Termini,Roberta, Carini,Elisabetta, Lazzarin,Adriano, Castagna,Antonella, Ranzenigo,Martina, Gianotti,Nicola, Galli,Laura, Poli,Andrea, Mastrangelo,Andrea, Bruzzesi,Elena, Chiurlo,Matteo, Nozza,Silvia, Bossolasco,Simona, Spagnuolo,Vincenzo, Mancusi,Daniela, Termini,Roberta, Carini,Elisabetta, Lazzarin,Adriano, and Castagna,Antonella

Abstract

Martina Ranzenigo,1,2 Nicola Gianotti,2 Laura Galli,2 Andrea Poli,2 Andrea Mastrangelo,1,2 Elena Bruzzesi,1,2 Matteo Chiurlo,1,2 Silvia Nozza,2 Simona Bossolasco,2 Vincenzo Spagnuolo,2 Daniela Mancusi,3 Roberta Termini,3 Elisabetta Carini,2 Adriano Lazzarin,2 Antonella Castagna1,2 1Vita-Salute San Raffaele University, Milan, Italy; 2Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy; 3Medical Affairs Department, Infectious Disease and Vaccines & PAH, Janssen-Cilag SpA, Cologno Monzese, ItalyCorrespondence: Daniela Mancusi, Medical Affairs Department, Infectious Disease and Vaccines & PAH, Janssen-Cilag SpA, Via Buonarroti 23, Cologno Monzese (MI), 20093, Italy, Tel +0039-345 9581944, Email dmancusi@its.jnj.comBackground: The primary objective of this study was to estimate the proportion of people living with HIV (PLWH) who switched from a non-protease inhibitor (PI)-based regimen [integrase strand transfer inhibitor (InSTI)-based or non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimen] to darunavir, cobicistat, emtricitabine, tenofovir alafenamide (D/C/F/TAF).Methods: This was a retrospective study on PLWH treated with a non-PI regimen in January 2017, who switched to D/C/F/TAF or to another antiretroviral therapy (ART) within November 2019. Follow-up was from the start date of D/C/F/TAF until the last available visit or discontinuation for any reason of this regimen. Virological failure (VF) was defined as 2 consecutive HIV-RNA values > 50 copies/mL. Characteristics were reported as median (interquartile range) or frequency (%). A univariate Poisson regression model was used to measure the incidence rate of switch to D/C/F/TAF. Changes in laboratory parameters during D/C/F/TAF were assessed by univariate mixed linear models.Results: Overall, 3076 PLWH were included; 83% were male, median age at ART switch was 50 (42– 56) years and median time on ART was 5.2 (0.3– 13.0) years. PLWH had a median follow-up of 4.76

Published
2022

50. Impact of Remdesivir on SARS-CoV-2 Clearance in a Real-Life Setting: A Matched-Cohort Study

Author

Spagnuolo,Vincenzo, Voarino,Marta, Tonelli,Marco, Galli,Laura, Poli,Andrea, Bruzzesi,Elena, Racca,Sara, Clementi,Nicola, Oltolini,Chiara, Tresoldi,Moreno, Rovere Querini,Patrizia, Dagna,Lorenzo, Zangrillo,Alberto, Ciceri,Fabio, Clementi,Massimo, Castagna,Antonella, Spagnuolo,Vincenzo, Voarino,Marta, Tonelli,Marco, Galli,Laura, Poli,Andrea, Bruzzesi,Elena, Racca,Sara, Clementi,Nicola, Oltolini,Chiara, Tresoldi,Moreno, Rovere Querini,Patrizia, Dagna,Lorenzo, Zangrillo,Alberto, Ciceri,Fabio, Clementi,Massimo, and Castagna,Antonella

Abstract

Vincenzo Spagnuolo,1 Marta Voarino,2 Marco Tonelli,2,3 Laura Galli,1 Andrea Poli,1 Elena Bruzzesi,2 Sara Racca,3 Nicola Clementi,2,3 Chiara Oltolini,1 Moreno Tresoldi,4 Patrizia Rovere Querini,2,5 Lorenzo Dagna,2,6 Alberto Zangrillo,2,7 Fabio Ciceri,2,8 Massimo Clementi,2,3 Antonella Castagna1,2 On behalf of the COVID-BioB Study Group1Unit of Infectious Diseases, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), San Raffaele Scientific Institute, Milan, Italy; 2Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Milan, Italy; 3Unit of Microbiology and Virology, IRCCS San Raffaele Scientific Institute, Milan, Italy; 4General Medicine and Advanced Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; 5Internal Medicine, Diabetes, and Endocrinology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; 6Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy; 7Anesthesia and Intensive Care Department, IRCCS San Raffaele Scientific Institute, Milan, Italy; 8Hematology and Bone Marrow Transplant Unit, IRCCS San Raffaele Scientific Institute, Milan, ItalyCorrespondence: Vincenzo Spagnuolo, Unit of Infectious Diseases, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), San Raffaele Scientific Institute, Milan, Italy, Tel +390226437907, Fax +390226437903, Email spagnuolo.vincenzo@hsr.itBackground: Evidence regarding the impact of remdesivir (RDV) on SARS-CoV-2 viral clearance (VC) is scarce. The aim of this study was to compare VC timing in hospitalized COVID-19 patients who did or did not receive RDV.Methods: This was a matched-cohort study of patients hospitalized with pneumonia, a SARS-CoV-2-positive nasopharyngeal swab (NPS) at admission, and at least one NPS during follow-up. Patients who received RDV (cases) and those who did not (controls) were matched in a 1:2 ratio by age, sex, and PaO2/FiO2 (P/F) values at admission. NPSs were analyzed using real-tim

Published
2022

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